LOCUS       NM_177350               4649 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus gliomedin (Gldn), mRNA.
ACCESSION   NM_177350
VERSION     NM_177350.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4649)
  AUTHORS   Jing,J., Feng,J., Yuan,Y., Guo,T., Lei,J., Pei,F., Ho,T.V. and
            Chai,Y.
  TITLE     Spatiotemporal single-cell regulatory atlas reveals neural crest
            lineage diversification and cellular function during tooth
            morphogenesis
  JOURNAL   Nat Commun 13 (1), 4803 (2022)
   PUBMED   35974052
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4649)
  AUTHORS   Eshed-Eisenbach,Y., Devaux,J., Vainshtein,A., Golani,O., Lee,S.J.,
            Feinberg,K., Sukhanov,N., Greenspan,D.S., Susuki,K., Rasband,M.N.
            and Peles,E.
  TITLE     Precise Spatiotemporal Control of Nodal Na+ Channel Clustering by
            Bone Morphogenetic Protein-1/Tolloid-like Proteinases
  JOURNAL   Neuron 106 (5), 806-815 (2020)
   PUBMED   32209430
  REMARK    GeneRIF: Precise Spatiotemporal Control of Nodal Na(+) Channel
            Clustering by Bone Morphogenetic Protein-1/Tolloid-like
            Proteinases.
REFERENCE   3  (bases 1 to 4649)
  AUTHORS   Moruzzo,D., Nobbio,L., Sterlini,B., Consalez,G.G., Benfenati,F.,
            Schenone,A. and Corradi,A.
  TITLE     The Transcription Factors EBF1 and EBF2 Are Positive Regulators of
            Myelination in Schwann Cells
  JOURNAL   Mol Neurobiol 54 (10), 8117-8127 (2017)
   PUBMED   27889898
REFERENCE   4  (bases 1 to 4649)
  AUTHORS   Hill,S.E., Donegan,R.K., Nguyen,E., Desai,T.M. and Lieberman,R.L.
  TITLE     Molecular Details of Olfactomedin Domains Provide Pathway to
            Structure-Function Studies
  JOURNAL   PLoS One 10 (6), e0130888 (2015)
   PUBMED   26121352
  REMARK    GeneRIF: OLF domains from H. sapiens olfactomedin-1 and M. musculus
            gliomedin were biophysically, biochemically, and structurally
            characterized.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4649)
  AUTHORS   Zhang,A., Desmazieres,A., Zonta,B., Melrose,S., Campbell,G.,
            Mahad,D., Li,Q., Sherman,D.L., Reynolds,R. and Brophy,P.J.
  TITLE     Neurofascin 140 is an embryonic neuronal neurofascin isoform that
            promotes the assembly of the node of Ranvier
  JOURNAL   J Neurosci 35 (5), 2246-2254 (2015)
   PUBMED   25653379
REFERENCE   6  (bases 1 to 4649)
  AUTHORS   Kwon,H.S., Johnson,T.V., Joe,M.K., Abu-Asab,M., Zhang,J., Chan,C.C.
            and Tomarev,S.I.
  TITLE     Myocilin mediates myelination in the peripheral nervous system
            through ErbB2/3 signaling
  JOURNAL   J Biol Chem 288 (37), 26357-26371 (2013)
   PUBMED   23897819
REFERENCE   7  (bases 1 to 4649)
  AUTHORS   Feinberg,K., Eshed-Eisenbach,Y., Frechter,S., Amor,V., Salomon,D.,
            Sabanay,H., Dupree,J.L., Grumet,M., Brophy,P.J., Shrager,P. and
            Peles,E.
  TITLE     A glial signal consisting of gliomedin and NrCAM clusters axonal
            Na+ channels during the formation of nodes of Ranvier
  JOURNAL   Neuron 65 (4), 490-502 (2010)
   PUBMED   20188654
  REMARK    GeneRIF: Here, we show that initial clustering of Na(+) channels at
            heminodes requires glial NrCAM and gliomedin, as well as their
            axonal receptor neurofascin 186 (NF186).
REFERENCE   8  (bases 1 to 4649)
  AUTHORS   Maertens,B., Hopkins,D., Franzke,C.W., Keene,D.R.,
            Bruckner-Tuderman,L., Greenspan,D.S. and Koch,M.
  TITLE     Cleavage and oligomerization of gliomedin, a transmembrane collagen
            required for node of ranvier formation
  JOURNAL   J Biol Chem 282 (14), 10647-10659 (2007)
   PUBMED   17293346
REFERENCE   9  (bases 1 to 4649)
  AUTHORS   Eshed,Y., Feinberg,K., Poliak,S., Sabanay,H., Sarig-Nadir,O.,
            Spiegel,I., Bermingham,J.R. Jr. and Peles,E.
