LOCUS       NM_010294               1915 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus glycerol kinase 2 (Gk2), mRNA.
ACCESSION   NM_010294
VERSION     NM_010294.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1915)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1915)
  AUTHORS   Shimada,K., Park,S., Miyata,H., Yu,Z., Morohoshi,A., Oura,S.,
            Matzuk,M.M. and Ikawa,M.
  TITLE     ARMC12 regulates spatiotemporal mitochondrial dynamics during
            spermiogenesis and is required for male fertility
  JOURNAL   Proc Natl Acad Sci U S A 118 (6) (2021)
   PUBMED   33536340
REFERENCE   3  (bases 1 to 1915)
  AUTHORS   Shimada,K., Kato,H., Miyata,H. and Ikawa,M.
  TITLE     Glycerol kinase 2 is essential for proper arrangement of
            crescent-like mitochondria to form the mitochondrial sheath during
            mouse spermatogenesis
  JOURNAL   J Reprod Dev 65 (2), 155-162 (2019)
   PUBMED   30662012
  REMARK    GeneRIF: GK2 is essential for proper arrangement of crescent-like
            mitochondria to form the mitochondrial sheath during mouse
            spermatogenesis.
REFERENCE   4  (bases 1 to 1915)
  AUTHORS   Chen,Y., Liang,P., Huang,Y., Li,M., Zhang,X., Ding,C., Feng,J.,
            Zhang,Z., Zhang,X., Gao,Y., Zhang,Q., Cao,S., Zheng,H., Liu,D.,
            Songyang,Z. and Huang,J.
  TITLE     Glycerol kinase-like proteins cooperate with Pld6 in regulating
            sperm mitochondrial sheath formation and male fertility
  JOURNAL   Cell Discov 3, 17030 (2017)
   PUBMED   28852571
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1915)
  AUTHORS   Zhang,D., Tomisato,W., Su,L., Sun,L., Choi,J.H., Zhang,Z.,
            Wang,K.W., Zhan,X., Choi,M., Li,X., Tang,M., Castro-Perez,J.M.,
            Hildebrand,S., Murray,A.R., Moresco,E.M.Y. and Beutler,B.
  TITLE     Skin-specific regulation of SREBP processing and lipid biosynthesis
            by glycerol kinase 5
  JOURNAL   Proc Natl Acad Sci U S A 114 (26), E5197-E5206 (2017)
   PUBMED   28607088
REFERENCE   6  (bases 1 to 1915)
  AUTHORS   Wergedal,J.E., Ackert-Bicknell,C.L., Beamer,W.G., Mohan,S.,
            Baylink,D.J. and Srivastava,A.K.
  TITLE     Mapping genetic loci that regulate lipid levels in a NZB/B1NJxRF/J
            intercross and a combined intercross involving NZB/B1NJ, RF/J,
            MRL/MpJ, and SJL/J mouse strains
  JOURNAL   J Lipid Res 48 (8), 1724-1734 (2007)
   PUBMED   17496333
REFERENCE   7  (bases 1 to 1915)
  AUTHORS   Chan,W.Y., Wu,S.M., Ruszczyk,L., Law,E., Lee,T.L., Baxendale,V.,
            Lap-Yin Pang,A. and Rennert,O.M.
  TITLE     The complexity of antisense transcription revealed by the study of
            developing male germ cells
  JOURNAL   Genomics 87 (6), 681-692 (2006)
   PUBMED   16458478
REFERENCE   8  (bases 1 to 1915)
  AUTHORS   Pan,Y., Decker,W.K., Huq,A.H. and Craigen,W.J.
  TITLE     Retrotransposition of glycerol kinase-related genes from the X
            chromosome to autosomes: functional and evolutionary aspects
  JOURNAL   Genomics 59 (3), 282-290 (1999)
   PUBMED   10444329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122875.2, BC050764.1 and BC061147.1.
