LOCUS       NM_001368879            7185 bp    mRNA    linear   ROD 20-OCT-2024
DEFINITION  Mus musculus glycerol kinase 5 (Gk5), transcript variant 1, mRNA.
ACCESSION   NM_001368879 XM_006511131
VERSION     NM_001368879.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 7185)
  AUTHORS   Zhang,D., Tomisato,W., Su,L., Sun,L., Choi,J.H., Zhang,Z.,
            Wang,K.W., Zhan,X., Choi,M., Li,X., Tang,M., Castro-Perez,J.M.,
            Hildebrand,S., Murray,A.R., Moresco,E.M.Y. and Beutler,B.
  TITLE     Skin-specific regulation of SREBP processing and lipid biosynthesis
            by glycerol kinase 5
  JOURNAL   Proc Natl Acad Sci U S A 114 (26), E5197-E5206 (2017)
   PUBMED   28607088
  REMARK    GeneRIF: GK5 formed a complex with the sterol regulatory
            element-binding proteins (SREBPs) through their C-terminal
            regulatory domains, inhibiting SREBP processing and activation.
REFERENCE   2  (bases 1 to 7185)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC166175.2.
            
            On Mar 7, 2019 this sequence version replaced XM_006511131.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK167217.1, AK076293.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-184               AC166175.2         88779-88962
            185-278             AC166175.2         98351-98444
            279-354             AC166175.2         102739-102814
            355-448             AC166175.2         107095-107188
            449-580             AC166175.2         109889-110020
            581-656             AC166175.2         115022-115097
            657-718             AC166175.2         119566-119627
            719-792             AC166175.2         119785-119858
            793-853             AC166175.2         120086-120146
            854-980             AC166175.2         122431-122557
            981-1085            AC166175.2         124743-124847
            1086-1180           AC166175.2         140810-140904
            1181-1284           AC166175.2         144040-144143
            1285-1344           AC166175.2         145580-145639
            1345-1478           AC166175.2         146769-146902
            1479-7185           AC166175.2         148271-153977
FEATURES             Location/Qualifiers
     source          1..7185
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="9"
                     /map="9 50.31 cM"
     gene            1..7185
                     /gene="Gk5"
                     /gene_synonym="C330018K18Rik; G630067D24Rik"
                     /note="glycerol kinase 5"
                     /db_xref="GeneID:235533"
                     /db_xref="MGI:MGI:2443336"
     exon            1..184
                     /gene="Gk5"
                     /gene_synonym="C330018K18Rik; G630067D24Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             23..1627
                     /gene="Gk5"
                     /gene_synonym="C330018K18Rik; G630067D24Rik"
                     /EC_number="2.7.1.30"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative glycerol kinase 5; GK 5; glycerokinase 5;
                     ATP:glycerol 3-phosphotransferase 5; glycerol kinase 5
                     (putative)"
                     /codon_start=1
                     /product="glycerol kinase 5 isoform 1"
