LOCUS       NM_147221               2904 bp    mRNA    linear   ROD 07-FEB-2025
DEFINITION  Mus musculus GLIS family zinc finger 1 (Glis1), mRNA.
ACCESSION   NM_147221
VERSION     NM_147221.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2904)
  AUTHORS   Rong,D., Wang,Y., Liu,L., Cao,H., Huang,T., Liu,H., Hao,X., Sun,G.,
            Sun,G., Zheng,Z., Kang,J., Xia,Y., Chen,Z., Tang,W. and Wang,X.
  TITLE     GLIS1 intervention enhances anti-PD1 therapy for hepatocellular
            carcinoma by targeting SGK1-STAT3-PD1 pathway
  JOURNAL   J Immunother Cancer 11 (2) (2023)
   PUBMED   36787938
  REMARK    GeneRIF: GLIS1 intervention enhances anti-PD1 therapy for
            hepatocellular carcinoma by targeting SGK1-STAT3-PD1 pathway.
REFERENCE   2  (bases 1 to 2904)
  AUTHORS   Nair,K.S., Srivastava,C., Brown,R.V., Koli,S., Choquet,H.,
            Kang,H.S., Kuo,Y.M., Grimm,S.A., Sutherland,C., Badea,A.,
            Johnson,G.A., Zhao,Y., Yin,J., Okamoto,K., Clark,G., Borras,T.,
            Zode,G., Kizhatil,K., Chakrabarti,S., John,S.W.M., Jorgenson,E. and
            Jetten,A.M.
  TITLE     GLIS1 regulates trabecular meshwork function and intraocular
            pressure and is associated with glaucoma in humans
  JOURNAL   Nat Commun 12 (1), 4877 (2021)
   PUBMED   34385434
  REMARK    GeneRIF: GLIS1 regulates trabecular meshwork function and
            intraocular pressure and is associated with glaucoma in humans.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2904)
  AUTHORS   Wang,H., Yang,C., Li,Y., Zhao,S., Ma,P. and Mao,B.
  TITLE     RNF220-mediated ubiquitination promotes aggresomal accumulation and
            autophagic degradation of cytoplasmic Gli via HDAC6
  JOURNAL   Biochem Biophys Res Commun 557, 323-328 (2021)
   PUBMED   33895473
  REMARK    GeneRIF: RNF220-mediated ubiquitination promotes aggresomal
            accumulation and autophagic degradation of cytoplasmic Gli via
            HDAC6.
REFERENCE   4  (bases 1 to 2904)
  AUTHORS   Li,L., Chen,K., Wang,T., Wu,Y., Xing,G., Chen,M., Hao,Z., Zhang,C.,
            Zhang,J., Ma,B., Liu,Z., Yuan,H., Liu,Z., Long,Q., Zhou,Y., Qi,J.,
            Zhao,D., Gao,M., Pei,D., Nie,J., Ye,D., Pan,G. and Liu,X.
  TITLE     Glis1 facilitates induction of pluripotency via an
            epigenome-metabolome-epigenome signalling cascade
  JOURNAL   Nat Metab 2 (9), 882-892 (2020)
   PUBMED   32839595
  REMARK    GeneRIF: Glis1 facilitates induction of pluripotency via an
            epigenome-metabolome-epigenome signalling cascade.
            Erratum:[Nat Metab. 2020 Oct;2(10):1179. doi:
            10.1038/s42255-020-00308-0.. PMID: 33033400]
REFERENCE   5  (bases 1 to 2904)
  AUTHORS   Guzzetta,A., Koska,M., Rowton,M., Sullivan,K.R., Jacobs-Li,J.,
            Kweon,J., Hidalgo,H., Eckart,H., Hoffmann,A.D., Back,R., Lozano,S.,
            Moon,A.M., Basu,A., Bressan,M., Pott,S. and Moskowitz,I.P.
  TITLE     Hedgehog-FGF signaling axis patterns anterior mesoderm during
            gastrulation
  JOURNAL   Proc Natl Acad Sci U S A 117 (27), 15712-15723 (2020)
   PUBMED   32561646
  REMARK    GeneRIF: Hedgehog-FGF signaling axis patterns anterior mesoderm
            during gastrulation.
REFERENCE   6  (bases 1 to 2904)
  AUTHORS   Guo,G., Huss,M., Tong,G.Q., Wang,C., Li Sun,L., Clarke,N.D. and
            Robson,P.
