LOCUS       NM_027450               2019 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus GLI pathogenesis-related 2 (Glipr2), mRNA.
ACCESSION   NM_027450 XM_357369
VERSION     NM_027450.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2019)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2019)
  AUTHORS   Zhao,Y., Zou,Z., Sun,D., Li,Y., Sinha,S.C., Yu,L., Bennett,L. and
            Levine,B.
  TITLE     GLIPR2 is a negative regulator of autophagy and the
            BECN1-ATG14-containing phosphatidylinositol 3-kinase complex
  JOURNAL   Autophagy 17 (10), 2891-2904 (2021)
   PUBMED   33222586
  REMARK    GeneRIF: GLIPR2 is a negative regulator of autophagy and the
            BECN1-ATG14-containing phosphatidylinositol 3-kinase complex.
REFERENCE   3  (bases 1 to 2019)
  AUTHORS   Dong,B., Vold,S., Olvera-Jaramillo,C. and Chang,H.
  TITLE     Functional redundancy of frizzled 3 and frizzled 6 in planar cell
            polarity control of mouse hair follicles
  JOURNAL   Development 145 (19) (2018)
   PUBMED   30237242
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2019)
  AUTHORS   Zhao,D., Jia,J. and Shao,H.
  TITLE     miR-30e targets GLIPR-2 to modulate diabetic nephropathy: in vitro
            and in vivo experiments
  JOURNAL   J Mol Endocrinol 59 (2), 181-190 (2017)
   PUBMED   28733476
  REMARK    GeneRIF: miR-30e is downregulated in diabetic nephropathy, and the
            overexpression of miR-30e can inhibit GLIPR-2.
REFERENCE   5  (bases 1 to 2019)
  AUTHORS   Laurent,F., Girdziusaite,A., Gamart,J., Barozzi,I., Osterwalder,M.,
            Akiyama,J.A., Lincoln,J., Lopez-Rios,J., Visel,A., Zuniga,A. and
            Zeller,R.
  TITLE     HAND2 Target Gene Regulatory Networks Control Atrioventricular
            Canal and Cardiac Valve Development
  JOURNAL   Cell Rep 19 (8), 1602-1613 (2017)
   PUBMED   28538179
REFERENCE   6  (bases 1 to 2019)
  AUTHORS   Bildsoe,H., Fan,X., Wilkie,E.E., Ashoti,A., Jones,V.J., Power,M.,
            Qin,J., Wang,J., Tam,P.P.L. and Loebel,D.A.F.
  TITLE     Transcriptional targets of TWIST1 in the cranial mesoderm regulate
            cell-matrix interactions and mesenchyme maintenance
  JOURNAL   Dev Biol 418 (1), 189-203 (2016)
   PUBMED   27546376
REFERENCE   7  (bases 1 to 2019)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 2019)
  AUTHORS   Baxter,R.M., Crowell,T.P., George,J.A., Getman,M.E. and Gardner,H.
  TITLE     The plant pathogenesis related protein GLIPR-2 is highly expressed
            in fibrotic kidney and promotes epithelial to mesenchymal
            transition in vitro
  JOURNAL   Matrix Biol 26 (1), 20-29 (2007)
   PUBMED   17055234
  REMARK    GeneRIF: Increased GLIPR-2 expression in kidney contributes to
            development of fibrosis by increasing the pool of activated
            fibroblasts, possibly through the induction of epithelial to
            mesenchymal transition.
REFERENCE   9  (bases 1 to 2019)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   10 (bases 1 to 2019)
  AUTHORS   Eisenberg,I., Barash,M., Kahan,T. and Mitrani-Rosenbaum,S.
  TITLE     Cloning and characterization of a human novel gene C9orf19 encoding
            a conserved putative protein with an SCP-like extracellular protein
            domain
  JOURNAL   Gene 293 (1-2), 141-148 (2002)
   PUBMED   12137952
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AL772204.13
            and AL732563.5.
