LOCUS       NM_010291               1706 bp    mRNA    linear   ROD 02-JUN-2024
DEFINITION  Mus musculus gap junction protein, beta 5 (Gjb5), mRNA.
ACCESSION   NM_010291
VERSION     NM_010291.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1706)
  AUTHORS   Ding,Y., Lang,D., Yan,J., Bu,H., Li,H., Jiao,K., Yang,J., Ni,H.,
            Morotti,S., Le,T., Clark,K.J., Port,J., Ekker,S.C., Cao,H.,
            Zhang,Y., Wang,J., Grandi,E., Li,Z., Shi,Y., Li,Y., Glukhov,A.V.
            and Xu,X.
  TITLE     A phenotype-based forward genetic screen identifies Dnajb6 as a
            sick sinus syndrome gene
  JOURNAL   Elife 11, e77327 (2022)
   PUBMED   36255053
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1706)
  AUTHORS   Pastar,V., Lozic,M., Kelam,N., Filipovic,N., Bernard,B.,
            Katsuyama,Y. and Vukojevic,K.
  TITLE     Connexin Expression Is Altered in Liver Development of Yotari (dab1
            -/-) Mice
  JOURNAL   Int J Mol Sci 22 (19), 10712 (2021)
   PUBMED   34639052
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1706)
  AUTHORS   Bernardo,A.S., Jouneau,A., Marks,H., Kensche,P., Kobolak,J.,
            Freude,K., Hall,V., Feher,A., Polgar,Z., Sartori,C., Bock,I.,
            Louet,C., Faial,T., Kerstens,H.H.D., Bouissou,C., Parsonage,G.,
            Mashayekhi,K., Smith,J.C., Lazzari,G., Hyttel,P., Stunnenberg,H.G.,
            Huynen,M., Pedersen,R.A. and Dinnyes,A.
  TITLE     Mammalian embryo comparison identifies novel pluripotency genes
            associated with the naive or primed state
  JOURNAL   Biol Open 7 (8) (2018)
   PUBMED   30026265
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1706)
  AUTHORS   Kibschull,M., Colaco,K., Matysiak-Zablocki,E., Winterhager,E. and
            Lye,S.J.
  TITLE     Connexin31.1 (Gjb5) deficiency blocks trophoblast stem cell
            differentiation and delays placental development
  JOURNAL   Stem Cells Dev 23 (21), 2649-2660 (2014)
   PUBMED   24866916
  REMARK    GeneRIF: Findings show delayed differentiation of connexin31.1
            (Gjb5)-deficient trophoblast stem cell.
REFERENCE   5  (bases 1 to 1706)
  AUTHORS   Nagarajan,P., Chin,S.S., Wang,D., Liu,S., Sinha,S. and
            Garrett-Sinha,L.A.
  TITLE     Ets1 blocks terminal differentiation of keratinocytes and induces
            expression of matrix metalloproteases and innate immune mediators
  JOURNAL   J Cell Sci 123 (Pt 20), 3566-3575 (2010)
   PUBMED   20930145
REFERENCE   6  (bases 1 to 1706)
  AUTHORS   Maeda,Y.Y., Funata,N., Takahama,S., Sugata,Y. and Yonekawa,H.
  TITLE     Two interactive genes responsible for a new inherited cataract
            (RCT) in the mouse
  JOURNAL   Mamm Genome 12 (4), 278-283 (2001)
   PUBMED   11309658
REFERENCE   7  (bases 1 to 1706)
  AUTHORS   Richard,G., Smith,L.E., Bailey,R.A., Itin,P., Hohl,D., Epstein,E.H.
            Jr., DiGiovanna,J.J., Compton,J.G. and Bale,S.J.
  TITLE     Mutations in the human connexin gene GJB3 cause erythrokeratodermia
            variabilis
  JOURNAL   Nat Genet 20 (4), 366-369 (1998)
   PUBMED   9843209
REFERENCE   8  (bases 1 to 1706)
  AUTHORS   Davies,T.C., Barr,K.J., Jones,D.H., Zhu,D. and Kidder,G.M.
  TITLE     Multiple members of the connexin gene family participate in
            preimplantation development of the mouse
  JOURNAL   Dev Genet 18 (3), 234-243 (1996)
   PUBMED   8631157
REFERENCE   9  (bases 1 to 1706)
  AUTHORS   Hennemann,H., Dahl,E., White,J.B., Schwarz,H.J., Lalley,P.A.,
            Chang,S., Nicholson,B.J. and Willecke,K.
  TITLE     Two gap junction genes, connexin 31.1 and 30.3, are closely linked
            on mouse chromosome 4 and preferentially expressed in skin
  JOURNAL   J Biol Chem 267 (24), 17225-17233 (1992)
   PUBMED   1512260
REFERENCE   10 (bases 1 to 1706)
  AUTHORS   Haefliger,J.A., Bruzzone,R., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Paul,D.L.
  TITLE     Four novel members of the connexin family of gap junction proteins.
            Molecular cloning, expression, and chromosome mapping
  JOURNAL   J Biol Chem 267 (3), 2057-2064 (1992)
   PUBMED   1370487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL626768.21.
