LOCUS       NM_001405828            2160 bp    mRNA    linear   ROD 01-MAY-2024
DEFINITION  Mus musculus gap junction protein, epsilon 1 (Gje1), transcript
            variant 1, mRNA.
ACCESSION   NM_001405828 XM_030245359
VERSION     NM_001405828.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2160)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2160)
  AUTHORS   Berthoud,V.M., Minogue,P.J., Snabb,J.I., Dzhashiashvili,Y.,
            Novak,L.A., Zoltoski,R.K., Popko,B. and Beyer,E.C.
  TITLE     Connexin23 deletion does not affect lens transparency
  JOURNAL   Exp Eye Res 146, 283-288 (2016)
   PUBMED   27038752
REFERENCE   3  (bases 1 to 2160)
  AUTHORS   Lachke,S.A., Ho,J.W., Kryukov,G.V., O'Connell,D.J., Aboukhalil,A.,
            Bulyk,M.L., Park,P.J. and Maas,R.L.
  TITLE     iSyTE: integrated Systems Tool for Eye gene discovery
  JOURNAL   Invest Ophthalmol Vis Sci 53 (3), 1617-1627 (2012)
   PUBMED   22323457
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2160)
  AUTHORS   Puk,O., Loster,J., Dalke,C., Soewarto,D., Fuchs,H., Budde,B.,
            Nurnberg,P., Wolf,E., de Angelis,M.H. and Graw,J.
  TITLE     Mutation in a novel connexin-like gene (Gjf1) in the mouse affects
            early lens development and causes a variable small-eye phenotype
  JOURNAL   Invest Ophthalmol Vis Sci 49 (4), 1525-1532 (2008)
   PUBMED   18385072
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC159336.13.
            
            On May 4, 2022 this sequence version replaced XM_030245359.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR17784645.73599.1,
                                           SRR17784644.292147.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-966               AC159336.13        18758-19723
            967-2160            AC159336.13        20158-21351
FEATURES             Location/Qualifiers
     source          1..2160
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 5.5 cM"
     gene            1..2160
                     /gene="Gje1"
                     /gene_synonym="AEY12; Cx23; Cxnt; D230044M03Rik; Gjf1;
                     Gsfaey12"
                     /note="gap junction protein, epsilon 1"
                     /db_xref="GeneID:76743"
                     /db_xref="MGI:MGI:1923993"
     exon            1..966
                     /gene="Gje1"
                     /gene_synonym="AEY12; Cx23; Cxnt; D230044M03Rik; Gjf1;
                     Gsfaey12"
                     /inference="alignment:Splign:2.1.0"
     CDS             712..1362
                     /gene="Gje1"
                     /gene_synonym="AEY12; Cx23; Cxnt; D230044M03Rik; Gjf1;
                     Gsfaey12"
                     /note="isoform 1 is encoded by transcript variant 1; gap
                     junction epsilon-1 protein; connexin 23; putative gap
                     junction protein connexin Cx43.4; connexin t"
                     /codon_start=1
                     /product="gap junction epsilon-1 protein isoform 1"
                     /protein_id="NP_001392757.1"
                     /db_xref="GeneID:76743"
                     /db_xref="MGI:MGI:1923993"
                     /translation="MNTSSQLSFLNVCFQLIFSLQNQQVKPPTVIGQFHTLFFGSVRM
                     FFLGVLGFAVYGNEALHFSCDPDKREINLFCYNQFRPITPQVFWALQLVIVLLPGAIF
                     HLYAACKSINQDCILQKPVYTVIYVLSVLLRISLEVFAFWLQIHLFGFQVKPIYLCDT
                     ESLGKKPNILKCMVPEHFEKTIFLIAMYTFTVITMVLCVAEVFEIIFRRSCFLFKR"
