LOCUS       NP_034424                554 aa            linear   ROD 02-MAY-2024
DEFINITION  glycerol kinase 2 [Mus musculus].
ACCESSION   NP_034424
VERSION     NP_034424.1
DBSOURCE    REFSEQ: accession NM_010294.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 554)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (residues 1 to 554)
  AUTHORS   Shimada,K., Park,S., Miyata,H., Yu,Z., Morohoshi,A., Oura,S.,
            Matzuk,M.M. and Ikawa,M.
  TITLE     ARMC12 regulates spatiotemporal mitochondrial dynamics during
            spermiogenesis and is required for male fertility
  JOURNAL   Proc Natl Acad Sci U S A 118 (6) (2021)
   PUBMED   33536340
REFERENCE   3  (residues 1 to 554)
  AUTHORS   Shimada,K., Kato,H., Miyata,H. and Ikawa,M.
  TITLE     Glycerol kinase 2 is essential for proper arrangement of
            crescent-like mitochondria to form the mitochondrial sheath during
            mouse spermatogenesis
  JOURNAL   J Reprod Dev 65 (2), 155-162 (2019)
   PUBMED   30662012
  REMARK    GeneRIF: GK2 is essential for proper arrangement of crescent-like
            mitochondria to form the mitochondrial sheath during mouse
            spermatogenesis.
REFERENCE   4  (residues 1 to 554)
  AUTHORS   Chen,Y., Liang,P., Huang,Y., Li,M., Zhang,X., Ding,C., Feng,J.,
            Zhang,Z., Zhang,X., Gao,Y., Zhang,Q., Cao,S., Zheng,H., Liu,D.,
            Songyang,Z. and Huang,J.
  TITLE     Glycerol kinase-like proteins cooperate with Pld6 in regulating
            sperm mitochondrial sheath formation and male fertility
  JOURNAL   Cell Discov 3, 17030 (2017)
   PUBMED   28852571
  REMARK    Publication Status: Online-Only
REFERENCE   5  (residues 1 to 554)
  AUTHORS   Zhang,D., Tomisato,W., Su,L., Sun,L., Choi,J.H., Zhang,Z.,
            Wang,K.W., Zhan,X., Choi,M., Li,X., Tang,M., Castro-Perez,J.M.,
            Hildebrand,S., Murray,A.R., Moresco,E.M.Y. and Beutler,B.
  TITLE     Skin-specific regulation of SREBP processing and lipid biosynthesis
            by glycerol kinase 5
  JOURNAL   Proc Natl Acad Sci U S A 114 (26), E5197-E5206 (2017)
   PUBMED   28607088
REFERENCE   6  (residues 1 to 554)
  AUTHORS   Wergedal,J.E., Ackert-Bicknell,C.L., Beamer,W.G., Mohan,S.,
            Baylink,D.J. and Srivastava,A.K.
  TITLE     Mapping genetic loci that regulate lipid levels in a NZB/B1NJxRF/J
            intercross and a combined intercross involving NZB/B1NJ, RF/J,
            MRL/MpJ, and SJL/J mouse strains
  JOURNAL   J Lipid Res 48 (8), 1724-1734 (2007)
   PUBMED   17496333
REFERENCE   7  (residues 1 to 554)
  AUTHORS   Chan,W.Y., Wu,S.M., Ruszczyk,L., Law,E., Lee,T.L., Baxendale,V.,
            Lap-Yin Pang,A. and Rennert,O.M.
  TITLE     The complexity of antisense transcription revealed by the study of
            developing male germ cells
  JOURNAL   Genomics 87 (6), 681-692 (2006)
   PUBMED   16458478
REFERENCE   8  (residues 1 to 554)
  AUTHORS   Pan,Y., Decker,W.K., Huq,A.H. and Craigen,W.J.
  TITLE     Retrotransposition of glycerol kinase-related genes from the X
            chromosome to autosomes: functional and evolutionary aspects
  JOURNAL   Genomics 59 (3), 282-290 (1999)
   PUBMED   10444329
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC122875.2, BC050764.1 and BC061147.1.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC061147.1, AF117734.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..554
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 47.71 cM"
     Protein         1..554
                     /product="glycerol kinase 2"
                     /EC_number="2.7.1.30"
                     /note="glucokinase activity, related sequence 2; GK 2;
                     glycerokinase 2; glycerol kinase, testis specific 2;
                     ATP:glycerol 3-phosphotransferase 2"
                     /calculated_mol_wt=60499
     Region          11..510
                     /region_name="ASKHA_NBD_FGGY_GK1-3-like"
                     /note="nucleotide-binding domain (NBD) of metazoan
                     glycerol kinase 1-3 (GK1-3) and similar proteins; cd07792"
                     /db_xref="CDD:466802"
     Site            526..546
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q9WU65.1)"
     CDS             1..554
                     /gene="Gk2"
                     /gene_synonym="Gk-rs2; GKTA"
                     /coded_by="NM_010294.2:47..1711"
                     /db_xref="CCDS:CCDS19454.1"
                     /db_xref="GeneID:14626"
                     /db_xref="MGI:MGI:1329027"
ORIGIN      
        1 maaskqtsag plvgavvqgt nstrflvfns ktaelvcshq veltqeypke gwveqdpkei
       61 lksvyeciak aceklaevni disnikaigv snqrettvvw dkftgdplyn avvwldlrtq
      121 stvetltkki pgnsnfvksk tglplstyfs avklrwmldn lrpiqkavee gramfgtids
      181 wliwcmtggv nggihctdvt nacrtmlfni hslewdkdlc dffeipmsil pnvcssseiy
      241 glmtsgaleg vpisgclgdq saalvgqmcf hegqakntyg tgcfllcntg qkcvfsehgl
      301 lttlayklgk nkpvfyaleg svaiagavir wlrdnfeiit tsgevenlar evgtsygcyf
      361 vpafsglyap ywepsargii cgltqftnkc hiafaaleav cfqtreilda mnrdcgipls
      421 hlqvdggmtn nrilmqlqad ilhipvvksv mpettalgaa maagaaegvn vwslepedls
      481 tilmeryepq iqateseirf stwkravmks mgwvtakdpe ngdnpvfscl plgffivssm
      541 tlligarcvs taee
//
