LOCUS       NM_026860                793 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus gastrokine 3 (Gkn3), mRNA.
ACCESSION   NM_026860 XM_355795 XM_915229
VERSION     NM_026860.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 793)
  AUTHORS   Chandrasekaran,P., Negretti,N.M., Sivakumar,A., Liberti,D.C.,
            Wen,H., Peers de Nieuwburgh,M., Wang,J.Y., Michki,N.S.,
            Chaudhry,F.N., Kaur,S., Lu,M., Jin,A., Zepp,J.A., Young,L.R.,
            Sucre,J.M.S. and Frank,D.B.
  TITLE     CXCL12 defines lung endothelial heterogeneity and promotes distal
            vascular growth
  JOURNAL   Development 149 (21) (2022)
   PUBMED   36239312
REFERENCE   2  (bases 1 to 793)
  AUTHORS   Znalesniak,E.B., Fu,T., Salm,F., Handel,U. and Hoffmann,W.
  TITLE     Transcriptional Responses in the Murine Spleen after Toxoplasma
            gondii Infection: Inflammasome and Mucus-Associated Genes
  JOURNAL   Int J Mol Sci 18 (6), 1245 (2017)
   PUBMED   28604600
  REMARK    GeneRIF: Gkn3, Fcgbp, and Muc2 might be involved in the transient
            disruption of the splenic architecture and its reorganization,
            which is characteristic after Toxoplasma gondii infection.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 793)
  AUTHORS   Geahlen,J.H., Lapid,C., Thorell,K., Nikolskiy,I., Huh,W.J.,
            Oates,E.L., Lennerz,J.K., Tian,X., Weis,V.G., Khurana,S.S.,
            Lundin,S.B., Templeton,A.R. and Mills,J.C.
  TITLE     Evolution of the human gastrokine locus and confounding factors
            regarding the pseudogenicity of GKN3
  JOURNAL   Physiol Genomics 45 (15), 667-683 (2013)
   PUBMED   23715263
REFERENCE   4  (bases 1 to 793)
  AUTHORS   Menheniott,T.R., Peterson,A.J., O'Connor,L., Lee,K.S.,
            Kalantzis,A., Kondova,I., Bontrop,R.E., Bell,K.M. and Giraud,A.S.
  TITLE     A novel gastrokine, Gkn3, marks gastric atrophy and shows evidence
            of adaptive gene loss in humans
  JOURNAL   Gastroenterology 138 (5), 1823-1835 (2010)
   PUBMED   20138039
  REMARK    GeneRIF: Gkn3 encodes a novel, functionally distinct gastrokine
            that is overexpressed and might restrain epithelial cell
            proliferation in gastric atrophy.
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC116955.1.
            
            On or before Sep 15, 2006 this sequence version replaced
            XM_915229.2, XM_355795.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC116955.1, AK004474.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849378, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..793
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.96 cM"
     gene            1..793
                     /gene="Gkn3"
                     /gene_synonym="1190003M12Rik"
                     /note="gastrokine 3"
                     /db_xref="GeneID:68888"
                     /db_xref="MGI:MGI:1916138"
     exon            1..142
                     /gene="Gkn3"
                     /gene_synonym="1190003M12Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..676
                     /gene="Gkn3"
                     /gene_synonym="1190003M12Rik"
                     /codon_start=1
                     /product="gastrokine-3 precursor"
                     /protein_id="NP_081136.1"
                     /db_xref="CCDS:CCDS20320.1"
                     /db_xref="GeneID:68888"
                     /db_xref="MGI:MGI:1916138"
                     /translation="MPLHSLERDNMRRLIAPSILVTVFLVPALALTNTSDSYPLDGSV
                     GTQTIHVDALRGVVSIRDNSVQSEWDGVMDYKNDLLAAKLFSKMACVLAKMDPAAFPS
                     LDDITQALGKQASGHYPPTRGLTYTVLPSRIKNLAQYGVPIKDLCRAVPTYFARQQKE
                     GTALTMDPDSCSELQLLSFMGLSICGEIPGL"
     exon            143..196
                     /gene="Gkn3"
                     /gene_synonym="1190003M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            197..331
                     /gene="Gkn3"
                     /gene_synonym="1190003M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            332..439
                     /gene="Gkn3"
                     /gene_synonym="1190003M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            440..581
                     /gene="Gkn3"
                     /gene_synonym="1190003M12Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            582..793
                     /gene="Gkn3"
                     /gene_synonym="1190003M12Rik"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 aaccagtccc tgagcccctt atcatagtga gacctgagag gctgaagtct atataaacta
       61 gacttgggaa atgaacggat catagaaaat tgtattatgc atgccgttgc attcgctgga
      121 gagagacaac atgagacgcc ttattgcgcc ttccattctt gtgactgtct ttctagttcc
      181 agctctggcg ctgacgaaca ctagcgacag ttatcctctg gatggctctg tggggaccca
      241 gaccatccat gtcgatgccc tcagaggtgt ggtcagcatc cgagacaaca gcgttcagag
      301 tgaatgggat ggagtcatgg actacaagaa cgacctcctg gcagctaagc tgtttagcaa
      361 gatggcctgt gttctggcaa agatggaccc agcagccttc ccaagtttgg atgatattac
      421 ccaggccctg ggcaaacagg cttccggtca ctacccacct actcgaggac tgacctacac
      481 agttttaccc agccgaatca aaaacttggc ccaatacgga gtgccaatca aagacctgtg
      541 cagagccgtc cccacctact ttgctcggca gcaaaaagaa ggtaccgccc tgacgatgga
      601 cccagactca tgttctgagc tccagcttct gtccttcatg ggactgtcca tttgtggtga
      661 gatccctggg ctctgaacct ctacgtcagc cagactggac agacctcatc tagcctctgc
      721 ctgtgagaag tgtctcattg cagtcctctg tgctccacat gttggcttcc catggaacct
      781 tgtgatctgg ggg
//
