LOCUS       NM_028923               3138 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus GLE1 RNA export mediator (Gle1), mRNA.
ACCESSION   NM_028923 XM_130106
VERSION     NM_028923.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3138)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3138)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3138)
  AUTHORS   Valnegri,P., Huang,J., Yamada,T., Yang,Y., Mejia,L.A., Cho,H.Y.,
            Oldenborg,A. and Bonni,A.
  TITLE     RNF8/UBC13 ubiquitin signaling suppresses synapse formation in the
            mammalian brain
  JOURNAL   Nat Commun 8 (1), 1271 (2017)
   PUBMED   29097665
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3138)
  AUTHORS   McKee,A.E., Minet,E., Stern,C., Riahi,S., Stiles,C.D. and
            Silver,P.A.
  TITLE     A genome-wide in situ hybridization map of RNA-binding proteins
            reveals anatomically restricted expression in the developing mouse
            brain
  JOURNAL   BMC Dev Biol 5, 14 (2005)
   PUBMED   16033648
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3138)
  AUTHORS   Suntharalingam,M. and Wente,S.R.
  TITLE     Peering through the pore: nuclear pore complex structure, assembly,
            and function
  JOURNAL   Dev Cell 4 (6), 775-789 (2003)
   PUBMED   12791264
  REMARK    Review article
REFERENCE   6  (bases 1 to 3138)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL928926.9, AK145748.1 and BY673167.1.
            
            On Apr 23, 2010 this sequence version replaced NM_028923.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK145748.1, AK133888.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-24                AL928926.9         113878-113901
            25-3096             AK145748.1         1-3072
            3097-3138           BY673167.1         318-359
FEATURES             Location/Qualifiers
     source          1..3138
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 20.88 cM"
     gene            1..3138
                     /gene="Gle1"
                     /gene_synonym="4933405K21Rik; Gle1l"
                     /note="GLE1 RNA export mediator"
                     /db_xref="GeneID:74412"
                     /db_xref="MGI:MGI:1921662"
     exon            1..190
                     /gene="Gle1"
                     /gene_synonym="4933405K21Rik; Gle1l"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..2191
                     /gene="Gle1"
                     /gene_synonym="4933405K21Rik; Gle1l"
                     /note="nucleoporin GLE1; GLE1-like protein"
                     /codon_start=1
                     /product="mRNA export factor GLE1"
                     /protein_id="NP_083199.1"
                     /db_xref="CCDS:CCDS15862.1"
                     /db_xref="GeneID:74412"
                     /db_xref="MGI:MGI:1921662"
                     /translation="MPSDGRCWETLRALRNTSKGRLRYDREWLLRYEDVLEECMSLPK
                     LSSYSGWVVDHILPNTSGHTQESAPSSDNSPSSGSASGLYQSSLLKSPVRSSPQSPSP
                     SSPNGTQSTHESPFTEPIAPQSSRAIKVEGCIRMYELAHRMRGTEGLRQWQEEQERKV
                     RALSEMASEQLKRFDELKELKLHKEFQDLQEVMEKSTREALGHQEKLKEEHRHRAKIL
                     NLKLREAEQQRVKQAEQEQLRKEEGQVRLRSLYSLQEEVLQLNQQLDASSQHKELLSV
                     DLAAFQTRGNQLCGLISSIIRTTLESGYPTAENQAEAERALQEMRDLLSDLEQEITRA
                     SQVKKKHEEEAKVKRQESQVQQGPAPPTQTSAPSPSPVGAQNEDLQVKVQDSTMQWYQ
                     QLQDASAKCVLAFEDLTSSKDSQTKKIKMDLQKAATIPVSQISTIAGSKLKEIFDKIH
                     SLLSGKPVQSGGRSVSVTLNPQGLDFVQYKLAEKFVKQGEEEVASHHEAAFPIAVVAS
                     GIWMLHPKVGDLILAHLHKKCPYSVPFYPAFKEGMALEDYQRMLGYQVTDSKVEQQDN