  TITLE     Resolution of cell fate decisions revealed by single-cell gene
            expression analysis from zygote to blastocyst
  JOURNAL   Dev Cell 18 (4), 675-685 (2010)
   PUBMED   20412781
REFERENCE   7  (bases 1 to 2904)
  AUTHORS   Yokoyama,S., Ito,Y., Ueno-Kudoh,H., Shimizu,H., Uchibe,K.,
            Albini,S., Mitsuoka,K., Miyaki,S., Kiso,M., Nagai,A., Hikata,T.,
            Osada,T., Fukuda,N., Yamashita,S., Harada,D., Mezzano,V., Kasai,M.,
            Puri,P.L., Hayashizaki,Y., Okado,H., Hashimoto,M. and Asahara,H.
  TITLE     A systems approach reveals that the myogenesis genome network is
            regulated by the transcriptional repressor RP58
  JOURNAL   Dev Cell 17 (6), 836-848 (2009)
   PUBMED   20059953
REFERENCE   8  (bases 1 to 2904)
  AUTHORS   Nakashima,M., Tanese,N., Ito,M., Auerbach,W., Bai,C., Furukawa,T.,
            Toyono,T., Akamine,A. and Joyner,A.L.
  TITLE     A novel gene, GliH1, with homology to the Gli zinc finger domain
            not required for mouse development
  JOURNAL   Mech Dev 119 (1), 21-34 (2002)
   PUBMED   12385751
  REMARK    GeneRIF: GliH1 has homology to the Gli zinc finger domain but is
            not required for mouse development
REFERENCE   9  (bases 1 to 2904)
  AUTHORS   Kim,Y.S., Lewandoski,M., Perantoni,A.O., Kurebayashi,S.,
            Nakanishi,G. and Jetten,A.M.
  TITLE     Identification of Glis1, a novel Gli-related, Kruppel-like zinc
            finger protein containing transactivation and repressor functions
  JOURNAL   J Biol Chem 277 (34), 30901-30913 (2002)
   PUBMED   12042312
  REMARK    GeneRIF: Glis1 may play a critical role in the control of gene
            expression during specific stages of embryonic development.
REFERENCE   10 (bases 1 to 2904)
  AUTHORS   Zhang,F., Nakanishi,G., Kurebayashi,S., Yoshino,K., Perantoni,A.,
            Kim,Y.S. and Jetten,A.M.
  TITLE     Characterization of Glis2, a novel gene encoding a Gli-related,
            Kruppel-like transcription factor with transactivation and
            repressor functions. Roles in kidney development and neurogenesis
  JOURNAL   J Biol Chem 277 (12), 10139-10149 (2002)
   PUBMED   11741991
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL626784.11, AL627259.8, BC066157.1 and AK145342.1.
            
            On Feb 2, 2007 this sequence version replaced NM_147221.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF486579.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-179               AL626784.11        116935-117113
            180-477             AL626784.11        117856-118153
            478-646             AL627259.8         36477-36645
            647-1373            AL627259.8         40251-40977
            1374-2121           BC066157.1         809-1556
            2122-2129           AK145342.1         646-653
            2130-2223           BC066157.1         1565-1658
            2224-2799           AK145342.1         749-1324
            2800-2904           BC066157.1         2235-2339
FEATURES             Location/Qualifiers
     source          1..2904
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 50.18 cM"
     gene            1..2904
                     /gene="Glis1"
                     /gene_synonym="Gli5; Gli6; GliH1"
                     /note="GLIS family zinc finger 1"
                     /db_xref="GeneID:230587"
                     /db_xref="MGI:MGI:2386723"
     exon            1..179
                     /gene="Glis1"
                     /gene_synonym="Gli5; Gli6; GliH1"
