LOCUS       NM_175452               2206 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus gap junction protein, gamma 2 (Gjc2), transcript
            variant 2, mRNA.
ACCESSION   NM_175452
VERSION     NM_175452.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2206)
  AUTHORS   Geng,X., Chen,L., Srinivasan,R.S., Kylat,R.J., Witte,M.H. and
            Erickson,R.J.
  TITLE     Lack of embryonic homozygous or adult heterozygous lymphatic
            phenotypes for a Sos1 mutation and lack of lymphatic embryonic
            phenotypes for a homozygous Cx47 mutation in mice
  JOURNAL   Lymphology 55 (3), 129-134 (2022)
   PUBMED   36446400
  REMARK    GeneRIF: Lack of embryonic homozygous or adult heterozygous
            lymphatic phenotypes for a Sos1 mutation and lack of lymphatic
            embryonic phenotypes for a homozygous Cx47 mutation in mice.
REFERENCE   2  (bases 1 to 2206)
  AUTHORS   Philippot,C., Griemsmann,S., Jabs,R., Seifert,G., Kettenmann,H. and
            Steinhauser,C.
  TITLE     Astrocytes and oligodendrocytes in the thalamus jointly maintain
            synaptic activity by supplying metabolites
  JOURNAL   Cell Rep 34 (3), 108642 (2021)
   PUBMED   33472059
REFERENCE   3  (bases 1 to 2206)
  AUTHORS   Wedel,M., Frob,F., Elsesser,O., Wittmann,M.T., Lie,D.C., Reis,A.
            and Wegner,M.
  TITLE     Transcription factor Tcf4 is the preferred heterodimerization
            partner for Olig2 in oligodendrocytes and required for
            differentiation
  JOURNAL   Nucleic Acids Res 48 (9), 4839-4857 (2020)
   PUBMED   32266943
REFERENCE   4  (bases 1 to 2206)
  AUTHORS   Zhao,Y., Yamasaki,R., Yamaguchi,H., Nagata,S., Une,H., Cui,Y.,
            Masaki,K., Nakamuta,Y., Iinuma,K., Watanabe,M., Matsushita,T.,
            Isobe,N. and Kira,J.I.
  TITLE     Oligodendroglial connexin 47 regulates neuroinflammation upon
            autoimmune demyelination in a novel mouse model of multiple
            sclerosis
  JOURNAL   Proc Natl Acad Sci U S A 117 (4), 2160-2169 (2020)
   PUBMED   31932428
  REMARK    GeneRIF: Oligodendroglia-specific Cx47 ablation induces severe
            inflammation upon autoimmune demyelination.
REFERENCE   5  (bases 1 to 2206)
  AUTHORS   Castorena-Gonzalez,J.A., Zawieja,S.D., Li,M., Srinivasan,R.S.,
            Simon,A.M., de Wit,C., de la Torre,R., Martinez-Lemus,L.A.,
            Hennig,G.W. and Davis,M.J.
  TITLE     Mechanisms of Connexin-Related Lymphedema
  JOURNAL   Circ Res 123 (8), 964-985 (2018)
   PUBMED   30355030
REFERENCE   6  (bases 1 to 2206)
  AUTHORS   Menichella,D.M., Goodenough,D.A., Sirkowski,E., Scherer,S.S. and
            Paul,D.L.
  TITLE     Connexins are critical for normal myelination in the CNS
  JOURNAL   J Neurosci 23 (13), 5963-5973 (2003)
   PUBMED   12843301
  REMARK    GeneRIF: Mice lacking either Cx47 or Cx32 are viable but mice
            lacking both connexins die by postnatal week 6 from CNS myelin
            sheath abnormalities, vacuolation, enlarged periaxonal collars,
            oligodendrocyte cell death, and axonal loss
REFERENCE   7  (bases 1 to 2206)
  AUTHORS   Sohl,G. and Willecke,K.
  TITLE     An update on connexin genes and their nomenclature in mouse and man
  JOURNAL   Cell Commun Adhes 10 (4-6), 173-180 (2003)
   PUBMED   14681012
  REMARK    Review article
REFERENCE   8  (bases 1 to 2206)
  AUTHORS   Odermatt,B., Wellershaus,K., Wallraff,A., Seifert,G., Degen,J.,
            Euwens,C., Fuss,B., Bussow,H., Schilling,K., Steinhauser,C. and
            Willecke,K.