                     /protein_id="NP_001355808.1"
                     /db_xref="CCDS:CCDS90642.1"
                     /db_xref="GeneID:235533"
                     /db_xref="MGI:MGI:2443336"
                     /translation="MSGQQERAERQREELSASASPPSRFVLGLDVGSTVIRCHVYDQT
                     ARVRGSSAQKVENVYPQPGWVEIDPDSLWAQFVAVIKDAVKAAGVQMNQIVGLGISTQ
                     RATFITWNKKTGHHFHNFISWQDLRAAELVKSWNNSLIMKLLHGATRVLHFFSRSKVM
                     LTVSRFNFSTQHATLRLTWILQNLSEVKRAVEEDNCCFGTIDTWLLYKLTKGSSYATD
                     YSNASTTGFFDPYAMRWSRLITTMVSIPLSILPPVKDTSYNFGSVDEKIFGVPIPVVA
                     LVGDQQSAMFGECCFETGDVKLTMGTGTFLDINTGKNLQHVNGGFYPLIGWKIGQELV
                     CLAEGNAGDTGTAIMWAQKLDLFTDAAETEKMALSLEDSEGVYFVPSFSGLQAPLNDP
                     CACASFMGLKHSTNKYHLVRAILESIAFRNKQLYDMLQREIQIPVTNIRADGGVCNNA
                     FVMQMTSDLINEKIDRPAHFDMSCLGAASLAGLAVGFWADKEELQKLRQSEMVFKPQK
                     KWQEYEVNMENWVKAVKRSMNWYNKT"
     exon            185..278
                     /gene="Gk5"
                     /gene_synonym="C330018K18Rik; G630067D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            279..354
                     /gene="Gk5"
                     /gene_synonym="C330018K18Rik; G630067D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            355..448
                     /gene="Gk5"
                     /gene_synonym="C330018K18Rik; G630067D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            449..580
                     /gene="Gk5"
                     /gene_synonym="C330018K18Rik; G630067D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            581..656
                     /gene="Gk5"
                     /gene_synonym="C330018K18Rik; G630067D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            657..718
                     /gene="Gk5"
                     /gene_synonym="C330018K18Rik; G630067D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            719..792
                     /gene="Gk5"
                     /gene_synonym="C330018K18Rik; G630067D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            793..853
                     /gene="Gk5"
                     /gene_synonym="C330018K18Rik; G630067D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            854..980
                     /gene="Gk5"
                     /gene_synonym="C330018K18Rik; G630067D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            981..1085
                     /gene="Gk5"
                     /gene_synonym="C330018K18Rik; G630067D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1086..1180
                     /gene="Gk5"
                     /gene_synonym="C330018K18Rik; G630067D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1181..1284
                     /gene="Gk5"
                     /gene_synonym="C330018K18Rik; G630067D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1285..1344
                     /gene="Gk5"
                     /gene_synonym="C330018K18Rik; G630067D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1345..1478
                     /gene="Gk5"
                     /gene_synonym="C330018K18Rik; G630067D24Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..7185
                     /gene="Gk5"
