LOCUS       NM_178596               3074 bp    mRNA    linear   ROD 12-FEB-2025
DEFINITION  Mus musculus gap junction protein, delta 3 (Gjd3), mRNA.
ACCESSION   NM_178596
VERSION     NM_178596.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3074)
  AUTHORS   Bhattacharyya,S., Kollipara,R.K., Orquera-Tornakian,G., Goetsch,S.,
            Zhang,M., Perry,C., Li,B., Shelton,J.M., Bhakta,M., Duan,J.,
            Xie,Y., Xiao,G., Evers,B.M., Hon,G.C., Kittler,R. and Munshi,N.V.
  TITLE     Global chromatin landscapes identify candidate noncoding modifiers
            of cardiac rhythm
  JOURNAL   J Clin Invest 133 (3), e153635 (2023)
   PUBMED   36454649
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3074)
  AUTHORS   Pelletier,R.M., Layeghkhavidaki,H., Kumar,N.M. and Vitale,M.L.
  TITLE     Cx30.2 deletion causes imbalances in testicular Cx43, Cx46, and
            Cx50 and insulin receptors. Reciprocally, diabetes/obesity alters
            Cx30.2 in mouse testis
  JOURNAL   Am J Physiol Regul Integr Comp Physiol 318 (6), R1078-R1090 (2020)
   PUBMED   32348681
REFERENCE   3  (bases 1 to 3074)
  AUTHORS   Bhattacharyya,S., Duan,J., Wang,L., Li,B., Bhakta,M.,
            Fernandez-Perez,A., Hon,G.C. and Munshi,N.V.
  TITLE     Using Gjd3-CreEGFP mice to examine atrioventricular node morphology
            and composition
  JOURNAL   Sci Rep 9 (1), 2106 (2019)
   PUBMED   30765799
  REMARK    Erratum:[Sci Rep. 2020 Feb 28;10(1):4069. doi:
            10.1038/s41598-020-60915-5.. PMID: 32107454]
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3074)
  AUTHORS   Coronel-Cruz,C., Sanchez,I., Hernandez-Tellez,B.,
            Rodriguez-Mata,V., Pinzon-Estrada,E., Castell-Rodriguez,A. and
            Perez-Armendariz,E.M.
  TITLE     Connexin 30.2 is expressed in exocrine vascular endothelial and
            ductal epithelial cells throughout pancreatic postnatal development
  JOURNAL   Acta Histochem 120 (6), 558-565 (2018)
   PUBMED   30100173
  REMARK    GeneRIF: results suggest that intercellular coupling mediated by
            Cx30.2 intercellular channels may synchronize the functional
            activity of ECs and SMCs of vascular cells, as well as of
            epithelial ductal cells after birth.
REFERENCE   5  (bases 1 to 3074)
  AUTHORS   Cho,E., Mysliwiec,M.R., Carlson,C.D., Ansari,A., Schwartz,R.J. and
            Lee,Y.
  TITLE     Cardiac-specific developmental and epigenetic functions of Jarid2
            during embryonic development
  JOURNAL   J Biol Chem 293 (30), 11659-11673 (2018)
   PUBMED   29891551
REFERENCE   6  (bases 1 to 3074)
  AUTHORS   Kreuzberg,M.M., Schrickel,J.W., Ghanem,A., Kim,J.S., Degen,J.,
            Janssen-Bienhold,U., Lewalter,T., Tiemann,K. and Willecke,K.
  TITLE     Connexin30.2 containing gap junction channels decelerate impulse
            propagation through the atrioventricular node
  JOURNAL   Proc Natl Acad Sci U S A 103 (15), 5959-5964 (2006)
   PUBMED   16571663
  REMARK    GeneRIF: Cx30.2 contributes to the slowdown of impulse propagation
            in the atrioventricular node and limits the maximum number of beats
            conducted from atria to ventricles
REFERENCE   7  (bases 1 to 3074)
  AUTHORS   Kreuzberg,M.M., Sohl,G., Kim,J.S., Verselis,V.K., Willecke,K. and
            Bukauskas,F.F.
  TITLE     Functional properties of mouse connexin30.2 expressed in the
            conduction system of the heart
  JOURNAL   Circ Res 96 (11), 1169-1177 (2005)
   PUBMED   15879306
  REMARK    GeneRIF: The electrical properties of homo- and hetero-typic
            junctions involving mCx30.2 may contribute to slow propagation
            velocity in nodal tissues and directional asymmetry of excitation
            spread in the AV nodal region.
REFERENCE   8  (bases 1 to 3074)
  AUTHORS   Buniello,A., Montanaro,D., Volinia,S., Gasparini,P. and Marigo,V.
