LOCUS       NM_009149               8134 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus golgi apparatus protein 1 (Glg1), transcript variant
            2, mRNA.
ACCESSION   NM_009149 XM_001001167
VERSION     NM_009149.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 8134)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 8134)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 8134)
  AUTHORS   Werneburg,S., Buettner,F.F., Erben,L., Mathews,M., Neumann,H.,
            Muhlenhoff,M. and Hildebrandt,H.
  TITLE     Polysialylation and lipopolysaccharide-induced shedding of
            E-selectin ligand-1 and neuropilin-2 by microglia and THP-1
            macrophages
  JOURNAL   Glia 64 (8), 1314-1330 (2016)
   PUBMED   27159043
  REMARK    GeneRIF: Study identifies NRP2 and ESL-1 as targets for
            polysialylation in murine microglia and human THP-1 macrophages and
            reveals a striking convergence in the regulation of the two
            polysialylated acceptors in the course of inflammatory activation.
            A pool of polysialylated NRP2 and ESL-1 is assembled after injury
            or in culture and its shedding is an early response to
            lipopolysaccharide-induced activation of microglia.
REFERENCE   4  (bases 1 to 8134)
  AUTHORS   Leiva,M., Quintana,J.A., Ligos,J.M. and Hidalgo,A.
  TITLE     Haematopoietic ESL-1 enables stem cell proliferation in the bone
            marrow by limiting TGFbeta availability
  JOURNAL   Nat Commun 7, 10222 (2016)
   PUBMED   26742601
  REMARK    GeneRIF: A cell-intrinsic mechanism whereby haematopoietic cells
            limit proliferation within the bone marrow is repressed by
            E-selectin ligand 1 (ESL-1).
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 8134)
  AUTHORS   Pruenster,M., Kurz,A.R., Chung,K.J., Cao-Ehlker,X., Bieber,S.,
            Nussbaum,C.F., Bierschenk,S., Eggersmann,T.K., Rohwedder,I.,
            Heinig,K., Immler,R., Moser,M., Koedel,U., Gran,S., McEver,R.P.,
            Vestweber,D., Verschoor,A., Leanderson,T., Chavakis,T., Roth,J.,
            Vogl,T. and Sperandio,M.
  TITLE     Extracellular MRP8/14 is a regulator of beta2 integrin-dependent
            neutrophil slow rolling and adhesion
  JOURNAL   Nat Commun 6, 6915 (2015)
   PUBMED   25892652
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 8134)
  AUTHORS   Gruenheid,S., Pinner,E., Desjardins,M. and Gros,P.
  TITLE     Natural resistance to infection with intracellular pathogens: the
            Nramp1 protein is recruited to the membrane of the phagosome
  JOURNAL   J Exp Med 185 (4), 717-730 (1997)
   PUBMED   9034150
REFERENCE   7  (bases 1 to 8134)
  AUTHORS   Mourelatos,Z., Gonatas,J.O., Cinato,E. and Gonatas,N.K.
  TITLE     Cloning and sequence analysis of the human MG160, a fibroblast
            growth factor and E-selectin binding membrane sialoglycoprotein of
            the Golgi apparatus
  JOURNAL   DNA Cell Biol 15 (12), 1121-1128 (1996)
   PUBMED   8985126
REFERENCE   8  (bases 1 to 8134)
  AUTHORS   Osanai,T., Feizi,T., Chai,W., Lawson,A.M., Gustavsson,M.L.,
            Sudo,K., Araki,M., Araki,K. and Yuen,C.T.
  TITLE     Two families of murine carbohydrate ligands for E-selectin
  JOURNAL   Biochem Biophys Res Commun 218 (2), 610-615 (1996)
   PUBMED   8561804
REFERENCE   9  (bases 1 to 8134)
  AUTHORS   Antony,C., Huchet,M., Changeux,J.P. and Cartaud,J.
  TITLE     Developmental regulation of membrane traffic organization during
            synaptogenesis in mouse diaphragm muscle
  JOURNAL   J Cell Biol 130 (4), 959-968 (1995)
   PUBMED   7642711
REFERENCE   10 (bases 1 to 8134)
  AUTHORS   Steegmaier,M., Levinovitz,A., Isenmann,S., Borges,E., Lenter,M.,
            Kocher,H.P., Kleuser,B. and Vestweber,D.
