LOCUS       NM_080454               2188 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus gap junction protein, gamma 2 (Gjc2), transcript
            variant 1, mRNA.
ACCESSION   NM_080454
VERSION     NM_080454.4
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2188)
  AUTHORS   Geng,X., Chen,L., Srinivasan,R.S., Kylat,R.J., Witte,M.H. and
            Erickson,R.J.
  TITLE     Lack of embryonic homozygous or adult heterozygous lymphatic
            phenotypes for a Sos1 mutation and lack of lymphatic embryonic
            phenotypes for a homozygous Cx47 mutation in mice
  JOURNAL   Lymphology 55 (3), 129-134 (2022)
   PUBMED   36446400
  REMARK    GeneRIF: Lack of embryonic homozygous or adult heterozygous
            lymphatic phenotypes for a Sos1 mutation and lack of lymphatic
            embryonic phenotypes for a homozygous Cx47 mutation in mice.
REFERENCE   2  (bases 1 to 2188)
  AUTHORS   Philippot,C., Griemsmann,S., Jabs,R., Seifert,G., Kettenmann,H. and
            Steinhauser,C.
  TITLE     Astrocytes and oligodendrocytes in the thalamus jointly maintain
            synaptic activity by supplying metabolites
  JOURNAL   Cell Rep 34 (3), 108642 (2021)
   PUBMED   33472059
REFERENCE   3  (bases 1 to 2188)
  AUTHORS   Wedel,M., Frob,F., Elsesser,O., Wittmann,M.T., Lie,D.C., Reis,A.
            and Wegner,M.
  TITLE     Transcription factor Tcf4 is the preferred heterodimerization
            partner for Olig2 in oligodendrocytes and required for
            differentiation
  JOURNAL   Nucleic Acids Res 48 (9), 4839-4857 (2020)
   PUBMED   32266943
REFERENCE   4  (bases 1 to 2188)
  AUTHORS   Zhao,Y., Yamasaki,R., Yamaguchi,H., Nagata,S., Une,H., Cui,Y.,
            Masaki,K., Nakamuta,Y., Iinuma,K., Watanabe,M., Matsushita,T.,
            Isobe,N. and Kira,J.I.
  TITLE     Oligodendroglial connexin 47 regulates neuroinflammation upon
            autoimmune demyelination in a novel mouse model of multiple
            sclerosis
  JOURNAL   Proc Natl Acad Sci U S A 117 (4), 2160-2169 (2020)
   PUBMED   31932428
  REMARK    GeneRIF: Oligodendroglia-specific Cx47 ablation induces severe
            inflammation upon autoimmune demyelination.
REFERENCE   5  (bases 1 to 2188)
  AUTHORS   Castorena-Gonzalez,J.A., Zawieja,S.D., Li,M., Srinivasan,R.S.,
            Simon,A.M., de Wit,C., de la Torre,R., Martinez-Lemus,L.A.,
            Hennig,G.W. and Davis,M.J.
  TITLE     Mechanisms of Connexin-Related Lymphedema
  JOURNAL   Circ Res 123 (8), 964-985 (2018)
   PUBMED   30355030
REFERENCE   6  (bases 1 to 2188)
  AUTHORS   Menichella,D.M., Goodenough,D.A., Sirkowski,E., Scherer,S.S. and
            Paul,D.L.
  TITLE     Connexins are critical for normal myelination in the CNS
  JOURNAL   J Neurosci 23 (13), 5963-5973 (2003)
   PUBMED   12843301
  REMARK    GeneRIF: Mice lacking either Cx47 or Cx32 are viable but mice
            lacking both connexins die by postnatal week 6 from CNS myelin
            sheath abnormalities, vacuolation, enlarged periaxonal collars,
            oligodendrocyte cell death, and axonal loss
REFERENCE   7  (bases 1 to 2188)
  AUTHORS   Sohl,G. and Willecke,K.
  TITLE     An update on connexin genes and their nomenclature in mouse and man
  JOURNAL   Cell Commun Adhes 10 (4-6), 173-180 (2003)
   PUBMED   14681012
  REMARK    Review article
REFERENCE   8  (bases 1 to 2188)
  AUTHORS   Odermatt,B., Wellershaus,K., Wallraff,A., Seifert,G., Degen,J.,
            Euwens,C., Fuss,B., Bussow,H., Schilling,K., Steinhauser,C. and
            Willecke,K.
