LOCUS       NM_025467                777 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus gastrokine 2 (Gkn2), mRNA.
ACCESSION   NM_025467
VERSION     NM_025467.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 777)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 777)
  AUTHORS   Steiner,S., Seleznik,G.M., Reding,T., Stopic,M., Lenggenhager,D.,
            Ten Buren,E., Eshmuminov,D., Endhardt,K., Hagedorn,C.,
            Heidenblut,A.M., Bratus-Neuenschwander,A., Grossmann,J.,
            Trachsel,C., Jabbar,K.S., Hahn,S.A., Berg,J.V., Graf,R. and
            Gupta,A.
  TITLE     De novo expression of gastrokines in pancreatic precursor lesions
            impede the development of pancreatic cancer
  JOURNAL   Oncogene 41 (10), 1507-1517 (2022)
   PUBMED   35082384
REFERENCE   3  (bases 1 to 777)
  AUTHORS   Inoue,K., Ogonuki,N., Kamimura,S., Inoue,H., Matoba,S., Hirose,M.,
            Honda,A., Miura,K., Hada,M., Hasegawa,A., Watanabe,N., Dodo,Y.,
            Mochida,K. and Ogura,A.
  TITLE     Loss of H3K27me3 imprinting in the Sfmbt2 miRNA cluster causes
            enlargement of cloned mouse placentas
  JOURNAL   Nat Commun 11 (1), 2150 (2020)
   PUBMED   32358519
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 777)
  AUTHORS   Zhang,Z., Xue,H., Dong,Y., Hu,J., Jiang,T., Shi,L. and Du,J.
  TITLE     Inhibition of GKN2 Attenuates Acute Gastric Lesions Through the
            NLRP3 Inflammasome
  JOURNAL   Adv Wound Care (New Rochelle) 9 (5), 219-232 (2020)
   PUBMED   32226647
  REMARK    GeneRIF: Inhibition of GKN2 Attenuates Acute Gastric Lesions
            Through the NLRP3 Inflammasome.
REFERENCE   5  (bases 1 to 777)
  AUTHORS   Piccand,J., Vagne,C., Blot,F., Meunier,A., Beucher,A., Strasser,P.,
            Lund,M.L., Ghimire,S., Nivlet,L., Lapp,C., Petersen,N.,
            Engelstoft,M.S., Thibault-Carpentier,C., Keime,C., Correa,S.J.,
            Schreiber,V., Molina,N., Schwartz,T.W., De Arcangelis,A. and
            Gradwohl,G.
  TITLE     Rfx6 promotes the differentiation of peptide-secreting
            enteroendocrine cells while repressing genetic programs controlling
            serotonin production
  JOURNAL   Mol Metab 29, 24-39 (2019)
   PUBMED   31668390
REFERENCE   6  (bases 1 to 777)
  AUTHORS   Antas,V.I., Brigden,K.W., Prudence,A.J. and Fraser,S.T.
  TITLE     Gastrokine-2 is transiently expressed in the endodermal and
            endothelial cells of the maturing mouse yolk sac
  JOURNAL   Gene Expr Patterns 16 (2), 69-74 (2014)
   PUBMED   25290738
  REMARK    GeneRIF: Yolk sac endothelial cells were found to express low
            levels of Gkn2 transcript and protein.
REFERENCE   7  (bases 1 to 777)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   8  (bases 1 to 777)
  AUTHORS   Archambaud,C., Nahori,M.A., Soubigou,G., Becavin,C., Laval,L.,
            Lechat,P., Smokvina,T., Langella,P., Lecuit,M. and Cossart,P.
  TITLE     Impact of lactobacilli on orally acquired listeriosis
  JOURNAL   Proc Natl Acad Sci U S A 109 (41), 16684-16689 (2012)
   PUBMED   23012479
REFERENCE   9  (bases 1 to 777)
  AUTHORS   Tang,T., Li,L., Tang,J., Li,Y., Lin,W.Y., Martin,F., Grant,D.,
            Solloway,M., Parker,L., Ye,W., Forrest,W., Ghilardi,N., Oravecz,T.,
            Platt,K.A., Rice,D.S., Hansen,G.M., Abuin,A., Eberhart,D.E.,
            Godowski,P., Holt,K.H., Peterson,A., Zambrowicz,B.P. and de
            Sauvage,F.J.
