LOCUS       NM_008130               8427 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus GLI-Kruppel family member GLI3 (Gli3), mRNA.
ACCESSION   NM_008130
VERSION     NM_008130.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8427)
  AUTHORS   Pina,J.O., Raju,R., Roth,D.M., Winchester,E.W., Padilla,C.,
            Iben,J., Faucz,F.R., Cotney,J.L. and D'Souza,R.N.
  TITLE     Spatial Multi-omics Reveals the Role of the Wnt Modulator, Dkk2, in
            Palatogenesis'
  JOURNAL   J Dent Res 103 (13), 1412-1420 (2024)
   PUBMED   38910391
REFERENCE   2  (bases 1 to 8427)
  AUTHORS   Zeng,H., Ali,S., Sebastian,A., Ramos-Medero,A.S., Albert,I.,
            Dean,C. and Liu,A.
  TITLE     CPLANE protein INTU regulates growth and patterning of the mouse
            lungs through cilia-dependent Hh signaling
  JOURNAL   Dev Biol 515, 92-101 (2024)
   PUBMED   39029571
REFERENCE   3  (bases 1 to 8427)
  AUTHORS   Kim,S.E., Kim,H.Y., Wlodarczyk,B.J. and Finnell,R.H.
  TITLE     Linkage between Fuz and Gpr161 genes regulates sonic hedgehog
            signaling during mouse neural tube development
  JOURNAL   Development 151 (19) (2024)
   PUBMED   39369306
REFERENCE   4  (bases 1 to 8427)
  AUTHORS   Havrylov,S., Chrystal,P., van Baarle,S., French,C.R.,
            MacDonald,I.M., Avasarala,J., Rogers,R.C., Berry,F.B., Kume,T.,
            Waskiewicz,A.J. and Lehmann,O.J.
  TITLE     Pleiotropy in FOXC1-attributable phenotypes involves altered
            ciliation and cilia-dependent signaling
  JOURNAL   Sci Rep 14 (1), 20278 (2024)
   PUBMED   39217245
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8427)
  AUTHORS   Almubarak,A., Zhang,Q., Zhang,C.H., Abdelwahab,N., Kume,T.,
            Lassar,A.B. and Berry,F.B.
  TITLE     FOXC1 and FOXC2 regulate growth plate chondrocyte maturation
            towards hypertrophy in the embryonic mouse limb skeleton
  JOURNAL   Development 151 (16) (2024)
   PUBMED   39012257
REFERENCE   6  (bases 1 to 8427)
  AUTHORS   Schimmang,T., Lemaistre,M., Vortkamp,A. and Ruther,U.
  TITLE     Expression of the zinc finger gene Gli3 is affected in the
            morphogenetic mouse mutant extra-toes (Xt)
  JOURNAL   Development 116 (3), 799-804 (1992)
   PUBMED   1289066
REFERENCE   7  (bases 1 to 8427)
  AUTHORS   Vortkamp,A., Franz,T., Gessler,M. and Grzeschik,K.H.
  TITLE     Deletion of GLI3 supports the homology of the human Greig
            cephalopolysyndactyly syndrome (GCPS) and the mouse mutant extra
            toes (Xt)
  JOURNAL   Mamm Genome 3 (8), 461-463 (1992)
   PUBMED   1322743
REFERENCE   8  (bases 1 to 8427)
  AUTHORS   Vortkamp,A., Gessler,M. and Grzeschik,K.H.
  TITLE     GLI3 zinc-finger gene interrupted by translocations in Greig
            syndrome families
  JOURNAL   Nature 352 (6335), 539-540 (1991)
   PUBMED   1650914
REFERENCE   9  (bases 1 to 8427)
  AUTHORS   Swank,R.T., Sweet,H.O., Davisson,M.T., Reddington,M. and Novak,E.K.
  TITLE     Sandy: a new mouse model for platelet storage pool deficiency
  JOURNAL   Genet Res 58 (1), 51-62 (1991)
   PUBMED   1936982
REFERENCE   10 (bases 1 to 8427)
  AUTHORS   Johnson,D.R.
  TITLE     The interfrontal bone and mutant genes in the mouse
  JOURNAL   J Anat 121 (Pt 3), 507-513 (1976)
   PUBMED   1018005
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163610.4, AC173115.2 and AC173210.3.