  TITLE     Connexin 47 (Cx47)-deficient mice with enhanced green fluorescent
            protein reporter gene reveal predominant oligodendrocytic
            expression of Cx47 and display vacuolized myelin in the CNS
  JOURNAL   J Neurosci 23 (11), 4549-4559 (2003)
   PUBMED   12805295
  REMARK    GeneRIF: Cx47-deficient mice revealed a vacuolation of nerve fibers
            at the site of the optic nerve where axons are first contacted by
            oligodendrocytes and myelination starts; Cx32/Cx47-double-deficient
            mice developed action tremor and died ca 51 d after birth
REFERENCE   9  (bases 1 to 2206)
  AUTHORS   Sohl,G., Eiberger,J., Jung,Y.T., Kozak,C.A. and Willecke,K.
  TITLE     The mouse gap junction gene connexin29 is highly expressed in
            sciatic nerve and regulated during brain development
  JOURNAL   Biol Chem 382 (6), 973-978 (2001)
   PUBMED   11501764
REFERENCE   10 (bases 1 to 2206)
  AUTHORS   Teubner,B., Odermatt,B., Guldenagel,M., Sohl,G., Degen,J.,
            Bukauskas,F., Kronengold,J., Verselis,V.K., Jung,Y.T., Kozak,C.A.,
            Schilling,K. and Willecke,K.
  TITLE     Functional expression of the new gap junction gene connexin47
            transcribed in mouse brain and spinal cord neurons
  JOURNAL   J Neurosci 21 (4), 1117-1126 (2001)
   PUBMED   11160382
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK046421.1, AK046609.1 and AI853334.1.
            
            On Jul 16, 2009 this sequence version replaced NM_175452.3.
            
            Transcript Variant: This variant (2) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK046421.1, BB645052.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-745               AK046421.1         2-746
            746-2187            AK046609.1         729-2170
            2188-2206           AI853334.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..2206
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.05 cM"
     gene            1..2206
                     /gene="Gjc2"
                     /gene_synonym="B230382L12Rik; Cx47; Cxno; Gja12"
                     /note="gap junction protein, gamma 2"
                     /db_xref="GeneID:118454"
                     /db_xref="MGI:MGI:2153060"
     exon            1..81
                     /gene="Gjc2"
                     /gene_synonym="B230382L12Rik; Cx47; Cxno; Gja12"
                     /inference="alignment:Splign:2.1.0"
     exon            82..2191
                     /gene="Gjc2"
                     /gene_synonym="B230382L12Rik; Cx47; Cxno; Gja12"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1423
                     /gene="Gjc2"
                     /gene_synonym="B230382L12Rik; Cx47; Cxno; Gja12"
                     /note="connexin 47 type A; connexin 47 type C; connexin 47
                     type D; connexin-47; gap junction alpha-12 protein; gap
                     junction membrane channel protein alpha 12; gap junction
                     protein, chi 2; connexin o"
                     /codon_start=1
                     /product="gap junction gamma-2 protein"
                     /protein_id="NP_780661.2"
                     /db_xref="CCDS:CCDS24760.1"
                     /db_xref="GeneID:118454"
                     /db_xref="MGI:MGI:2153060"
                     /translation="MTNMSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGE
                     SIYSDEQSKFTCNTRQPGCDNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRL
                     ARASEQERRRALRRRPGTRRLPRAQLPPPPPGWPDTTDLGEAEPILALEEDEDEEPGA
