LOCUS       NM_031184               3619 bp    mRNA    linear   ROD 13-MAY-2024
DEFINITION  Mus musculus GLIS family zinc finger 2 (Glis2), mRNA.
ACCESSION   NM_031184
VERSION     NM_031184.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3619)
  AUTHORS   Zhang,C., Rehman,M., Tian,X., Pei,S.L.C., Gu,J., Bell,T.A. 3rd,
            Dong,K., Tham,M.S., Cai,Y., Wei,Z., Behrens,F., Jetten,A.M.,
            Zhao,H., Lek,M. and Somlo,S.
  TITLE     Glis2 is an early effector of polycystin signaling and a target for
            therapy in polycystic kidney disease
  JOURNAL   Nat Commun 15 (1), 3698 (2024)
   PUBMED   38693102
  REMARK    GeneRIF: Glis2 is an early effector of polycystin signaling and a
            target for therapy in polycystic kidney disease.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3619)
  AUTHORS   Wang,T., Chen,Y., Liu,Z., Zhou,J., Li,N., Shan,Y. and He,Y.
  TITLE     Long noncoding RNA Glis2 regulates podocyte mitochondrial
            dysfunction and apoptosis in diabetic nephropathy via sponging
            miR-328-5p
  JOURNAL   J Cell Mol Med 28 (7), e18204 (2024)
   PUBMED   38506068
  REMARK    GeneRIF: Long noncoding RNA Glis2 regulates podocyte mitochondrial
            dysfunction and apoptosis in diabetic nephropathy via sponging
            miR-328-5p.
REFERENCE   3  (bases 1 to 3619)
  AUTHORS   Zhang,H., Zhou,P., Xing,W., Chen,L., Zhou,Y., Yang,H., Fu,K. and
            Liu,Z.
  TITLE     GLIS2 Prevents Hepatic Fibrosis by Competitively Binding HDAC3 to
            Inhibit Hepatic Stellate Cell Activation
  JOURNAL   Cell Mol Gastroenterol Hepatol 15 (2), 355-372 (2023)
   PUBMED   36397300
  REMARK    GeneRIF: GLIS2 Prevents Hepatic Fibrosis by Competitively Binding
            HDAC3 to Inhibit Hepatic Stellate Cell Activation.
REFERENCE   4  (bases 1 to 3619)
  AUTHORS   Thirouard,L., Holota,H., Monrose,M., Garcia,M., de Haze,A.,
            Damon-Soubeyrand,C., Renaud,Y., Saru,J.P., Perino,A.,
            Schoonjans,K., Beaudoin,C. and Volle,D.H.
  TITLE     Identification of a Crosstalk among TGR5, GLIS2, and TP53 Signaling
            Pathways in the Control of Undifferentiated Germ Cell Homeostasis
            and Chemoresistance
  JOURNAL   Adv Sci (Weinh) 9 (17), e2200626 (2022)
   PUBMED   35435331
  REMARK    GeneRIF: Identification of a Crosstalk among TGR5, GLIS2, and TP53
            Signaling Pathways in the Control of Undifferentiated Germ Cell
            Homeostasis and Chemoresistance.
REFERENCE   5  (bases 1 to 3619)
  AUTHORS   Niborski,L.L., Paces-Fessy,M., Ricci,P., Bourgeois,A.,
            Magalhaes,P., Kuzma-Kuzniarska,M., Lesaulnier,C., Reczko,M.,
            Declercq,E., Zurbig,P., Doucet,A., Umbhauer,M. and Cereghini,S.
  TITLE     Hnf1b haploinsufficiency differentially affects developmental
            target genes in a new renal cysts and diabetes mouse model
  JOURNAL   Dis Model Mech 14 (5) (2021)
   PUBMED   33737325
REFERENCE   6  (bases 1 to 3619)
  AUTHORS   Sharov,A.A., Piao,Y., Matoba,R., Dudekula,D.B., Qian,Y.,
            VanBuren,V., Falco,G., Martin,P.R., Stagg,C.A., Bassey,U.C.,
            Wang,Y., Carter,M.G., Hamatani,T., Aiba,K., Akutsu,H., Sharova,L.,
            Tanaka,T.S., Kimber,W.L., Yoshikawa,T., Jaradat,S.A., Pantano,S.,
            Nagaraja,R., Boheler,K.R., Taub,D., Hodes,R.J., Longo,D.L.,
            Schlessinger,D., Keller,J., Klotz,E., Kelsoe,G., Umezawa,A.,
            Vescovi,A.L., Rossant,J., Kunath,T., Hogan,B.L., Curci,A.,
            D'Urso,M., Kelso,J., Hide,W. and Ko,M.S.