            
            On Aug 14, 2018 this sequence version replaced NM_008130.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC141135.1, X95255.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-389               AC163610.4         125197-125585       c
            390-554             AC163610.4         111144-111308       c
            555-797             AC163610.4         40666-40908         c
            798-903             AC173115.2         127228-127333
            904-1109            AC173115.2         154518-154723
            1110-1256           AC173115.2         157743-157889
            1257-1458           AC173115.2         161970-162171
            1459-1672           AC173115.2         173411-173624
            1673-1786           AC173115.2         174330-174443
            1787-1927           AC173115.2         175839-175979
            1928-2077           AC173210.3         140732-140881       c
            2078-2242           AC173210.3         139266-139430       c
            2243-2533           AC173210.3         134035-134325       c
            2534-2861           AC173210.3         130613-130940       c
            2862-8427           AC173210.3         124354-129919       c
FEATURES             Location/Qualifiers
     source          1..8427
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 5.43 cM"
     gene            1..8427
                     /gene="Gli3"
                     /gene_synonym="add; Bph; GLI3-190; GLI3FL; Pdn; Xt"
                     /note="GLI-Kruppel family member GLI3"
                     /db_xref="GeneID:14634"
                     /db_xref="MGI:MGI:95729"
     exon            1..389
                     /gene="Gli3"
                     /gene_synonym="add; Bph; GLI3-190; GLI3FL; Pdn; Xt"
                     /inference="alignment:Splign:2.1.0"
     exon            390..554
                     /gene="Gli3"
                     /gene_synonym="add; Bph; GLI3-190; GLI3FL; Pdn; Xt"
                     /inference="alignment:Splign:2.1.0"
     CDS             431..5182
                     /gene="Gli3"
                     /gene_synonym="add; Bph; GLI3-190; GLI3FL; Pdn; Xt"
                     /note="zinc finger protein GLI3; GLI3 form of 190 kDa;
                     GLI3 full length protein; extra toes; brachyphalangy;
                     polydactyly Nagoya; anterior digit pattern deformity"
                     /codon_start=1
                     /product="transcriptional activator GLI3"
                     /protein_id="NP_032156.2"
                     /db_xref="CCDS:CCDS36603.1"
                     /db_xref="GeneID:14634"
                     /db_xref="MGI:MGI:95729"
                     /translation="MEAQAHSSTATERKKAENSIGKCPTRTDVSEKAVASSTTSNEDE
                     SPGQIYHRERRNAITMQPQSVQGLNKISEEPSTSSDERASLIKKEIHGSLPHLAEPSL
                     PYRGTVFAMDPRNGYMEPHYHPPHLFPAFHPPVPIDARHHEGRYHYDPSPIPPLHVPS
                     ALSSSPTYPDLPFIRISPHRNPTAASESPFSPPHPYINPYMDYIRSLHSSPSLSMISA
                     ARGLSPTDAPHAGVSPAEYYHQMALLTGQRSPYADILPSAATAGAGAIHMEYLHAMDS