  TITLE     The E-selectin-ligand ESL-1 is a variant of a receptor for
            fibroblast growth factor
  JOURNAL   Nature 373 (6515), 615-620 (1995)
   PUBMED   7531823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC163625.5 and AC093451.25.
            
            On Feb 6, 2019 this sequence version replaced NM_009149.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: X84037.1, AK154581.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-440               AC163625.5         148028-148467       c
            441-473             AC163625.5         90783-90815         c
            474-560             AC163625.5         89393-89479         c
            561-776             AC163625.5         86850-87065         c
            777-980             AC163625.5         81781-81984         c
            981-1052            AC163625.5         80447-80518         c
            1053-1236           AC163625.5         77924-78107         c
            1237-1451           AC163625.5         76971-77185         c
            1452-1573           AC163625.5         71788-71909         c
            1574-1675           AC163625.5         70192-70293         c
            1676-1829           AC163625.5         68090-68243         c
            1830-1967           AC163625.5         66902-67039         c
            1968-2054           AC163625.5         63491-63577         c
            2055-2117           AC163625.5         62459-62521         c
            2118-2231           AC163625.5         61672-61785         c
            2232-2320           AC163625.5         60487-60575         c
            2321-2438           AC163625.5         58745-58862         c
            2439-2531           AC163625.5         57918-58010         c
            2532-2669           AC163625.5         54814-54951         c
            2670-2793           AC163625.5         53028-53151         c
            2794-2936           AC163625.5         51895-52037         c
            2937-3038           AC163625.5         51624-51725         c
            3039-3146           AC163625.5         50683-50790         c
            3147-3267           AC163625.5         49878-49998         c
            3268-3374           AC163625.5         49056-49162         c
            3375-8134           AC093451.25        193796-198555       c
FEATURES             Location/Qualifiers
     source          1..8134
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 57.98 cM"
     gene            1..8134
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /note="golgi apparatus protein 1"
                     /db_xref="GeneID:20340"
                     /db_xref="MGI:MGI:104967"
     exon            1..440
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     CDS             15..3542
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /note="isoform 2 precursor is encoded by transcript
                     variant 2; E-selectin ligand 1; golgi sialoglycoprotein
                     MG-160; selectin, endothelial cell, ligand"
                     /codon_start=1
                     /product="Golgi apparatus protein 1 isoform 2 precursor"
                     /protein_id="NP_033175.1"
                     /db_xref="CCDS:CCDS22671.1"
                     /db_xref="GeneID:20340"
                     /db_xref="MGI:MGI:104967"
                     /translation="MAVCGRVRGMFRLSAALPLLLLAAAGAQNGHGQGQGPGTNFGPF
                     PGQGGGGSPAGQQPPQQPQLSQQQQQPPPQQQQQQQQQSLFAAGGLPARRGGAGPGGT
