LOCUS       NM_010290               2884 bp    mRNA    linear   ROD 26-NOV-2024
DEFINITION  Mus musculus gap junction protein, delta 2 (Gjd2), transcript
            variant 1, mRNA.
ACCESSION   NM_010290
VERSION     NM_010290.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2884)
  AUTHORS   So,C., Zhang,T., Wang,Q., Qiu,C., Elie,L.A. and Pan,F.
  TITLE     The response of retinal ganglion cells to optical defocused visual
            stimuli in mouse retinas
  JOURNAL   Exp Eye Res 241, 109834 (2024)
   PUBMED   38382575
REFERENCE   2  (bases 1 to 2884)
  AUTHORS   Pelz,L., Dossou,L., Kompier,N., Juttner,R., Siemonsmeier,G.,
            Meyer,N., Lowenstein,E.D., Lahmann,I., Kettenmann,H., Birchmeier,C.
            and Rathjen,F.G.
  TITLE     The IgCAM BT-IgSF (IgSF11) is essential for connexin43-mediated
            astrocyte-astrocyte coupling in mice
  JOURNAL   eNeuro 11 (3) (2024) In press
   PUBMED   38388443
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 2884)
  AUTHORS   Hong,H., Moore,L.A., Apostolides,P.F. and Trussell,L.O.
  TITLE     Calcium-Sensitive Subthreshold Oscillations and Electrical Coupling
            in Principal Cells of Mouse Dorsal Cochlear Nucleus
  JOURNAL   J Neurosci 44 (6), e0106202023 (2024)
   PUBMED   37968120
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2884)
  AUTHORS   Kim,M.H., Strazza,P. Jr., Puthussery,T., Gross,O.P., Taylor,W.R.
            and von Gersdorff,H.
  TITLE     Functional maturation of the rod bipolar to AII-amacrine cell
            ribbon synapse in the mouse retina
  JOURNAL   Cell Rep 42 (11), 113440 (2023)
   PUBMED   37976158
REFERENCE   5  (bases 1 to 2884)
  AUTHORS   Nath,A., Grimes,W.N. and Diamond,J.S.
  TITLE     Layers of inhibitory networks shape receptive field properties of
            AII amacrine cells
  JOURNAL   Cell Rep 42 (11), 113390 (2023)
   PUBMED   37930888
REFERENCE   6  (bases 1 to 2884)
  AUTHORS   Guldenagel,M., Ammermuller,J., Feigenspan,A., Teubner,B., Degen,J.,
            Sohl,G., Willecke,K. and Weiler,R.
  TITLE     Visual transmission deficits in mice with targeted disruption of
            the gap junction gene connexin36
  JOURNAL   J Neurosci 21 (16), 6036-6044 (2001)
   PUBMED   11487627
REFERENCE   7  (bases 1 to 2884)
  AUTHORS   Gulisano,M., Parenti,R., Spinella,F. and Cicirata,F.
  TITLE     Cx36 is dynamically expressed during early development of mouse
            brain and nervous system
  JOURNAL   Neuroreport 11 (17), 3823-3828 (2000)
   PUBMED   11117498
REFERENCE   8  (bases 1 to 2884)
  AUTHORS   Cicirata,F., Parenti,R., Spinella,F., Giglio,S., Tuorto,F.,
            Zuffardi,O. and Gulisano,M.
  TITLE     Genomic organization and chromosomal localization of the mouse
            Connexin36 (mCx36) gene
  JOURNAL   Gene 251 (2), 123-130 (2000)
   PUBMED   10876089
REFERENCE   9  (bases 1 to 2884)
  AUTHORS   Sohl,G., Degen,J., Teubner,B. and Willecke,K.
  TITLE     The murine gap junction gene connexin36 is highly expressed in
            mouse retina and regulated during brain development
  JOURNAL   FEBS Lett 428 (1-2), 27-31 (1998)
   PUBMED   9645468
REFERENCE   10 (bases 1 to 2884)
  AUTHORS   Condorelli,D.F., Parenti,R., Spinella,F., Trovato Salinaro,A.,
            Belluardo,N., Cardile,V. and Cicirata,F.