                     TRFPSPRLSARPSRKRTLSISPLSDHSFDLQTMIRTSPNSLVTILNNSRSSSSASGSY
                     GHLSASAISPALSFTYPSAPVSLHMHQQILSRQQSLGSAFGHSPPLIHPAPTFPTQRP
                     IPGIPTVLNPVQVSSGPSESSQSKPTSESAVSSTGDPMHNKRSKIKPDEDLPSPGSRG
                     QQEQPEGTTLVKEEADKDESKQEPEVIYETNCHWEGCTREFDTQDQLVHHINNDHIHG
                     EKKEFVCRWLDCSREQKPFKAQYMLVVHMRRHTGEKPHKCTFEGCTKAYSRLENLKTH
                     LRSHTGEKPYVCEHEGCNKAFSNASDRAKHQNRTHSNEKPYVCKIPGCTKRYTDPSSL
                     RKHVKTVHGPEAHVTKKQRGDMHPRPPPPRDSGSHSQSRSPGRPTQGAFGEQKELSNT
                     TSKREECLQVKTVKAEKPMTSQPSPGGQSSCSSQQSPISNYSNSGLELPLTDGGSVAD
                     LSAIDETPIMDSTISTATTALALQARRNPAGTKWMEHIKLERLKQVNGMFPRLNPILP
                     SKAPAVSPLIGNGTQSNNNYSSGGPGTLLPSRSDLSGVDFTVLNTLNRRDSNTSTISS
                     AYLSSRRSSGISPCFSSRRSSEASQAEGRPQNVSVADSYDPISTDASRRSSEASQGDG
                     LPSLLSLTPVQQYRLKAKYAAATGGPPPTPLPHMERLSLKTKMALLGEGRDSGVTLPP
                     VHPPRRCSDGGGHTYRGRHLMPHDALANSVRRASDPVRTVSENMSLARVQRFSSLNSF
                     NPPNLPPSVEKRSLVLQNYTRQESSQPRYFQASPCPPSITENVALEALTMDADANLND
                     EDLLPDDVVQYLNSQNQTGYGQQLQSGISEDSKVAHEPEDLDLAGLPDSHVGQEYPAL
                     EQPCSEGSKTDLPIQWNEVSSGTSDLSSSKLKCGQQRPSAQQPRGFGLYNNMVVHPHN
                     LWKVGTGPAGGYQTLGENSSTYNGPEHFAIHSGDGLGTNGNTFHEQPFKTQQYGSQLN
                     RQPLTSSALDHACGTGIQGSKLKGNSLQENGGLLDFSLSVAPNELAGNTVNGMQTQDQ
                     MGQGYIAHQLLSGSMQHQGPSRPGQQVLGQVGATSHINIYQGTESCLPGTQDNSSQPS
                     SMAAIRGYQPCASYGGNRRQAMPRGNLTLQQGQLSDMSQSSRVNSIKMEAQGQSQQLC
                     STVQNYSGQFYDQTMGFSQQDRKAGSFSLSDANCLLQGNGTENSELLSPGANQVTSTV
                     DSFESHDLEGVQIDFDAIIDDGDHTSLMSGALSPSIIQNLSHSSSRLTTPRASLPFPS
                     LSMGTTNMAIGDMSSLLTSLAEESKFLAVMQ"
     exon            555..797
                     /gene="Gli3"
                     /gene_synonym="add; Bph; GLI3-190; GLI3FL; Pdn; Xt"
                     /inference="alignment:Splign:2.1.0"
     exon            798..903
                     /gene="Gli3"
                     /gene_synonym="add; Bph; GLI3-190; GLI3FL; Pdn; Xt"
                     /inference="alignment:Splign:2.1.0"
     exon            904..1109
                     /gene="Gli3"
                     /gene_synonym="add; Bph; GLI3-190; GLI3FL; Pdn; Xt"
                     /inference="alignment:Splign:2.1.0"
     exon            1110..1256
                     /gene="Gli3"
                     /gene_synonym="add; Bph; GLI3-190; GLI3FL; Pdn; Xt"
                     /inference="alignment:Splign:2.1.0"
     exon            1257..1458
                     /gene="Gli3"
                     /gene_synonym="add; Bph; GLI3-190; GLI3FL; Pdn; Xt"
                     /inference="alignment:Splign:2.1.0"
     exon            1459..1672
                     /gene="Gli3"
                     /gene_synonym="add; Bph; GLI3-190; GLI3FL; Pdn; Xt"
                     /inference="alignment:Splign:2.1.0"
     exon            1673..1786
                     /gene="Gli3"
