LOCUS       NP_001152854             396 aa            linear   ROD 27-APR-2025
DEFINITION  gap junction gamma-1 protein [Mus musculus].
ACCESSION   NP_001152854
VERSION     NP_001152854.1
DBSOURCE    REFSEQ: accession NM_001159382.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 396)
  AUTHORS   Toro,C.A., De Gasperi,R., Vanselow,K., Harlow,L., Johnson,K.,
            Aslan,A., Bauman,W.A., Cardozo,C.P. and Graham,Z.A.
  TITLE     Muscle-restricted knockout of connexin 43 and connexin 45
            accelerates and improves locomotor recovery after contusion spinal
            cord injury
  JOURNAL   Front Physiol 15, 1486691 (2024)
   PUBMED   39524606
  REMARK    Publication Status: Online-Only
REFERENCE   2  (residues 1 to 396)
  AUTHORS   Skelin,L., Racetin,A., Kelam,N., Ogorevc,M., Znaor,L.,
            Saraga-Babic,M., Filipovic,N., Katsuyama,Y., Pogorelic,Z. and
            Vukojevic,K.
  TITLE     Connexin Expression Is Altered in the Eye Development of Yotari
            Mice: A Preliminary Study
  JOURNAL   Biomolecules 14 (9), 1174 (2024)
   PUBMED   39334940
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 396)
  AUTHORS   Davis,M.J., Castorena-Gonzalez,J.A., Li,M., Zawieja,S.D.,
            Simon,A.M., Geng,X. and Srinivasan,R.S.
  TITLE     Connexin-45 is expressed in mouse lymphatic endothelium and
            required for lymphatic valve function
  JOURNAL   JCI Insight 9 (16), e169931 (2024)
   PUBMED   39074069
  REMARK    GeneRIF: Connexin-45 is expressed in mouse lymphatic endothelium
            and required for lymphatic valve function.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 396)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   5  (residues 1 to 396)
  AUTHORS   Hilgen,G.
  TITLE     Connexin45 colocalization patterns in the plexiform layers of the
            developing mouse retina
  JOURNAL   J Anat 243 (2), 258-264 (2023)
   PUBMED   35315057
  REMARK    GeneRIF: Connexin45 colocalization patterns in the plexiform layers
            of the developing mouse retina.
REFERENCE   6  (residues 1 to 396)
  AUTHORS   Butterweck,A., Elfgang,C., Willecke,K. and Traub,O.
  TITLE     Differential expression of the gap junction proteins connexin45,
            -43, -40, -31, and -26 in mouse skin
  JOURNAL   Eur J Cell Biol 65 (1), 152-163 (1994)
   PUBMED   7889986
REFERENCE   7  (residues 1 to 396)
  AUTHORS   Butterweck,A., Gergs,U., Elfgang,C., Willecke,K. and Traub,O.
  TITLE     Immunochemical characterization of the gap junction protein
            connexin45 in mouse kidney and transfected human HeLa cells
  JOURNAL   J Membr Biol 141 (3), 247-256 (1994)
   PUBMED   7807524
REFERENCE   8  (residues 1 to 396)
  AUTHORS   Schwarz,H.J., Chang,Y.S., Hennemann,H., Dahl,E., Lalley,P.A. and
            Willecke,K.
  TITLE     Chromosomal assignments of mouse connexin genes, coding for gap
            junctional proteins, by somatic cell hybridization
  JOURNAL   Somat Cell Mol Genet 18 (4), 351-359 (1992)
   PUBMED   1332196
REFERENCE   9  (residues 1 to 396)
  AUTHORS   Hennemann,H., Kozjek,G., Dahl,E., Nicholson,B. and Willecke,K.
  TITLE     Molecular cloning of mouse connexins26 and -32: similar genomic
            organization but distinct promoter sequences of two gap junction
            genes
  JOURNAL   Eur J Cell Biol 58 (1), 81-89 (1992)
   PUBMED   1322820
REFERENCE   10 (residues 1 to 396)
  AUTHORS   Hennemann,H., Schwarz,H.J. and Willecke,K.
  TITLE     Characterization of gap junction genes expressed in F9 embryonic
            carcinoma cells: molecular cloning of mouse connexin31 and -45
            cDNAs
  JOURNAL   Eur J Cell Biol 57 (1), 51-58 (1992)
   PUBMED   1322300
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC050840.1 and AL929067.8.
            
            Transcript Variant: This variant (2) represents use of an alternate
            promoter and 5' UTR, compared to variant 1. Variants 1 through 4
            encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050840.1, SRR10662772.3519929.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..396
                     /organism="Mus musculus"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 66.48 cM"
     Protein         1..396
                     /product="gap junction gamma-1 protein"
                     /note="connexin-45; gap junction alpha-7 protein; gap
                     junction membrane channel protein alpha 7; connexin q"
                     /calculated_mol_wt=45535
     Region          2..255
                     /region_name="Connexin"
                     /note="pfam00029"
                     /db_xref="CDD:459638"
     Site            23..45
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P28229.1)"
     Site            76..95
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P28229.1)"
     Region          145..165
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P28229.1)"
     Site            176..198
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P28229.1)"
     Site            229..248
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (P28229.1)"
     Region          357..396
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (P28229.1)"
     CDS             1..396
                     /gene="Gjc1"
                     /gene_synonym="C130009G16Rik; Cnx45; Cx45; Cxnq; Gja-7;
                     Gja7"
                     /coded_by="NM_001159382.1:287..1477"
                     /db_xref="CCDS:CCDS25504.1"
                     /db_xref="GeneID:14615"
                     /db_xref="MGI:MGI:95718"
ORIGIN      
        1 mswsfltrll eeihnhstfv gkiwltvliv frivltavgg esiyydeqsk fvcnteqpgc
       61 envcydafap lshvrfwvfq iilvatpsvm ylgyaihkia kmehgeadkk aarskpyamr
      121 wkqhraleet eedheedpmm ypemelesek enkeqsqpkp khdgrrrire dglmkiyvlq
      181 llartvfevg fligqyflyg fqvhpfyvcs rlpcphkidc fisrptekti fllimygvtg
      241 lclllniwem lhlgfgtird slnskrreld dpgaynypft wntpsappgy niavkpdqiq
      301 ytelsnakia ykqnkaniaq eqqygsheeh lpadletlqr eirmaqerld laiqayhhqn
      361 nphgprekka kvgsksgsnk ssissksgdg ktsvwi
//
