LOCUS       NM_008127               1445 bp    mRNA    linear   ROD 23-DEC-2022
DEFINITION  Mus musculus gap junction protein, beta 4 (Gjb4), mRNA.
ACCESSION   NM_008127 XM_001005325
VERSION     NM_008127.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1445)
  AUTHORS   Pastar V, Lozic M, Kelam N, Filipovic N, Bernard B, Katsuyama Y and
            Vukojevic K.
  TITLE     Connexin Expression Is Altered in Liver Development of Yotari (dab1
            -/-) Mice
  JOURNAL   Int J Mol Sci 22 (19), 10712 (2021)
   PUBMED   34639052
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1445)
  AUTHORS   Gassler A, Quiclet C, Kluth O, Gottmann P, Schwerbel K, Helms A,
            Stadion M, Wilhelmi I, Jonas W, Ouni M, Mayer F, Spranger J,
            Schurmann A and Vogel H.
  TITLE     Overexpression of Gjb4 impairs cell proliferation and insulin
            secretion in primary islet cells
  JOURNAL   Mol Metab 41, 101042 (2020)
   PUBMED   32565358
  REMARK    GeneRIF: Overexpression of Gjb4 impairs cell proliferation and
            insulin secretion in primary islet cells.
REFERENCE   3  (bases 1 to 1445)
  AUTHORS   Saito M, Asai Y, Imai K, Hiratoko S and Tanaka K.
  TITLE     Connexin30.3 is expressed in mouse embryonic stem cells and is
            responsive to leukemia inhibitory factor
  JOURNAL   Sci Rep 7, 42403 (2017)
   PUBMED   28205646
  REMARK    GeneRIF: These indicate possible involvement of Cx30.3 in the rapid
            formation and/or decomposition of gap junctions; implying a
            functional relay between Cx30.3 and other systems such as adhesion
            proteins.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1445)
  AUTHORS   Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK,
            Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L,
            Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre
            JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A,
            Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ,
            Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall
            S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA,
            Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR,
            Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana
            S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG,
            Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC,
            Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL,
            de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown
            SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M and Murray
            SA.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. PMID: 29144450]
REFERENCE   5  (bases 1 to 1445)
  AUTHORS   Pannasch U, Freche D, Dallerac G, Ghezali G, Escartin C, Ezan P,
            Cohen-Salmon M, Benchenane K, Abudara V, Dufour A, Lubke JH, Deglon
            N, Knott G, Holcman D and Rouach N.
  TITLE     Connexin 30 sets synaptic strength by controlling astroglial
            synapse invasion
  JOURNAL   Nat Neurosci 17 (4), 549-558 (2014)
   PUBMED   24584052
  REMARK    GeneRIF: Cx30 regulates cell adhesion and migration; its modulation
            of glutamate transport occurs independently of its channel function
            and is mediated by morphological changes controlling insertion of
            astroglial processes into synaptic clefts.
REFERENCE   6  (bases 1 to 1445)
  AUTHORS   Maeda YY, Funata N, Takahama S, Sugata Y and Yonekawa H.
  TITLE     Two interactive genes responsible for a new inherited cataract
            (RCT) in the mouse
  JOURNAL   Mamm Genome 12 (4), 278-283 (2001)
   PUBMED   11309658
REFERENCE   7  (bases 1 to 1445)
  AUTHORS   Mignon C, Fromaget C, Mattei MG, Gros D, Yamasaki H and Mesnil M.
  TITLE     Assignment of connexin 26 (GJB2) and 46 (GJA3) genes to human
            chromosome 13q11-->q12 and mouse chromosome 14D1-E1 by in situ
            hybridization
  JOURNAL   Cytogenet Cell Genet 72 (2-3), 185-186 (1996)
   PUBMED   8978770
REFERENCE   8  (bases 1 to 1445)
  AUTHORS   Davies TC, Barr KJ, Jones DH, Zhu D and Kidder GM.
  TITLE     Multiple members of the connexin gene family participate in
            preimplantation development of the mouse
  JOURNAL   Dev Genet 18 (3), 234-243 (1996)
   PUBMED   8631157
REFERENCE   9  (bases 1 to 1445)
  AUTHORS   Hennemann H, Dahl E, White JB, Schwarz HJ, Lalley PA, Chang S,
            Nicholson BJ and Willecke K.
  TITLE     Two gap junction genes, connexin 31.1 and 30.3, are closely linked
            on mouse chromosome 4 and preferentially expressed in skin
  JOURNAL   J Biol Chem 267 (24), 17225-17233 (1992)
   PUBMED   1512260
REFERENCE   10 (bases 1 to 1445)
  AUTHORS   Willecke K, Hennemann H, Dahl E, Jungbluth S and Heynkes R.
  TITLE     The diversity of connexin genes encoding gap junctional proteins
  JOURNAL   Eur J Cell Biol 56 (1), 1-7 (1991)
   PUBMED   1666038
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK076408.1 and AL626768.21.