                     GGGWKLAEEESCREDVTRVCPKHTWSNNLAVLECLQDVREPENEISSDCNHLLWNYKL
                     NLTTDPKFESVAREVCKSTISEIKECAEEPVGKGYMVSCLVDHRGNITEYQCHQYITK
                     MTAIIFSDYRLICGFMDDCKNDINLLKCGSIRLGEKDAHSQGEVVSCLEKGLVKEAEE
                     KEPKIQVSELCKKAILRVAELSSDDFHLDRHLYFACRDDRERFCENTQAGEGRVYKCL
                     FNHKFEESMSEKCREALTTRQKLIAQDYKVSYSLAKSCKSDLKKYRCNVENLPRSREA
                     RLSYLLMCLESAVHRGRQVSSECQGEMLDYRRMLMEDFSLSPEIILSCRGEIEHHCSG
                     LHRKGRTLHCLMKVVRGEKGNLGMNCQQALQTLIQETDPGADYRIDRALNEACESVIQ
                     TACKHIRSGDPMILSCLMEHLYTEKMVEDCEHRLLELQYFISRDWKLDPVLYRKCQGD
                     ASRLCHTHGWNETSELMPPGAVFSCLYRHAYRTEEQGRRLSRECRAEVQRILHQRAMD
                     VKLDPALQDKCLIDLGKWCSEKTETGQELECLQDHLDDLAVECRDIVGNLTELESEDI
                     QIEALLMRACEPIIQNFCHDVADNQIDSGDLMECLIQNKHQKDMNEKCAIGVTHFQLV
                     QMKDFRFSYKFKMACKEDVLKLCPNIKKKVDVVICLSTTVRNDTLQEAKEHRVSLKCR
                     KQLRVEELEMTEDIRLEPDLYEACKSDIKNYCSTVQYGNAQIIECLKENKKQLSTRCH
                     QKVFKLQETEMMDPELDYTLMRVCKQMIKRFCPEADSKTMLQCLKQNKNSELMDPKCK
                     QMITKRQITQNTDYRLNPVLRKACKADIPKFCHGILTKAKDDSELEGQVISCLKLRYA
                     DQRLSSDCEDQIRIIIQESALDYRLDPQLQLHCSDEIANLCAEEAAAQEQTGQVEECL
                     KVNLLKIKTELCKKEVLNMLKESKADIFVDPVLHTACALDIKHHCAAITPGRGRQMSC
                     LMEALEDKRVRLQPECKKRLNDRIEMWSYAAKVAPADGFSDLAMQVMTSPSKNYILSV
                     ISGSICILFLIGLMCGRITKRVTRELKDR"
     exon            441..473
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     exon            474..560
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     exon            561..776
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     exon            777..980
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1052
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     exon            1053..1236
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1451
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     exon            1452..1573
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     exon            1574..1675
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     exon            1676..1829
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     exon            1830..1967
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     exon            1968..2054
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     exon            2055..2117
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     exon            2118..2231
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     exon            2232..2320
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     exon            2321..2438
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     exon            2439..2531
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     exon            2532..2669
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..2793
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     exon            2794..2936
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     exon            2937..3038
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     exon            3039..3146
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     exon            3147..3267
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     exon            3268..3374
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     exon            3375..8134
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8105..8110