                     /gene_synonym="C330018K18Rik; G630067D24Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      7135..7140
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gk5"
                     /gene_synonym="C330018K18Rik; G630067D24Rik"
                     /note="hexamer: AATAAA"
     regulatory      7141..7146
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gk5"
                     /gene_synonym="C330018K18Rik; G630067D24Rik"
                     /note="hexamer: ATTAAA"
     polyA_site      7156
                     /gene="Gk5"
                     /gene_synonym="C330018K18Rik; G630067D24Rik"
                     /note="major polyA site"
     polyA_site      7160
                     /gene="Gk5"
                     /gene_synonym="C330018K18Rik; G630067D24Rik"
                     /note="major polyA site"
ORIGIN      
        1 gactgcagtg ttcggggtcg cgatgtcagg gcagcaggag cgtgcagagc ggcagcgaga
       61 ggaactgagc gcgtcggcct cgccgccctc ccgcttcgtg ctggggctgg acgtgggcag
      121 cacggtgatc cgctgccacg tctatgacca gacggcgcga gtgcgaggct ccagcgcgca
      181 gaaggtagaa aatgtttacc ctcaacctgg ctgggttgaa atcgatcctg attctctctg
      241 ggctcagttt gttgccgtaa taaaagatgc tgtcaaagct gcaggggtgc agatgaatca
      301 aattgtcggt cttggcatat caacacagag agccactttc attacatgga acaagaaaac
      361 aggccatcat tttcacaact tcattagctg gcaagaccta agggcagctg aacttgtaaa
      421 gtcctggaat aattctctca taatgaagct attgcatggg gccacccgag tccttcattt
      481 cttcagtaga agtaaagtaa tgctaacggt cagccgcttc aatttcagca cccagcatgc
      541 caccttaaga ttgacctgga ttttacaaaa cctatctgag gtgaaaaggg cagttgaaga
      601 agacaattgt tgctttggga cgattgatac ctggctgtta tacaagctca cgaaaggttc
      661 ttcctacgcc acggattatt caaatgccag caccactgga ttttttgatc cctatgcgat
      721 gcgctggagc aggctcataa ccaccatggt ctccatccca ctgtctatcc tgcctcctgt
      781 gaaggatacc agctataatt ttggatcagt ggatgagaag atatttggcg tgcctatacc
      841 agttgttgcc ttggttggtg accagcagtc ggccatgttt ggagagtgct gcttcgagac
      901 gggagatgtg aagctaacca tgggaactgg aacatttttg gatatcaata ctggaaaaaa
      961 ccttcagcat gttaatggag gcttttatcc actaattgga tggaagattg ggcaagaact
     1021 tgtatgttta gctgaaggca atgcaggaga cacgggcacc gccataatgt gggctcaaaa
     1081 attagatctc ttcacagacg ctgctgagac tgaaaaaatg gccctgagcc tggaagattc
     1141 tgaaggggtt tactttgttc cgtcgtttag tggattacag gctccattaa atgacccctg
     1201 tgcctgtgcc tcttttatgg gtttgaagca ctccactaat aaataccatc ttgtccgagc
     1261 aatattggag tcaatagctt tcaggaacaa acagttgtac gacatgctgc agagagaaat
     1321 ccagattccc gtcacgaaca tccgggcaga tggaggcgtg tgtaacaacg ctttcgtcat
     1381 gcagatgact tcagacctga taaatgagaa gatagacaga cctgcccact tcgacatgtc
     1441 ctgcttgggg gcagcctctc tggctggcct cgctgttgga ttttgggcgg acaaggaaga
     1501 gctccagaag ctgaggcaaa gcgagatggt tttcaagcct cagaagaagt ggcaggaata
     1561 cgaggtgaat atggaaaact gggtaaaagc ggtgaagcgc tccatgaatt ggtataacaa
     1621 gacgtagccc cgaggagcca aggaaaacct gcaggccggg ggacaggatg tgccggtggg
     1681 ggctgcacag gggtcaccgt gtgactgtgg ccgagaggaa aagattcgaa acaagccttg
     1741 caggctgaaa gaagaagcca ggctctttta aacaaaacaa aacaaaacaa aacaacctca
     1801 catacaaaaa aaaatacttc ttatttttta aattcaaatc atagtgaaat ttttaggcag
     1861 caagacctca aaattgagtc ttctttcttc tggcgatttc caaaggacac tgtccacttc
     1921 taactgcatt tcagatactt gtgagtcctc tttttttata cagggagaat ggcacatact
