LOCUS       NM_001271663            2198 bp    mRNA    linear   ROD 12-SEP-2023
DEFINITION  Mus musculus gap junction protein, beta 6 (Gjb6), transcript
            variant 3, mRNA.
ACCESSION   NM_001271663
VERSION     NM_001271663.1
KEYWORDS    RefSeq.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2198)
  AUTHORS   Hardy E, Moulard J, Walter A, Ezan P, Bemelmans AP, Mouthon F,
            Charveriat M, Rouach N and Rancillac A.
  TITLE     Upregulation of astroglial connexin 30 impairs hippocampal synaptic
            activity and recognition memory
  JOURNAL   PLoS Biol 21 (4), e3002075 (2023)
   PUBMED   37040348
  REMARK    GeneRIF: Upregulation of astroglial connexin 30 impairs hippocampal
            synaptic activity and recognition memory.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2198)
  AUTHORS   Hashimoto Y, Yamasaki R, Ko S, Matsuo E, Kobayakawa Y, Masaki K,
            Matsuse D and Isobe N.
  TITLE     Connexin 30 Deficiency Ameliorates Disease Progression at the Early
            Phase in a Mouse Model of Amyotrophic Lateral Sclerosis by
            Suppressing Glial Inflammation
  JOURNAL   Int J Mol Sci 23 (24), 16046 (2022)
   PUBMED   36555685
  REMARK    GeneRIF: Connexin 30 Deficiency Ameliorates Disease Progression at
            the Early Phase in a Mouse Model of Amyotrophic Lateral Sclerosis
            by Suppressing Glial Inflammation.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2198)
  AUTHORS   Ye Q, Bhojwani A and Hu JK.
  TITLE     Understanding the development of oral epithelial organs through
            single cell transcriptomic analysis
  JOURNAL   Development 149 (16) (2022)
   PUBMED   35831953
REFERENCE   4  (bases 1 to 2198)
  AUTHORS   Petitpre C, Faure L, Uhl P, Fontanet P, Filova I, Pavlinkova G,
            Adameyko I, Hadjab S and Lallemend F.
  TITLE     Single-cell RNA-sequencing analysis of the developing mouse inner
            ear identifies molecular logic of auditory neuron diversification
  JOURNAL   Nat Commun 13 (1), 3878 (2022)
   PUBMED   35790771
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2198)
  AUTHORS   Zhang L, Wang W, Kim SM, Wang J, Zhou B, Kong W, Zheng J and Lin X.
  TITLE     Virally Mediated Connexin 26 Expression in Postnatal Scala Media
            Significantly and Transiently Preserves Hearing in Connexin 30 Null
            Mice
  JOURNAL   Front Cell Dev Biol 10, 900416 (2022)
   PUBMED   35573684
  REMARK    Erratum:[Front Cell Dev Biol. 2022 Jul 18;10:969989. PMID:
            35923852]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2198)
  AUTHORS   Houghton FD, Barr KJ, Walter G, Gabriel HD, Grummer R, Traub O,
            Leese HJ, Winterhager E and Kidder GM.
  TITLE     Functional significance of gap junctional coupling in
            preimplantation development
  JOURNAL   Biol Reprod 66 (5), 1403-1412 (2002)
   PUBMED   11967204
REFERENCE   7  (bases 1 to 2198)
  AUTHORS   Kelley PM, Abe S, Askew JW, Smith SD, Usami Si and Kimberling WJ.
  TITLE     Human connexin 30 (GJB6), a candidate gene for nonsyndromic hearing
            loss: molecular cloning, tissue-specific expression, and assignment
            to chromosome 13q12
  JOURNAL   Genomics 62 (2), 172-176 (1999)
   PUBMED   10610709
REFERENCE   8  (bases 1 to 2198)
  AUTHORS   Nagy JI, Patel D, Ochalski PA and Stelmack GL.