                     PEGPGEDTEEERAEDVAAKGGGGDGKTVVTPGPAGQHDGRRRIQREGLMRVYVAQLVV
                     RAAFEVAFLVGQYLLYGFEVPPFFACSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCL
                     CLLLNLCEMAHLGLGSAQDAVRGRRGASAAGPGPTPRPPPCAFPAAAAGLACPPDYSL
                     VVRAAERARAHDQNLANLALQALRDGAAVAAVSADRDSPPCAGLNATSRGAPRVGGLA
                     SGTGSATSGGTVGEQSRPGAQEQLATKPRAGSEKGSTGSRDGKATVWI"
     regulatory      2164..2169
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gjc2"
                     /gene_synonym="B230382L12Rik; Cx47; Cxno; Gja12"
                     /note="hexamer: AATAAA"
     polyA_site      2191
                     /gene="Gjc2"
                     /gene_synonym="B230382L12Rik; Cx47; Cxno; Gja12"
                     /note="major polyA site"
ORIGIN      
        1 agtatgccct tagagaggat cagcatccag ccggcaggtg gaggggctca gccgaaggtt
       61 tgcatttcca gcctggagaa ggtcccacct gctcgctccc atgaccaaca tgagctggag
      121 cttcctgacg cggctgctgg aggagatcca caatcattcc accttcgtgg gcaaagtttg
      181 gctcactgtg ctggtggtct tccgcattgt gctgacagcc gtcggtggtg agtccatcta
      241 ttcagatgag caatccaagt tcacctgcaa cacgcggcaa ccgggttgtg acaacgtctg
      301 ctatgacgcc tttgcgcccc tgtctcatgt gcgcttctgg gtcttccaga tagtggtcat
      361 ctccacacct tctgtcatgt acctgggcta tgcagtccac cgcttggcgc gggcctcgga
      421 acaggagcgc agacgcgctc tccgacgtcg ccctggcacc cggcgcttgc ccagggcgca
      481 gctgccaccg ccgccacctg gctggccgga caccaccgat ctgggagagg cggagcccat
      541 attggctcta gaggaggatg aggacgagga gccgggggcg cccgagggcc ccggagaaga
      601 cacggaggag gagcgagcgg aggatgtggc tgccaaaggg ggcggaggtg atggcaagac
      661 ggtggtcact cctggcccgg ccgggcagca cgatgggcgg cggcgcatcc agagggaggg
      721 cctgatgcgt gtgtacgtgg ctcagctggt ggttagggcg gccttcgagg tggcctttct
      781 ggtgggccag tacctactgt acggcttcga ggtgccaccc ttctttgcct gcagccgcca
      841 gccttgcccc cacgtagtgg attgcttcgt gtcgcggccg accgagaaga cggtcttctt
      901 gctggtcatg tacgtggtta gctgtctatg cttgttgctc aacctctgtg agatggcgca
      961 cctgggtctc ggcagtgcgc aggatgctgt gcgcggccgt cggggagcct cagcggcggg
     1021 gcctggcccc acgccgcgcc caccgccctg cgctttcccg gccgcggccg ccggcctggc
     1081 ttgccctcca gactacagcc tggtggtgcg tgcagctgag cgcgcgcgag cgcacgacca
     1141 gaacttggcg aacctagcgc tgcaggcgtt gcgcgatggg gcggcggtgg cggcggtttc
     1201 cgcggaccgc gacagtccgc cgtgcgctgg gctcaatgca acctctcggg gggcacccag
     1261 ggtgggcggc ctagcttccg gaaccggcag cgccacgtcg gggggcaccg ttggggagca
     1321 gagccggccg ggagctcagg aacaactggc cactaagccc agggctggct ctgaaaaggg
     1381 cagtacaggc agcagagacg gcaaggccac cgtgtggatc tgagggccct gcggagagct
     1441 cagggagggc ttggcatgag gattcagtgg aaatctttgt gccctcaacc agtgatcagt
     1501 gatcagacct cgttaggggt ctttaaaaga aggagctgaa gccccttagg aggtgctggc
     1561 tcaggtacct ccctgcggga taggaagggg agtgaccagg gtcttatatg tgacccctga
     1621 gggtgtgggg acagagctgt gtcctaggaa ttgactgccc ctccaggcta tgctgagcag
     1681 ggatgacccc tctgctgggc ctgccagccc ttccttccaa ggctctctcg cagcttcccc
     1741 ataggattgg gggtgtctgg cacgaacctt ttggggactg agcttatcct cactgcagca
     1801 gcagaccggg ttcctctgca gcgccctcgg cccttacaga gccagagaac tcccaggtca
     1861 gggacaggca gcagcactga ttactctcgg cccttggctc cccacttgag gcagactgag
     1921 cgagacccaa aggaggcctg gaccaagaac agctcctctc tctgagctga gatcgtttgg
     1981 tatgacttcc ttcttagggg acatcctgga agttctgttg tgccttgctg cttagatgca
     2041 tatagctgta gcccagggct gtggcgttgg ccatgttgga aaattagagc tctggggggc
     2101 ctgtccctat cttctgtccc cttctccctg ttttaaagcc aacttctaga acaaaggaag
     2161 taaaataaaa ctaacttttg tttacactca aaaaaaaaaa aaaaaa
//