  TITLE     Cloning of a new gap junction gene (Cx36) highly expressed in
            mammalian brain neurons
  JOURNAL   Eur J Neurosci 10 (3), 1202-1208 (1998)
   PUBMED   9753189
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC133157.1.
            
            On Mar 18, 2023 this sequence version replaced NM_010290.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC058595.1, SRR17784643.901909.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849379
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-565               AC133157.1         94197-94761
            566-2884            AC133157.1         95902-98220
FEATURES             Location/Qualifiers
     source          1..2884
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="2"
                     /map="2 57.54 cM"
     gene            1..2884
                     /gene="Gjd2"
                     /gene_synonym="connexin36; cx36; Cxns; Gja9"
                     /note="gap junction protein, delta 2"
                     /db_xref="GeneID:14617"
                     /db_xref="MGI:MGI:1334209"
     exon            1..565
                     /gene="Gjd2"
                     /gene_synonym="connexin36; cx36; Cxns; Gja9"
                     /inference="alignment:Splign:2.1.0"
     CDS             495..1460
                     /gene="Gjd2"
                     /gene_synonym="connexin36; cx36; Cxns; Gja9"
                     /note="connexin-36; gap junction alpha-9 protein; gap
                     junction membrane channel protein alpha 9; gap junction
                     protein, alpha 9; connexin s"
                     /codon_start=1
                     /product="gap junction delta-2 protein"
                     /protein_id="NP_034420.2"
                     /db_xref="CCDS:CCDS16563.1"
                     /db_xref="GeneID:14617"
                     /db_xref="MGI:MGI:1334209"
                     /translation="MGEWTILERLLEAAVQQHSTMIGRILLTVVVIFRILIVAIVGET
                     VYDDEQTMFVCNTLQPGCNQACYDRAFPISHIRYWVFQIIMVCTPSLCFITYSVHQSA
                     KQRERRYSTVFLALDRDPAESIGGPGGTGGGGSGGSKREDKKLQNAIVNGVLQNTETT
                     SKETEPDCLEVKELTPHPSGLRTAARSKLRRQEGISRFYIIQVVFRNALEIGFLVGQY
                     FLYGFSVPGLYECNRYPCIKEVECYVSRPTEKTVFLVFMFAVSGICVVLNLAELNHLG
                     WRKIKLAVRGAQAKRKSVYEIRNKDLPRVSVPNFGRTQSSDSAYV"
     exon            566..2884
                     /gene="Gjd2"
                     /gene_synonym="connexin36; cx36; Cxns; Gja9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2858..2863
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gjd2"
                     /gene_synonym="connexin36; cx36; Cxns; Gja9"
                     /note="hexamer: AATAAA"
     polyA_site      2884
                     /gene="Gjd2"
                     /gene_synonym="connexin36; cx36; Cxns; Gja9"
                     /note="major polyA site"
ORIGIN      
        1 ggattcccca gccccgcagc tagctctgcg cgccgcagcg cgggagcgcc aggtgcccgc
       61 tccagtgaca ggcgccgggg tccgtgcgcg gaccctccct cagaccgcaa gatcgcgggg
      121 accgcggcgc aggcaccggt ctcccgcggg caggagctcg gccacctgca cgctgccacc
      181 cagccccgcc cctcgccggg agactgcggg agtccatctg acccccggac ggcaccgagg
      241 tgctgtccag ctcttccgca ccgcgccagc agctccattg gttgggacgc acatagattg