  TITLE     Gliomedin mediates Schwann cell-axon interaction and the molecular
            assembly of the nodes of Ranvier
  JOURNAL   Neuron 47 (2), 215-229 (2005)
   PUBMED   16039564
REFERENCE   10 (bases 1 to 4649)
  AUTHORS   Graveel,C.R., Harkins-Perry,S.R., Acevedo,L.G. and Farnham,P.J.
  TITLE     Identification and characterization of CRG-L2, a new marker for
            liver tumor development
  JOURNAL   Oncogene 22 (11), 1730-1736 (2003)
   PUBMED   12642876
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC162180.2.
            
            On Oct 19, 2007 this sequence version replaced NM_177350.4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK031523.1, AF548022.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164137, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-401               AC162180.2         64286-64686         c
            402-453             AC162180.2         38229-38280         c
            454-471             AC162180.2         30724-30741         c
            472-579             AC162180.2         30277-30384         c
            580-726             AC162180.2         19149-19295         c
            727-846             AC162180.2         17850-17969         c
            847-930             AC162180.2         16683-16766         c
            931-1056            AC162180.2         16391-16516         c
            1057-1207           AC162180.2         15268-15418         c
            1208-4649           AC162180.2         9395-12836          c
FEATURES             Location/Qualifiers
     source          1..4649
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 29.52 cM"
     gene            1..4649
                     /gene="Gldn"
                     /gene_synonym="Clom; Colm; CRG-L2; Crgl2; Crlg2"
                     /note="gliomedin"
                     /db_xref="GeneID:235379"
                     /db_xref="MGI:MGI:2388361"
     exon            1..401
                     /gene="Gldn"
                     /gene_synonym="Clom; Colm; CRG-L2; Crgl2; Crlg2"
                     /inference="alignment:Splign:2.1.0"
     CDS             39..1688
                     /gene="Gldn"
                     /gene_synonym="Clom; Colm; CRG-L2; Crgl2; Crlg2"
                     /note="collomin; olfactomedin-related protein; cancer
                     related gene - liver 2; cancer-related gene liver 2
                     protein"
                     /codon_start=1
                     /product="gliomedin"
                     /protein_id="NP_796324.1"
                     /db_xref="CCDS:CCDS23189.1"
                     /db_xref="GeneID:235379"
                     /db_xref="MGI:MGI:2388361"
                     /translation="MTRAAERGQGATGWGLRGALVAIALLSALNAAGTVFVLCQWRGL
                     SAALRALEAQRGREQREDSALRAFLAELSRAPGRVPEPSQDPMSAARNKRSHNGEPAS
                     HIRAESQDMMMMMTYSMVPIRVMIDLCNSTQGICLTGPPGPPGPPGAGGLPGHNGSDG
                     QPGLQGPKGEKGAIGKRGKMGLPGATGNPGEKGEKGDAGELGLPGNEGPPGQKGDKGD
                     KGDVSNDVLLTGAKGDQGPPGPPGPPGPPGPPGSRRSKGPRPPNVFNSQCPGETCVIP
                     NDDTLVGRADEKANERHSPQTESMITSIGNPAQVLKVRETFGTWMRESANKSDDRIWV
                     TEHFSGIMVKEFKDLPALLNSSFTLLHLPHYFHGCGHAVYNNSLYYHKGGSNTIVRFE
                     FGKETPQTLKLENALYFDRKYLFANSKTYFNIAVDEKGIWIIYASSVDGSSILVAQLD
                     ERTFSVTQHINTTYPKSKAGNAFIARGILYVTDTKDTRVTFAFDLLGGKQINANFDFR
                     MSQSVLAMLSYNMRDQHLYSWEDGHLMLYPVQFLSAASSQR"
     exon            402..453
                     /gene="Gldn"
                     /gene_synonym="Clom; Colm; CRG-L2; Crgl2; Crlg2"
                     /inference="alignment:Splign:2.1.0"
     exon            454..471
