LOCUS       NM_010296               3662 bp    mRNA    linear   ROD 11-MAR-2025
DEFINITION  Mus musculus GLI-Kruppel family member GLI1 (Gli1), mRNA.
ACCESSION   NM_010296 XM_989852
VERSION     NM_010296.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3662)
  AUTHORS   Wu,Y., Korobeynyk,V.I., Zamboni,M., Waern,F., Cole,J.D., Mundt,S.,
            Greter,M., Frisen,J., Llorens-Bobadilla,E. and Jessberger,S.
  TITLE     Multimodal transcriptomics reveal neurogenic aging trajectories and
            age-related regional inflammation in the dentate gyrus
  JOURNAL   Nat Neurosci 28 (2), 415-430 (2025)
   PUBMED   39762661
REFERENCE   2  (bases 1 to 3662)
  AUTHORS   Chen,X., Tober,J., Dominguez,M., Tang,A.T., Bockman,J., Yang,J.,
            Mani,S., Lee,C.N., Chen,M., Thillaikumaran,T., Mericko-Ishizuka,P.,
            Mainigi,M., Speck,N.A. and Kahn,M.L.
  TITLE     Lineage tracing studies suggest that the placenta is not a de novo
            source of hematopoietic stem cells
  JOURNAL   PLoS Biol 23 (1), e3003003 (2025)
   PUBMED   39874373
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3662)
  AUTHORS   Dang,K., Singh,A., Chen,X., Cotton,J.L., Guo,S., Hu,X., Tao,Z.,
            Liu,H., Zhu,L.J., Ip,Y.T., Wu,X. and Mao,J.
  TITLE     Mesenchymal Hippo signaling regulates intestinal homeostasis in
            adult mice
  JOURNAL   iScience 28 (2), 111847 (2025)
   PUBMED   39981512
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3662)
  AUTHORS   Song,C., Sawall,J.K., Ji,X., Song,F., Liao,X., Peng,R., Ren,H.,
            Koyama,E., Pacifici,M. and Long,F.
  TITLE     Tgfbeta signaling stimulates glycolysis to promote the genesis of
            synovial joint interzone in developing mouse embryonic limbs
  JOURNAL   Sci Adv 11 (2), eadq4991 (2025)
   PUBMED   39772668
REFERENCE   5  (bases 1 to 3662)
  AUTHORS   Khan,I.S., Molina,C., Ren,X., Auyeung,V.C., Cohen,M., Tsukui,T.,
            Atakilit,A. and Sheppard,D.
  TITLE     Impaired myofibroblast proliferation is a central feature of
            pathologic post-natal alveolar simplification
  JOURNAL   Elife 13, 94425 (2024)
   PUBMED   39660606
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3662)
  AUTHORS   el-Baradi,T. and Pieler,T.
  TITLE     Zinc finger proteins: what we know and what we would like to know
  JOURNAL   Mech Dev 35 (3), 155-169 (1991)
   PUBMED   1768617
  REMARK    Review article
REFERENCE   7  (bases 1 to 3662)
  AUTHORS   Kwon,B.S., Chintamaneni,C., Kozak,C.A., Copeland,N.G.,
            Gilbert,D.J., Jenkins,N., Barton,D., Francke,U., Kobayashi,Y. and
            Kim,K.K.
  TITLE     A melanocyte-specific gene, Pmel 17, maps near the silver coat
            color locus on mouse chromosome 10 and is in a syntenic region on
            human chromosome 12
  JOURNAL   Proc Natl Acad Sci U S A 88 (20), 9228-9232 (1991)
   PUBMED   1924386
REFERENCE   8  (bases 1 to 3662)
  AUTHORS   Ashworth,A. and Denny,P.
  TITLE     Zinc finger protein genes in the mouse genome
  JOURNAL   Mamm Genome 1 (3), 196-200 (1991)
   PUBMED   1797234
  REMARK    Review article
REFERENCE   9  (bases 1 to 3662)
  AUTHORS   Copeland,N.G., Gilbert,D.J., Cho,B.C., Donovan,P.J., Jenkins,N.A.,
            Cosman,D., Anderson,D., Lyman,S.D. and Williams,D.E.
  TITLE     Mast cell growth factor maps near the steel locus on mouse
            chromosome 10 and is deleted in a number of steel alleles
  JOURNAL   Cell 63 (1), 175-183 (1990)
   PUBMED   1698554
REFERENCE   10 (bases 1 to 3662)
  AUTHORS   Justice,M.J., Siracusa,L.D., Gilbert,D.J., Heisterkamp,N.,
            Groffen,J., Chada,K., Silan,C.M., Copeland,N.G. and Jenkins,N.A.
