LOCUS       NM_001159382            1984 bp    mRNA    linear   ROD 10-DEC-2024
DEFINITION  Mus musculus gap junction protein, gamma 1 (Gjc1), transcript
            variant 2, mRNA.
ACCESSION   NM_001159382
VERSION     NM_001159382.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1984)
  AUTHORS   Toro,C.A., De Gasperi,R., Vanselow,K., Harlow,L., Johnson,K.,
            Aslan,A., Bauman,W.A., Cardozo,C.P. and Graham,Z.A.
  TITLE     Muscle-restricted knockout of connexin 43 and connexin 45
            accelerates and improves locomotor recovery after contusion spinal
            cord injury
  JOURNAL   Front Physiol 15, 1486691 (2024)
   PUBMED   39524606
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1984)
  AUTHORS   Skelin,L., Racetin,A., Kelam,N., Ogorevc,M., Znaor,L.,
            Saraga-Babic,M., Filipovic,N., Katsuyama,Y., Pogorelic,Z. and
            Vukojevic,K.
  TITLE     Connexin Expression Is Altered in the Eye Development of Yotari
            Mice: A Preliminary Study
  JOURNAL   Biomolecules 14 (9), 1174 (2024)
   PUBMED   39334940
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1984)
  AUTHORS   Davis,M.J., Castorena-Gonzalez,J.A., Li,M., Zawieja,S.D.,
            Simon,A.M., Geng,X. and Srinivasan,R.S.
  TITLE     Connexin-45 is expressed in mouse lymphatic endothelium and
            required for lymphatic valve function
  JOURNAL   JCI Insight 9 (16), e169931 (2024)
   PUBMED   39074069
  REMARK    GeneRIF: Connexin-45 is expressed in mouse lymphatic endothelium
            and required for lymphatic valve function.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1984)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (bases 1 to 1984)
  AUTHORS   Hilgen,G.
  TITLE     Connexin45 colocalization patterns in the plexiform layers of the
            developing mouse retina
  JOURNAL   J Anat 243 (2), 258-264 (2023)
   PUBMED   35315057
  REMARK    GeneRIF: Connexin45 colocalization patterns in the plexiform layers
            of the developing mouse retina.
REFERENCE   6  (bases 1 to 1984)
  AUTHORS   Butterweck,A., Elfgang,C., Willecke,K. and Traub,O.
  TITLE     Differential expression of the gap junction proteins connexin45,
            -43, -40, -31, and -26 in mouse skin
  JOURNAL   Eur J Cell Biol 65 (1), 152-163 (1994)
   PUBMED   7889986
REFERENCE   7  (bases 1 to 1984)
  AUTHORS   Butterweck,A., Gergs,U., Elfgang,C., Willecke,K. and Traub,O.
  TITLE     Immunochemical characterization of the gap junction protein
            connexin45 in mouse kidney and transfected human HeLa cells
  JOURNAL   J Membr Biol 141 (3), 247-256 (1994)
   PUBMED   7807524
REFERENCE   8  (bases 1 to 1984)
  AUTHORS   Schwarz,H.J., Chang,Y.S., Hennemann,H., Dahl,E., Lalley,P.A. and
            Willecke,K.
  TITLE     Chromosomal assignments of mouse connexin genes, coding for gap
            junctional proteins, by somatic cell hybridization
  JOURNAL   Somat Cell Mol Genet 18 (4), 351-359 (1992)
   PUBMED   1332196
REFERENCE   9  (bases 1 to 1984)
  AUTHORS   Hennemann,H., Kozjek,G., Dahl,E., Nicholson,B. and Willecke,K.
  TITLE     Molecular cloning of mouse connexins26 and -32: similar genomic
            organization but distinct promoter sequences of two gap junction
            genes
  JOURNAL   Eur J Cell Biol 58 (1), 81-89 (1992)
   PUBMED   1322820
REFERENCE   10 (bases 1 to 1984)
  AUTHORS   Hennemann,H., Schwarz,H.J. and Willecke,K.
  TITLE     Characterization of gap junction genes expressed in F9 embryonic
            carcinoma cells: molecular cloning of mouse connexin31 and -45
            cDNAs
  JOURNAL   Eur J Cell Biol 57 (1), 51-58 (1992)
   PUBMED   1322300
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC050840.1 and AL929067.8.