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /note="hexamer: AATAAA"
     polyA_site      8127
                     /gene="Glg1"
                     /gene_synonym="CFR; CFR-1; ESL-1; MG-160; MG160; Selel"
                     /note="major polyA site"
ORIGIN      
        1 gccgcgaacc caagatggcg gtgtgtggac gtgtacgggg gatgttccgc ttgtcggcgg
       61 cgttgccgct gctgctgctc gcggcagcag gggcccagaa tggtcacggt cagggccagg
      121 gtccggggac caactttggg cccttcccag ggcaaggtgg aggcggcagc ccggccggcc
      181 aacagccgcc tcagcagcct cagttatcgc agcagcagca gcagccgccg cctcagcagc
      241 agcagcagca acagcagcag tcgcttttcg cggcgggcgg gctcccggcc cggcggggcg
      301 gagcggggcc cggtgggact ggcggaggct ggaagctggc ggaggaagag tcctgccggg
      361 aggacgtgac ccgtgtgtgc cccaaacaca cctggagcaa caacctggcg gtgctcgagt
      421 gcctgcagga cgtgagggag cccgagaacg agatttcttc agactgcaat catttgttgt
      481 ggaattacaa gctgaacctg actactgatc ccaaatttga atctgtggcc agggaggttt
      541 gcaagtcaac tatttccgag attaaagaat gtgcggaaga accagttgga aaaggttaca
      601 tggtttcctg cttggtggat catcgaggca acatcactga gtatcagtgt catcaataca
      661 ttaccaagat gacggccatc attttcagtg attatcgctt gatctgcggc ttcatggatg
      721 actgcaaaaa tgatatcaac ctcttgaaat gtggcagcat tcgtcttggg gaaaaggatg
      781 cacattcaca aggtgaggtg gtatcatgtt tggaaaaagg cctggtaaaa gaggcagaag
      841 aaaaagagcc gaagattcaa gtctcagaac tctgcaagaa agccattctt agggtggctg
      901 agctgtcctc ggatgacttt catttagacc ggcatttgta ttttgcttgc cgagatgatc
      961 gggagcgctt ttgcgagaat acacaagctg gtgaaggaag agtgtataaa tgcctattta
     1021 accataagtt tgaagaatcc atgagtgaaa agtgtagaga agcactaact acacgccaga
     1081 agctcattgc ccaggattat aaagtcagtt actcattagc caaatcctgt aagagtgact
     1141 tgaaaaaata ccggtgcaat gtggaaaacc ttcctcggtc ccgggaagcc aggctctcct
     1201 accttctgat gtgcctggag tcagcagtgc acagagggcg gcaggtgagc agtgagtgcc
     1261 aaggtgagat gctggattac cgacgcatgc tgatggaaga cttctctctg agccccgaga
     1321 tcatcctgag ctgtcgaggg gagattgaac accattgttc tggattacat cggaaagggc
     1381 gaaccctcca ctgtctgatg aaagtggttc ggggtgaaaa ggggaacctt ggaatgaact
     1441 gccaacaggc gcttcagaca ctgattcagg agactgaccc tggtgcagac taccgcattg
     1501 atcgagcttt gaatgaagct tgtgagtctg taatacagac agcctgcaaa cacatacgat
     1561 ccggagaccc aatgattctc tcatgtctga tggagcattt atacacagag aagatggtgg
     1621 aagactgtga acaccggctc ttagagctac agtattttat ctctcgggat tggaagttgg
     1681 accctgtttt ataccgaaaa tgccagggag atgcttcccg cctttgccat acccatggtt
     1741 ggaatgagac cagtgaactt atgccccctg gagctgtgtt ttcttgccta tacagacatg
     1801 cctaccgcac agaagagcaa ggaaggaggc tctcacgaga atgtcgagct gaagtccaga
     1861 ggatcctgca ccagcgagcc atggatgtta agctggatcc tgccctccag gacaagtgcc
     1921 tcatagacct agggaagtgg tgcagtgaga agacggagac tgggcaggag cttgagtgcc
     1981 ttcaggacca tctcgatgac ttagctgtgg aatgcagaga catcgtgggc aacctcaccg
     2041 agttagagtc cgaggatata caaatagaag ctttgctgat gagagcctgt gagcctatca
     2101 ttcagaactt ttgccacgat gtggcagaca accagatcga ctctggggac ctgatggagt
     2161 gtctgatcca gaacaagcac cagaaggaca tgaacgagaa gtgtgccatt ggcgtcactc
     2221 acttccagct ggtacagatg aaggattttc gattctctta caagttcaaa atggcctgca
     2281 aggaggatgt gttaaagctt tgccccaaca taaaaaagaa ggtggacgta gtgatctgcc
     2341 tgagcaccac tgtgcgcaac gacactctgc aggaggccaa ggagcaccga gtatcactca
     2401 agtgccgcaa gcagcttcgt gtggaagagc tggagatgac agaggacatc cgtttggaac
     2461 cagatctgta tgaagcctgc aagagtgaca tcaagaacta ctgttctaca gtgcaatatg
     2521 gaaatgctca gattattgaa tgtctaaaag aaaacaagaa gcagctgagt acccgttgcc