  TITLE     Connexin30 in rodent, cat and human brain: selective expression in
            gray matter astrocytes, co-localization with connexin43 at gap
            junctions and late developmental appearance
  JOURNAL   Neuroscience 88 (2), 447-468 (1999)
   PUBMED   10197766
REFERENCE   9  (bases 1 to 2198)
  AUTHORS   Brady KP, Rowe LB, Her H, Stevens TJ, Eppig J, Sussman DJ, Sikela J
            and Beier DR.
  TITLE     Genetic mapping of 262 loci derived from expressed sequences in a
            murine interspecific cross using single-strand conformational
            polymorphism analysis
  JOURNAL   Genome Res 7 (11), 1085-1093 (1997)
   PUBMED   9371744
REFERENCE   10 (bases 1 to 2198)
  AUTHORS   Dahl E, Manthey D, Chen Y, Schwarz HJ, Chang YS, Lalley PA,
            Nicholson BJ and Willecke K.
  TITLE     Molecular cloning and functional expression of mouse connexin-30,a
            gap junction gene highly expressed in adult brain and skin
  JOURNAL   J Biol Chem 271 (30), 17903-17910 (1996)
   PUBMED   8663509
  REMARK    Erratum:[J Biol Chem 1996 Oct 18;271(42):26444]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119952.12.
            
            [WARNING] On Sep 25, 2023 this sequence was replaced by
            NM_001271663.2.
            
            Transcript Variant: This variant (3) uses an alternate splice site
            in the 5' UTR compared to variant 2. Both variants 2 and 3 encode
            the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660813.58076.1, BI904602.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164131
                                           [ECO:0000348]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-426               AC119952.12        43523-43948
            427-682             AC119952.12        46170-46425
            683-2198            AC119952.12        52318-53833
FEATURES             Location/Qualifiers
     source          1..2198
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 30.1 cM"
     gene            1..2198
                     /gene="Gjb6"
                     /gene_synonym="Cx30; Cxnf; D14Bwg0506e"
                     /note="gap junction protein, beta 6"
                     /db_xref="GeneID:14623"
                     /db_xref="MGI:MGI:107588"
     exon            1..426
                     /gene="Gjb6"
                     /gene_synonym="Cx30; Cxnf; D14Bwg0506e"
                     /inference="alignment:Splign:2.1.0"
     exon            427..682
                     /gene="Gjb6"
                     /gene_synonym="Cx30; Cxnf; D14Bwg0506e"
                     /inference="alignment:Splign:2.1.0"
     exon            683..2198
                     /gene="Gjb6"
                     /gene_synonym="Cx30; Cxnf; D14Bwg0506e"
                     /inference="alignment:Splign:2.1.0"
     CDS             697..1482
                     /gene="Gjb6"
                     /gene_synonym="Cx30; Cxnf; D14Bwg0506e"
                     /note="connexin-30; gap junction membrane channel protein
                     beta 6; connexin f"
                     /codon_start=1
                     /product="gap junction beta-6 protein"
                     /protein_id="NP_001258592.1"
                     /db_xref="CCDS:CCDS27154.1"