     1981 tcatagtcat tgtttaccct aatggttccg ggtcacattt tgttaaaaat gatgaaatgt
     2041 tttcttaaat ttgaaatcaa gagggctctt tgaaacccac atagctaaaa cgaagaggta
     2101 gttgagagga cgttttatat ataaagccat aattgtcaag tgtcatatcc tcagataagc
     2161 tctgacgtca ctcttcagtg acctccttag tcagcgcacg cgttcctttg tcatgcataa
     2221 agacacggcc ttaattcttc tgcacaacct gagctgtttc gttgttttca ttgaggcaca
     2281 gtgtcaccac gtagcccagg ctagcctgaa acatgacctt cttcctcatc tctcagattc
     2341 taagattata ggcgggcacc atcgtgcctg ggtgggcact cagcatacat tgaggaacgc
     2401 atctcagtgg actgaaaggg atgttgaggc tgggcatggt ggcaaatatg gggactttcg
     2461 aggctgcggc caggggagct tgagcttgga gcctgtccag acgatgcagt gaagtccagg
     2521 caatctgggt gacacagtga ggccttgtct ttgaaaatat ctcatttgtt tgagagaaga
     2581 tcctgtttag cccatgccag tttctaactc ttgaaccccc aactttagtc tctagagttg
     2641 tgtgtcacat tctattttta taaaatgcaa gcagttaatg taaacctttc ttcctggctc
     2701 tttatctttc ttgacttgtt gaaatgctcg cataaatgtc ccctttttaa aaagtgccta
     2761 cttcacagag tttaattatt gttagttttg tttgtttgtt tgtttgtttg ttttggcaac
     2821 cgagtctcat tatgtagctc aggctagcct aaaactcccg aacctcttga cttagtctcc
     2881 tgaggtgcca ggtttgttgg cgcttactct gacatcacag tttatgttga agcaccccag
     2941 cttatcagta acttaagaat tgcctttctg ggttacttga tgtgactttt ggtatttgtc
     3001 ctgctcacct ctgagggata gcagaggctg gcagatcagg tgatggaatg tgtcttggtg
     3061 acaatggctg taaaccagtc agccactaag cagcagtccc ctgttaggaa acttcgtggc
     3121 tggaagcagg tggaggagtc agtagagaga ggcctcagac tgggtataaa attgtcctgg
     3181 ggtggttggc agtgctccag cctcttttac taaactctgt tgcctctcac gtcatggaga
     3241 tttggatttt cttgaggtac atgaacttgc ccccatctgg tccatatccc ataaaagtgc
     3301 tactgttcta gaactatcta ctacataatt acctcactaa aggagcaact cttaagaggg
     3361 aatgttatat ttctgtcata tgttcatttg ggagtcagtt attctagaat aacaggtaca
     3421 ttgtgttttt ttgcaaatta ttttcttggg ctcccagtgt cttcaattgt taaaaatgtt
     3481 tcttaatggc aacattatag caaacatgta gcttcgttta ttctattaac ttttggagac
     3541 aagccaacaa gatgtctcag caggtaaaag cacttgttac acaggcttac cagcctgagt
     3601 taaatcccca gaaggaacgt gtgtccaggt agaggaagaa aactgactcc agagttttct
     3661 tatgacttcc acgtgtacat ggtgctgtgc acacttcctc cataataata ctacaaagtc
     3721 taaaaggctt ggaaaggtct ttgttagagg tgcatttgtt tactgtagca aaccagatct
     3781 taggtagaaa atatcttttt ctttctcttc tgcagcatcg ttgcaggttt cccataaatc
     3841 ttgtgagaac tgctttatgt ggaggttttt acaggttctg ctgataggtt cctaggatgt
     3901 aactcggtcc ctttgtatca ggagagacta aactgtgatg ttaactatga acggtctctt
     3961 tgccgttcct tccctacact cttcctaact gacagctgtg cagtcaggga taaatgccct
     4021 tcagatactg tgaaaaacac ctaatgtgtc atctggattg aaacatcgac tttctttctt
     4081 cctccgtggc tctggatgct actcttttcc ttttttcatt tctggccata ttttaatgac
     4141 agggcttagt gatgcttgta atcattaagt aaaatcagaa atgttatgtc atttgctttt
     4201 gaggtcgcag gaacagttgt taatcaaaaa cagttgaaga atattgtccc ttcatctgcc
     4261 tcttgaaaat aatttctaat atgctaatat ttctcagcat attttctctt ccttttgtaa
     4321 atctaccagg cattttaaga ggactccagc aaactcagaa aggacagtgt tcctgtctta
     4381 acgtggcact aactgcatta tctatgactt actgatcttc gagtctcttg tattcatcag
     4441 tggtatggtt tctcagtgtc agcattgatc tttgttttgt ttttatgaca gggtctcaat
     4501 gtgtagccct ggctgtcctg gaactcactg tgtagaccag gttgcctcct cattcacaga