            
            On Aug 30, 2022 this sequence version replaced NM_010291.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK082917.1, M91236.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-139               AL626768.21        116948-117086       c
            140-1706            AL626768.21        113729-115295       c
FEATURES             Location/Qualifiers
     source          1..1706
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 61.51 cM"
     gene            1..1706
                     /gene="Gjb5"
                     /gene_synonym="Cnx31.1; Cx31.1; Cxna; Gjb-5"
                     /note="gap junction protein, beta 5"
                     /db_xref="GeneID:14622"
                     /db_xref="MGI:MGI:95723"
     exon            1..139
                     /gene="Gjb5"
                     /gene_synonym="Cnx31.1; Cx31.1; Cxna; Gjb-5"
                     /inference="alignment:Splign:2.1.0"
     exon            140..1706
                     /gene="Gjb5"
                     /gene_synonym="Cnx31.1; Cx31.1; Cxna; Gjb-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1292..1297
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gjb5"
                     /gene_synonym="Cnx31.1; Cx31.1; Cxna; Gjb-5"
                     /note="hexamer: AATAAA"
     regulatory      1298..1303
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gjb5"
                     /gene_synonym="Cnx31.1; Cx31.1; Cxna; Gjb-5"
                     /note="hexamer: GATAAA"
     polyA_site      1316
                     /gene="Gjb5"
                     /gene_synonym="Cnx31.1; Cx31.1; Cxna; Gjb-5"
                     /note="major polyA site"
     polyA_site      1320
                     /gene="Gjb5"
                     /gene_synonym="Cnx31.1; Cx31.1; Cxna; Gjb-5"
     regulatory      1684..1689
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gjb5"
                     /gene_synonym="Cnx31.1; Cx31.1; Cxna; Gjb-5"
                     /note="hexamer: AATAAA"
     polyA_site      1706
                     /gene="Gjb5"
                     /gene_synonym="Cnx31.1; Cx31.1; Cxna; Gjb-5"
ORIGIN      
        1 gctcaacagc ctctgcccca agaatgagct ttaccagaaa cccttccctg attctgacat
       61 gaattctgat gcttgctgaa ccccaactgc tggcttccag gagcgggtac taagggagcc
      121 ctaaggagtc gctgctcagg agcagccagc ccttgagtcc accatgaact ggagtgtttt
      181 tgagggactc ctgagcggag tcaacaagta ctccacagcc tttggtcgca tctggctgtc
      241 tctggtcttc gtcttccgtg tgctggtgta cctggtgaca gctgagcgcg tgtggggaga
      301 cgaccagaag gattttgact gcaacaccag gcaaccgggc tgtaccaatg tctgctacga
      361 tgagttcttc cccgtgtctc acgtgcgcct ctgggctctg cagctcatcc tggtcacctg
      421 cccctctttg cttgtggtca tgcatgtggc ctatcgaaag gctcgagaga agaagtacca
      481 ggaaaagatt ggtgaaggtt acctttaccc gaatcccggc aagaagcggg gtggactctg
      541 gtggacatac gtcttcagcc tctcgttcaa ggccaccata gacattatct tcctctacct
      601 cttccacgca ttctatccca gatataccct cccttctatg gtcaagtgcc atgcggagcc
      661 gtgtcccaac acagtggact gcttcattgc caagccctcc gagaaaaaca tcttcattgt
      721 cttcatggtg gtcacggccg tcatctgcat cctgcttaac cttgtggagc tgatctacct
      781 agtgattaag cggtgttctg agtgtgcgca gctgaggaga ccacccactg cacatgcaaa
      841 gaatgaccca aactgggcca actctcctag caaagagaag gacttcctct catgcgacct
      901 catctttctg ggctcggacg ctcacccgcc tctgttacca gaccgccctc gagcccacgt
      961 gaagaaaacc attctgtgaa gggtccctag actggactgg cagggtgggc atgacctgga
     1021 aggttccaga atctctcatg aatgtagctg atggggagaa gagctgagtt ggcattggag
     1081 gcaagcaaaa gggaggactc ccagagcttt gggatccagt tgtgcctccc ggctgactgg
     1141 ccttcgctga gtcacccctc tcctctgtac ctccatttcc ttttctgtta aataaacaca
     1201 ccgagggcca cttcgcaggg ctcctgggag gggagtttca cgaaggcacc gatgagcaaa
     1261 tgccttcctg tgtggcccag ggtgagagct aaataaagat aaatgggttt acagattcaa
     1321 ggtgtccttt gggtcttggc ctttgtaccc ttcctgaagt caaggggttt ccctctcctc
     1381 tagaaaagga gtatctaact tttcctcagg gctgttccaa agctaacctt ttgtcccagc
     1441 tggaagtctg ggctgtgggt gtctgcagag atgatggagt ttggcagaac cgtatgttgg
     1501 gatggaaaac acccagactc tgagtaagcg tggctgcatc agaactcgga caacttcagc
     1561 tgagttccta atgcattgcc tgtgggggtc actgtgagca atggcaagta cctggcacga
     1621 ccagagttag ccagccaaaa aggccacgta cgtgtgaatc actgctgtta gggagtgctc
     1681 aataataaat gcttgtgtga agtgaa
//