                     /db_xref="GeneID:14623"
                     /db_xref="MGI:MGI:107588"
                     /translation="MDWGTLHTVIGGVNKHSTSIGKVWITVIFIFRVMILVVAAQEVW
                     GDEQEDFVCNTLQPGCKNVCYDHFFPVSHIRLWALQLIFVSTPALLVAMHVAYYRHET
                     ARKFIRGEKRNEFKDLEDIKRQKVRIEGSLWWTYTSSIFFRIIFEAAFMYVFYFLYNG
                     YHLPWVLKCGIDPCPNLVDCFISRPTEKTVFTVFMISASVICMLLNVAELCYLLLKLC
                     FRRSKRTQAQRNHPNHALKESKQNEMNELISDSGQNAITSFPS"
ORIGIN      
        1 ggaagaccag cctacacctg gagtctctcc taggggacac tcgcagtggt ccctggcttc
       61 agaagaagga tcccaacgag tgccctaata tagtaccact aagacctggc cctaacaggg
      121 aaggtcccct gccccttgct ccacagaagg ggacccgccc cgctcctctg tcccggagag
      181 agggcggtgc gcaccacaga aggcgcgtcg agtgcccgcg ctcctctccc gcagccctcc
      241 cgtgcggcgt caggcagagg cggggtgggg gcgcggttaa aagaagccac aggtggaaac
      301 cggggctcca cccgcactgt ccccgattcc attcccgctg tgaaccgccg gcgcctgatc
      361 caacctacgc tcagggtagg agctctgagt gccgctgcga gcctggagcc ggctcccacc
      421 gagcaggtga cattcccact gtgaccctaa acagagcagc agtgcagtgc caccaccact
      481 accgctgctg atgtccagag gagtaggagg gaaagacaga agtccttgca gagggatttt
      541 gcagtgactc ttgagctggg cgccctggaa gccctggaga acaagactca ggtttgggtg
      601 ttttgcttga gtctggtttt cttatccctt cagctctaca tcagagtgtg ctttcctctt
      661 gggtctatta aatcatcacc agaataagcc tgcacgatgg actgggggac cctgcacacc
      721 gtcatcggtg gcgtgaacaa gcactctacc agcataggga aggtgtggat cacggtcatc
      781 tttattttcc gagtcatgat cctagtggtg gctgcccagg aagtgtgggg tgatgagcag
      841 gaggactttg tctgcaacac tctgcagcca gggtgcaaga acgtctgcta tgaccatttc
      901 ttcccggtgt ctcacatccg gctctgggcc ctgcagctga tctttgtgtc taccccagcc
      961 ctgttggtgg ccatgcacgt ggcctactac agacatgaaa ctgcccgaaa gtttatacgt
     1021 ggggagaaga gaaacgagtt taaagacctg gaggacatca aacggcagaa ggtgcgcatt
     1081 gagggctccc tgtggtggac gtacaccagc agcattttct tccgcatcat cttcgaagcc
     1141 gccttcatgt atgtgttcta cttcctctac aatgggtacc acctaccctg ggtactgaaa
     1201 tgtggcattg acccctgccc caatctcgtg gactgcttca tttcgaggcc aactgagaaa
     1261 acggtgttca ctgtttttat gatttccgca tccgtgattt gcatgctgct caatgtggcc
     1321 gagttgtgtt acctgctgct taaattgtgc tttaggagat ccaaaagaac acaggcgcag
     1381 agaaaccacc ccaaccatgc cctgaaagag agcaagcaga atgaaatgaa tgagctgatc
     1441 tcagatagtg gccagaatgc aatcacaagt ttcccaagtt aagcacttca aggtcaagtg
     1501 taggtgagcc cttctgagca tgtaccctct ttgtagacaa cattgatctg acaactcctc
     1561 ctctaggtca agagtttgtc tataagtgac tcatagaaag tggatacttg agttcgatta
     1621 ttgtagaaca cctgagctgt tcatacacaa tataagtcaa aattgtggtc tatctctgaa
     1681 aaccaagccc tcgtgacaac tgggccttgg agtcacctgg acaagtccta tgtgaactat
     1741 atgacttagt atttcctgaa accttatata acttgtttat aaagaacaat ttatctaaaa
     1801 attaatagtt ttatcagtaa gatattttta taggaatgaa tattttagtt ctgactttga
     1861 atttatataa agtatttttt taatgactgg ccttccttac ctggaaaaaa atatacaaag
     1921 ttagctttac aagtgcaccc caagtatcta aagtttgaac ttgtaaaggg tctagcagat
     1981 tacaaatatt gttttcactc tgtctgagga cagtttaatg agctagtgtg tgctcttaag
     2041 gtgggatgtg ttcattggac aatatacatt gccgattgct gaatatgaat ggaatcgaag
     2101 gaagtgggac cctttttaaa atgagccttt ccacctatgg tgaacagtgc agacatgaat
     2161 atgatctcgc caataaagct tgaccctgtt gcttcagc
//