  TITLE     Transcriptome analysis of mouse stem cells and early embryos
  JOURNAL   PLoS Biol 1 (3), E74 (2003)
   PUBMED   14691545
REFERENCE   7  (bases 1 to 3619)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 3619)
  AUTHORS   Phan,L.K., Lin,F., LeDuc,C.A., Chung,W.K. and Leibel,R.L.
  TITLE     The mouse mahoganoid coat color mutation disrupts a novel C3HC4
            RING domain protein
  JOURNAL   J Clin Invest 110 (10), 1449-1459 (2002)
   PUBMED   12438443
REFERENCE   9  (bases 1 to 3619)
  AUTHORS   Zhang,F., Nakanishi,G., Kurebayashi,S., Yoshino,K., Perantoni,A.,
            Kim,Y.S. and Jetten,A.M.
  TITLE     Characterization of Glis2, a novel gene encoding a Gli-related,
            Kruppel-like transcription factor with transactivation and
            repressor functions. Roles in kidney development and neurogenesis
  JOURNAL   J Biol Chem 277 (12), 10139-10149 (2002)
   PUBMED   11741991
  REMARK    GeneRIF: Characterization of Glis2, a novel gene encoding a
            Gli-related, Kruppel-like transcription factor with transactivation
            and repressor functions
REFERENCE   10 (bases 1 to 3619)
  AUTHORS   Lamar,E., Kintner,C. and Goulding,M.
  TITLE     Identification of NKL, a novel Gli-Kruppel zinc-finger protein that
            promotes neuronal differentiation
  JOURNAL   Development 128 (8), 1335-1346 (2001)
   PUBMED   11262234
  REMARK    GeneRIF: positive regulator of neuronal differentiation
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CF727873.1, CX563691.1, CN703218.1 and AC087899.40.
            
            On May 9, 2006 this sequence version replaced NM_031184.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC021517.1, SRR7652917.96793.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-444               CF727873.1         1-444
            445-1047            CX563691.1         122-724
            1048-1192           CN703218.1         519-663
            1193-3619           AC087899.40        71594-74020         c
FEATURES             Location/Qualifiers
     source          1..3619
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="16"
                     /map="16 2.45 cM"
     gene            1..3619
                     /gene="Glis2"
                     /gene_synonym="Gli5; Klf16; Nkl"
                     /note="GLIS family zinc finger 2"
                     /db_xref="GeneID:83396"
                     /db_xref="MGI:MGI:1932535"
     exon            1..223
                     /gene="Glis2"
                     /gene_synonym="Gli5; Klf16; Nkl"
                     /inference="alignment:Splign:2.1.0"
     exon            224..444
                     /gene="Glis2"
                     /gene_synonym="Gli5; Klf16; Nkl"
                     /inference="alignment:Splign:2.1.0"
     CDS             273..1838
                     /gene="Glis2"
                     /gene_synonym="Gli5; Klf16; Nkl"
                     /note="Kruppel-like factor 16 (neuronal); GLI-Kruppel
                     family member GLI5; GLI-similar 2; zinc finger protein
                     GLI5; neuronal Krueppel-like protein"
                     /codon_start=1
                     /product="zinc finger protein GLIS2"
                     /protein_id="NP_112461.2"
                     /db_xref="CCDS:CCDS27920.1"