            
            Transcript Variant: This variant (2) represents use of an alternate
            promoter and 5' UTR, compared to variant 1. Variants 1 through 4
            encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050840.1, SRR10662772.3519929.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1880              BC050840.1         1-1880
            1881-1984           AL929067.8         56332-56435         c
FEATURES             Location/Qualifiers
     source          1..1984
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.48 cM"
     gene            1..1984
                     /gene="Gjc1"
                     /gene_synonym="C130009G16Rik; Cnx45; Cx45; Cxnq; Gja-7;
                     Gja7"
                     /note="gap junction protein, gamma 1"
                     /db_xref="GeneID:14615"
                     /db_xref="MGI:MGI:95718"
     exon            1..190
                     /gene="Gjc1"
                     /gene_synonym="C130009G16Rik; Cnx45; Cx45; Cxnq; Gja-7;
                     Gja7"
                     /inference="alignment:Splign:2.1.0"
     exon            191..266
                     /gene="Gjc1"
                     /gene_synonym="C130009G16Rik; Cnx45; Cx45; Cxnq; Gja-7;
                     Gja7"
                     /inference="alignment:Splign:2.1.0"
     exon            267..1984
                     /gene="Gjc1"
                     /gene_synonym="C130009G16Rik; Cnx45; Cx45; Cxnq; Gja-7;
                     Gja7"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..1477
                     /gene="Gjc1"
                     /gene_synonym="C130009G16Rik; Cnx45; Cx45; Cxnq; Gja-7;
                     Gja7"
                     /note="connexin-45; gap junction alpha-7 protein; gap
                     junction membrane channel protein alpha 7; connexin q"
                     /codon_start=1
                     /product="gap junction gamma-1 protein"
                     /protein_id="NP_001152854.1"
                     /db_xref="CCDS:CCDS25504.1"
                     /db_xref="GeneID:14615"
                     /db_xref="MGI:MGI:95718"
                     /translation="MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIY
                     YDEQSKFVCNTEQPGCENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKM
                     EHGEADKKAARSKPYAMRWKQHRALEETEEDHEEDPMMYPEMELESEKENKEQSQPKP
                     KHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKI
                     DCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKRRELDDPGAYN
                     YPFTWNTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANIAQEQQYGSHEEHLPAD
                     LETLQREIRMAQERLDLAIQAYHHQNNPHGPREKKAKVGSKSGSNKSSISSKSGDGKT
                     SVWI"
     regulatory      1857..1862
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gjc1"
                     /gene_synonym="C130009G16Rik; Cnx45; Cx45; Cxnq; Gja-7;
                     Gja7"
                     /note="hexamer: ATTAAA"
     polyA_site      1880
                     /gene="Gjc1"
                     /gene_synonym="C130009G16Rik; Cnx45; Cx45; Cxnq; Gja-7;
                     Gja7"
                     /note="major polyA site"
ORIGIN      
        1 gagagggagg cggcgggcgc ggccggagcg gcttcagcct cggcttgaag gctgaggcga
       61 aggaggcggc ggcggtggcg gcggcggcga ggcggcgaag gtgatggcga cgcggggccc
      121 atgaggcggc ggccggcggg acgggccgag gcccggcgga ggaggcggct tcgggggcgc
      181 ccaccgccgg agagaatttg ggaaagcaac aaacaaagta cagaatctga aagaaggttt
      241 tgggtaacag gagttctggt gaacagggca aaccaattcc accaccatga gttggagctt
      301 cctgactcgc ctgctagagg agatccacaa ccattcgaca tttgtaggga agatctggct
      361 cactgtgctg attgtctttc gaattgtcct aactgctgta ggaggagagt ccatctacta
      421 tgatgaacaa agcaaatttg tgtgcaacac agagcagccg ggctgtgaga atgtctgcta
      481 tgatgccttt gccccgctct cccacgtgcg cttctgggta ttccagatca tcctggttgc
      541 aactccctct gtgatgtacc tgggatatgc tattcataag attgccaaaa tggagcatgg
      601 cgaggcagac aagaaggcag ctcggagcaa accctatgcc atgcgttgga aacagcaccg
      661 ggctctggaa gaaacggaag aggaccatga agaggatcct atgatgtatc cagagatgga
      721 gttagaaagc gaaaaagaaa ataaagagca gagccaacca aaacctaagc atgatggccg
      781 acgacgaatt cgagaggatg ggctcatgaa aatctatgtg ttgcagctgc tggccaggac
      841 tgtgtttgag gtgggctttc taatagggca gtatttcctg tatggcttcc aagtccaccc
      901 attttatgtg tgcagcagac ttccttgccc tcataagata gactgcttta tttctagacc
      961 cactgaaaag accatcttcc ttctgataat gtatggtgtc acaggcctct gcctattgct
     1021 taacatttgg gagatgcttc acttagggtt tgggacaatt cgagactcac taaacagtaa
     1081 aaggagggaa cttgatgatc cgggtgctta taattatcct ttcacttgga acacaccctc
     1141 tgctccccct ggctataaca ttgctgtcaa accagatcag atccagtaca ctgagctgtc
     1201 caatgctaag attgcctaca agcaaaacaa agccaatatt gcccaggaac agcagtacgg
     1261 cagccacgag gaacacctcc cggctgatct ggagactctg cagcgggaga tcagaatggc
     1321 tcaggaacgc ttggacctag caatccaggc ctaccatcac caaaacaacc cccatggtcc
     1381 tcgggaaaag aaggccaaag tggggtccaa atctgggtcc aacaaaagca gtattagtag
     1441 caaatcaggg gatgggaaga cctccgtctg gatttaatct tggttgggct taaaacttgg
     1501 gttttcatag tttatggtaa gcagcaactt gctgaataat gacttccatt gagtaaacat
     1561 ttggctctgg ttatcttcag ggatgctgtt ggctcatgat ccaaactcag gggactctga
     1621 aggtggagct gggatgagtc gggagaggga aacacagtgt tcccaggcac atgttctcag
     1681 caataatgca gttgcagaac tttcaggttg tgtcttccag atccagagaa gaactgatat
     1741 atttaaatca ttcttgttgg acagtttttg tatgtacagt attatggtac agttttttta
     1801 gtataaattt tttttttgta tttgtacatt ggactgctgt agttacactt ttttatatta
     1861 aaggaaaaaa tccttgtaaa taatgtctgt taaagggtaa tgttattact ttgtttagca
     1921 aatattatct tgtgattaga attttggtag atggtacact taataaaagt gcctctcgtg
     1981 tttc
//