            
            [WARNING] On May 6, 2023 this sequence was replaced by NM_008127.5.
            
            On Nov 2, 2012 this sequence version replaced NM_008127.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK076408.1, SRR5189682.28602.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849376
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               AK076408.1         2-250
            250-1445            AL626768.21        110008-111203       c
FEATURES             Location/Qualifiers
     source          1..1445
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 61.51 cM"
     gene            1..1445
                     /gene="Gjb4"
                     /gene_synonym="Cnx30.3; Cx30.3; Cxnb; Gjb-4"
                     /note="gap junction protein, beta 4"
                     /db_xref="GeneID:14621"
                     /db_xref="MGI:MGI:95722"
     exon            1..49
                     /gene="Gjb4"
                     /gene_synonym="Cnx30.3; Cx30.3; Cxnb; Gjb-4"
                     /inference="alignment:Splign:2.1.0"
     exon            50..1445
                     /gene="Gjb4"
                     /gene_synonym="Cnx30.3; Cx30.3; Cxnb; Gjb-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             385..1185
                     /gene="Gjb4"
                     /gene_synonym="Cnx30.3; Cx30.3; Cxnb; Gjb-4"
                     /note="connexin-30.3; gap junction membrane channel
                     protein beta 4; connexin b"
                     /codon_start=1
                     /product="gap junction beta-4 protein"
                     /protein_id="NP_032153.1"
                     /db_xref="CCDS:CCDS18669.1"
                     /db_xref="GeneID:14621"
                     /db_xref="MGI:MGI:95722"
                     /translation="MNWGFLQGILSGVNKYSTALGRIWLSVVFIFRVLVYVVAAEEVW
                     DDDQKDFICNTKQPGCPNVCYDEFFPVSHVRLWALQLILVTCPSLLVVMHVAYREERE
                     RKHRLKHGPNAPALYSNLSKKRGGLWWTYLLSLIFKAAVDSGFLYIFHCIYKDYDMPR
                     VVACSVTPCPHTVDCYIARPTEKKVFTYFMVVTAAICILLNLSEVVYLVGKRCMEVFR
                     PRRRKASRRHQLPDTCPPYVISKGGHPQDESVILTKAGMATVDAGVYP"
ORIGIN      
        1 agacagacaa gccggcaccg gagagtgagg acacggggac ccaagaagga aggaaagaga
       61 tgctgacttc cgtcggaatc tgaaggccaa ggttcaagac cacctgtgct acttgctgct
      121 gtgatctcgg gcaggagacc tctcacctct cagccatcac acactttcct gtgaaatggg
      181 gaccgtgacc gtcccaccac tgagtcaccg tgaatgacga cacaaatgtc ctcatggttg
      241 ttgtgaaacc atctagtcct cagcatcatc tacaaagaca tccatctgca ggctctccca
      301 ggcctcgtga ctcccagagt ctgagaggtt agcacacaag ggcacacaca cacgtccacg
      361 tgaggcaccg aggacacagc cagcatgaac tggggatttc tccagggaat cctgagtggt
      421 gtgaacaagt actccacggc actgggccgc atctggctgt ctgtggtctt catcttccgg
      481 gtgctggtgt atgtggtggc ggcagaggag gtgtgggacg acgatcaaaa ggatttcatc
      541 tgcaatacca agcagccagg ctgccccaac gtctgctatg atgagttctt ccccgtgtcc
      601 cacgtgcgcc tctgggccct gcagctcatc ctggtcacct gtccttccct gttagtggtc
      661 atgcatgtgg cctatcgtga agagcgagaa aggaaacatc gcctcaaaca tgggcccaat
      721 gccccagccc tgtacagcaa cctgagcaag aagaggggtg gcctgtggtg gacatacctg
      781 ctgagtctca tcttcaaggc tgctgtggac tctggctttc tctacatctt ccattgcatt
      841 tacaaggact atgacatgcc ccgagtggta gcttgctctg tgactccctg cccccacact
      901 gtggactgtt acatcgcccg acccacagag aagaaggtct tcacctactt catggtagtc
      961 acggcagcca tttgtattct actcaacctc agtgaggtcg tctacctggt gggcaagaga
     1021 tgcatggagg tcttccgtcc ccggcgccgg aaagcttcca ggaggcacca actgccagat
     1081 acgtgcccac cgtatgtgat ctccaaagga ggtcaccctc aagatgagag cgtgatccta
     1141 acaaaggccg ggatggccac ggtggatgca ggtgtgtatc catgacctgc aggtatggtt
     1201 atgaggtgac tgtctgtcca ctgaagccac ccaggaaaat gggcgaaggg agtgtggtct
     1261 tctgcagcag gtcaggtggg aaacatggct gtggggactc cagaagttca tccaagagct
     1321 agcggaagat gggaagcacc cttgagtccc tagaacttga gcctccaggg acttgatggc
     1381 tggtggggat gttatatttg tcaatgagga cctcaactcc attaataaat atgatgttcc
     1441 cagtg
//