     2581 accagaaagt atttaagctg caggagacgg agatgatgga cccagagcta gactatactc
     2641 tgatgagagt ctgcaagcag atgattaagc ggttctgtcc agaagcagat tctaaaacta
     2701 tgttgcagtg tttaaaacaa aataagaaca gtgaattgat ggatcccaaa tgcaaacaga
     2761 tgataaccaa gcgccagatc acccagaaca cagattaccg cttaaaccct gtgctaagga
     2821 aggcctgtaa agctgacatt cctaagttct gtcatggcat cctgaccaag gctaaggacg
     2881 attcagagct agaaggccaa gttatctcat gcctcaagct gagatatgct gaccagcgcc
     2941 tgtcctcaga ctgtgaggac cagatccgta tcatcatcca ggagtctgct ctggattacc
     3001 gcctggaccc tcagctccag ctgcactgct cagatgagat tgccaatcta tgtgctgaag
     3061 aagcagcagc ccaggagcaa acaggccaag tggaagagtg cctgaaggtc aacctgctca
     3121 agatcaagac agagctgtgt aaaaaggaag tgttaaacat gttgaaggaa agcaaagcag
     3181 acatctttgt ggaccccgtt cttcacacag catgtgcctt ggacattaaa caccactgtg
     3241 cagccatcac ccctggccgc gggcgtcaga tgtcctgcct gatggaggcc ctggaagata
     3301 agcgagtgag attgcagcca gagtgcaaaa agcgcctcaa tgaccggatt gagatgtgga
     3361 gttatgcagc caaggtggct ccagcagatg gcttctctga tcttgccatg caagtgatga
     3421 catctccctc aaagaactac atcctgtctg tgatcagcgg gagcatctgc atactcttcc
     3481 tgattggcct gatgtgtgga cggatcacca agagagtgac acgagagctg aaggacaggt
     3541 agaggcgcag gcctgaccac caaggagcca ccgcccgggc ccgcctgtac agccgtcctg
     3601 tatagtgtac cctctcactg cgccctctaa cggtggcact gacacccaca gtagagcagc
     3661 atcaggtgcc cactgcatct tcccatccag acttggccat gtcctcggtg tcctcctcct
     3721 cctcctcctc ccagctgccc ttgcagcgtc ggcagctggc tgctttggtg gtagcttttg
     3781 ttggcgaagg tttacctgcc tgtagacaat tctgtcatac ctacagaact gctggtactt
     3841 ccagaccgac tcacctgacc tgcaactcaa atttttaaaa aaaaaaaaca aaaaaacaaa
     3901 agacaaaaaa attttaaaaa ggaaaaagtg tatatagtag aacttctcct tcagtcttga
     3961 ctcaaacagt aggattattc tttcatgtaa atgcagcagg tgtcagcagg acttggagga
     4021 gcgatgcata tcccgtgcct gatcattgac atgtctgttt cctctcccag aagcaacttt
     4081 ggcccacatc aaggcaggga cttcagcaag tagtggggac actaagcagc ctgctctagg
     4141 gcctgtttgc ttctactgca gtgtgatgcc ttctaccctc taccccagac gagccactgc
     4201 gacccacagt ctcatagcaa caggcatttc tgtgtcgccc acttcagtgc agatgtgagc
     4261 ctctctgtgt cagtggaagc ggactaggga gggagcagag tctgaagcag gcctgggtgc
     4321 acagccagca ggggcccagc catcctcttc ctccaagatg ggatagagct gcctcatctt
     4381 gatgaaccct cataaatgtg gggttccctg gaagttctct acctcgacaa gaagtagtta
     4441 ctaagttggg gtgtagggct tctaagatga gggtgggggt ggcagggcag gaaggaacag
     4501 gtgtaggact tgcttcactt agtttgctga acaatagtac aggccagaag agatggcttc
     4561 tgaagattta gcgtgatctc gggtgcgtgg ctggcattga agcctgactt tctgtgcatg
     4621 ccaggcagac ttcctgactg acaggcagac ttcctgacca acaagctcct ttgtgcctct
     4681 aaatgaaggg atgtggaaag tgattgcatt aaaagatgga ggattttctt cgttcttttt
     4741 tccctccttt ctgttcattt gctgcgtgta cccactccag taggcactgg ctcagtgtta
     4801 cattttggtg atctgacaac cttccatagt ctgagcttta caggagcagg atccccagcc
     4861 atcttccctc actcctccag tgtgaagatg acagggccgg agcataggag ggaggagccc
     4921 aggcactgca gttccccttt ggcgagtttg ggccatggtg tcacagtggc tgtacagagg
     4981 gtggcatgta cagtaggaga tatatttata taatatatat tttattaacc tgttagatgt
     5041 ccacagagta ttataaatca tgtgcctaga actgtccaca cagacccagg ccccctcggt
     5101 gccgccctgc tcctgcctcc catatgcacc tacagctgct gccgcactgg agccatgtgt
     5161 cttcctgaga tgcgttctgt gcaggctctg tcagttgctc caaatcactc tgtgtctcac
     5221 ctgactgaca ttcatttgaa tactgtggtt ttcttttctg ctgccttttc tggtggcagt
     5281 gagttccagg gctagctgtg tatcccctgc atagggtaat agaagtcacc aggggaaaat