     4561 actccgcctg cctctgcctc ctgagttctg gggttaaagg tgtgcaccac cacaccttgc
     4621 aacattgaca ttttgaactg catctgactt tgctttggga tgctatgctg gacacagtgg
     4681 gatgcttggc agtatccctg acctccactg ttcagcattc ccctgggttt tatggcccca
     4741 aatgcctgcc aacattggcc atcctgggag gcaaaaatca ttgtcatttg agaaccactg
     4801 atgcaggctg ttagaataaa catgaggatt tggtgaatat agtcacattc ccaatagtct
     4861 atgcactgtt ttctcctggg aaatgaattc ttaacagtga aaaagtagag agtatcctaa
     4921 agtgcggttt cggttttgct cggtaatgaa gaaaaagtgt tggttggttg tgtcccttac
     4981 ccatcacctc tgaagatgga tcaaacctac agccttgagc ctgatagtca actattccac
     5041 tactgagcta catcccatcc cgtaagtctc ttgtagtact tatgtacctc agctctgctc
     5101 ctgtgtgttc acaattagtg gacatttggc ctcacgatat gacggttata ttctgtagac
     5161 catctgttcc tacccctgca cttctgagac agggcccagg ttggtctgga actcatggca
     5221 gtattcctgc ctcagcctcc tgggtgctga gatcacaggc atgaatcacc atgcctggct
     5281 ttgcttcagt tttatctctg aacaaggaaa ggactaccac tgtcccaaag cttcactcga
     5341 tgcttcctga agccaaagcc acgtttgctc cccacagaac ttaacactgt gccttcctgt
     5401 ctgtgggtgg atttttactt cacatttatc tttgatctta catttattgg tagtatctta
     5461 tacttgtcta aaaggaagat atctacagct aggggtgtga tgtttattgt ttaaaaaaaa
     5521 aaaggttaca tgtctgtata tttcgagtat atttttgtag agatatacat ccatagatac
     5581 acatggtata agctggtctg ggaattcacc ccagagtctg gtgcatgcta agcatgccca
     5641 gctactttga acttcttaag gtatacttga aactttcatc cacagtttta tatgttagac
     5701 tgcagctaac tagccttgtg ttgtgcccaa cactttggtg ctatagaaga aacctcataa
     5761 gtagcctctt cattaagcaa acacctatct ataccaggga ccagtttctt tgtgttgtgt
     5821 gtgtgtgttc ttttgttttg tcttttaagg ttttttgttt gtttgtttta ttttttttga
     5881 gagagtgtct cactatgtag ctctgactat cctggaacta gagatctgcc tgcctctgcc
     5941 tcccaagtgc tggtattaaa ggtctcctcc cggagctact gggcctggat ttggggactg
     6001 gttatcaagg taaactacag ctcaagaggc tggcaagact ttttcagttc atagaaataa
     6061 ttgctatgcc tcagagtcct ccaactttga gtctacggtc accaaaacta gtctaaagaa
     6121 ggctcggatc agctcgaagg agtctggatc cctttgggaa gcttcgattg tgctttttcg
     6181 agtcagggca agaagcttca ggcataccct gaacctttaa gattctcctg attgggaatc
     6241 caaagcctga aagaggcttc acaattaggt aattctgaag tcctgttctt ctattcttac
     6301 agcctctttg ccctttgcat tttttcccca cgtctagata gctatgggga ttgcttagga
     6361 aaaactgatg taggagctca catggttcat gggtggggtg gcacggtgct tgtatagtga
     6421 gcatagtgcc ctaggtttgt ccccagaggt acaagtcaga aagaaacgat caagaaccac
     6481 actcagagtg gctgttccat tttatgtttc tgccctccat tcctgtgtga gtggtccagt
     6541 ctctccatgt tctctcacca gcattcagtg atgttaaata ctatttcatg tgctttctgc
     6601 catctgcttg ccctcatctt ttacatcttt gttcttgtct ttgtcagttt gtcaattaga
     6661 ttgtttacta aacgagccat atcttttagt aaagttttaa aaataatatc tgacttcaga
     6721 agtcaggaaa taggactttt caaatcattt aagtcagaat tttaaagcat cttgaacatt
     6781 gtcttacagt gtgcccaaca gaagggcatt tacttctggg ctcattacac agtgtgaggc
     6841 tcatgctgtg aaaagaacaa aaacaaggtt tctacggcaa ctttacttaa gatttcctgt
     6901 agtgtgtccg gagacatact ttatatatag caattatcat gtttctaact gtgcaatggt
     6961 atgatttatg taaagattca aaatgatttt gtggaaaatt aattagcaaa gatggataag
     7021 tgtagatttg aattcttatg tatcagtaat ttatgatctt atttctctgt tattgtgaat
     7081 gttggtttta ttaaagagtt attgaaactg tcataaacca ttttataggt ctttaataaa
     7141 attaaagatg aaatcagcaa tagaaatact tttcatatgc atatt
//