  TITLE     An expression atlas of connexin genes in the mouse
  JOURNAL   Genomics 83 (5), 812-820 (2004)
   PUBMED   15081111
REFERENCE   9  (bases 1 to 3074)
  AUTHORS   Sohl,G. and Willecke,K.
  TITLE     An update on connexin genes and their nomenclature in mouse and man
  JOURNAL   Cell Commun Adhes 10 (4-6), 173-180 (2003)
   PUBMED   14681012
  REMARK    Review article
REFERENCE   10 (bases 1 to 3074)
  AUTHORS   Nielsen,P.A. and Kumar,N.M.
  TITLE     Differences in expression patterns between mouse connexin-30.2
            (Cx30.2) and its putative human orthologue, connexin-31.9
  JOURNAL   FEBS Lett 540 (1-3), 151-156 (2003)
   PUBMED   12681499
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL591067.35.
            
            On Jun 21, 2019 this sequence version replaced NM_178596.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3074              AL591067.35        123371-126444       c
FEATURES             Location/Qualifiers
     source          1..3074
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 62.89 cM"
     gene            1..3074
                     /gene="Gjd3"
                     /gene_synonym="cx30.2; Cxnr; Gja11; Gjc1"
                     /note="gap junction protein, delta 3"
                     /db_xref="GeneID:353155"
                     /db_xref="MGI:MGI:2384150"
     exon            1..3074
                     /gene="Gjd3"
                     /gene_synonym="cx30.2; Cxnr; Gja11; Gjc1"
                     /inference="alignment:Splign:2.1.0"
     CDS             5..841
                     /gene="Gjd3"
                     /gene_synonym="cx30.2; Cxnr; Gja11; Gjc1"
                     /note="connexin 30.2; gap junction chi-1 protein; gap
                     junction alpha-11 protein; gap junction membrane channel
                     protein chi 1; connexin r"
                     /codon_start=1
                     /product="gap junction delta-3 protein"
                     /protein_id="NP_848711.2"
                     /db_xref="CCDS:CCDS25369.1"
                     /db_xref="GeneID:353155"
                     /db_xref="MGI:MGI:2384150"
                     /translation="MGEWAFLGSLLDAVQLQSPLVGRLWLVIMLIFRILVLATVGGAV
                     FEDEQEEFVCNTLQPGCRQTCYDRAFPVSHYRFWLFHILLLSAPPVLFVIYSMHQASK
                     EAGGAQLAPPCARGRAEAPCSPCALRARRARRCYLLSVALRLLAELAFLGGQALLYGF
                     RVDPHYACAGPPCPHTVDCFVSRPTEKTVFVVFYFAVGLLSALLSVAELGHLLWKGRQ
                     RAKLLPPPPPSPSLPSQRGDPDPFGPPAYAHRSPAGDSEGEGGSGHSKASLATVRQDL
                     AI"
     regulatory      1244..1249
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gjd3"
                     /gene_synonym="cx30.2; Cxnr; Gja11; Gjc1"
                     /note="hexamer: AGTAAA"
     polyA_site      1264
                     /gene="Gjd3"
                     /gene_synonym="cx30.2; Cxnr; Gja11; Gjc1"
                     /note="major polyA site"
     regulatory      3042..3047
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gjd3"
                     /gene_synonym="cx30.2; Cxnr; Gja11; Gjc1"
                     /note="hexamer: ATTAAA"
     polyA_site      3074
                     /gene="Gjd3"
                     /gene_synonym="cx30.2; Cxnr; Gja11; Gjc1"
ORIGIN      
        1 cgtcatgggg gagtgggcgt tcctaggctc cctgctggac gcggtgcagc tacagtcgcc
       61 gctcgtgggt cgtctctggc tggtgatcat gctgatcttc cgcatcctgg tgctggccac
      121 ggtgggaggt gcggtgttcg aggacgagca ggaggagttc gtgtgtaaca cgttgcagcc
      181 cggctgtcgc cagacctgct acgatcgcgc cttcccggtg tcccactacc gcttctggct