                     /inference="alignment:Splign:2.1.0"
     exon            180..477
                     /gene="Glis1"
                     /gene_synonym="Gli5; Gli6; GliH1"
                     /inference="alignment:Splign:2.1.0"
     CDS             222..2591
                     /gene="Glis1"
                     /gene_synonym="Gli5; Gli6; GliH1"
                     /note="Glis1 Kruppel-like zinc finger protein; GLI-Kruppel
                     family member GLI6; GLI-similar 1; gli homologous protein
                     1; zinc finger transcription factor Gli5"
                     /codon_start=1
                     /product="zinc finger protein GLIS1"
                     /protein_id="NP_671754.2"
                     /db_xref="CCDS:CCDS38831.1"
                     /db_xref="GeneID:230587"
                     /db_xref="MGI:MGI:2386723"
                     /translation="MHCEVAEALSDKRPKEAPGAPGQGRGPVSLGAHMAFRIAVSGGG
                     CGDGNPLDLLPRLPVPPPRAHDLLRPRSPRDYGVSKTGSGKVNGSYGHSSEKSLLDLD
                     LAEGPSPSCHQGLFLPAGTPPPRGHPPVCEKLLHFPHPNRSPRPQATFVNGSLPAAQH
                     IKQEALPDYQAMVSAHTPLPTHCRAPSSMGLPSDLDFPDRGLTNPAPSCYLLGNEPIS
                     DLGPQPEAHLPEGSLKRCCLLGLPPTSSASSSPCASSDINPVIHSSQTALVSCVNGLR
                     SPPLPGDLGGPPKRSRPGPASSDGQEGSLQLEACRKSGFLKQEPMDEFSELFAPHHQG
                     LPPPYPLPQLPTGPGLGGLGLGLAGRMVAGRQACRWVDCCAAYEQQEELVRHIEKSHI
                     DQRKGEDFTCFWAGCVRRYKPFNARYKLLIHMRVHSGEKPNKCMFEGCSKAFSRLENL
                     KIHLRSHTGEKPYLCQHPGCQKAFSNSSDRAKHQRTHLDTKPYACQIPGCSKRYTDPS
                     SLRKHVKAHSAKEQQVRKKLHTGADPEADVLSECLSLQQLQASTLLPASRGKGSQTLS
                     QELLPGVYPGSVTPQNGLASGILSPSHDVPSRHHPLEVPTGSHHHLSPLPTAESTRDG
                     LGPSLLSPMVSPLKGLGPPPLPPASQSQSPGGQSFSTVPSKPTYPSFQSPPPLPSPQG
                     YQGSFHSIQNCFPYADCYRATEPAASRDGLVGDAHGFNPLRPSTYSSLSTPLSAPGYE
                     TLAETPCPPALQPQPAEDLVPSGPEDCGFFPNGAFDHCLSHIPSIYTDT"
     exon            478..646
                     /gene="Glis1"
                     /gene_synonym="Gli5; Gli6; GliH1"
                     /inference="alignment:Splign:2.1.0"
     exon            647..1529
                     /gene="Glis1"
                     /gene_synonym="Gli5; Gli6; GliH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1530..1691
                     /gene="Glis1"
                     /gene_synonym="Gli5; Gli6; GliH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1692..1802
                     /gene="Glis1"
                     /gene_synonym="Gli5; Gli6; GliH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1803..1935
                     /gene="Glis1"
                     /gene_synonym="Gli5; Gli6; GliH1"
                     /inference="alignment:Splign:2.1.0"
     exon            1936..2092
                     /gene="Glis1"
                     /gene_synonym="Gli5; Gli6; GliH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2093..2265
                     /gene="Glis1"
                     /gene_synonym="Gli5; Gli6; GliH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2266..2433
                     /gene="Glis1"
                     /gene_synonym="Gli5; Gli6; GliH1"
                     /inference="alignment:Splign:2.1.0"
     exon            2434..2904
                     /gene="Glis1"
                     /gene_synonym="Gli5; Gli6; GliH1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 ggggacccag tggcgtccga atccgggagc tctggggtgg cgcggggctc gccgaggggc
       61 gaggcgaatt tgggggccct gaggcctcgc tctcgcggga atgatgctgg aaatgatgct