                     /gene_synonym="add; Bph; GLI3-190; GLI3FL; Pdn; Xt"
                     /inference="alignment:Splign:2.1.0"
     exon            1787..1927
                     /gene="Gli3"
                     /gene_synonym="add; Bph; GLI3-190; GLI3FL; Pdn; Xt"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2077
                     /gene="Gli3"
                     /gene_synonym="add; Bph; GLI3-190; GLI3FL; Pdn; Xt"
                     /inference="alignment:Splign:2.1.0"
     exon            2078..2242
                     /gene="Gli3"
                     /gene_synonym="add; Bph; GLI3-190; GLI3FL; Pdn; Xt"
                     /inference="alignment:Splign:2.1.0"
     exon            2243..2533
                     /gene="Gli3"
                     /gene_synonym="add; Bph; GLI3-190; GLI3FL; Pdn; Xt"
                     /inference="alignment:Splign:2.1.0"
     exon            2534..2861
                     /gene="Gli3"
                     /gene_synonym="add; Bph; GLI3-190; GLI3FL; Pdn; Xt"
                     /inference="alignment:Splign:2.1.0"
     exon            2862..8427
                     /gene="Gli3"
                     /gene_synonym="add; Bph; GLI3-190; GLI3FL; Pdn; Xt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8404..8409
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gli3"
                     /gene_synonym="add; Bph; GLI3-190; GLI3FL; Pdn; Xt"
                     /note="hexamer: AATAAA"
     polyA_site      8427
                     /gene="Gli3"
                     /gene_synonym="add; Bph; GLI3-190; GLI3FL; Pdn; Xt"
                     /note="major polyA site"
ORIGIN      
        1 ctggacgggc ccttagtcgt tgaaaagtcg acttgacggt cggggggctc ctttctttct
       61 ctttctcctc ccacccgcgg ttgaaccaaa tcagaactgt cactcagggc cggtgactca
      121 gagggatcag attacaggat ccctgaaact gatgcgcggg ctgcagcggc gggagggagc
      181 ggaccgggcc gcaccgccgg cgcccgcaca ctcgtccgcc cgcccgccgc tcccctcctc
      241 gcccgctcgc cccgtcgccg gcccacgcca caccatgccc gccggggccg cacgctggga
      301 tcagtcaggc catccacggt agcccgagtc cgcctgccgc tccgccggcg caggtctgtg
      361 gatttgggac ctgacagcca aagccgcagg gattcctttg agaaacaagc tgaagtaatg
      421 agaagacatt atggaggccc aggcccacag ctctacggcg actgagagga agaaagctga
      481 aaattccatt gggaaatgtc ccacgagaac agatgtcagc gagaaggccg tggcctctag
      541 taccacttcc aatgaggatg aaagtcctgg acagatctat caccgagaga gaagaaacgc
      601 aatcactatg cagcctcaga gtgtgcaggg tctcaacaaa atcagtgagg agccctcgac
      661 gtctagtgat gagagggcct cgctgatcaa gaaagagatc catggctctc taccacatct
      721 ggcggagccc tctctccctt accgtgggac tgtgtttgcc atggatcccc ggaatggcta
      781 catggagcct cactaccacc ctcctcatct tttccctgcc ttccatcctc ctgtaccaat
      841 tgatgccaga catcatgagg gccgttacca ttatgatcca tctcctattc ctccattaca
      901 tgtgccttct gccttatcta gtagcccgac gtatccagac ttgcccttca ttaggatctc
      961 cccacaccgt aatcccactg cagcctcaga gtcccccttc agccccccac acccctacat
     1021 caacccatat atggactaca tccgctcatt gcacagcagc ccatccctct ccatgatctc
     1081 tgctgcccga gggctgagcc ctacagatgc tccccatgct ggagtcagcc ctgcggaata