                     /gene="Gldn"
                     /gene_synonym="Clom; Colm; CRG-L2; Crgl2; Crlg2"
                     /inference="alignment:Splign:2.1.0"
     exon            472..579
                     /gene="Gldn"
                     /gene_synonym="Clom; Colm; CRG-L2; Crgl2; Crlg2"
                     /inference="alignment:Splign:2.1.0"
     exon            580..726
                     /gene="Gldn"
                     /gene_synonym="Clom; Colm; CRG-L2; Crgl2; Crlg2"
                     /inference="alignment:Splign:2.1.0"
     exon            727..846
                     /gene="Gldn"
                     /gene_synonym="Clom; Colm; CRG-L2; Crgl2; Crlg2"
                     /inference="alignment:Splign:2.1.0"
     exon            847..930
                     /gene="Gldn"
                     /gene_synonym="Clom; Colm; CRG-L2; Crgl2; Crlg2"
                     /inference="alignment:Splign:2.1.0"
     exon            931..1056
                     /gene="Gldn"
                     /gene_synonym="Clom; Colm; CRG-L2; Crgl2; Crlg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1057..1207
                     /gene="Gldn"
                     /gene_synonym="Clom; Colm; CRG-L2; Crgl2; Crlg2"
                     /inference="alignment:Splign:2.1.0"
     exon            1208..4649
                     /gene="Gldn"
                     /gene_synonym="Clom; Colm; CRG-L2; Crgl2; Crlg2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 cagtgctgcc ctgagccgcc cggcctgagc acgcagacat gacccgagcc gcagagcgag
       61 gccaaggggc tacaggctgg gggctgcgcg gcgccctggt ggccatagcg ctgctgtccg
      121 cactgaacgc cgcgggcacc gtgttcgtgc tgtgccagtg gcgggggtta agcgcggcgc
      181 tacgggcgct ggaggctcaa cgcggccgag agcagcgcga ggacagcgcc ctacgcgcct
      241 ttctggccga attgagtcgt gcgccgggcc gggtccccga accatcccag gaccccatga
      301 gcgcagcgcg caacaagcgc agccacaacg gcgagcctgc gtcacacatc cgtgcggaga
      361 gccaggacat gatgatgatg atgacctact ccatggtgcc gattcgagtg atgatagacc
      421 tgtgcaacag tacccagggc atctgcctca caggaccacc gggcccacca ggacctccag
      481 gagccggcgg gttaccaggc cacaatggat cagatggaca gcctggtctc cagggcccaa
      541 aaggagaaaa aggagcaatt ggcaagagag gaaaaatggg gttacctgga gccaccggaa
      601 atccagggga aaagggagaa aagggagatg ctggtgaact gggtctacct ggaaatgagg
      661 gcccaccagg gcagaaaggt gacaagggag acaaaggaga cgtgtccaat gacgtgcttt
      721 tgacaggtgc caaaggtgac caaggtcccc ctggcccccc tggacctcca gggcctccag
      781 gccctcctgg aagcagaaga tccaaaggcc ctcggccacc aaacgtgttc aacagccagt
      841 gtccagggga gacgtgtgtc atacccaatg atgatacctt ggtgggaaga gctgatgaga
      901 aagcaaatga acgccattca ccacaaacag aatctatgat cacttccatt ggcaacccag
      961 cccaagtcct aaaagtgaga gagacttttg ggacttggat gagagagtct gctaacaaaa
     1021 gtgacgaccg catttgggtg actgaacatt tttcaggcat catggtgaag gagttcaaag
     1081 acctgccggc gctcctcaat agcagcttca ccctcctcca cctcccacat tatttccacg
     1141 gctgtgggca cgctgtttac aacaactctc tctactacca caaaggaggc tccaacacca
     1201 tagtgagatt tgaatttggg aaagagacac ctcagactct gaagctggaa aatgctttgt
     1261 attttgatcg aaaatacctc tttgcaaatt ccaagactta cttcaacata gcagtggatg
     1321 agaagggcat ctggattatc tacgcttcaa gtgtggatgg ctcaagcatc cttgtagcac
     1381 agctggatga gaggacattc tccgtgacac agcacatcaa caccacatac cccaaatcca
     1441 aggctggcaa tgccttcata gcccgaggga tcctctatgt cacagacacc aaagatacga
     1501 gggtcacgtt tgcctttgat ttgttaggag gaaagcaaat caatgcaaac tttgatttca
     1561 gaatgtccca gtctgttctt gccatgctgt catacaacat gagagatcag catttatact
     1621 cgtgggaaga tggccatctg atgctctatc ctgtgcagtt tctgtcagcg gcatcaagtc
     1681 agcggtaggg ttccctcggc tgtctgctcc ctctctatac tccacattgt ctagggtttg