      121 gaggctccgg cgtgagactt gcggctgccg gcggagcgga gtgtgagccg gtgaatgggg
      181 agcctggcgc gacccccagc cgtgcgcccc gccccggcgc catgcattgc gaggtggccg
      241 aggcactttc ggacaagagg ccaaaggagg cccctggtgc tcctggccag ggccgcgggc
      301 ctgtcagcct gggagcgcac atggccttca ggattgctgt gagtggtggc ggctgcgggg
      361 acgggaaccc gctagacctg ctgcctcggc taccggtgcc accaccacgt gcccacgatc
      421 tccttcggcc ccggagccct cgagactatg gtgtgtccaa gaccggcagc gggaaggtga
      481 acgggagcta cgggcacagc tcagagaaga gcctgctgga cctggacctg gccgagggtc
      541 ccagcccctc ctgccaccag ggtctgtttc ttcctgcagg gaccccacca ccccggggtc
      601 acccccctgt ctgtgagaag ctgctgcact tcccccaccc aaacaggtca cccagacctc
      661 aggctacgtt tgtgaacggc agcctcccag ccgctcagca catcaagcaa gaagccctac
      721 cggactacca ggccatggtc agcgcccaca cacccctgcc cacccactgc cgagccccat
      781 cgtccatggg tctgccctca gacctggact ttccagaccg aggcctcacc aaccctgcac
      841 cttcctgcta ccttctgggc aatgaaccca tctcagacct gggtccccaa cccgaggccc
      901 acctccccga gggcagcctg aaacgctgct gcctcctggg cctgcccccc acctcttcag
      961 cctcctcctc accctgtgcc tcctcagata tcaatcctgt catccactcc tcccagacag
     1021 ctctagttag ctgtgtaaat ggactccgaa gcccacctct gccgggagac ctggggggcc
     1081 ctcccaagcg gtcacggccc gggcctgcat ccagtgacgg ccaggagggc agcttgcagc
     1141 ttgaagcatg ccggaagtca ggcttcctga agcaggagcc catggacgag ttttcagagc
     1201 tttttgctcc acaccaccag ggtttgccac ccccttaccc cttgcctcag ttgccaactg
     1261 gccccggcct cggaggccta gggctgggcc tggcaggtag gatggttgcc ggtcggcagg
     1321 catgccgctg ggtggactgc tgcgcagcct acgagcagca ggaggagctg gtgcggcaca
     1381 tcgagaagag ccacatcgac cagcgcaagg gcgaagactt cacctgcttc tgggccgggt
     1441 gtgtgcggcg ctacaagccc ttcaatgccc gctacaagct gctcatccac atgagggtac
     1501 actcaggcga gaagcccaac aagtgcatgt tcgaaggctg cagtaaagcc ttttcccgtc
     1561 tggagaacct gaagatccat ctgcggagcc acacaggcga gaaaccatac ctgtgccagc
     1621 acccaggctg ccagaaggcc ttcagcaact ccagcgaccg tgccaagcac caacgcaccc
     1681 acctcgacac gaagccatat gcttgtcaga tccctggctg ctccaagcgc tacacggacc
     1741 ccagctccct ccgcaagcac gtgaaggccc actcagccaa agagcagcag gtgcgtaaga
     1801 agctgcacac aggtgccgac ccagaggctg atgttctgtc cgagtgtctg tccctgcagc
     1861 agctccaagc atccacactg ttgccggcca gcagagggaa gggcagccaa accctgagcc
     1921 aggagctcct cccaggtgtg tatcctggct ccgtcacccc acaaaacggg cttgcttcag
     1981 gcatcctgtc cccctcccac gatgtccctt ccaggcacca cccactggag gtccccactg
     2041 gttcccacca ccacctgtcc cctctgccca cagctgagag caccagggat ggcctggggc
     2101 ccagtctcct ttcacccatg gtcagcccac tgaaggggct tggtccccca ccgctaccac
     2161 cagcctccca gagtcagtct ccagggggac agtcattctc tacagtcccc agcaagccta
     2221 cctacccatc cttccaaagc ccaccacctc tgcccagccc ccaaggctac caaggcagtt
     2281 tccattccat ccagaactgc ttcccctacg ctgactgcta ccgggccact gagccagcag
     2341 cctccaggga tggactggtg ggtgatgccc acggtttcaa ccccttgcga cccagcacat
     2401 actccagcct cagcacacct ttatccgcac caggctacga gaccctggca gaaacgccgt
     2461 gtcccccagc gctgcagcca cagccagctg aagacctggt acctagtggt cctgaggact
     2521 gtggcttctt ccccaatggg gcctttgacc actgtctgag tcacatcccg tccatctaca
     2581 ctgacacctg aaggaagggg cgctgctctg cctgcctgcc tggctcctga gctacttcac
     2641 ctacctgcca tctgctggtg cttcccacac ggggcagcaa ggccacacca cagggtactt
     2701 ccctacctgg agggctgtct ggtccagagc tgcctgccag gagctatggc cctctgacag
     2761 ccccatggct gtgtcttcct ctctctccat aaggttctca aatcacagac ctcgtgtata
     2821 tacaatgtac aggacctctt ttccgccgcc ctgcaagttt tatatttttg gttttacaag
     2881 aaaaacatta aaaactggaa acta
//
