LOCUS       NP_997609                553 aa            linear   ROD 13-MAY-2025
DEFINITION  glycerol kinase isoform 2 [Mus musculus].
ACCESSION   NP_997609
VERSION     NP_997609.1
DBSOURCE    REFSEQ: accession NM_212444.2
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 553)
  AUTHORS   Yamamoto,T., Maurya,S.K., Pruzinsky,E., Batmanov,K., Xiao,Y.,
            Sulon,S.M., Sakamoto,T., Wang,Y., Lai,L., McDaid,K.S.,
            Shewale,S.V., Leone,T.C., Koves,T.R., Muoio,D.M., Dierickx,P.,
            Lazar,M.A., Lewandowski,E.D. and Kelly,D.P.
  TITLE     RIP140 deficiency enhances cardiac fuel metabolism and protects
            mice from heart failure
  JOURNAL   J Clin Invest 133 (9), e162309 (2023)
   PUBMED   36927960
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 553)
  AUTHORS   Zapateria,B., Sevillano,J., Sanchez-Alonso,M.G., Limones,M.,
            Pizarro-Delgado,J., Zuccaro,A., Herradon,G., Medina-Gomez,G. and
            Ramos-Alvarez,M.P.
  TITLE     Deletion of pleiotrophin impairs glucose tolerance and liver
            metabolism in pregnant mice: Moonlighting role of glycerol kinase
  JOURNAL   FASEB J 35 (10), e21911 (2021)
   PUBMED   34551152
  REMARK    GeneRIF: Deletion of pleiotrophin impairs glucose tolerance and
            liver metabolism in pregnant mice: Moonlighting role of glycerol
            kinase.
REFERENCE   3  (residues 1 to 553)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (residues 1 to 553)
  AUTHORS   Miao,L., Su,F., Yang,Y., Liu,Y., Wang,L., Zhan,Y., Yin,R., Yu,M.,
            Li,C., Yang,X. and Ge,C.
  TITLE     Glycerol kinase enhances hepatic lipid metabolism by repressing
            nuclear receptor subfamily 4 group A1 in the nucleus
  JOURNAL   Biochem Cell Biol 98 (3), 370-377 (2020)
   PUBMED   31813231
  REMARK    GeneRIF: Glycerol kinase enhances hepatic lipid metabolism by
            repressing nuclear receptor subfamily 4 group A1 in the nucleus.
REFERENCE   5  (residues 1 to 553)
  AUTHORS   Iwase,M., Tokiwa,S., Seno,S., Mukai,T., Yeh,Y.S., Takahashi,H.,
            Nomura,W., Jheng,H.F., Matsumura,S., Kusudo,T., Osato,N.,
            Matsuda,H., Inoue,K., Kawada,T. and Goto,T.
  TITLE     Glycerol kinase stimulates uncoupling protein 1 expression by
            regulating fatty acid metabolism in beige adipocytes
  JOURNAL   J Biol Chem 295 (20), 7033-7045 (2020)
   PUBMED   32273338
  REMARK    GeneRIF: Glycerol kinase stimulates uncoupling protein 1 expression
            by regulating fatty acid metabolism in beige adipocytes.
REFERENCE   6  (residues 1 to 553)
  AUTHORS   Huq,A.H., Lovell,R.S., Ou,C.N., Beaudet,A.L. and Craigen,W.J.
  TITLE     X-linked glycerol kinase deficiency in the mouse leads to growth
            retardation, altered fat metabolism, autonomous glucocorticoid
            secretion and neonatal death
  JOURNAL   Hum Mol Genet 6 (11), 1803-1809 (1997)
   PUBMED   9302256
REFERENCE   7  (residues 1 to 553)
  AUTHORS   Bassett,D.E. Jr., Boguski,M.S., Spencer,F., Reeves,R., Kim,S.,
            Weaver,T. and Hieter,P.
  TITLE     Genome cross-referencing and XREFdb: implications for the
            identification and analysis of genes mutated in human disease
  JOURNAL   Nat Genet 15 (4), 339-344 (1997)
   PUBMED   9090377
REFERENCE   8  (residues 1 to 553)
  AUTHORS   Guo,W., Lovell,R.S., Zhang,Y.H., Huang,B.L., Burris,T.P.,
            Craigen,W.J. and McCabe,E.R.
  TITLE     Ahch, the mouse homologue of DAX1: cloning, characterization and
            synteny with GyK, the glycerol kinase locus
  JOURNAL   Gene 178 (1-2), 31-34 (1996)
   PUBMED   8921887
REFERENCE   9  (residues 1 to 553)
  AUTHORS   Huq,A.H., Lovell,R.S., Sampson,M.J., Decker,W.K., Dinulos,M.B.,
            Disteche,C.M. and Craigen,W.J.
  TITLE     Isolation, mapping, and functional expression of the mouse X
            chromosome glycerol kinase gene
  JOURNAL   Genomics 36 (3), 530-534 (1996)
   PUBMED   8884278
REFERENCE   10 (residues 1 to 553)
  AUTHORS   Makalowski,W., Zhang,J. and Boguski,M.S.
  TITLE     Comparative analysis of 1196 orthologous mouse and human
            full-length mRNA and protein sequences
  JOURNAL   Genome Res 6 (9), 846-857 (1996)
   PUBMED   8889551
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL672056.4 and AL645567.7.
            
            Transcript Variant: This variant (2) lacks an alternate in-frame
            exon in the central coding region compared to variant 4. The
            encoded isoform (2) is shorter than isoform 4.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK088373.1, SRR13948564.4046636.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..553
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 39.32 cM"
     Protein         1..553
                     /product="glycerol kinase isoform 2"
                     /EC_number="2.7.1.30"
                     /note="glycerokinase; ATP:glycerol 3-phosphotransferase"
                     /calculated_mol_wt=60431
     Region          11..510
                     /region_name="ASKHA_NBD_FGGY_GK1-3-like"
                     /note="nucleotide-binding domain (NBD) of metazoan
                     glycerol kinase 1-3 (GK1-3) and similar proteins; cd07792"
                     /db_xref="CDD:466802"
     Site            526..546
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q64516.2)"
     CDS             1..553
                     /gene="Gk"
                     /gene_synonym="D930012N15Rik; Gyk"
                     /coded_by="NM_212444.2:317..1978"
                     /note="isoform 2 is encoded by transcript variant 2"
                     /db_xref="CCDS:CCDS41050.1"
                     /db_xref="GeneID:14933"
                     /db_xref="MGI:MGI:106594"
ORIGIN      
        1 maaakkavlg plvgavdqgt sstrflvfns ktaellshhq veikqefpre gwveqdpkei
       61 lqsvyeciek tceklgqlni disnikaigv snqrettvvw dkvtgeplyn avvwldlrtq
      121 stvenlskri pgnnnfvksk tglplstyfs avklrwlldn vkkvqeavee nralfgtids
      181 wliwsltggi hggvhctdvt nasrtmlfni hslewdkelc effgipmeil pnvrssseiy
      241 glmkagaleg vpisgclgdq saalvgqmcf qdgqakntyg tgcfllcntg hkcvfsehgl
      301 lttvayklgr dkpvyyaleg svaiagavir wlrdnlgiik sseeieklak evgtsygcyf
      361 vpafsglyap ywepsargii cgltqftnkc hiafaaleav cfqtreilda mnrdcgipls
      421 hlqvdggmts nkilmqlqad ilyipvvkps mpettalgaa maagaaegvg vwslepedls
      481 avtmerfepq inaeeseiry stwkkavmks igwvttqspe sgdpsifcsl plgffivssm
      541 vmligaryis gip
//