     5341 ttgcaaagct tcctgggccc ctacttactg cttctagagt cttcctgatt ctcagcagct
     5401 gtcctgggat tcttgagttt gatgagactt aaaactcctg ctctgtaagc aacctcctcc
     5461 actgctagct ggctgagcca atctaaaggt ccctccctcc ctcccccgag agtctccgtg
     5521 tcacattgat gttccacagt tagacggggg tagaatcata gctctgatcc tgtggctccc
     5581 ttccggtatg tgcttagcat atgatgtgtg tctcagcact gctgcttctg cactgacagg
     5641 aatccacact gcctgcagca gatttggagg tttggtgggt ttggtgaatt tgattcttaa
     5701 actatttgcc attagacatg gtcagaatag aaaaaaaaaa tagctactag tgttttaaat
     5761 tgcttagtac aaggaagtga ccatattcct tggagtagtt cttatgactt gatggtccta
     5821 ggcctggtct taagcaggtt tttctaggct atgtctaagg ggcccagtgc tgtctattct
     5881 gtagctcatt gggcttagta gggtgggctc tgtgccctca taagtcagtc atgggtataa
     5941 attagataga catgaacttg ccaagaaccc caacctggcc gggcagtggt ggcacatgcc
     6001 tttaatccca ggacttggga ggcagaggta ggcgaattac tgagttcaag accagcctgg
     6061 tctacagagt gagttccagg acagccaggg ttacagagaa accctgtctt gaaaaaaaaa
     6121 aaaacaaaac aaaacaaaac aaaacacaga cctacagtgc gagccaaagt ctgagcctca
     6181 cccttcactg tcctgctttc attgcctaag aatagcagtt agggggtgta ggccaaggct
     6241 caggcactgc taagtcactg tgggctagct tgccagctca tgccagtgtc ttggggacca
     6301 ctggtggtag gtacatttcc ctttggtatt tcaaaaagcc ggggcctggg ccagggacag
     6361 ggcatctgtg gaccaggtca gaaatctgtc aatgagccaa gaaccagaca aactaaactt
     6421 cttttctgat ggggctgctt ctagtgaagg gactccagga gcaagacatt tcttttaacc
     6481 cggtccctgg acttgactgt tgtcgctgct cttgggggta ttttagcagt ctgaccctgg
     6541 gaaagcctta actctctgca ttcccagaga acttctggcc accatttcca gtcctggttc
     6601 tgtggatcaa gccagcttgc tgagccatgc atccttaata ggcaagggca ctccagagcc
     6661 actgatgagg tgacatctag tgatcaggtg ataacaaaag agttcagtac aggtaccatg
     6721 actaccacct cctgttctta gataggagca tgcagtccac tgtcccagac gagttggcag
     6781 aaagttatcc aactttttat gtcttcctgt tgaaatcagc tgatggaaga tgctctgctt
     6841 ctcagacact aggacgaggg tggagttgtg tgattagtat cctcggcctt cctagagagc
     6901 atccactctt gtgcatcagt gtgacttcca gaacccccgc ctcccttaga ggctatggta
     6961 ccgtttctgg actttctgga aagaaacctc ccttccattc ttttttccct accccaaaac
     7021 aaaacaagct ttttccactt gcccccagtt cagtatctca gaagtcaact ggcccagtct
     7081 ggtatcctgc agcctaacac agggccagag aaccaaaaga aggtgtggct ttttgaatcc
     7141 catgcttctt ggaagtttgt gtttcttctt gtgagtgtga aaattcaaca cagctccgaa
     7201 cacccccttg agttttttgc tctttgggca cacttagtag ttctgaagag tgtgaccttc
     7261 agggcccagg tctcctgacc catctctgcc ccacttggct tcagttccca aggggctgta
     7321 cctgacctct cgcctcccct tccctccagg tagctttggt ttgccatctg tttagctcca
     7381 cttctccctg gcctctccac tacggaggcc tggatcacct gttatagtaa ccaagtctaa
     7441 agccaaattt cccttcttgc tacccagacc tcaaacaaca gtgagttgta aagcaaccaa
     7501 gattaaacct cagggtgaca cactcccctg agcagacagt gagactgctg tggcggctta
     7561 gaggctgctt gtcacccaga acacaaagat acggttgtct gtgcagacag gtggtgacaa
     7621 ggggttttct ctgacatctt cacctgggca ctgagcacca ggcactggag agcttccaag
     7681 gtgaggaggt gcgcagacag accgtgtctc tatgtcacgt ttcaccttct cccagctcac
     7741 actgacatga gaacctcaga gcgtggggtc cttacaggaa caggtcccag gtcacttggc
     7801 agcacggtcg tggccgagcg cttcctgatg gctactccca gcaagcaggt cagcggcaat
     7861 ggaaaggcag agcgcacagc atgctgtgca gggtcttggg cctctaacct gtctttgctt
     7921 ttcgtttttg ttttttgaaa gaaaagtaca attaacaaac ctcttttgta aatggatttc
     7981 ctttctatgt ataaatcccc tgcagttcct tgtttttact gttcatgctg tgtaattttg
     8041 agatgttact gagattctga acataatgtg catttttttc tgtacagatg aaatgggaga
     8101 atttaataaa gagtttgcag gtttgtattt gtcg
//