            
            On Sep 26, 2017 this sequence version replaced NM_010294.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC061147.1, AF117734.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC122875.2         77889-77890         c
            3-1883              BC050764.1         1-1881
            1884-1915           BC061147.1         1848-1879
FEATURES             Location/Qualifiers
     source          1..1915
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 47.71 cM"
     gene            1..1915
                     /gene="Gk2"
                     /gene_synonym="Gk-rs2; GKTA"
                     /note="glycerol kinase 2"
                     /db_xref="GeneID:14626"
                     /db_xref="MGI:MGI:1329027"
     exon            1..1894
                     /gene="Gk2"
                     /gene_synonym="Gk-rs2; GKTA"
                     /inference="alignment:Splign:2.1.0"
     CDS             47..1711
                     /gene="Gk2"
                     /gene_synonym="Gk-rs2; GKTA"
                     /EC_number="2.7.1.30"
                     /note="glucokinase activity, related sequence 2; GK 2;
                     glycerokinase 2; glycerol kinase, testis specific 2;
                     ATP:glycerol 3-phosphotransferase 2"
                     /codon_start=1
                     /product="glycerol kinase 2"
                     /protein_id="NP_034424.1"
                     /db_xref="CCDS:CCDS19454.1"
                     /db_xref="GeneID:14626"
                     /db_xref="MGI:MGI:1329027"
                     /translation="MAASKQTSAGPLVGAVVQGTNSTRFLVFNSKTAELVCSHQVELT
                     QEYPKEGWVEQDPKEILKSVYECIAKACEKLAEVNIDISNIKAIGVSNQRETTVVWDK
                     FTGDPLYNAVVWLDLRTQSTVETLTKKIPGNSNFVKSKTGLPLSTYFSAVKLRWMLDN
                     LRPIQKAVEEGRAMFGTIDSWLIWCMTGGVNGGIHCTDVTNACRTMLFNIHSLEWDKD
                     LCDFFEIPMSILPNVCSSSEIYGLMTSGALEGVPISGCLGDQSAALVGQMCFHEGQAK
                     NTYGTGCFLLCNTGQKCVFSEHGLLTTLAYKLGKNKPVFYALEGSVAIAGAVIRWLRD
                     NFEIITTSGEVENLAREVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHI
                     AFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTNNRILMQLQADILHIPVVKSV
                     MPETTALGAAMAAGAAEGVNVWSLEPEDLSTILMERYEPQIQATESEIRFSTWKRAVM
                     KSMGWVTAKDPENGDNPVFSCLPLGFFIVSSMTLLIGARCVSTAEE"
     regulatory      1866..1871
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gk2"
                     /gene_synonym="Gk-rs2; GKTA"
                     /note="hexamer: AATAAA"
     polyA_site      1894
                     /gene="Gk2"
                     /gene_synonym="Gk-rs2; GKTA"
                     /note="major polyA site"
ORIGIN      
        1 gtctcctaac tggcatcacc agggaaacag tccactgacc agtttcatgg cagcctcgaa
       61 gcaaacctct gcgggaccgt tggtaggagc ggtggtccag ggaaccaact ccactcgctt
      121 tctagttttc aatagcaaaa cagcagaact agtttgctct catcaggtgg aactgacaca
      181 agaataccca aaagaaggat gggtggagca agaccccaag gaaatcctta aatctgtcta
      241 tgagtgcata gcgaaagctt gtgaaaaact tgctgaagtg aacattgata tttccaacat
      301 taaagctatc ggcgtgagta accagcggga aaccactgtg gtctgggaca agttcacggg
      361 agaccctctg tacaatgccg tggtgtggct tgatctcaga acccagtcta ctgtggagac
      421 tctcactaag aaaatcccag gaaatagcaa ctttgtcaag tctaagaccg gccttcctct
      481 tagcacttac ttcagtgctg tgaagctgcg gtggatgctg gacaacctaa gacccattca
      541 aaaggctgtt gaggaaggca gagccatgtt tggaaccatc gactcttggc tcatctggtg
      601 tatgaccgga ggagtcaatg gaggcatcca ttgcaccgat gtaacaaatg catgcagaac
      661 gatgcttttt aacatccact ctttggaatg ggataaagat ctctgtgact tttttgaaat
      721 tccaatgagc atcctcccaa atgtatgcag ttcttctgag atctatggcc tgatgacatc
      781 aggggccttg gaaggcgtgc caatatctgg atgtttgggg gatcagtctg ctgctttagt
      841 gggacaaatg tgtttccatg aaggtcaagc caaaaacaca tacggaacag gctgtttttt
      901 actatgtaat acaggccaga aatgtgtgtt ttctgaacat ggccttctga ccacattggc
      961 ttacaaacta ggcaaaaata agccagtttt ttatgcctta gaaggttctg ttgctatagc
     1021 tggtgctgtt attcgctggc taagagacaa tttcgaaatt ataacaacct caggggaagt
     1081 tgaaaatctt gcaagagagg taggcacttc ctatggctgc tactttgtcc cagccttttc
     1141 ggggctgtat gcaccttact gggaacccag tgcaagaggg ataatctgtg gtctcactca
     1201 gttcaccaac aaatgccata ttgcctttgc tgcgttagaa gctgtttgtt tccaaacccg
     1261 agagattttg gatgccatga atcgcgactg tggaattcca ctcagtcatt tgcaggtcga
     1321 tggaggaatg accaacaaca ggattcttat gcagctacag gcagatattc tgcacattcc
     1381 ggtagttaag tctgtcatgc ctgaaacgac ggccctggga gctgccatgg cagccggagc
     1441 tgcagaaggg gtaaatgttt ggagtcttga acctgaagat ttgtctacga tcttgatgga
     1501 acgatatgaa ccacaaatcc aagccacaga gagtgaaatt cgtttttcaa catggaagag
     1561 agcagtgatg aagtcaatgg gttgggttac agcaaaggac cctgaaaatg gcgataaccc
     1621 tgtcttctct tgtctgccct tgggtttttt tatagtgagt agcatgacgt tattaattgg
     1681 agcaagatgt gtctcaactg ctgaagagta atttgaacca cggacttgca atgtgtgaac
     1741 tttttacaga aagaattcca tcttttagtg tgaaaccaat attataggtt tatttttacc
     1801 tataggccac ttgcttacag gaacccatga ggcccctaca aatactcctt aaaataaagg
     1861 ttttgaataa agagaacaca ttagaaaaac agtaaaaaaa aaaaaaaaaa aaaaa
//
