LOCUS       NM_028608               1081 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus GLI pathogenesis related 1 (Glipr1), mRNA.
ACCESSION   NM_028608
VERSION     NM_028608.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1081)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1081)
  AUTHORS   Peng,W., Wu,Y., Zhang,G., Zhu,W., Chang,M., Rouzi,A., Jiang,W.,
            Tong,L., Wang,Q., Liu,J., Song,Y., Li,H., Li,K. and Zhou,J.
  TITLE     GLIPR1 Protects Against Cigarette Smoke-Induced Airway Inflammation
            via PLAU/EGFR Signaling
  JOURNAL   Int J Chron Obstruct Pulmon Dis 16, 2817-2832 (2021)
   PUBMED   34675506
  REMARK    GeneRIF: GLIPR1 Protects Against Cigarette Smoke-Induced Airway
            Inflammation via PLAU/EGFR Signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1081)
  AUTHORS   Friend,N., Noll,J.E., Opperman,K.S., Clark,K.C., Mrozik,K.M.,
            Vandyke,K., Hewett,D.R. and Zannettino,A.C.W.
  TITLE     GLIPR1 expression is reduced in multiple myeloma but is not a
            tumour suppressor in mice
  JOURNAL   PLoS One 15 (1), e0228408 (2020)
   PUBMED   31995627
  REMARK    GeneRIF: Results find that Glipr1 expression is lost in the 5TGM1
            murine multiple myeloma (MM) cell line. Its overexpression in a
            HMCL/5TGM1 cells did not significantly alter tumor cell growth in
            vitro or in vivo. These results suggest that GLIPR1 is unlikely to
            be a potent tumor suppressor in multiple myeloma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1081)
  AUTHORS   Gaikwad,A.S., Anderson,A.L., Merriner,D.J., O'Connor,A.E.,
            Houston,B.J., Aitken,R.J., O'Bryan,M.K. and Nixon,B.
  TITLE     GLIPR1L1 is an IZUMO-binding protein required for optimal
            fertilization in the mouse
  JOURNAL   BMC Biol 17 (1), 86 (2019)
   PUBMED   31672133
  REMARK    GeneRIF: Collectively, this study characterizes multimeric protein
            complexes on the sperm surface and identifies GLIPRL1L1 as a
            physiologically relevant regulator of IZUMO1 function and the
            fertilization process.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1081)
  AUTHORS   Sheng,X., Bowen,N. and Wang,Z.
  TITLE     GLI pathogenesis-related 1 functions as a tumor-suppressor in lung
            cancer
  JOURNAL   Mol Cancer 15, 25 (2016)
   PUBMED   26988096
  REMARK    GeneRIF: This study reveals a novel pathway that PRMT5/WDR77
            regulates GLIPR1 expression to control lung cancer cell growth.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1081)
  AUTHORS   Li,L., Ren,C., Yang,G., Fattah,E.A., Goltsov,A.A., Kim,S.M.,
            Lee,J.S., Park,S., Demayo,F.J., Ittmann,M.M., Troncoso,P. and
            Thompson,T.C.
  TITLE     GLIPR1 suppresses prostate cancer development through targeted
            oncoprotein destruction
  JOURNAL   Cancer Res 71 (24), 7694-7704 (2011)
   PUBMED   22025562
REFERENCE   7  (bases 1 to 1081)
  AUTHORS   Palaniswamy,R., Teglund,S., Lauth,M., Zaphiropoulos,P.G. and
            Shimokawa,T.
  TITLE     Genetic variations regulate alternative splicing in the 5'
            untranslated regions of the mouse glioma-associated oncogene 1,
            Gli1
  JOURNAL   BMC Mol Biol 11, 32 (2010)
   PUBMED   20433698
  REMARK    GeneRIF: The genetic variation is a key determining factor for the
            alternative splicing events in the Gli1 5' UTRs, which have
            functional implications on translational efficiency.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 1081)
  AUTHORS   Li,L., Abdel Fattah,E., Cao,G., Ren,C., Yang,G., Goltsov,A.A.,
            Chinault,A.C., Cai,W.W., Timme,T.L. and Thompson,T.C.
  TITLE     Glioma pathogenesis-related protein 1 exerts tumor suppressor
            activities through proapoptotic reactive oxygen species-c-Jun-NH2
            kinase signaling
  JOURNAL   Cancer Res 68 (2), 434-443 (2008)
   PUBMED   18199537
REFERENCE   9  (bases 1 to 1081)
  AUTHORS   Hoffman,B.G., Zavaglia,B., Witzsche,J., Ruiz de Algara,T.,
            Beach,M., Hoodless,P.A., Jones,S.J., Marra,M.A. and Helgason,C.D.
  TITLE     Identification of transcripts with enriched expression in the
            developing and adult pancreas
  JOURNAL   Genome Biol 9 (6), R99 (2008)
   PUBMED   18554416
REFERENCE   10 (bases 1 to 1081)
  AUTHORS   Ren,C., Li,L., Goltsov,A.A., Timme,T.L., Tahir,S.A., Wang,J.,
            Garza,L., Chinault,A.C. and Thompson,T.C.
  TITLE     mRTVP-1, a novel p53 target gene with proapoptotic activities
  JOURNAL   Mol Cell Biol 22 (10), 3345-3357 (2002)
   PUBMED   11971968
  REMARK    GeneRIF: Identification of a novel mouse gene, mRTVP-1, as a p53
            target gene. The mRTVP-1 protein has 255 amino acids and differs
            from the human RTVP-1 protein by two short in-frame deletions of
            two and nine amino acids. (mRTVP-1)
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BB869923.1, BC098231.1 and BY540964.1.