                     /db_xref="GeneID:83396"
                     /db_xref="MGI:MGI:1932535"
                     /translation="MHSLDEPLDLKLSITKLRAAREKRERTLGVVRHHALHRELGLVD
                     DSPAPGSPGSPPPGFLLNPKFPEKVDGRFSAAPLVDLSLSPPSGLDSPNGSSSLSPEC
                     QGNGDLPPLPTAVDFQPLRYLDGVPSSFQFFLPLGSGGALHLPASSFLPPPKDKCLSP
                     ELPLAKQLVCRWAKCNQLFELLQDLVDHVNDHHVKPEQDARYCCHWEGCARHGRGFNA
                     RYKMLIHIRTHTNEKPHRCPTCNKSFSRLENLKIHNRSHTGEKPYVCPYEGCNKRYSN
                     SSDRFKHTRTHYVDKPYYCKMPGCHKRYTDPSSLRKHIKAHGHFVSHEQQELLQLRPP
                     PKPPLPTPDSGSYVSGAQIIIPNPAALFGGPSLPGLPLPLPPGPLDLSALACGNGGGG
                     GGGIGPGLPGSVLPLNLAKNPLLPSPFGAGGLGLPVVSLLGGSAGSKAEGEKGRGSVP
                     ARVLGLEDHKTPLERTERSRSRPSPDGLPLLPGTVLDLSTGNSAASSPEVLTPGWVVI
                     PPGSVLLKPAVVN"
     exon            445..617
                     /gene="Glis2"
                     /gene_synonym="Gli5; Klf16; Nkl"
                     /inference="alignment:Splign:2.1.0"
     exon            618..794
                     /gene="Glis2"
                     /gene_synonym="Gli5; Klf16; Nkl"
                     /inference="alignment:Splign:2.1.0"
     exon            795..928
                     /gene="Glis2"
                     /gene_synonym="Gli5; Klf16; Nkl"
                     /inference="alignment:Splign:2.1.0"
     exon            929..1047
                     /gene="Glis2"
                     /gene_synonym="Gli5; Klf16; Nkl"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..3619
                     /gene="Glis2"
                     /gene_synonym="Gli5; Klf16; Nkl"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3585..3590
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Glis2"
                     /gene_synonym="Gli5; Klf16; Nkl"
                     /note="hexamer: AATAAA"
     polyA_site      3615
                     /gene="Glis2"
                     /gene_synonym="Gli5; Klf16; Nkl"
                     /note="major polyA site"
ORIGIN      
        1 cttgcaaaga catccccgca cagcccggcc gccgcggcca ccttccctgc cccgagctgc
       61 agatgtggcg gagcggccgg gtgccgcgcg gcgccagggg agcccgtgcc ccgtaagcct
      121 cgcgccccgg cccccgcccg ccccggccct ccccctcgcc cgctccccgc tgccccagga
      181 ccgccggaac ccgcagccgg agccagtcag cccggcagcc gaggttcctg cctcaagacc
      241 agttgggtac atctttgaca cgccctccca ccatgcactc cttggacgag cccctcgacc
      301 taaagctgag catcaccaag ctccgagcgg caagagagaa gagagaaagg acactgggtg
      361 tggtccggca tcatgctttg catcgagagc tgggcctggt ggacgatagc cccgcccctg
      421 gctccccagg ctctccacca ccaggtttcc tgctgaaccc caaattccct gagaaggtgg
      481 acggacgctt ttctgcagcc cccttggtgg acctcagctt gtcaccaccc tctggactgg
      541 actctcccaa tggcagcagc tccctgtctc ctgagtgcca gggcaatggg gacttgcctc
      601 cactgcctac tgctgtggat ttccagccac ttcgctattt ggatggtgtc cccagttcct
      661 tccagttctt cttgcccctg ggttctggtg gggctctgca cctacctgct tcctccttcc
      721 ttcccccccc caaggacaag tgcctctcac cagagctgcc cctggccaag cagctggtgt
      781 gtcgatgggc caagtgtaac cagctctttg agctcctcca agacctggtt gaccatgtca
      841 acgaccatca tgtcaagcct gaacaggatg ctcgatactg ctgtcattgg gagggctgcg
      901 cccgccatgg ccgtggcttc aatgccaggt acaagatgct cattcacatc cggacacaca
      961 ccaacgagaa gccgcaccga tgccccacct gtaacaagag cttctcccgc ctggagaacc