     1741 gtcaagccca acagaaagct agccggtaaa ggatacccag gcactcggag cgtaagccca
     1801 tgccacgggc tcttgcacaa gcggcgagtc cgctctaagc caggttgttg aaatagctac
     1861 agattagaaa tggatgtgga agagatctgg tgacccagta tccctcctca aactcagcaa
     1921 gttagctctc ccccgaccgt agcgtcccca taggtaatac gaaacatctg agtatgactg
     1981 acatttcctc ttcctagatg aaattctgtg attcttgcct gattatatat tagaatgctt
     2041 tctggattct tttttttttt ttctccacat gtaagtgagc ttacttgcag cttgaggggt
     2101 gggcctttca gtgatgactt atttggtatt tagggaaggt gcactggctc ttatggcttc
     2161 taaggtttta ttttattcat aatttgttat tttctctgaa tattcaccta ccactacaga
     2221 atgatcattg ttttcagctc ctaaacacaa atccaagatt aataaacaaa caaacaaacc
     2281 atgaatagat acaggctcag aactctaaat ggagctgcat caggcccata ggccatctag
     2341 atgctgtcaa tttctgatca tattgtttgc tgctgggaaa gtaaacagga tatcttcagt
     2401 tcgtggtccc ttttgccaag gccatgggat tgttatcaga gtgtcaaaca ctaagtggcc
     2461 aataatctgg ttagaagcat ggaaacatga tggttttttc agaaaacagg caccatttat
     2521 acttactgtt tagaatgagg gaaggcaatt ggctcaaagg ccaaagtcag cttagctctt
     2581 tttcctgtac catcgcatcc ctgcacctaa gaatctcgcc tcagagtgtg tcagcagtga
     2641 agcagagccg ctctgtaaat cctgaaccat tactgcctgg cctttacaga aagaaagaaa
     2701 aaaaaatgtt gacctttcat ctaaggacag ggaacgagcc aggttctcag aagggctcac
     2761 tccctgagtc tggttaggct ttctacggac tgacaggcag cattttatgt ggcttgggct
     2821 ttggcagagg gaacagctaa ggacagcatc agatggagta agagaacctc cagccgtgga
     2881 gatgttcact cccacgtggt cctcaaagtt gggtctgtcc tcttggatag caaggatcta
     2941 gtttaattgg ttcctacaag accttaaata accacgttct ctgtcaactc attgagttcc
     3001 aggcaggcct gtggagcttc aaagaggaag ctgtggattt catcgccccc ccccccccgg
     3061 aatatagaaa aagacactac agaaactgtc caggaaagac tggccagctg ttccaaaccc
     3121 actctcagtg ggcctgtgac ctggtttagt ttttttaata gaagcatctt gaggcttggg
     3181 gtatgcattt taactattta actttccctg ccctctgaaa gcacccaggc agctgttact
     3241 ggtgaacctg ttgagttctc aaggtcatgg gtcccaaagc ttccccactt cttgattaga
     3301 tggttttgca gttggtcatc acagctttta aagatattct ctcagattca tttgttgcaa
     3361 tgtagagttc taatgtttca tcagtgtatc taatgaatgg tattgttctt ttaaagtatt
     3421 caaatatgag atactgtttc tgagtgcggt agacctggat atacatataa ttccattttt
     3481 ttattactta gtagcattgc tgagaataga tacaatacta attgtacata caagcaaaat
     3541 agtttagtta ttgaattagc tcatttttaa tatctgaact agcaaatgtc ttagctttcc
     3601 tttacttttt tctttctttt cctttctttt ctcttctttt cctttctttc ctttcctttt
     3661 cttttctttt ttttaaagca atgtctttgt gttcgcccag acttatcaca aactcctgct
     3721 tcagattcct gggtgctggg accacaggca cagtggctct ttgactctct taattgtgtg
     3781 taaggaatca tacatatact cacgattaga gaaactcgtc tgaagatttt gtttcttttc
     3841 atggttgttt ctttctttct ttctttcttt ctttctttcg ttatagtgta gtgggattag
     3901 aacaagtaag gttgactggt gtttaatgaa tttatctttg cagaaggaaa ggaattaagg
     3961 ttttattcct tttcttgcaa acaggacttc attctatatc actcaacaca gtgtttcagg
     4021 ctcactgcta aaatagtgtg cacatcttat atttttaaat gaagatagta atcaaccctg
     4081 ctgtcacttg tagccaagct gttctaaaag cacttcattt atgtctgtat gaaatcaagt
     4141 gattctccaa ttcctctgaa atctaaagta gataccatta tactagaaac cacaccttcc
     4201 agcttcaaag gtaggccaga ctcaacattt acaaagcatt tctattaact aatatagagt
     4261 ccaactaagg ttgcagagtt ggctctggcc tcaatgtatc atgtatcaat gtatcagaga
     4321 acgtggtccg ggctgaatat ttcagatcaa ttctggtgct gggctcattc gaagtctttt
     4381 taccctcata atcaaatgac aaggtgagat gacaaatgag gaagcacagt ccttgaaaag
     4441 tcactcgtca tcctccaagc atagcaagta ccttactcag gcattgcctg tctggtgttg
     4501 agctacctga aggaaaagtg gggggtggag ctcttcagtt ttcatcagtg ctgtggcctt
     4561 atttatctca taatctccca tcagtaacca cagattctaa acgaccagca agtaacagtt
     4621 gtaagtagta aaataaaatt atcctgaat
//
