LOCUS       NM_080450               3607 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus gap junction protein, gamma 3 (Gjc3), transcript
            variant 1, mRNA.
ACCESSION   NM_080450
VERSION     NM_080450.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3607)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3607)
  AUTHORS   Baskin,K.K., Makarewich,C.A., DeLeon,S.M., Ye,W., Chen,B.,
            Beetz,N., Schrewe,H., Bassel-Duby,R. and Olson,E.N.
  TITLE     MED12 regulates a transcriptional network of calcium-handling genes
            in the heart
  JOURNAL   JCI Insight 2 (14), 91920 (2017)
   PUBMED   28724790
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3607)
  AUTHORS   Kagiava,A., Theophilidis,G., Sargiannidou,I., Kyriacou,K. and
            Kleopa,K.A.
  TITLE     Oxaliplatin-induced neurotoxicity is mediated through gap junction
            channels and hemichannels and can be prevented by octanol
  JOURNAL   Neuropharmacology 97, 289-305 (2015)
   PUBMED   26044641
REFERENCE   4  (bases 1 to 3607)
  AUTHORS   Moon,Y., Choi,S.Y., Kim,K., Kim,H. and Sun,W.
  TITLE     Expression of connexin29 and 32 in the penumbra region after
            traumatic brain injury of mice
  JOURNAL   Neuroreport 21 (18), 1135-1139 (2010)
   PUBMED   20926974
  REMARK    GeneRIF: Induction of Cxs 29 and 32 in the injury border suggests
            that altered Cx expression may contribute to the propagation of
            injury-related and/or regeneration signals after acute brain
            injury.
REFERENCE   5  (bases 1 to 3607)
  AUTHORS   Parenti,R., Cicirata,F., Zappala,A., Catania,A., La Delia,F.,
            Cicirata,V., Tress,O. and Willecke,K.
  TITLE     Dynamic expression of Cx47 in mouse brain development and in the
            cuprizone model of myelin plasticity
  JOURNAL   Glia 58 (13), 1594-1609 (2010)
   PUBMED   20578039
REFERENCE   6  (bases 1 to 3607)
  AUTHORS   Nagy,J.I., Ionescu,A.V., Lynn,B.D. and Rash,J.E.
  TITLE     Connexin29 and connexin32 at oligodendrocyte and astrocyte gap
            junctions and in myelin of the mouse central nervous system
  JOURNAL   J Comp Neurol 464 (3), 356-370 (2003)
   PUBMED   12900929
  REMARK    GeneRIF: Comparative mapping of Y1 and Y5 receptor subtypes within
            cell bodies and nerve fibers in the brain. Together with
            physiological and electrophysiological studies, provides better
            understanding of NPY neural circuitries.
REFERENCE   7  (bases 1 to 3607)
  AUTHORS   Sohl,G. and Willecke,K.
  TITLE     An update on connexin genes and their nomenclature in mouse and man
  JOURNAL   Cell Commun Adhes 10 (4-6), 173-180 (2003)
   PUBMED   14681012
  REMARK    Review article
REFERENCE   8  (bases 1 to 3607)
  AUTHORS   Li,X., Lynn,B.D., Olson,C., Meier,C., Davidson,K.G., Yasumura,T.,
            Rash,J.E. and Nagy,J.I.
  TITLE     Connexin29 expression, immunocytochemistry and freeze-fracture
            replica immunogold labelling (FRIL) in sciatic nerve
  JOURNAL   Eur J Neurosci 16 (5), 795-806 (2002)
   PUBMED   12372015
  REMARK    GeneRIF: Cx29 is a second connexin expressed in Schwann cells of
            sciatic nerve.
REFERENCE   9  (bases 1 to 3607)
  AUTHORS   Altevogt,B.M., Kleopa,K.A., Postma,F.R., Scherer,S.S. and Paul,D.L.
  TITLE     Connexin29 is uniquely distributed within myelinating glial cells
            of the central and peripheral nervous systems
  JOURNAL   J Neurosci 22 (15), 6458-6470 (2002)
   PUBMED   12151525
REFERENCE   10 (bases 1 to 3607)
  AUTHORS   Sohl,G., Eiberger,J., Jung,Y.T., Kozak,C.A. and Willecke,K.
  TITLE     The mouse gap junction gene connexin29 is highly expressed in
            sciatic nerve and regulated during brain development
  JOURNAL   Biol Chem 382 (6), 973-978 (2001)
   PUBMED   11501764
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY741110.1, AK047368.1 and AW495171.1.
            
            On Oct 17, 2017 this sequence version replaced NM_080450.4.