            
            On Apr 9, 2009 this sequence version replaced NM_028608.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC098231.1, AK137557.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                BB869923.1         2-36
            36-1074             BC098231.1         10-1048
            1075-1081           BY540964.1         373-379
FEATURES             Location/Qualifiers
     source          1..1081
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 59.98 cM"
     gene            1..1081
                     /gene="Glipr1"
                     /gene_synonym="2410114O14Rik; gliPR 1; mRTVP-1; RTVP-1;
                     RTVP1"
                     /note="GLI pathogenesis related 1"
                     /db_xref="GeneID:73690"
                     /db_xref="MGI:MGI:1920940"
     exon            1..407
                     /gene="Glipr1"
                     /gene_synonym="2410114O14Rik; gliPR 1; mRTVP-1; RTVP-1;
                     RTVP1"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1001
                     /gene="Glipr1"
                     /gene_synonym="2410114O14Rik; gliPR 1; mRTVP-1; RTVP-1;
                     RTVP1"
                     /note="related to testes-specific, vespid, and
                     pathogenesis proteins; glioma pathogenesis-related protein
                     1; GLI pathogenesis-related 1 (glioma)"
                     /codon_start=1
                     /product="glioma pathogenesis-related protein 1 precursor"
                     /protein_id="NP_082884.1"
                     /db_xref="CCDS:CCDS24169.1"
                     /db_xref="GeneID:73690"
                     /db_xref="MGI:MGI:1920940"
                     /translation="MQVILAVIVWMASSVSSSSFTASTLPDITNEDFIKECVQVHNQL
                     RSKVSPPARNMLYMSWDPKLAQIAKAWTKSCEFKHNPQLHSRIHPNFTALGENIWLGS
                     LSIFSVSSAISAWYEEIKHYDFSTRKCRHVCGHYTQVVWADSYKLGCAVQLCPNGANF
                     ICDYGPAGNYPTWPYKQGATCSDCPKDDKCLNSLCINPRRDQVSRYYSVDYPDWPIYL
                     RNRYTSLFLIAKSVLLLLSVIITIWVKHKYPNLVLLD"
     exon            408..647
                     /gene="Glipr1"
                     /gene_synonym="2410114O14Rik; gliPR 1; mRTVP-1; RTVP-1;
                     RTVP1"
                     /inference="alignment:Splign:2.1.0"
     exon            648..733
                     /gene="Glipr1"
                     /gene_synonym="2410114O14Rik; gliPR 1; mRTVP-1; RTVP-1;
                     RTVP1"
                     /inference="alignment:Splign:2.1.0"
     exon            734..819
                     /gene="Glipr1"
                     /gene_synonym="2410114O14Rik; gliPR 1; mRTVP-1; RTVP-1;
                     RTVP1"
                     /inference="alignment:Splign:2.1.0"
     exon            820..846
                     /gene="Glipr1"
                     /gene_synonym="2410114O14Rik; gliPR 1; mRTVP-1; RTVP-1;
                     RTVP1"
                     /inference="alignment:Splign:2.1.0"
     exon            847..1081
                     /gene="Glipr1"
                     /gene_synonym="2410114O14Rik; gliPR 1; mRTVP-1; RTVP-1;
                     RTVP1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1053..1058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Glipr1"
                     /gene_synonym="2410114O14Rik; gliPR 1; mRTVP-1; RTVP-1;
                     RTVP1"
                     /note="hexamer: AATAAA"
     polyA_site      1074
                     /gene="Glipr1"
                     /gene_synonym="2410114O14Rik; gliPR 1; mRTVP-1; RTVP-1;
                     RTVP1"
                     /note="major polyA site"
ORIGIN      
        1 gttctgctct caggctcctc aagctgaagt aggctgtgct ttgtaaagct ggtcataaaa
       61 aaaaaaccca gcatgctgaa gatggagctc agaggcagag cacttgtcta gcataaacaa
      121 ccctgggtta atccgagctc caacagggaa acagtctgca gactgagaga accgagcatt
      181 ctatcagaac cccgcagctc tggattctag gtccagcagc aaccagagag accatgcagg
      241 tcatccttgc tgtgatagtc tggatggctt cgtctgtgtc tagttcttca tttacagcaa
      301 gcactttgcc agatataaca aacgaggact tcattaaaga atgtgttcaa gttcacaacc
      361 agcttcggtc aaaagtgagt ccaccagccc ggaatatgct gtacatgtct tgggacccaa
      421 aactagccca aattgcaaaa gcatggacaa aatcttgtga atttaaacac aacccacagc
      481 tgcattcacg gatacaccca aatttcaccg ccctgggaga gaatatctgg cttggctctc
      541 tatccatctt ttcagtatcc tcagccatct ctgcctggta tgaagaaatt aagcactatg
      601 acttcagcac taggaaatgt agacatgtct gtggccatta tactcaggtt gtttgggcag
      661 acagttacaa acttggctgt gcagtgcaac tttgccctaa tggagcaaat tttatatgcg
      721 actatggacc agcaggaaat tacccaacgt ggccatataa gcaaggagcc acgtgcagtg
      781 attgcccaaa agatgacaag tgtctcaaca gtctctgcat taacccacga cgagaccagg
      841 tctcacgtta ctactctgtc gattatccag actggcctat atacctgcgt aacagataca
      901 catctctctt tctcattgct aagtcggttc tcctattact gtctgttata attaccatct
      961 gggtaaagca caaatatcct aacttggttc ttttggacta aagctgtggt tgggggacaa
     1021 ctgaatcaca tgcggctatt taaaaacttt tcaataaaat ctcagtcaaa agaatttctt
     1081 c
//