  TITLE     A genetic linkage map of mouse chromosome 10: localization of
            eighteen molecular markers using a single interspecific backcross
  JOURNAL   Genetics 125 (4), 855-866 (1990)
   PUBMED   1975791
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AF026305.1, CJ062804.1, CV782971.1, CF898732.1 and AC114678.20.
            
            On or before May 4, 2006 this sequence version replaced
            XM_989852.1, NM_010296.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB025922.1, AF026305.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-220               AF026305.1         1-220
            221-448             CJ062804.1         205-432
            449-607             AF026305.1         449-607
            608-1295            CV782971.1         2-689
            1296-1462           AF026305.1         1296-1462
            1463-1973           CF898732.1         26-536
            1974-3662           AC114678.20        125880-127568
FEATURES             Location/Qualifiers
     source          1..3662
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 74.5 cM"
     gene            1..3662
                     /gene="Gli1"
                     /gene_synonym="Zfp-5; Zfp5"
                     /note="GLI-Kruppel family member GLI1"
                     /db_xref="GeneID:14632"
                     /db_xref="MGI:MGI:95727"
     exon            1..21
                     /gene="Gli1"
                     /gene_synonym="Zfp-5; Zfp5"
                     /inference="alignment:Splign:2.1.0"
     exon            22..135
                     /gene="Gli1"
                     /gene_synonym="Zfp-5; Zfp5"
                     /inference="alignment:Splign:2.1.0"
     exon            136..261
                     /gene="Gli1"
                     /gene_synonym="Zfp-5; Zfp5"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..3497
                     /gene="Gli1"
                     /gene_synonym="Zfp-5; Zfp5"
                     /note="glioma-associated oncogene homolog; zinc finger
                     protein 5"
                     /codon_start=1
                     /product="zinc finger protein GLI1"
                     /protein_id="NP_034426.2"
                     /db_xref="CCDS:CCDS24238.1"
                     /db_xref="GeneID:14632"
                     /db_xref="MGI:MGI:95727"
                     /translation="MFNPMTPPQVNSYSEPCCLRPLHSQGVPSMGTEGLSGLPFCHQA
                     NFMSGSQGYGAARETSSCTEGSLFPPPPPPRSSVKLTKKRALSISPLSDASLDLQTVI
                     RTSPSSLVAFINSRCTSPGGSYGHLSIGTMSPSLGFPPQMSHQKGTSPPYGVQPCVPH
                     DSTRGSMMLHPQSRGPRATCQLKSELDMMVGKCPEDPLEGDMSSPNSTGTQDHLLGML
                     DGREDLEREEKPEPESVYETDCRWDGCSQEFDSQEQLVHHINSEHIHGERKEFVCHWG
                     GCSRELRPFKAQYMLVVHMRRHTGEKPHKCTFEGCRKSYSRLENLKTHLRSHTGEKPY
                     MCEQEGCSKAFSNASDRAKHQNRTHSNEKPYVCKLPGCTKRYTDPSSLRKHVKTVHGP
                     DAHVTKRHRGDGPLPRAQPLSTVEPKREREGGSGREESRLTVPESAMPQQSPGAQSSC
                     SSDHSPAGSAANTDSGVEMAGNAGGSTEDLSSLDEGPCVSATGLSTLRRLENLRLDQL
                     HQLRPIGSRGLKLPSLTHAGAPVSRRLGPPVSLDRRSSSSSSMSSAYTVSRRSSLASP
                     FPPGTPPENGASSLPGLTPAQHYMLRARYASARGSGTPPTAAHSLDRMGGLSVPPWRS
                     RTEYPGYNPNAGVTRRASDPARAADHPAPARVQRFKSLGCVHTPPSVATGRNFDPHHP
                     TSVYSPQPPSITENVAMDTRGLQEEPEVGTSVMGNGLNPYMDFSSTDTLGYGGPEGTA
                     AEPYEARGPGSLPLGPGPPTNYGPGHCAQQVSYPDPTPENWGEFPSHAGVYPSNKAPG