      301 cttcccccac tcccctcttt taagtgcaat aaagggggag ggcctcgtgg atttttttaa
      361 aaaacaattt ttgtttgctt ctttaattgg gggcaattcg ctccctgtca ggaggtgagg
      421 cccggggagg ggccaggacc aagaacgtgc ccggtactgc ccagtctttg tctgctgcct
      481 ccggatgcac agcgatgggg gaatggacca tcttggagag gctgctggaa gccgcggtgc
      541 agcagcactc cactatgatt gggaggatcc tgttgactgt ggtggtgatc ttccggatac
      601 tcattgtggc cattgtaggg gagacggtgt acgatgatga gcagaccatg tttgtgtgca
      661 acaccctaca gcccggctgt aaccaggcct gctatgaccg cgcctttccc atctcccata
      721 tacgttactg ggtcttccag atcataatgg tgtgcacccc cagtctctgt tttatcacct
      781 attctgtgca ccaatccgcc aagcagcgag aacgccggta ctctactgtc ttcctagccc
      841 tggacagaga ccctgctgag tctatagggg gacctggagg aactgggggt gggggcagcg
      901 gagggagcaa acgagaagat aagaagttgc aaaatgccat tgtcaatggg gtgctgcaga
      961 acacagagac caccagtaag gagacagaac cagattgctt agaggttaaa gagctgactc
     1021 cacatccatc tgggctgcgc acagcagcaa ggtccaagct ccgaagacag gaaggtatct
     1081 cccgcttcta catcatccaa gtggtgtttc gaaatgctct ggagattggg tttctggtgg
     1141 gccagtactt tctatatggc ttcagtgttc cagggttgta tgagtgcaac cgttacccct
     1201 gcatcaagga ggtagaatgt tatgtgtcta gacctaccga gaagacagtc tttctggtgt
     1261 tcatgtttgc tgtgagcggc atttgtgtgg tgctcaatct ggctgaactt aaccatctgg
     1321 gatggcggaa gatcaaactg gctgtccggg gagcccaggc caagaggaag tcagtctatg
     1381 agatacgtaa caaagatctg cctcgagtca gtgttcccaa tttcggcagg actcagtcca
     1441 gtgactctgc ctatgtgtga aagggcaggt ttggggaagg cctgctaggt ggcaagtagc
     1501 cccaaggcag ataatgactc ggggtttaca ggtttgccct cattcgggtg atgctcgctg
     1561 tgaaggtcta ggatacagat attaagaggt cttcatcaac aaagaggaga ggtagaactg
     1621 tcatcacgtg ttacatcatc agttctacag aaaccattgg gtagagtgac aagatggcta
     1681 agctggacat tcttgggcct tcttctttta atggcccttc ctgctcctga tcatagtgaa
     1741 ctggcatagc tgccaagcaa gaattagctc tgctgagctc tgtattctgg tgaatggcat
     1801 gagtcaaaca ctcattgata taaaatttgt gacccatctc agcacatacc cttatcctgg
     1861 gctgcagaaa aaaaaatcct ggaggatatt tctccccctt cagcatgccc ctttcccaaa
     1921 cccaggatag catgccagct tttctttttc cttgatctgg ccttacatta gccctaacac
     1981 agtttatctg caagctagag ggaattacgt ggggtgcttt ttggagacta gccagggcag
     2041 aggtttgcag tagagcccca tatgactggc tcttagtcat taaacaaaac acaaacctta
     2101 ggaatgtctc aatatttcca attttttaaa actcaaattg cactggtgct gtttattagg
     2161 ggtggggaat gggagggggg aatttcaaca ccacttatga gatggtcatt tcactcaccg
     2221 ttgagcatgt gtttatgagc tttgggatat ttctgccttc tagattatgg actgtggata
     2281 gaattaaaaa tatgtgggtt tttgttttgt tttgttgtta ttgttgttgt tgttgaaatg
     2341 gagggtatct actcaagcca cagaatttct aactggtaga tcttactata atttcttacc
     2401 taatcttgtg ctacgcagct gcacatcatt ttgccatggt ttgaacttac ctgtgtgctc
     2461 acaccagaga ccttaatcag cccgtgtcaa tcccaactta ttgtgtcatc aattattttt
     2521 tgcaatacac acacatgcac acaattactg gcttaacaaa cctggaagta aatattattg
     2581 gttaagatat gtttatggat atttatttga gacatatacc aaaggttcat aaacctgttg
     2641 tttggactga gacaattttc ctctcgttgc tcttattcat ttaagtgcca tattcctcct
     2701 ttcctgccca ctgtgcattt agctgaagca ctaggcaaga gtagcattga gataatatgt
     2761 ttttatggaa gccctctatt tcatttgaat ccttcttctt atgggtttgt ttttgattta
     2821 gatatggatg tggtatgtta tatttggatt tgtttaaaat aaagttcttg cctttttttg
     2881 taaa
//
