LOCUS       NM_019832               1534 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus G kinase anchoring protein 1 (Gkap1), mRNA.
ACCESSION   NM_019832 XM_985973 XM_986008
VERSION     NM_019832.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1534)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1534)
  AUTHORS   Wang,H., Wang,G., Dai,Y., Li,Z., Zhu,Y. and Sun,F.
  TITLE     Functional role of GKAP1 in the regulation of male germ cell
            spontaneous apoptosis and sperm number
  JOURNAL   Mol Reprod Dev 86 (9), 1199-1209 (2019)
   PUBMED   31318116
  REMARK    GeneRIF: hese results suggest that a deficiency of GKAP1 in mouse
            testis could increase sperm production through a reduction of the
            spontaneous apoptosis of germ cells in the testis, possibly because
            of a change in the activity of the cGK-Ialpha pathway.
REFERENCE   3  (bases 1 to 1534)
  AUTHORS   Ando,Y., Shinozawa,Y., Iijima,Y., Yu,B.C., Sone,M., Ooi,Y.,
            Watanaka,Y., Chida,K., Hakuno,F. and Takahashi,S.
  TITLE     Tumor necrosis factor (TNF)-alpha-induced repression of GKAP42
            protein levels through cGMP-dependent kinase (cGK)-Ialpha causes
            insulin resistance in 3T3-L1 adipocytes
  JOURNAL   J Biol Chem 290 (9), 5881-5892 (2015)
   PUBMED   25586176
  REMARK    GeneRIF: Data show that cGMP-dependent kinase (cGK-Ialpha)
            knockdown partially rescued TNF-alpha-induced decrease in 42-kDa
            cGMP-dependent protein kinase-anchoring protein (GKAP42) and
            impairment of insulin signals.
REFERENCE   4  (bases 1 to 1534)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   5  (bases 1 to 1534)
  AUTHORS   Yuasa,K., Omori,K. and Yanaka,N.
  TITLE     Binding and phosphorylation of a novel male germ cell-specific
            cGMP-dependent protein kinase-anchoring protein by cGMP-dependent
            protein kinase Ialpha
  JOURNAL   J Biol Chem 275 (7), 4897-4905 (2000)
   PUBMED   10671526
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC052347.1 and W84281.1.
            
            On Jan 24, 2017 this sequence version replaced NM_019832.3.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC052347.1, SRR7652917.1197511.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1518              BC052347.1         1-1518
            1519-1534           W84281.1           1-16                c
FEATURES             Location/Qualifiers
     source          1..1534
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="13"
                     /map="13 30.97 cM"
     gene            1..1534
                     /gene="Gkap1"
                     /gene_synonym="42kDa; 4933400B15Rik; D13Ertd340e; Gkap42"
                     /note="G kinase anchoring protein 1"
                     /db_xref="GeneID:56278"
                     /db_xref="MGI:MGI:1891694"
     exon            1..115
                     /gene="Gkap1"
                     /gene_synonym="42kDa; 4933400B15Rik; D13Ertd340e; Gkap42"
                     /inference="alignment:Splign:2.1.0"
     exon            116..373
                     /gene="Gkap1"
                     /gene_synonym="42kDa; 4933400B15Rik; D13Ertd340e; Gkap42"
                     /inference="alignment:Splign:2.1.0"
     exon            374..517
                     /gene="Gkap1"
                     /gene_synonym="42kDa; 4933400B15Rik; D13Ertd340e; Gkap42"
                     /inference="alignment:Splign:2.1.0"
     exon            518..595
                     /gene="Gkap1"
                     /gene_synonym="42kDa; 4933400B15Rik; D13Ertd340e; Gkap42"
                     /inference="alignment:Splign:2.1.0"
     exon            596..719
                     /gene="Gkap1"
                     /gene_synonym="42kDa; 4933400B15Rik; D13Ertd340e; Gkap42"