            
            Transcript Variant: This variant (1) represents the longer,
            protein-coding transcript.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK147913.1, AK047368.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164131 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               BY741110.1         2-140
            140-3151            AK047368.1         2-3013
            3152-3607           AW495171.1         1-456               c
FEATURES             Location/Qualifiers
     source          1..3607
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="5"
                     /map="5 76.91 cM"
     gene            1..3607
                     /gene="Gjc3"
                     /gene_synonym="Cx29; Cxnp1; Gje1"
                     /note="gap junction protein, gamma 3"
                     /db_xref="GeneID:118446"
                     /db_xref="MGI:MGI:2153041"
     exon            1..233
                     /gene="Gjc3"
                     /gene_synonym="Cx29; Cxnp1; Gje1"
                     /inference="alignment:Splign:2.1.0"
     CDS             202..1011
                     /gene="Gjc3"
                     /gene_synonym="Cx29; Cxnp1; Gje1"
                     /note="connexin-29; gap junction epsilon-1 protein; gap
                     junction membrane channel protein epsilon 1; connexin p1"
                     /codon_start=1
                     /product="gap junction gamma-3 protein"
                     /protein_id="NP_536698.2"
                     /db_xref="CCDS:CCDS19782.1"
                     /db_xref="GeneID:118446"
                     /db_xref="MGI:MGI:2153041"
                     /translation="MLLLELPIKCRMCGRFLRQLLAQESQHSTPVGRFLLPMLMGFRL
                     LILVSSGPGVFGNDENEFICHLGQPGCKTICYDVFRPLSPLRFWAFQVILMAVPSAIY
                     VAFTLYHVIGYWEVPGKENKEQETQISKGDHSKDVSGAKSLKLLWAYVAHLGVRLALE
                     GAALGVQYNLYGFKMSSTFICREDPCIGSTTCFQSHPSEKTIFLNIMFGISGACFLFI
                     FLELALLGLGRFWRIYKHKLSFLKKLPTSESSVRSKDTTDELSVVEAKEPF"
     exon            234..1018
                     /gene="Gjc3"
                     /gene_synonym="Cx29; Cxnp1; Gje1"
                     /inference="alignment:Splign:2.1.0"
     exon            1019..3590
                     /gene="Gjc3"
                     /gene_synonym="Cx29; Cxnp1; Gje1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gtcactttcc agagatcgcg gcttgagggc agggtcctct ggtccttcag ttggaattct
       61 tttatgctgc agcgagcctg ccaggaatga aaaagagaag gcgaaagggt gggtggctgc
      121 aggaggcagg gccatcgcaa gatcctagac cctgcaggct ccagtgtgaa gattcctttt
      181 ggcttctttc ctctgtggtt gatgcttctg ctggagttgc caatcaagtg caggatgtgc
      241 ggcaggttcc tgagacagct attggctcag gagagccagc actccacccc tgtggggcgc
      301 ttccttcttc ccatgctcat gggattccgt ctcctgatct tggtttccag tggacctggg
      361 gttttcggca atgatgagaa tgaattcata tgtcatttag ggcagccagg ctgcaagacc
      421 atttgctatg atgtcttccg ccctctctct ccattgcgct tctgggcctt ccaagtcatt
      481 ctgatggctg tacccagtgc catttatgtg gctttcactc tgtatcatgt gattggatac
      541 tgggaggtac caggaaagga aaacaaggag caagagaccc agattagcaa aggggatcat
      601 agcaaggatg tctcaggggc taaaagcctc aagcttctct gggcctatgt ggcacacctt
      661 ggggtacggc tggcccttga gggagcagct ctaggtgttc agtacaatct gtatggtttc
      721 aagatgtcca gcacttttat atgtcgtgag gatccttgta ttggcagcac aacctgtttc
      781 cagtctcacc cctctgagaa gaccatcttc ctcaacatca tgtttgggat cagcggggcc