     1141 ctatcaccag atggctctgc tgacaggcca gcgcagccct tatgcagaca tccttccctc
     1201 agctgccact gctggtgcag gggccatcca tatggagtac cttcatgcca tggacagcac
     1261 cagatttccc agccctaggc tgtcagctag gcccagccga aagcgcacac tgtcaatatc
     1321 gccactgtca gatcatagct tcgaccttca gaccatgata agaacatccc ctaactcctt
     1381 ggttacaatc ctcaataatt cccgtagcag ctcttcagca agtggttcct atgggcactt
     1441 atcggcaagt gcaatcagcc ctgcattgag cttcacctac ccctccgctc ctgtgtctct
     1501 tcacatgcat caacagatcc taagccgaca gcaaagctta ggctccgcat tcggacacag
     1561 ccctcctctc atccaccctg ctccaacatt tccaacacag agacctatcc ctgggattcc
     1621 gacagttctg aaccccgtcc aggtcagctc tggcccttct gagtcctcac agagcaagcc
     1681 cacaagcgag tctgcagtga gcagcactgg tgaccctatg cataataagc ggtccaagat
     1741 caagcctgat gaagacctcc ccagcccagg gtcacggggc cagcaggaac agccggaagg
     1801 aacaacccta gtcaaggagg aagcggacaa agatgaaagc aagcaggagc ctgaagtcat
     1861 ctacgagaca aactgccact gggaaggctg caccagagag ttcgacaccc aagatcagct
     1921 tgtgcatcat atcaataatg accacattca tggagaaaag aaggagttcg tgtgccgctg
     1981 gcttgattgt tcacgagagc agaaaccgtt caaagcccag tacatgttgg tagtgcatat
     2041 gagaagacac actggggaga agcctcacaa atgtacattt gaaggttgca caaaagccta
     2101 ctcaagactc gaaaacctga aaacccactt gagatctcac actggagaga agccatacgt
     2161 ctgtgagcat gagggctgca acaaggcttt ctctaatgct tcagatcggg ccaagcacca
     2221 aaacagaaca cattccaatg agaaaccgta tgtatgcaaa atccctggct gcaccaagcg
     2281 ttacacagac cccagctctc tccggaaaca cgtgaagact gtgcatggcc ctgaggctca
     2341 tgttaccaag aagcagcgtg gggacatgca ccctcggcct ccacccccga gagattccgg
     2401 cagccattca cagtccaggt cccctggccg gccaactcag ggagcatttg gtgagcagaa
     2461 ggagctgagc aacactacct caaagcggga agagtgcctc caggtgaaga ctgtcaaggc
     2521 tgagaagccc atgacatctc agccaagccc tggtggtcag tcttcatgca gcagccaaca
     2581 gtcccccatc agcaactatt ccaacagtgg gctcgagctt cctctgactg atggaggtag
     2641 tgtagcagac ctcagtgcca tcgatgaaac cccaatcatg gactcgacca tttccacggc
     2701 aaccacagcc cttgctttgc aagccaggag aaacccggca gggaccaaat ggatggagca
     2761 catcaaactt gaaaggctaa aacaagtgaa tggaatgttt ccaagactga accctattct
     2821 accctccaaa gcccctgcgg tatctcctct cataggaaat ggcacacagt ccaataacaa
     2881 ctatagctcg ggtgggcccg ggaccctcct cccgagcaga agtgacctgt caggtgtaga
     2941 cttcacagtg ctgaacacac tcaacaggag agacagcaat accagcacta tcagctctgc
     3001 ctacctgagc agccgcagat cctcgggcat ctccccctgc ttttccagcc gcaggtccag
     3061 cgaggcgtcc caggctgaag ggcgacccca gaatgtgagt gtggctgact cctacgatcc
     3121 catctccaca gatgcttcaa ggaggtccag cgaggccagc cagggtgacg ggctgcccag
     3181 tctgctcagc ctcacacccg tgcagcagta ccgccttaag gccaagtatg cagctgccac
     3241 aggtggccca ccacccacac ctctgcccca catggagagg ctgagcctga agaccaagat
     3301 ggccttgcta ggggaaggga gggactctgg ggtgaccctg cctccagtcc atcctcctcg
     3361 aagatgcagt gatgggggag gtcacacata cagagggcgt cacctgatgc ctcatgatgc
     3421 actagcgaac agtgtgagga gagccagcga ccctgtgagg acagtctcgg agaacatgtc
     3481 acttgccagg gttcaacgct tcagcagcct caatagcttt aatcctccaa atttgcctcc
     3541 atcggtggaa aagcgtagct tagtgctgca aaattatacc cggcaggaga gcagccaacc