  TITLE     Connexin 47 (Cx47)-deficient mice with enhanced green fluorescent
            protein reporter gene reveal predominant oligodendrocytic
            expression of Cx47 and display vacuolized myelin in the CNS
  JOURNAL   J Neurosci 23 (11), 4549-4559 (2003)
   PUBMED   12805295
  REMARK    GeneRIF: Cx47-deficient mice revealed a vacuolation of nerve fibers
            at the site of the optic nerve where axons are first contacted by
            oligodendrocytes and myelination starts; Cx32/Cx47-double-deficient
            mice developed action tremor and died ca 51 d after birth
REFERENCE   9  (bases 1 to 2188)
  AUTHORS   Sohl,G., Eiberger,J., Jung,Y.T., Kozak,C.A. and Willecke,K.
  TITLE     The mouse gap junction gene connexin29 is highly expressed in
            sciatic nerve and regulated during brain development
  JOURNAL   Biol Chem 382 (6), 973-978 (2001)
   PUBMED   11501764
REFERENCE   10 (bases 1 to 2188)
  AUTHORS   Teubner,B., Odermatt,B., Guldenagel,M., Sohl,G., Degen,J.,
            Bukauskas,F., Kronengold,J., Verselis,V.K., Jung,Y.T., Kozak,C.A.,
            Schilling,K. and Willecke,K.
  TITLE     Functional expression of the new gap junction gene connexin47
            transcribed in mouse brain and spinal cord neurons
  JOURNAL   J Neurosci 21 (4), 1117-1126 (2001)
   PUBMED   11160382
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK046609.1 and AI853334.1.
            
            On Jul 16, 2009 this sequence version replaced NM_080454.3.
            
            Transcript Variant: This variant (1) uses a different segment for
            its 5' UTR, compared to variant 2. Variants 1 and 2 encode the same
            protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY394498.1, AK046609.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2169              AK046609.1         2-2170
            2170-2188           AI853334.1         1-19                c
FEATURES             Location/Qualifiers
     source          1..2188
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 37.05 cM"
     gene            1..2188
                     /gene="Gjc2"
                     /gene_synonym="B230382L12Rik; Cx47; Cxno; Gja12"
                     /note="gap junction protein, gamma 2"
                     /db_xref="GeneID:118454"
                     /db_xref="MGI:MGI:2153060"
     exon            1..63
                     /gene="Gjc2"
                     /gene_synonym="B230382L12Rik; Cx47; Cxno; Gja12"
                     /inference="alignment:Splign:2.1.0"
     exon            64..2173
                     /gene="Gjc2"
                     /gene_synonym="B230382L12Rik; Cx47; Cxno; Gja12"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1405
                     /gene="Gjc2"
                     /gene_synonym="B230382L12Rik; Cx47; Cxno; Gja12"
                     /note="connexin 47 type A; connexin 47 type C; connexin 47
                     type D; connexin-47; gap junction alpha-12 protein; gap
                     junction membrane channel protein alpha 12; gap junction
                     protein, chi 2; connexin o"
                     /codon_start=1
                     /product="gap junction gamma-2 protein"
                     /protein_id="NP_536702.3"
                     /db_xref="CCDS:CCDS24760.1"
                     /db_xref="GeneID:118454"
                     /db_xref="MGI:MGI:2153060"
                     /translation="MTNMSWSFLTRLLEEIHNHSTFVGKVWLTVLVVFRIVLTAVGGE
                     SIYSDEQSKFTCNTRQPGCDNVCYDAFAPLSHVRFWVFQIVVISTPSVMYLGYAVHRL
