LOCUS       NM_025466               1220 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus gastrokine 1 (Gkn1), mRNA.
ACCESSION   NM_025466
VERSION     NM_025466.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1220)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1220)
  AUTHORS   Steiner,S., Seleznik,G.M., Reding,T., Stopic,M., Lenggenhager,D.,
            Ten Buren,E., Eshmuminov,D., Endhardt,K., Hagedorn,C.,
            Heidenblut,A.M., Bratus-Neuenschwander,A., Grossmann,J.,
            Trachsel,C., Jabbar,K.S., Hahn,S.A., Berg,J.V., Graf,R. and
            Gupta,A.
  TITLE     De novo expression of gastrokines in pancreatic precursor lesions
            impede the development of pancreatic cancer
  JOURNAL   Oncogene 41 (10), 1507-1517 (2022)
   PUBMED   35082384
REFERENCE   3  (bases 1 to 1220)
  AUTHORS   Overstreet,A.C., Grayson,B.E., Boger,A., Bakke,D., Carmody,E.M.,
            Bales,C.E., Paski,S.C., Murphy,S.F., Dethlefs,C.R., Shannon,K.J.,
            Adlaka,K.R., Wolford,C.E., Campiti,V.J., Raghunandan,C.V.,
            Seeley,R.J. and Boone,D.L.
  TITLE     Gastrokine-1, an anti-amyloidogenic protein secreted by the
            stomach, regulates diet-induced obesity
  JOURNAL   Sci Rep 11 (1), 9477 (2021)
   PUBMED   33947892
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1220)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643. PMID: 29144450]
REFERENCE   5  (bases 1 to 1220)
  AUTHORS   Chen,P., Li,Y.C. and Toback,F.G.
  TITLE     AMP-18 Targets p21 to Maintain Epithelial Homeostasis
  JOURNAL   PLoS One 10 (4), e0125490 (2015)
   PUBMED   25919700
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1220)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 1220)
  AUTHORS   Verzi,M.P., Khan,A.H., Ito,S. and Shivdasani,R.A.
  TITLE     Transcription factor foxq1 controls mucin gene expression and
            granule content in mouse stomach surface mucous cells
  JOURNAL   Gastroenterology 135 (2), 591-600 (2008)
   PUBMED   18558092
REFERENCE   8  (bases 1 to 1220)
  AUTHORS   Danciger,M., Yang,H., Ralston,R., Liu,Y., Matthes,M.T., Peirce,J.
            and Lavail,M.M.
  TITLE     Quantitative genetics of age-related retinal degeneration: a second
            F1 intercross between the A/J and C57BL/6 strains
  JOURNAL   Mol Vis 13, 79-85 (2007)
   PUBMED   17277741
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 1220)
  AUTHORS   Martin,T.E., Powell,C.T., Wang,Z., Bhattacharyya,S.,
            Walsh-Reitz,M.M., Agarwal,K. and Toback,F.G.
  TITLE     A novel mitogenic protein that is highly expressed in cells of the
            gastric antrum mucosa
  JOURNAL   Am J Physiol Gastrointest Liver Physiol 285 (2), G332-G343 (2003)
   PUBMED   12851218
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK008622.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008622.1, AK028136.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849376, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1220
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 37.96 cM"
     gene            1..1220
                     /gene="Gkn1"
                     /gene_synonym="2200002K21Rik; AMP-18; BRICD1; Fov"
                     /note="gastrokine 1"
                     /db_xref="GeneID:66283"
                     /db_xref="MGI:MGI:1913533"
     exon            1..55
                     /gene="Gkn1"
                     /gene_synonym="2200002K21Rik; AMP-18; BRICD1; Fov"
                     /inference="alignment:Splign:2.1.0"
     exon            56..106
                     /gene="Gkn1"
                     /gene_synonym="2200002K21Rik; AMP-18; BRICD1; Fov"
                     /inference="alignment:Splign:2.1.0"
     exon            107..247
                     /gene="Gkn1"
                     /gene_synonym="2200002K21Rik; AMP-18; BRICD1; Fov"
                     /inference="alignment:Splign:2.1.0"
     exon            248..358
                     /gene="Gkn1"
                     /gene_synonym="2200002K21Rik; AMP-18; BRICD1; Fov"
                     /inference="alignment:Splign:2.1.0"
     exon            359..500
                     /gene="Gkn1"
                     /gene_synonym="2200002K21Rik; AMP-18; BRICD1; Fov"
                     /inference="alignment:Splign:2.1.0"
     exon            501..1220
                     /gene="Gkn1"
                     /gene_synonym="2200002K21Rik; AMP-18; BRICD1; Fov"
                     /inference="alignment:Splign:2.1.0"
     regulatory      692..697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gkn1"
                     /gene_synonym="2200002K21Rik; AMP-18; BRICD1; Fov"
                     /note="hexamer: AATAAA"
     polyA_site      717
                     /gene="Gkn1"
                     /gene_synonym="2200002K21Rik; AMP-18; BRICD1; Fov"
                     /note="major polyA site"
ORIGIN      
        1 gagcacgccg cctgatcctc tgctccacca cactcctgcc gccatgaagc tcacaatgtt
       61 cgtcgtgggt ctgcttggcc tccttgcagc tcctggtttt gcttacacgg tcaacatcaa
      121 tggtaatgat ggcaatgtag acggaagtgg acagcagtcg gtgagcatca atggtgtgca
      181 caacgtggcc aatatcgaca acaataacgg ctgggactcc tggaatagcc tctgggacta
      241 tgaaaacagt ttcgctgcca cgagactctt ctccaagaag tcatgcattg tgcacagaat
      301 gaacaaggat gccatgccct cccttcagga cctcgataca atggtcaagg aacagaaggg
      361 taaagggcct ggaggagctc ctcccaagga cttgatgtac tccgtcaacc ctaccagagt
      421 ggaggacctg aatacattcg gaccaaagat tgctggcatg tgcaggggca tccctaccta
      481 tgtggccgag gagattccag gaccaaacca gcctttgtac tcaaagaagt gctacacagc
      541 tgacatactc tggattctgc ggatgtcctt ctgtggaaca tcagtggaga catactagaa
      601 gtcacaggaa aacaacccgt gggctctgac catcgcaatg cttgattatg agagtgttct
      661 ctgggggttg tgattagctt ctttaaggct caataaaccc acgtggcagc acatccagtt
      721 tgtaatgaca tgcctcatga cttctatggg agtccaatgt ggcacctgcc agcctgtatt
      781 caggacctct ccgctataaa gcatccctcc agagttttca aatactacaa agcacagcct
      841 gggtttgggc tcagataggc cactgctgcc tgactacatt acagacaaac aagttttaaa
      901 agaaagaaaa aagagctcag agtggctgga atcagcaagg gtgtttttcc tgcaaggagc
      961 cagaagtatc aataatcacc caaggaggag acactgggaa tgagagacta gaacacacgc
     1021 ctgcagatac ggagaacctc agattgccgc tctctcccat aactgcacac ccccttctgt
     1081 aaactctgct tctttctttc acctgaagat ggcccttgct tttttttatt ataggacagg
     1141 ataactagac cagaaagtca gcctgactct ctacatttat atgtcttccc agttcaagaa
     1201 atattattta ctgttgaatg
//