      841 tgtttcttat ttattttctt ggagcttgcg cttttgggtt tagggaggtt ttggaggata
      901 tacaagcaca aactttcctt cttaaagaag ttgccaactt cagagagctc tgtaagatcc
      961 aaggacacaa ccgatgaatt gtcagtggtg gaggcaaaag agccattttg agatgcagag
     1021 ttgtaaagtt gcctggattg cctgcagaaa actctgggac ttgatcttca atacatccag
     1081 tgaggtggcc ggggagatgg tacaggggta aaggtgcttg cagtcaagcc tcatgatctg
     1141 agattgatct ccagaaccca cacggagaag ggagaaaacc aactcccaca agttgcccac
     1201 atacatgtca tgaagagtac acacacacac acacacacac acacacacac acacaaagaa
     1261 taaataaaat aataaaatct cagaaaacaa aacaagacct cctacatcaa ttagctgcca
     1321 cttctaattt ttctttcctg tctctccact aaatataaac aaaaaacagg ctactttctg
     1381 ttctaatgga ttatctatcc tattctggga ttgtatagag atggaatcat acagtatgct
     1441 tattaatcac ttgtatatct ttgtagaaaa gaccaagttt tttgccaatt aaattaggtt
     1501 atttattttt gccttgtata aactatataa ttgttagata cctatcaagt ggctcatttc
     1561 aaaacattct cttctattcc atgggtcatc ttcattttct tcctgagtag catttcttta
     1621 aaattattta ttctttgata atttcctaca tgtatacagt gtgttttgat cacgtctacc
     1681 ctatatccct gtatcactgc tcttggatct cctgacatgt ccctatccta atttcttgtc
     1741 ctcttctttt ctttataacc cactgagaac aaaaatcagt gctactcaaa gtgtgaattg
     1801 gtgtgaagct atctacccga acacagtcaa cctactcgat gccacaccca aagaagatgg
     1861 agtcttcctc tgccagcatt gatcaactgc caacagttcc tcagttgtgg gtagtccttc
     1921 tctcattcat cctgtaatgc tgagtgtctt gagcttgtgc aggcaaccac tgcttctgtg
     1981 agtttatgaa tgcaagttcc tgctgtgttc ataagatgtt gtttcatagc agatctccca
     2041 gagcactgga tctttacatt tttctttccc atttctccat cttctctaat gttcccttga
     2101 gctttggggg gcaaggatgt gctgtcgatg tctcatttga gactgaatat tacatggaca
     2161 cctgtttctg catttacaaa ttgtaagtct gtatattggc cactgttcac tgtaaaaaga
     2221 aaaagtctgt ggtcagtgtt gaaaactgac ctaatctatg agtttcgaga atcatttaga
     2281 agacagtttg atactatgtc aatttagcaa actaatagtg acttttctgt agggcttttg
     2341 agctccgcag gatgggttct tggccagatt tgtagtacca ggcatggggt ttctcttgtg
     2401 gagtgaatcc tcaatcgaat cagaaagcag ttggttactc ctgtaccagc tacaccactg
     2461 tttcacccat gcatgtgtct tgtgaggctg gttgttggaa ctcatcagat tcatacatga
     2521 gaaagagttt tgatgactag gaaggctacc cagcatagag ttggcaatat tttttgatgt
     2581 acaaaacttt acattttttt cccaattctt ttttgagaca gggtttctct gtgtagccct
     2641 ggctgtcctg gaactcactc tgtagaccag gctggcctcg aactcagaaa tctgcctgcc
     2701 tctacctccc gagtgctggg attaaaggcg tgcgccacca cgcccagcat tttccccaat
     2761 tttttattag gtattttctt catttgcatt tcaaatgcta tctagaaagt cccctatacc
     2821 ctccccccgc gccctgctcc ccgctcccct acccacccac tcccatttct tggccctggc
     2881 gttcccctgt actggggcat ataaagtttg caaaaccaag ggacctctct tcccaatgat
     2941 ggcagagtag gccatcttct gctacatatg cagctagaga caggagctat ggcggtactg
     3001 gttagttcat attgttgttc cacctatagg gttgcagatc ccttcagctc cttgggtact
     3061 ttctctagct cctccattgg ggaccctgtg ttccatccaa tagatgactg tgagcgtcca
     3121 cttctgtatt tgccaggcac tggtaaaacc tcacaagaga cagctatatc agggtccttt
     3181 tagcaaaatc ttgctggcat atgcaatggt gtctgtgttt ggtggctgat tatgggatgg
     3241 atccctgggt ggggtagtct ctggatgcat tttacatttt aatgaactct aattacttgt
     3301 ttttcttttg gcttttgtga atttggtgct acatttaaga gaccattgtt tgactcaaaa
     3361 ctatgagttt acacttgtgt ttccatctaa gaattttata cttttaactt atgtttgact
     3421 ctgatctctt atggagtgga aaaaaaaaga caaaatgaca ttatctttct tattggaaac
     3481 aatgtaaatg agcaaagtat ttgaattgta agaaagaaaa atttactgtt aatctagagg
     3541 cccatgattg gcagaactaa ctctcagaag taaaggcaaa gataagcatt aaaaaaaaaa
     3601 aaaaaaa
//