     3601 ccggtacttc caggcatccc cttgccctcc cagcatcaca gagaatgttg ccctggaggc
     3661 tctgaccatg gatgctgatg ctaacttgaa tgatgaagac ctcctgccag atgatgtggt
     3721 acagtattta aattcccaga accaaacagg gtatgggcag cagttgcaga gtggcatctc
     3781 tgaagacagc aaagtagccc atgagccaga ggacttggac ttagcagggc tgccagacag
     3841 tcatgttggc caggagtacc cagctctgga gcagccctgc tctgagggca gtaaaactga
     3901 tttgcccatc cagtggaacg aggtcagttc tggaacttct gatctgtcat cctccaagct
     3961 gaagtgtggt cagcagcgcc ctagcgcaca gcagcctcgg ggttttgggc tatacaacaa
     4021 tatggtggta cacccacata atctgtggaa ggttggcact ggcccagctg ggggatatca
     4081 gaccctcggg gagaatagca gtacctacaa tggcccagag cactttgcaa tccacagtgg
     4141 ggatggactt ggcaccaatg gaaatacttt ccatgaacag ccctttaaga cccagcagta
     4201 tgggagccag ctcaacaggc agccactgac ttccagtgct ctagatcatg cctgtggtac
     4261 agggattcaa gggtccaagc taaaaggcaa cagcttgcaa gagaatgggg gtttgctaga
     4321 tttcagcctg tccgtggcac caaatgagtt agctggcaac acagtgaatg gcatgcaaac
     4381 ccaagatcaa atgggacagg gatacattgc ccatcagcta ctcagtggca gcatgcaaca
     4441 ccaggggccc agccgccctg gtcaacaggt actagggcag gttggtgcta cctcacatat
     4501 caacatctat caagggacag agagctgcct accagggact caggacaaca gcagccagcc
     4561 atcaagcatg gcagctatca ggggctacca gccctgtgcc agctatgggg gtaacaggcg
     4621 tcaggcaatg ccaaggggca acctcactct gcaacaagga cagctcagtg acatgagtca
     4681 gagcagcagg gtgaacagca tcaaaatgga ggcacaaggt cagtcccagc agctctgctc
     4741 taccgtgcag aattattccg gtcagttcta tgaccaaacc atgggcttca gtcagcaaga
     4801 caggaaagct ggctcgttct ccctctcaga tgccaactgc ctgctccaag ggaatggcac
     4861 tgaaaactct gagttactct ccccaggtgc taaccaggta acaagcacag ttgacagctt
     4921 tgagagtcat gacctagaag gtgtgcagat tgattttgat gccatcatag atgatgggga
     4981 ccataccagc ctaatgtcag gggccttgag cccaagtatt attcagaacc tttcccacag
     5041 ctcctcccgt ctcaccactc cgcgggcatc cctcccattc ccatccctat ccatgggcac
     5101 caccaacatg gctatcgggg atatgagttc tttgctgacc tcccttgcag aagaaagcaa
     5161 gttccttgca gttatgcagt aggcggtagg caaggaggac cacaaacaca aagactgaaa
     5221 tgacttggga tttttttttc ttttttaagt tctgtgtgta ttttagcaat ctcatctcac
     5281 ctgattggga tgtgtctcaa gtatattcct tttatggaaa aggactctga aaaaccctaa
     5341 ggtattctag gggaggaact gtcttccatt tcagtttgaa tcagtattgt gacattcaaa
     5401 tcacccttgt ttttttgttt tttgtatttt tttaaacctg taagcctgcc ctcttttgag
     5461 tgaaccaatg taaatgtata ctgcgcatgt tctttctttt agaagagaag tcatcaagtt
     5521 aaaagatttg gcctgcttct ctgctaaccc aggaactagg aattggtggg cttgtgacca
     5581 aggggtaaca ggtccacctt tttaaagttt ttctttacag tactcagtga cttgctttta
     5641 tgtgtgtatg tgtatttttt attcccacac tgagtacaag aattgaatga atagtgagct
     5701 tgaagattat ttgtgggtgc actatagtta gtataaatag caggttttca cgtgtcctcc
     5761 accttgattc aattcagggc atacttttaa cagcttcaca aaagtggaaa tgtggggatc
     5821 ctggaaatga agtagtttga tgagggtttt tatagggggt aattcttatg taagtacgca
     5881 tcccgtgggt atgtctatat ggtcagctct ccattatctc ctgtacattc ccttcacctt
     5941 tatgaacatt cagtgttatt tagcactgca gtgagagtgg acaggcagtt ggtgttcaga