                     AAYSQCPRLEHYGQVQVKPEQGCPVGSDSTGLAPCLNAHPSEGSPGPQPLFSHHPQLP
                     QPQYPQSGPYPQPPHGYLSTEPRLGLNFNPSSSHSTGQLKAQLVCNYVQSQQELLWEG
                     RNRGGLPNQELPYQSPKFLGGSQVSQSPAKTPAAAAAAYGSGFAPASANHKSGSYPAP
                     SPCHETFTVGVNRPSHRPAAPPRLLPPLSPCYGPLKVGDTNPSCGHPEVGRLGAGPAL
                     YPPPEGQVCNALDSLDLDNTQLDFVAILDEAQGLSPPLSHEQGDSSKNTPSPSGPPNM
                     AVGNMSVLLGSLPGETQFLNSSA"
     exon            262..354
                     /gene="Gli1"
                     /gene_synonym="Zfp-5; Zfp5"
                     /inference="alignment:Splign:2.1.0"
     exon            355..559
                     /gene="Gli1"
                     /gene_synonym="Zfp-5; Zfp5"
                     /inference="alignment:Splign:2.1.0"
     exon            560..704
                     /gene="Gli1"
                     /gene_synonym="Zfp-5; Zfp5"
                     /inference="alignment:Splign:2.1.0"
     exon            705..794
                     /gene="Gli1"
                     /gene_synonym="Zfp-5; Zfp5"
                     /inference="alignment:Splign:2.1.0"
     exon            795..932
                     /gene="Gli1"
                     /gene_synonym="Zfp-5; Zfp5"
                     /inference="alignment:Splign:2.1.0"
     exon            933..1082
                     /gene="Gli1"
                     /gene_synonym="Zfp-5; Zfp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1083..1247
                     /gene="Gli1"
                     /gene_synonym="Zfp-5; Zfp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1478
                     /gene="Gli1"
                     /gene_synonym="Zfp-5; Zfp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..1743
                     /gene="Gli1"
                     /gene_synonym="Zfp-5; Zfp5"
                     /inference="alignment:Splign:2.1.0"
     exon            1744..3662
                     /gene="Gli1"
                     /gene_synonym="Zfp-5; Zfp5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3641..3646
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gli1"
                     /gene_synonym="Zfp-5; Zfp5"
                     /note="hexamer: AATAAA"
     polyA_site      3662
                     /gene="Gli1"
                     /gene_synonym="Zfp-5; Zfp5"
                     /note="major polyA site"
ORIGIN      
        1 gagcaccgcg ccccgacgga ggtctctttg tccgcgcctc tcccacatac tagaaatctc
       61 tccctttctt gaggttggga tgaagaagca gttgggacgg ccagctggag gtctgcgtgg
      121 tagagggaac tccaggtccc ctcatccttc cctgagacgc catgttcaat ccaatgactc
      181 caccacaagt caatagctat agtgagccat gctgtctccg acccctccac agccaaggag
      241 tccccagcat gggaacagaa ggactttctg gtctgccctt ttgccaccaa gccaacttta
      301 tgtcagggtc ccagggttat ggagcagcca gagagaccag cagctgcact gaaggatctc
      361 tctttcctcc tcctcctcct cctcggagtt cagtcaaatt aacaaagaag cgggctctct
      421 ccatctcgcc cctttctgat gccagcctcg acctgcaaac cgtaatccgg acctcaccca
      481 gctccctggt ggctttcatc aactctcgct gtacatctcc gggcggttcc tacggccatc
      541 tctccattgg taccatgagc ccttctttag gattcccacc tcagatgagt catcaaaaag
      601 gaacttcacc tccctatgga gtccagccct gtgtaccaca tgactctact cggggttcaa
      661 tgatgcttca cccccagtcc cggggaccac gtgcaacctg ccagctgaag tcagagctgg
      721 atatgatggt tggcaagtgc ccggaggacc ctttggaagg ggacatgtct agccccaact
      781 ccacaggcac acaggatcac ctgttgggga tgctggatgg gcgggaggac ctggagagag
      841 aggagaagcc tgagcctgag tctgtgtatg agacagactg ccgctgggat ggttgcagcc