                     ARASEQERRRALRRRPGTRRLPRAQLPPPPPGWPDTTDLGEAEPILALEEDEDEEPGA
                     PEGPGEDTEEERAEDVAAKGGGGDGKTVVTPGPAGQHDGRRRIQREGLMRVYVAQLVV
                     RAAFEVAFLVGQYLLYGFEVPPFFACSRQPCPHVVDCFVSRPTEKTVFLLVMYVVSCL
                     CLLLNLCEMAHLGLGSAQDAVRGRRGASAAGPGPTPRPPPCAFPAAAAGLACPPDYSL
                     VVRAAERARAHDQNLANLALQALRDGAAVAAVSADRDSPPCAGLNATSRGAPRVGGLA
                     SGTGSATSGGTVGEQSRPGAQEQLATKPRAGSEKGSTGSRDGKATVWI"
     regulatory      2146..2151
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gjc2"
                     /gene_synonym="B230382L12Rik; Cx47; Cxno; Gja12"
                     /note="hexamer: AATAAA"
     polyA_site      2173
                     /gene="Gjc2"
                     /gene_synonym="B230382L12Rik; Cx47; Cxno; Gja12"
                     /note="major polyA site"
ORIGIN      
        1 agtggttgtt gccagctacc cccacccggt ggtcagccac agctctgcct tgtgcatctc
       61 caggtcccac ctgctcgctc ccatgaccaa catgagctgg agcttcctga cgcggctgct
      121 ggaggagatc cacaatcatt ccaccttcgt gggcaaagtt tggctcactg tgctggtggt
      181 cttccgcatt gtgctgacag ccgtcggtgg tgagtccatc tattcagatg agcaatccaa
      241 gttcacctgc aacacgcggc aaccgggttg tgacaacgtc tgctatgacg cctttgcgcc
      301 cctgtctcat gtgcgcttct gggtcttcca gatagtggtc atctccacac cttctgtcat
      361 gtacctgggc tatgcagtcc accgcttggc gcgggcctcg gaacaggagc gcagacgcgc
      421 tctccgacgt cgccctggca cccggcgctt gcccagggcg cagctgccac cgccgccacc
      481 tggctggccg gacaccaccg atctgggaga ggcggagccc atattggctc tagaggagga
      541 tgaggacgag gagccggggg cgcccgaggg ccccggagaa gacacggagg aggagcgagc
      601 ggaggatgtg gctgccaaag ggggcggagg tgatggcaag acggtggtca ctcctggccc
      661 ggccgggcag cacgatgggc ggcggcgcat ccagagggag ggcctgatgc gtgtgtacgt
      721 ggctcagctg gtggttaggg cggccttcga ggtggccttt ctggtgggcc agtacctact
      781 gtacggcttc gaggtgccac ccttctttgc ctgcagccgc cagccttgcc cccacgtagt
      841 ggattgcttc gtgtcgcggc cgaccgagaa gacggtcttc ttgctggtca tgtacgtggt
      901 tagctgtcta tgcttgttgc tcaacctctg tgagatggcg cacctgggtc tcggcagtgc
      961 gcaggatgct gtgcgcggcc gtcggggagc ctcagcggcg gggcctggcc ccacgccgcg
     1021 cccaccgccc tgcgctttcc cggccgcggc cgccggcctg gcttgccctc cagactacag
     1081 cctggtggtg cgtgcagctg agcgcgcgcg agcgcacgac cagaacttgg cgaacctagc
     1141 gctgcaggcg ttgcgcgatg gggcggcggt ggcggcggtt tccgcggacc gcgacagtcc
     1201 gccgtgcgct gggctcaatg caacctctcg gggggcaccc agggtgggcg gcctagcttc
     1261 cggaaccggc agcgccacgt cggggggcac cgttggggag cagagccggc cgggagctca
     1321 ggaacaactg gccactaagc ccagggctgg ctctgaaaag ggcagtacag gcagcagaga
     1381 cggcaaggcc accgtgtgga tctgagggcc ctgcggagag ctcagggagg gcttggcatg
     1441 aggattcagt ggaaatcttt gtgccctcaa ccagtgatca gtgatcagac ctcgttaggg
     1501 gtctttaaaa gaaggagctg aagcccctta ggaggtgctg gctcaggtac ctccctgcgg
     1561 gataggaagg ggagtgacca gggtcttata tgtgacccct gagggtgtgg ggacagagct
     1621 gtgtcctagg aattgactgc ccctccaggc tatgctgagc agggatgacc cctctgctgg
     1681 gcctgccagc ccttccttcc aaggctctct cgcagcttcc ccataggatt gggggtgtct
     1741 ggcacgaacc ttttggggac tgagcttatc ctcactgcag cagcagaccg ggttcctctg
     1801 cagcgccctc ggcccttaca gagccagaga actcccaggt cagggacagg cagcagcact
     1861 gattactctc ggcccttggc tccccacttg aggcagactg agcgagaccc aaaggaggcc
     1921 tggaccaaga acagctcctc tctctgagct gagatcgttt ggtatgactt ccttcttagg
     1981 ggacatcctg gaagttctgt tgtgccttgc tgcttagatg catatagctg tagcccaggg
     2041 ctgtggcgtt ggccatgttg gaaaattaga gctctggggg gcctgtccct atcttctgtc
     2101 cccttctccc tgttttaaag ccaacttcta gaacaaagga agtaaaataa aactaacttt
     2161 tgtttacact caaaaaaaaa aaaaaaaa
//