     6001 tgtgtcacac ttttagcttt ttggtacgaa gttagaccaa ttataggttg aaacaattgg
     6061 gtagaattac ttggaggact gttttttgga cttgctataa ttattcatta gtcccacctc
     6121 tttcctcatt gtcataggta actgagaatt gaattgacta tacatagctc taagtaggta
     6181 tttaagcagc ccacaactgg atacatcact accgtttatt aaattcacta cagcaagaga
     6241 atatgtcctt tctaagtgcc ctattataaa ggaaagatgt gtaaaaccta gttataaaag
     6301 gcaaaactca catacattga catcagaaat aaattacttt aaccagtttt agcactggag
     6361 agcatgaaag ttgatgttta gtagccatgt gaatttcaga taccattagt ccttaccatt
     6421 ggactagggc ttttgttttg tattcagatt ttaaagattt acacagtgca gctgctcttc
     6481 acatgtagat cagatatgag agtcatactg tgtgtacaca gagttcaggg attatcttag
     6541 catactactt taaaaccgta aacaattaaa gtgtttaccc atcagcccca acatggaatt
     6601 tccccaaggc tgttattgac cgggttgtgt gacttctcct cttaaatcct gcctgtaaat
     6661 ttaggagtag gaaggcgaaa cccagtaggt gttaggtaat aggaaggatg ctatgaccag
     6721 ccaatttcac ttaggcctgt tttctctctt ttggagccca aacttcacca gggaagaaac
     6781 tttgccatgt aggatgacgt tgtggctaag ctagctttct gatagatgtc cccaggacca
     6841 gtcaaaccat ctgtaagttc accgtgccct gcagccttct cccagaggtt ccttataaat
     6901 caaaggacag cccacaagaa aggggaatta ctggtctgag ttcaggagag taaataaagc
     6961 aaggcttctt tttgcctcaa acaggtcaca gtgtcatcac aaaatgggtg atggaatccc
     7021 tgaatttcat ttatcaaaag tcttttttgt tttttaatct ctggtttggg tctgacctgg
     7081 catgccttat tatttggcca aatctcttta ttacttttga tttcaaagaa ggggttcagg
     7141 aattcttcct tcctcagcaa gaagaatgag cttggtttct ggtcacaccc attgcctcct
     7201 gcagcagaga cctctctagg tggaggcctt gcatgtgacc ttgatgttct caagtgcagt
     7261 gattttccat gttagcggtc cctcctagga atgcagtgca cagagccagc acccctgcct
     7321 tcttaccttc tgcttttgac tttttcattg ttttcttttt tcattgtttt tttttttcat
     7381 ccttattttt caagctattg cctttagatt tttggagttg atgtttccac tcactatctg
     7441 acctttcttg atatgaagat ttcaggatac agatttaaaa aaaaaaaaaa aaaaaaaaaa
     7501 ggagagtcaa aagtgttcta tcccaagatt tcaccaatct gtcctgatag tccagttcaa
     7561 gaatgatcat ttggtcacta tagctaaccc atgggacatg agatctcttt aggcttggtc
     7621 tttcctgtca aaatcccact cctggtcagc agcccctttc cagtccttgg ctcttgtatt
     7681 taggagaaac agctttggct ctctcatgtc acacacagct gctttttaat gaaagtacag
     7741 gctcatacat ggtactcttg tttaatgtct gtgttaaatg gtttggtgtt tgtttgtttt
     7801 tttccataat ttttctaaag aattaaagaa ctcacttccc tgctcctcac gtgttggctt
     7861 gtcctgagcc acgggttttg attcttgcaa tgtatgtgcc ttattttatg tttctcttgt
     7921 cgatgagaag gaccagttgt tgttgttgtc cagtcagcac tcagaggctg catgcccaga
     7981 cagtgtcacc aggaagtgaa cacaggactg tggcagtctg cggtgttggg tgacccgatt
     8041 tcctgtgttg tttgaagcta ataggagggt gttctcctct gacaagttac gcttgtatat
     8101 cctgcagatg tgtaaaataa actgtgttcc ttttcgccac cattttttag attttttaaa
     8161 gaagaaaatg tgtaatcctt tttaaagaac aacacaatgt aaatacattc aagtattgta
     8221 gacgtagagt tgggatgtga tggcctcggg ccttccttgg aaaagcctgt ggctgctcag
     8281 tgctcctaag ccatgagaat ggcagcccag aaacatgaac tctgccttgg ctttcagaac
     8341 cacttagtcc ttttataaca aagaaaaaaa taaataaata ataaaaatgt ttcttacagt
     8401 gtcaataaaa aaaactttgt actgaaa
//