  TITLE     A mouse knockout library for secreted and transmembrane proteins
  JOURNAL   Nat Biotechnol 28 (7), 749-755 (2010)
   PUBMED   20562862
REFERENCE   10 (bases 1 to 777)
  AUTHORS   Otto,W.R., Patel,K., McKinnell,I., Evans,M.D., Lee,C.Y., Frith,D.,
            Hanrahan,S., Blight,K., Blin,N., Kayademir,T., Poulsom,R.,
            Jeffery,R., Hunt,T., Wright,N.A., McGregor,F. and Oien,K.A.
  TITLE     Identification of blottin: a novel gastric trefoil factor family-2
            binding protein
  JOURNAL   Proteomics 6 (15), 4235-4245 (2006)
   PUBMED   16888721
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AK007705.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK007705.1, AY943909.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..777
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.96 cM"
     gene            1..777
                     /gene="Gkn2"
                     /gene_synonym="1810036H07Rik; Bricd1b"
                     /note="gastrokine 2"
                     /db_xref="GeneID:66284"
                     /db_xref="MGI:MGI:1913534"
     exon            1..43
                     /gene="Gkn2"
                     /gene_synonym="1810036H07Rik; Bricd1b"
                     /inference="alignment:Splign:2.1.0"
     CDS             32..586
                     /gene="Gkn2"
                     /gene_synonym="1810036H07Rik; Bricd1b"
                     /note="blottin"
                     /codon_start=1
                     /product="gastrokine-2 precursor"
                     /protein_id="NP_079743.1"
                     /db_xref="CCDS:CCDS39546.1"
                     /db_xref="GeneID:66284"
                     /db_xref="MGI:MGI:1913534"
                     /translation="MKPLVAFLVVLSIFGIQSQAEEIFNIFVPSKNGGNIQETVTIDN
                     QQNTATINIHSGSCSSTTIFDYKHGYIASRVLSRRACYVIKMDHKAIPALDKLQRFLY
                     EKQTMNAIDSPEYTWVRYNPLKSLITKVDWFLFGSPIRQLCKHMPLYEGEVATKPKEV
                     STGACAKVGLLGILGVSICGGIHL"
     exon            44..97
                     /gene="Gkn2"
                     /gene_synonym="1810036H07Rik; Bricd1b"
                     /inference="alignment:Splign:2.1.0"
     exon            98..235
                     /gene="Gkn2"
                     /gene_synonym="1810036H07Rik; Bricd1b"
                     /inference="alignment:Splign:2.1.0"
     exon            236..346
                     /gene="Gkn2"
                     /gene_synonym="1810036H07Rik; Bricd1b"
                     /inference="alignment:Splign:2.1.0"
     exon            347..503
                     /gene="Gkn2"
                     /gene_synonym="1810036H07Rik; Bricd1b"
                     /inference="alignment:Splign:2.1.0"
     exon            504..777
                     /gene="Gkn2"
                     /gene_synonym="1810036H07Rik; Bricd1b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      652..657
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gkn2"
                     /gene_synonym="1810036H07Rik; Bricd1b"
                     /note="hexamer: AATAAA"
     polyA_site      674
                     /gene="Gkn2"
                     /gene_synonym="1810036H07Rik; Bricd1b"
                     /note="major polyA site"
ORIGIN      
        1 acactgctcc agcaacttct cttcaggcaa aatgaaaccc ctcgtggcat ttctggtggt
       61 gctgtccatc tttggaatac aatcgcaggc agaggagatt tttaatatct tcgtcccaag
      121 caaaaatgga ggcaatatcc aggagacagt gaccatcgac aaccagcaga acacggccac
      181 catcaacatc cactcaggct cgtgctcctc caccacgatt tttgactata agcatggtta
      241 catcgcatcc cgggtgctct cccggagagc ctgttacgtc atcaagatgg accacaaagc
      301 catccctgct ctggacaaac tccaacggtt cctctacgag aagcagacaa tgaatgctat
      361 cgactcccca gagtatacct gggtcaggta caaccctctg aagtctctga tcacgaaggt
      421 ggactggttc ctgtttgggt cgcctattcg acagctatgc aagcacatgc ccctgtatga
      481 gggtgaggtg gctacaaagc caaaagaggt gagcactgga gcctgtgcaa aggttggact
      541 cctggggatc ctgggagtct ccatctgtgg aggaattcac ctttaagatg gtccatcaac
      601 tggcttcatc ttttcaaaga aatatacctt tggtttccac tcagaagcca aaataaattc
      661 ttcccaacat tccatctact tatgaaatcg aataataaca caaaatatgt atctgtgatg
      721 atatatttat cattatagat attattatca aaaatatatc tgtaatgata tatttac
//