                     FLKRMSGMIRLYAAIIQLQWPYGNRQEAHPHGLNHGWRWLAQVLNMEPLSDVTATLLF
                     DFLEVCGNALMKQYQVQFWKMILLIKEDYFPRIEAITSSGQMGSFIRLKQFLEKCLQR
                     REIPVPRGFLTTSFWRS"
     exon            191..418
                     /gene="Gle1"
                     /gene_synonym="4933405K21Rik; Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            419..529
                     /gene="Gle1"
                     /gene_synonym="4933405K21Rik; Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            530..678
                     /gene="Gle1"
                     /gene_synonym="4933405K21Rik; Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            679..739
                     /gene="Gle1"
                     /gene_synonym="4933405K21Rik; Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            740..994
                     /gene="Gle1"
                     /gene_synonym="4933405K21Rik; Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            995..1223
                     /gene="Gle1"
                     /gene_synonym="4933405K21Rik; Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1224..1336
                     /gene="Gle1"
                     /gene_synonym="4933405K21Rik; Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1337..1406
                     /gene="Gle1"
                     /gene_synonym="4933405K21Rik; Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1549
                     /gene="Gle1"
                     /gene_synonym="4933405K21Rik; Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1740
                     /gene="Gle1"
                     /gene_synonym="4933405K21Rik; Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1741..1870
                     /gene="Gle1"
                     /gene_synonym="4933405K21Rik; Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1871..1975
                     /gene="Gle1"
                     /gene_synonym="4933405K21Rik; Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            1976..2058
                     /gene="Gle1"
                     /gene_synonym="4933405K21Rik; Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2059..2122
                     /gene="Gle1"
                     /gene_synonym="4933405K21Rik; Gle1l"
                     /inference="alignment:Splign:2.1.0"
     exon            2123..3108
                     /gene="Gle1"
                     /gene_synonym="4933405K21Rik; Gle1l"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2581..2586
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gle1"
                     /gene_synonym="4933405K21Rik; Gle1l"
                     /note="hexamer: AATAAA"
     polyA_site      2605
                     /gene="Gle1"
                     /gene_synonym="4933405K21Rik; Gle1l"
                     /note="major polyA site"
     regulatory      3074..3079
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gle1"
                     /gene_synonym="4933405K21Rik; Gle1l"
                     /note="hexamer: AATAAA"
     polyA_site      3098
                     /gene="Gle1"
                     /gene_synonym="4933405K21Rik; Gle1l"
                     /note="major polyA site"
ORIGIN      
        1 tgtggggcgg acaccccgga agcggaaggc ggcgccacct cggcggcgga ttcgagggtt
       61 tgttgtcagt cgtgtcagct ggtgacatgc catgccgtcc gatggtcgct gctgggaaac
      121 tctgagggcg ctccgcaaca ccagcaaagg ccgcctgcgc tacgaccgcg agtggctgct
      181 gcgctacgag gatgttttgg aagaatgcat gtctcttccc aaactgtctt cttactctgg
      241 atgggtggta gatcacatcc tacccaacac ctcaggccac acgcaagaga gtgctccttc