            
            On Nov 17, 2006 this sequence version replaced NM_027450.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC031750.1, AK154433.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-72                AL772204.13        33977-34048
            73-181              AL772204.13        44387-44495
            182-285             AL772204.13        44847-44950
            286-363             AL732563.5         3356-3433
            364-2019            AL732563.5         10319-11974
FEATURES             Location/Qualifiers
     source          1..2019
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 23.07 cM"
     gene            1..2019
                     /gene="Glipr2"
                     /gene_synonym="5730414A08Rik; GAPR-1"
                     /note="GLI pathogenesis-related 2"
                     /db_xref="GeneID:384009"
                     /db_xref="MGI:MGI:1917770"
     exon            1..72
                     /gene="Glipr2"
                     /gene_synonym="5730414A08Rik; GAPR-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             60..524
                     /gene="Glipr2"
                     /gene_synonym="5730414A08Rik; GAPR-1"
                     /note="gliPR 2; golgi-associated PR-1 protein; glioma
                     pathogenesis-related protein 2"
                     /codon_start=1
                     /product="Golgi-associated plant pathogenesis-related
                     protein 1"
                     /protein_id="NP_081726.1"
                     /db_xref="CCDS:CCDS18117.1"
                     /db_xref="GeneID:384009"
                     /db_xref="MGI:MGI:1917770"
                     /translation="MGKSASKQFNNEVLKAHNEYRAQHGVPPLKLCKKLNREAQQYSE
                     ALASTRILKHSPESSRGQCGENLAWASYDQTGKDVADRWYSEIKSYNFQQPGFTSGTG
                     HFTAMVWKNTKKIGVGKASASDGSSFVVARYFPAGNIVNQGFFEENVPPPKK"
     exon            73..181
                     /gene="Glipr2"
                     /gene_synonym="5730414A08Rik; GAPR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            182..285
                     /gene="Glipr2"
                     /gene_synonym="5730414A08Rik; GAPR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            286..363
                     /gene="Glipr2"
                     /gene_synonym="5730414A08Rik; GAPR-1"
                     /inference="alignment:Splign:2.1.0"
     exon            364..2019
                     /gene="Glipr2"
                     /gene_synonym="5730414A08Rik; GAPR-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1994..1999
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Glipr2"
                     /gene_synonym="5730414A08Rik; GAPR-1"
                     /note="hexamer: AATAAA"
     polyA_site      2019
                     /gene="Glipr2"
                     /gene_synonym="5730414A08Rik; GAPR-1"
                     /note="major polyA site"
ORIGIN      
        1 cgctagccag cgcagcgcaa cgcagccgca gcggagcgga ggagcgcaca cagcaggcca
       61 tgggcaaatc agcttccaaa cagtttaata acgaggtcct gaaggcccac aacgagtacc
      121 gggcccagca cggtgtcccg cccctgaagc tttgtaagaa gctcaaccgg gaagcccagc
      181 agtattcgga ggccctggcc agcacgagaa ttctcaagca cagcccagag tccagtcgtg
      241 gccagtgtgg agagaacctt gcgtgggcgt cctatgatca gacaggaaag gatgtggccg
      301 ataggtggta cagcgaaatc aagagctaca acttccagca gcctggtttc acttcaggga
      361 ctgggcactt tacagccatg gtatggaaga ataccaagaa gataggcgtg gggaaggcat
      421 ctgcgagtga cgggtcctcc tttgtggtgg ctagatactt cccagcaggg aatattgtca
      481 accagggctt cttcgaagag aatgtcccac ctccaaagaa gtagctctcg ccagcaagtg
      541 taacgagatg gagatgcata tatgaagtgc ctatagaacc acaaaagcac cagcgagtgt
      601 ctgtccccgt gggtgtgtgt atttatgtgt ttacctgtga gcatctctcg tgacagctac
      661 acctgagtac cttctgattg aaggatggcc atctgaaaca tttgtccaga gggctagcta
      721 accacaattg ggtaagatta gttctgaaat cttttttctg tttttgtttg gttggggttt
      781 tgtttgtttg ttttgctttt atttttgttt tgttttgttt tttcaaggca gggtttctcg
      841 gtgtagcctt ggctgtccta gaatttgctc tgcagaccag gctggcagag atgcacctgc
      901 ctgtgcctcc caagtgtggg attaaaggca tgagccacca ctgcctggtt tttgtttttg
      961 ctttttaaag cagacttcat ttgaaacttt cttccttcta atatccatcc ttgggctttg
     1021 aggattctga atatttgcca ttctcagaag tgaggtcctt tcctaggccc ttcctgcact
     1081 gtaatcttct tgtggtagat actgaaggga tcgacacgtc ctttaggtgt gacataaagc
     1141 agctagtgtt aaaaacattt ggccagctgc atctcacagg accagtgaga tctctcattc
     1201 tcagttggaa gacatgatat catcctgcat cctccaggat tccctaatag aactgccaaa
     1261 gagcaaatgg agatggaaaa aagagcctta cattcttgaa gtttttcaac ctttaaagag
     1321 caaataccac agccactagc acctctcaca cctcatatgt gggttgtttg tttgttcgtt
     1381 tgtttttgtt ttttgttttt aagtttcatt gctcacagcc ctactctggc tcctgggggg
     1441 tggggttagg tctggaatgc agccccgccc ccctattccc ccagtcatct cgggtgaccc
     1501 tcactctgtc tgggctcttg gccaaggcct tggactatga tgaagtcaat agagcagagg
     1561 tgagggtgag cttccctgga ggaagcccca aagcctctgt ccttccccaa ctctgcaggc
     1621 ggtgaccacc caggcctgtc cccagcagct gtggctacag ctgcgccttg gcttcctccc
     1681 ggaatgtgtg acaagcccag atgctcccgg gaggaggccc aaacaaggag attaggaacg
     1741 ctaatttgat cctgtgtttt gcctcaaact atacacagtt tcctctgaaa aaactgattt
     1801 aaccacgtct gccagggagg gatcaagcca gaggttcaat tgtggatccc tgaaatggtg
     1861 gtatcccctc ctgcaaggag ataaaagggt tgttggccta atgacagcaa ggctggctgg
     1921 tctttgttac actgtgaaca gtcccacact gcgccacttg gttcatccag ggatagcaac
     1981 aaacaaacga gacaataaaa tcctttcctt tttgtgtaa
//