      901 aggagttcga ttcccaggag cagctggtgc accacatcaa cagtgagcat atccacgggg
      961 agcggaagga attcgtgtgc cattggggag gttgctccag ggagctgagg cccttcaagg
     1021 cccaatacat gctggtggtg cacatgcgca gacacacggg cgagaagcca cacaagtgca
     1081 cgtttgaagg ctgtcggaag tcctattcac gccttgaaaa cctcaagacg caccttcggt
     1141 cgcacacggg tgagaagcct tacatgtgtg agcaagaagg ttgcagcaag gcctttagca
     1201 atgccagtga ccgcgccaag caccagaatc ggacccactc caatgagaag ccatacgtgt
     1261 gcaagctccc cggctgcacc aagcgctaca cagatcccag ctcgctccgc aaacacgtga
     1321 agacagtgca tggtccggat gcccacgtga ccaagcggca tcgaggggat ggccccttgc
     1381 cacgggctca gcccctctcc acagtggagc ccaagcggga aagggaagga ggatccggca
     1441 gggaagagag cagactgact gtgcccgaga gtgccatgcc gcagcagagc cccggagcgc
     1501 agtcctcttg cagcagcgac cactccccag caggcagtgc ggccaacacg gacagcggcg
     1561 tggagatggc cggcaacgcc gggggcagca ctgaggactt gtccagcttg gatgaaggac
     1621 cttgtgtctc ggccaccgga ctctccacgc ttcgccgcct ggagaacctt aggctggatc
     1681 agctgcatca gctccggccc atagggtctc ggggtctcaa actgcccagc ttaacccacg
     1741 ctggcgcacc tgtgtctcgc cgtctgggcc ccccagtctc cctggaccgc cgcagcagca
     1801 gctccagcag catgagctct gcttacacag tcagccgcag gtcctccctg gcatcccctt
     1861 tcccgccggg aaccccacca gagaatgggg catcgtcact acctggcctc acacctgctc
     1921 agcactacat gctccgtgcc agatatgctt cagccagggg gagtggcacc ccgcccactg
     1981 cagctcacag cctggatcgg atgggaggtc tttctgttcc tccttggaga agccgaaccg
     2041 agtacccggg atacaaccca aatgcagggg tcactcggag ggccagtgac ccagcccggg
     2101 ctgctgacca cccagctcca gccagagtcc agcggttcaa gagcctggga tgtgtccaca
     2161 cgccccctag tgtggcaacg ggacggaact tcgatcccca ccaccctacc tctgtctatt
     2221 cgccacagcc ccccagcatc accgaaaatg ttgccatgga tactaggggg ctacaggagg
     2281 agccagaggt tggaacttct gtgatgggca atggtctgaa cccatacatg gatttttcct
     2341 ccactgatac tctgggatat gggggacccg aggggacggc agctgagcct tatgaagcta
     2401 ggggtccagg ttccctgcct cttgggcctg gtccaccaac caactatggc cctggccact
     2461 gtgcccagca ggtctcctat cctgatccca ccccagaaaa ctggggtgag ttcccttctc
     2521 atgctggggt gtaccctagc aataaggctc cgggtgctgc ctatagccag tgtcctcgac
     2581 ttgagcatta tggacaagtg caggtaaaac cagaacaagg gtgcccagtg gggtctgact
     2641 ccaccggatt ggcaccctgc ctcaatgccc accccagtga agggtcccca ggcccgcagc
     2701 ctctgttttc acatcatccc cagctccctc agccccagta tccccagtcg ggtccctatc
     2761 ctcagcctcc ccatggttat ctctcaacag aacccaggct tggcctcaat ttcaacccct
     2821 cctcctctca ttccacagga cagctcaaag ctcagctggt gtgtaattac gttcagtcgc
     2881 agcaggaatt gttgtgggag ggaagaaacc ggggagggct ccccaaccag gaactcccat
     2941 accagagccc caagtttctg gggggttccc aagttagtca gagccctgcc aagaccccag
     3001 cagcagcggc ggcagcatat ggatctggct ttgcacctgc ttcggccaat cacaaatcag
     3061 gctcctatcc tgccccttca ccctgccatg aaactttcac cgtgggagta aacaggcctt
     3121 cccacaggcc agcagcacca ccccgacttc tgcccccgct gtccccttgc tatgggcccc
     3181 tcaaggtggg ggataccaac cccagctgtg gccatcctga ggtgggcagg ttaggagcag
     3241 gccctgcctt gtaccctcct cctgaagggc aggtgtgtaa cgctctggac tctcttgacc
     3301 tggacaacac tcagctggac tttgtggcta tcctagatga ggcccagggc ctgagccctc
     3361 ctctttccca tgagcaaggg gacagctcta aaaacacccc atctccctct gggcccccca
     3421 acatggcagt gggtaacatg agtgtcttgc tggggtctct gcctggagag acacaattcc
     3481 tcaactctag tgcctaaaag ggtaaggaac cccaagcaga tggtatttcc taaatggcta
     3541 catgaggtgc ccagggatgg gaggtttggg ctgggggctg tatttagtct atgtatgttc
     3601 caggaaagaa caaactttaa taatgacaca gtttcctgac aataaaggaa tactgagaac
     3661 aa
//