      241 cttccacatc ctgctgctgt cggcgccgcc ggtgctgttc gtcatctact ccatgcacca
      301 ggccagcaag gaggcgggtg gtgcgcagct ggccccgccg tgcgcgcgcg ggcgtgccga
      361 ggcgccgtgc tccccgtgcg ccctgcgcgc tcgccgcgcg cgccgctgct acctgctgag
      421 cgtggctctg cgcctgctcg ccgagctggc tttcctgggc ggccaggcgc tgctctacgg
      481 cttccgcgtg gacccgcact acgcgtgcgc cgggccacct tgtccgcaca cggtcgactg
      541 tttcgtgagc cggcccaccg agaagaccgt cttcgtggtc ttctacttcg ccgtcgggct
      601 gctgtcggcg ctgctcagcg tggcggagct gggtcacctg ctctggaagg gtcgccagcg
      661 cgccaagctg ctcccgccgc cgccgccgtc gccctctttg ccatcgcagc gcggggaccc
      721 cgaccctttc ggcccgccag cctacgcgca ccgctcaccg gcaggcgaca gcgagggcga
      781 aggcggcagc ggccacagca aagcgtcgct ggctaccgtg cgccaggacc tggccatcta
      841 gcggcgagat cggaggctgg atatcagcac ccgggtcctt ggaggcagaa ggctttgctt
      901 ctgaaagact gcgtaggacc ctgcctgagc agaagatgag cagaggggac cgccagggtt
      961 cgggtggggg aggtgtcgca cttcctagtg ctggttacgg cagccgtgtt aaatcaggga
     1021 ggctcctcgg tgctgtgatc cctgcggaaa gggaggacgc caagggctcc cctgagaggc
     1081 ggcaaaccgg ccgtgggtga cctgattgtt gcaccgggga caaaaatcaa cagtgatggc
     1141 aacattccca ggttccctgc taattcagag aagagtggtt ttccgtgagc gctctgcaca
     1201 cactctctct ggacacactc agatgggttg gctgctcaag catagtaaac ctctatgagc
     1261 tgtgtgtatt tgcatgtgta tgcttgtgag ggtccgcaca tgcgtgtgtc cacacgtata
     1321 catctcccaa gtgacaggcg atagagacct gggttcatgc ctgcgtgcac agaaatgtac
     1381 atgtatgtcc ttgaaggctc tgtgtggatg catgtacgca tgcgtcctgt gttagctctg
     1441 tatacacacc tatacacacg tacattctgt gtgtgcatcc gccaccactg tcagtcacta
     1501 acccagccac ctatgaggca actctgtccc caacaggaac tgacagcaaa cagtcctgtt
     1561 cagtcagatg tgttctgggc ccagtggcca ggcagggtag cccagtggct aggcagggta
     1621 gctaagctcc accttggagg ctgactggga ctggggtggg gctcgacttg aaacagtgct
     1681 gtgctttcgg cttacttcat ctctggtccc acctgccatt gttccctgta atctataaat
     1741 gtgactgact cctaccaatc gtcaaggaaa gctgcccttc aaagagaggt gtttctgggt
     1801 ccccattccc ttgcaactag cctagacttt ttgtttttgt ttttcgagac agggtttctc
     1861 tgtgtagccc tggctgtcct ggaactcact ttgtagacca ggttggcctc gaactcagaa
     1921 atccacctgc ctctgcctcc cgagtgctgg gatcaaaggt gtgcgccacc gacttttttt
     1981 ttttccaaag agatgccaca tggctctgtc acccttttcg ttctgtcctc tcacctgtgt
     2041 tcctcctttg tcacctgtgt ggccatcctg aataccctca ctaggaccaa gtgattaagc
     2101 cctgacagag caggcctggc tgccttcccc tgcacccctg gctctgtcag atccactgcc
     2161 caggccctgc cgttagccac cataccccaa acagctcgtt ctcccccaca ccagccttcc
     2221 tctggccttt gtatgccctg ggagctttct acatagcctt attggccata ggggaattcc
     2281 ctgttcttgg ggtacaacca gccttttccc caggcttgct gcacactagg ctccccttag
     2341 ttgggcctcc acccctacct tgccatccgt caaaccagcc tgaagtttct gtccccggca
     2401 agcatgccca cttggtatgc cagttttaga catgctgttg ggtgcagtct tactttctga
     2461 aggcctgccc cccccccatt gcctgccttt gtcttttggt ctcatttgaa gaaaatgtgc
     2521 ctcaaggcat ggctttctct gccctgagct acagtcaggc accctgtgtt ccagcctcgt
     2581 accatctggg catgacatat agtgttttgg gctccatcac tccatcacca tgctgaagcc
     2641 cacgcccgca ctcccagtgg acgagtctgg ttctcggatg tcgggtcgaa agcctggaac
     2701 cctccactca agcatactcg tggatgtcca gctgccttcc aaagacagtc actcaacaat
     2761 agcggttcaa gatcactcac attcaataca gttgcacatg agacacaatg taatatttag
     2821 gtttgatttt gatttctgag ataggatttt tggggttttg tgttttgttt tgttttgttt
     2881 ttgttttgtt tgagatagat acatagccct ggctggctag gaactcaatt tgaggctgac
     2941 ctcaaattca gtgacttcag agactgtccc tggctcccac tgccaggatt aaaagcacac
     3001 atccatactt acaatgtaat ttccaatttt cattcaacca cattaaaaaa gcaaacggac
     3061 acaggcaaga ttaa
//