                     /inference="alignment:Splign:2.1.0"
     exon            720..742
                     /gene="Gkap1"
                     /gene_synonym="42kDa; 4933400B15Rik; D13Ertd340e; Gkap42"
                     /inference="alignment:Splign:2.1.0"
     exon            743..895
                     /gene="Gkap1"
                     /gene_synonym="42kDa; 4933400B15Rik; D13Ertd340e; Gkap42"
                     /inference="alignment:Splign:2.1.0"
     exon            896..997
                     /gene="Gkap1"
                     /gene_synonym="42kDa; 4933400B15Rik; D13Ertd340e; Gkap42"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1061
                     /gene="Gkap1"
                     /gene_synonym="42kDa; 4933400B15Rik; D13Ertd340e; Gkap42"
                     /inference="alignment:Splign:2.1.0"
     exon            1062..1132
                     /gene="Gkap1"
                     /gene_synonym="42kDa; 4933400B15Rik; D13Ertd340e; Gkap42"
                     /inference="alignment:Splign:2.1.0"
     exon            1133..1210
                     /gene="Gkap1"
                     /gene_synonym="42kDa; 4933400B15Rik; D13Ertd340e; Gkap42"
                     /inference="alignment:Splign:2.1.0"
     exon            1211..1520
                     /gene="Gkap1"
                     /gene_synonym="42kDa; 4933400B15Rik; D13Ertd340e; Gkap42"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1497..1502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gkap1"
                     /gene_synonym="42kDa; 4933400B15Rik; D13Ertd340e; Gkap42"
                     /note="hexamer: AATAAA"
     polyA_site      1520
                     /gene="Gkap1"
                     /gene_synonym="42kDa; 4933400B15Rik; D13Ertd340e; Gkap42"
                     /note="major polyA site"
ORIGIN      
        1 gccgccctcc gcgggcccgt tactgcggac gccccgcggc ccgcgcccaa cgcccggggg
       61 tagcgcggga gcggcgggga gacgggagcg gccgcaccgc ggcgagggag gcccggagtt
      121 actattgagc aagcgtttaa gcccccagtt ctgagccatg gcctctgcag tcctcagctc
      181 tgtgctcaca actgcctctc gctttgccct gctacaagtg gacagcggca gtggctctga
      241 ttccgagcct gggaaaggca aaggccggag taatgggaag tctcaaactc tgggaaacaa
      301 agcaacctca aatgagaaga aacgggagaa gagaagaaaa aagaaggaac agcagcagag
      361 tgaagcaaac gagctcagga atcttgcttt caagaaaatt ccccagaaat cctcccattc
      421 catttgcaat gttcaacatg agctttcatc gccaaaccca gcacagaagg agtcacggga
      481 agaaaactgg caagagtgga gacagaaaga tgaacagctg acctctgaaa tgtttgaagc
      541 tgaccttgag aaggcgttgc tgttgagtaa gctggagtat gaagagcaca aacaggatta
      601 tgaaaatgct gagactgctt caactcagac aaaaggtata aataaaaaag ataaaaggaa
      661 gaaccaccag ggcaaggaca aacctgtcac ggtgtcactc aaagacttcc agtgtgaaga
      721 tcatattagt aaaaaggcag aggaatcgaa ttctgctcag actttatcac acgatggggg
      781 attcttcaat agactggaag atgatgttca taagattctg attagagaaa aaaggagaga
      841 acaactcaca gagcacaacg gaacagataa ctctcccgct ccagagcaca accaggaagt
      901 aggtctaaaa gatggaagaa ttgaaagact aaagttagaa cttgaaagga aagacgcaga
      961 aattcagaag ctcaaagctg tgatcactca gtgggaggca aagtataaag aagtaaaagc
     1021 aagaaatgga caattactga aaatgcttca ggagggagag atgaaagata aggccgagat
     1081 acttctgcaa gtggatgagt ctcagagcat caagaacgag ctgacggtcc aggtgtcttc
     1141 acttcatgcc gcactggaac aagaaagatc taaagtgaaa gtattacagg cagaattagc
     1201 caaataccag ggaggcagga aggggaaaag gaacttcgaa cctgaccatt gcaggtgatc
     1261 gtggcctcgg aggccagcac agaattcttt cacacttttg cagaaatgtg tatatttaat
     1321 gctgtgcgac tgctaaactg caggtttttg ttgaaggaac taaaagcaac tagttcactc
     1381 atagtctaca gttttatgtt cttttggctt aaagttaaaa gaaaatacag aataccagca
     1441 gaacttgatt attgttttct gtccaaactt cttatgactt tagtttttca tcagtcaata
     1501 aaattaattt actcttccaa aaaaaaaaaa aaaa
//