     exon            967..2160
                     /gene="Gje1"
                     /gene_synonym="AEY12; Cx23; Cxnt; D230044M03Rik; Gjf1;
                     Gsfaey12"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2136..2141
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gje1"
                     /gene_synonym="AEY12; Cx23; Cxnt; D230044M03Rik; Gjf1;
                     Gsfaey12"
                     /note="hexamer: AATAAA"
     polyA_site      2160
                     /gene="Gje1"
                     /gene_synonym="AEY12; Cx23; Cxnt; D230044M03Rik; Gjf1;
                     Gsfaey12"
                     /note="major polyA site"
ORIGIN      
        1 agaagcaatc tgacagcata gttcagcaac agcccacggg gatgccagga taacacctcc
       61 tgaaagatgt ctctaaatta catcaagaac ttctatgaag gatgtgtaag tagcaagcaa
      121 gaaaatcaat tgcatggtta tttgtctgtg tattttaaat caattggcat gtgtggcgat
      181 gaatatattt actatacatt tactaagaaa ataaaataac catctgctgt aaaatattct
      241 gaattctaaa ttacaggtag atttaactct gaggtacatt catccattga tgctttaaag
      301 tagctcacac tcttaattca atattaagta taaaaaacaa cacttgccaa aactaaataa
      361 atactgttct gtcattatga tagtatgtgt tctaagttta atgttgtatt tgtcacctca
      421 tcttccaaaa gaggaaatca gacattctaa gatatttatg gttttatttc aaagggatta
      481 caagagaagg aagtattcct cacattcaaa gctgtttaaa gtatttctaa acttacccat
      541 gttattggca gtagatctct atttgatgtg tgtactttat aatttatgcg taaagtggaa
      601 taatgatgtc ataatgaggg cttaaccgtg aacttgacca tctcaaagag tctatcttgc
      661 taaaaacttc tcagatctca accttttaaa aattcttttt aaaatgggat catgaataca
      721 tcctcccaat tgtccttttt aaatgtttgt ttccaactaa ttttttccct ccaaaaccaa
      781 caggttaagc ctccaactgt gatcggccag ttccacactc tcttcttcgg ctcagtgcgg
      841 atgttcttcc tcggagtgct gggctttgct gtctacggga atgaggcgtt gcacttcagc
      901 tgtgacccag acaagcgaga gataaacctg ttctgttaca atcagttccg gccaataact
      961 ccccaagtgt tctgggcatt gcagctagtg attgtcctgc ttcctggagc tattttccac
     1021 ctgtatgctg catgcaaaag catcaatcaa gactgcattc ttcagaagcc cgtgtacact
     1081 gtgatttacg tcctctcggt cttgttaaga atcagcctgg aggtgttcgc attctggctt
     1141 cagattcacc tcttcggctt ccaagtgaag ccgatatact tgtgtgatac tgaatctctt
     1201 ggtaaaaaac caaatattct aaaatgcatg gttccagagc actttgaaaa gactattttc
     1261 ctcattgcaa tgtacacatt tactgtgatc acgatggtat tatgtgttgc tgaggttttt
     1321 gagatcatat ttagaagatc atgttttctc tttaaacgat gaccgggttg atagcctatt
     1381 accataccat agttcctatc agtcatttat acttaatttt cccatcaagt atttcaattc
     1441 caaatgttct ttaaacttta gtgtgtctat aatttatgta tactagaaaa taggatacca
     1501 agttctaaac taggtgtttt tgagcaaata tttcctccta ttgtaatggt ataacttatt
     1561 atgtaataat gtacatgtaa gcctaatgat agctcttttt tttttttccc gagacagggt
     1621 ttctctgtat agccctggct gtcctggaac tcactctgta gaccaggctg gtctcgaact
     1681 cagaaatccg cctgcctctg cctcctgagt gctgggatta aaggcgtgca ccaccaccac
     1741 caactggcga tagctcattt tttaaaatac taaatgtaca ggcttctctc atgtacaata
     1801 ctttaagtga tcaccttatt tttggccaaa gagacttctt atgtagatta aagactggaa
     1861 atttgatgtt cagagatgat atttatgtgc catgtcacac aaccaaacca gaatttacct
     1921 ctttccctac acactgaaac atgtgtcttt aactccaaag acataattat ctttgcattt
     1981 gtgtaaaata tacctttaaa cacaaaatat aaattaatta aaagtcatat aatttaatca
     2041 ctaactcaaa gaaggcaagc aattgaattt ttaaatatta aaacccatat tgttttgctg
     2101 gaatcaatat taaatgatta tggagatagt tgccgaataa attagagttg ttatgaataa
//