     1021 tgaagatcca caaccgctcc cacacaggtg agaagcccta cgtctgcccc tatgagggct
     1081 gcaacaagcg ttactccaac tccagtgacc gcttcaagca cacccgtacc cactacgtag
     1141 acaagcccta ctactgcaag atgcccggct gtcacaagcg ttacacggac cccagttcac
     1201 tgcgcaaaca catcaaggcc catggccact ttgtgtcaca tgagcagcag gagctcctgc
     1261 agctgcgccc accccctaaa ccaccactgc ccactcctga cagtggctcc tatgtcagcg
     1321 gggctcagat catcatcccg aaccctgctg ccctttttgg aggccccagt ctgcctggcc
     1381 tgccattacc tctacctcct ggcccccttg acctcagtgc tctggcctgt ggcaatggtg
     1441 gaggtggggg tgggggtatt ggccctgggc tgccaggctc tgttctgccc ctcaatctgg
     1501 ccaagaaccc gctgttgccc tcaccctttg gggctggtgg actaggcctg cctgtggttt
     1561 ctctcctggg tggctctgcc ggtagcaagg ccgaggggga gaagggtcgt gggtcagtac
     1621 ctgccagggt cctgggcctg gaagatcaca agacgcccct ggaaaggacg gagcgcagcc
     1681 gctcccggcc aagccctgat ggactccctt tgctcccagg cactgtactg gacctgtcca
     1741 caggcaactc agcagccagc agtccagagg tgttaactcc tggctgggtg gtcattccac
     1801 cagggtctgt gctgctcaaa ccagctgtgg taaactgaaa ctgggcaacc catctaccag
     1861 ctgtgacagc ccagccacct accgtgggct catcccccga cgaacagaaa ctcttctgcg
     1921 aaatagcaat aatatcctac tgccccaggg ccaagctgca gccccagaca agctgggtgg
     1981 caaggtggca aggatggtgc tagaaggtct gtgctggcct cctggctcca aagtgaggac
     2041 ttggcttgga cctgctgtcc aagaagagcc attctcttgg gtgctaaggc ctcaatcact
     2101 tccatttccc tagtctgtag tctgggtgag gcctttgcct gtcctcccag gacgctcagt
     2161 cctgcctctt gctctggtgc gttcctctct atggccaccc tggctgggca gggttccagt
     2221 cctccctgcc ttacctactt gtcagctagg agcccccagt gatcatagat aggcccacac
     2281 ttgggaattc cttagacccc tttccctctg gtccacctct agagggagag caagacagac
     2341 actgctgcct tctcctgcct gctgctatga caaggtgctt ctctgcttgc ttagcagaga
     2401 agcctgctct gccagcactt ctctttcctg ccagagggtt ggcaatactt tccaaagagg
     2461 aggggtagct gaccactcaa ccttctcctt ggggatgtgc aggcaggtac aagggtcact
     2521 gtgctgacct ggcccggctt ggcctggcct gagcagtgtt actctgcaga agcttataag
     2581 gcactagtct acaccacgtg ggctctcaag cttgggacac agctacaggt ttgggggcac
     2641 caagtaatgg gatgcaggga agaagactca ttggaaaggc gctttctaga aagcactgac
     2701 tgaagcccct gagtgttaag ggaggctagg cagccaagca cagcattagc ttgggaaaaa
     2761 gctagctaga gaaaggcctg gccatctggc agggttcttt cctgactcta gttgaaccct
     2821 tttcttggtg ctgcctctct tgcccatgag ctctgcccaa gccagcgacc ccagggcttg
     2881 tgcaacaaac caaggacatt ggaggactgt gtgctccata gctccaaaag gctagctgcc
     2941 ccagcttggg cttcttgctg tcccctgtac tatgctgcag tggctaagcc cctcatgtcc
     3001 ccatctgtag aacaagagag ctgctgaggt gctagtgggt ccttggctct gtggttcctc
     3061 tgagcagttc tgtctagtct ttttctcaga ctgcctttct gtttcagaag ggtcaccctt
     3121 ccctaaccta cctgactgct ggccttagaa ccccagccct gatggggctc ggctgtgctg
     3181 gctctccttg atggggctgt gagcaagtta aggagctggt ctcctacctt tgggtctgcc
     3241 taggatccaa gcaactcctg gctctattag ggtcctaggc cttaagtccc tggctggggg
     3301 atttggtttg agactcaagc caaggagaag aacagagcac tggacattag ctcagcatgt
     3361 gactcaagtg atagaccagg ctcagaaggg ctggttactt cctgtcagtt tgttgcacat
     3421 tccaggattc agtattttaa caggttctaa gtgcctttct cttgtagtgt atggttttcc
     3481 tccttctggc tccatggctg ttagcataga gtttaaaaaa agagagataa gctaatgact
     3541 ataacaatat attcctccat gggagaggaa gtttatacag aaacaataaa gtgagttgca
     3601 aagatggttt ctgcacgtg
//