      301 ttctgataat tcaccatcct ctggatctgc atctggcttg taccaatcct cactactaaa
      361 atctcctgtc agaagtagcc cacaatcccc gtcaccctca tcaccaaatg gaacccagag
      421 cacacatgag tccccgttca cagaacctat tgcacctcag tcctcccggg cgatcaaagt
      481 ggaaggttgc atccgaatgt acgaattggc gcacagaatg agaggaacag agggcctgag
      541 gcaatggcag gaggagcaag agaggaaggt gcgagccctc tcagagatgg catcggagca
      601 gctaaagagg tttgacgagc tgaaggagct gaagctgcat aaggagttcc aggacttaca
      661 ggaagtgatg gagaagagta ccagggaggc cctgggccat caggagaagc tgaaagagga
      721 gcaccgccac agagccaaga ttctcaacct aaagcttcga gaggcagagc agcagcgtgt
      781 gaagcaggca gagcaggagc agcttcggaa ggaggaaggt caggtccgtc tgcgcagcct
      841 gtactccctg caagaggagg tcctgcagct caaccagcag ttggatgcct ccagtcagca
      901 caaagagctg ctgagtgtgg acctggctgc cttccagacc cggggcaacc agctgtgtgg
      961 cctcatctcc agcatcatcc gcaccacctt ggagagtggt tatcccacag cagagaacca
     1021 agctgaggca gagcgagccc tgcaggaaat gcgggacctc ctctcagatt tggagcagga
     1081 gatcaccaga gcctctcaag tgaagaagaa gcacgaagag gaggccaagg tcaagcggca
     1141 ggagtcacag gtgcagcagg ggccagcgcc tcccacccag acctctgcac ccagcccaag
     1201 cccagtagga gcacagaatg aagacctgca ggtgaaggtg caagatagta cgatgcagtg
     1261 gtaccagcaa cttcaggatg cttctgccaa gtgtgtgttg gccttcgagg acctgaccag
     1321 cagcaaggat agtcagacca agaagataaa gatggacttg cagaaggcag ccaccatccc
     1381 agtgagccag atctccacca ttgcaggttc aaagctgaag gagatctttg acaagatcca
     1441 tagccttctc tctggaaagc ctgttcagtc tggtgggcgt tccgtgtctg tcactcttaa
     1501 ccctcagggg ctggactttg tccagtacaa actggcagag aaatttgtga aacaagggga
     1561 ggaggaagtg gcctctcacc acgaagcggc attccccatt gcagtggtgg catctggtat
     1621 ctggatgctc caccctaaag tgggagacct cattcttgct catctccaca agaagtgtcc
     1681 atactctgtt cctttctacc cagctttcaa ggaagggatg gccttggagg actatcaaag
     1741 gatgcttggc taccaagtga cggattccaa ggttgagcaa caggacaact ttctaaaacg
     1801 catgtctggg atgatccgtc tgtatgccgc catcatccag ctccagtggc cgtatgggaa
     1861 ccggcaggag gctcatcctc atggcttaaa tcatggctgg cgctggttgg cccaggtctt
     1921 aaacatggag cctctctcag atgtgacagc taccctcctg tttgacttct tggaggtgtg
     1981 cgggaacgcc cttatgaagc agtaccaggt ccagttctgg aagatgatac ttctcatcaa
     2041 agaggactac ttccccagaa ttgaagccat cacgagctca ggacagatgg gctctttcat
     2101 acgtctgaag cagttcttgg agaaatgtct gcaacgaagg gagattcctg tgcccagagg
     2161 ctttctgaca acctccttct ggcgctcctg atgtcctccg tcacactgtg tggcaggagg
     2221 ggcaacaata aagcaactgg gacagcgggc ttggaagaat catgtcagat tgagaaattc
     2281 gtcagtgtgt ttttatatat ctgtacccca tgaataaggc ttttatagtt cacagcctct
     2341 gtcattctct tgtcaggttt ggtagttgtg ttggcgtcac agacagatag agaagtggcc
     2401 tttctaattc tcacaggtta caaaagagat aagaaggggc acttagcact tggctgcact
     2461 tggtctctag tgtctgtcgc tcagaaagct ggtgattctt tctctgcttg actcggacct
     2521 gtagtgagcc ctccattttc cctccacact gccccactgt tcatacacat actgagaaag
     2581 aataaaccgc caagagtccc ttaaagtgtc aggtactgtt tgcagtctgg ggatgaggta
     2641 aagtgcttac actgtgtggc ttgtggcgta tgtgtgtatt cagaagacat gaatgatgtt
     2701 ggtgtggact gaaccccaga gtgtatcagg gactgggtat atggatcatg actgggagca
     2761 tgcactgtag agaactctgt ccccttgatt tagaatttgg cccctggctg gctgagggtg
     2821 ctgtactaga ttaggtacct ttttgttgtt tttccaacaa gaattgagtt gggttgacca
     2881 tcagcagtgc gtgtgctggg gtggaggagc tgtctgtctc agttggaagt tggtgtttgt
     2941 ttacagacac actaactctg ctgcagaagc cgagcctctg ctctggtcat gagggcctgt
     3001 gtggcaggca ttctcattag cactctcgaa tggcttaagc attttaattg tggactagag
     3061 ttcccaaaaa tgtaataaag cttgagtttt aaaagttctg tcctgataaa aaaaaaaaaa
     3121 aaaaaaaaaa aaaaaaaa
//
