LOCUS       NM_001160012            1876 bp    mRNA    linear   ROD 07-AUG-2024
DEFINITION  Mus musculus gap junction protein, beta 3 (Gjb3), transcript
            variant 1, mRNA.
ACCESSION   NM_001160012
VERSION     NM_001160012.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1876)
  AUTHORS   Liu,J., Wang,X., Jiang,W., Azoitei,A., Eiseler,T., Eckstein,M.,
            Hartmann,A., Stilgenbauer,S., Elati,M., Hohwieler,M., Kleger,A.,
            John,A., Wezel,F., Zengerling,F., Bolenz,C. and Gunes,C.
  TITLE     Impairment of alpha-tubulin and F-actin interactions of GJB3
            induces aneuploidy in urothelial cells and promotes bladder cancer
            cell invasion
  JOURNAL   Cell Mol Biol Lett 29 (1), 94 (2024)
   PUBMED   38956497
  REMARK    GeneRIF: Impairment of alpha-tubulin and F-actin interactions of
            GJB3 induces aneuploidy in urothelial cells and promotes bladder
            cancer cell invasion.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1876)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1876)
  AUTHORS   Lee,J.G., Yon,J.M., Kim,G., Lee,S.G., Kim,C.Y., Cheong,S.A.,
            Kim,H.Y., Yu,J., Kim,K., Sung,Y.H., Yoo,H.J., Woo,D.C., Rho,J.K.,
            Ha,C.H., Pack,C.G., Oh,S.H., Lim,J.S., Han,Y.M., Hong,E.J.,
            Seong,J.K., Lee,H.W., Lee,S.W., Lee,K.U., Kim,C.J., Nam,S.Y.,
            Cho,Y.S. and Baek,I.J.
  TITLE     PIBF1 regulates trophoblast syncytialization and promotes
            cardiovascular development
  JOURNAL   Nat Commun 15 (1), 1487 (2024)
   PUBMED   38374152
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1876)
  AUTHORS   Lee,J.G., Kim,G., Park,S.G., Yon,J.M., Yeom,J., Song,H.E.,
            Cheong,S.A., Lim,J.S., Sung,Y.H., Kim,K., Yoo,H.J., Hong,E.J.,
            Nam,K.H., Seong,J.K., Kim,C.J., Nam,S.Y. and Baek,I.J.
  TITLE     Lipid signatures reflect the function of the murine primary
            placentationdagger
  JOURNAL   Biol Reprod 106 (3), 583-596 (2022)
   PUBMED   34850819
REFERENCE   5  (bases 1 to 1876)
  AUTHORS   Au,A., Shao,Q., White,K.K., Lucaciu,S.A., Esseltine,J.L., Barr,K.
            and Laird,D.W.
  TITLE     Comparative Analysis of Cx31 and Cx43 in Differentiation-Competent
            Rodent Keratinocytes
  JOURNAL   Biomolecules 10 (10), 1443 (2020)
   PUBMED   33066499
  REMARK    GeneRIF: Comparative Analysis of Cx31 and Cx43 in
            Differentiation-Competent Rodent Keratinocytes.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1876)
  AUTHORS   Butterweck,A., Elfgang,C., Willecke,K. and Traub,O.
  TITLE     Differential expression of the gap junction proteins connexin45,
            -43, -40, -31, and -26 in mouse skin
  JOURNAL   Eur J Cell Biol 65 (1), 152-163 (1994)
   PUBMED   7889986
REFERENCE   7  (bases 1 to 1876)
  AUTHORS   Schwarz,H.J., Chang,Y.S., Hennemann,H., Dahl,E., Lalley,P.A. and
            Willecke,K.
  TITLE     Chromosomal assignments of mouse connexin genes, coding for gap
            junctional proteins, by somatic cell hybridization
  JOURNAL   Somat Cell Mol Genet 18 (4), 351-359 (1992)
   PUBMED   1332196
REFERENCE   8  (bases 1 to 1876)
  AUTHORS   Hennemann,H., Kozjek,G., Dahl,E., Nicholson,B. and Willecke,K.
  TITLE     Molecular cloning of mouse connexins26 and -32: similar genomic
            organization but distinct promoter sequences of two gap junction
            genes
  JOURNAL   Eur J Cell Biol 58 (1), 81-89 (1992)
   PUBMED   1322820
REFERENCE   9  (bases 1 to 1876)
  AUTHORS   Hennemann,H., Schwarz,H.J. and Willecke,K.
  TITLE     Characterization of gap junction genes expressed in F9 embryonic
            carcinoma cells: molecular cloning of mouse connexin31 and -45
            cDNAs
  JOURNAL   Eur J Cell Biol 57 (1), 51-58 (1992)
   PUBMED   1322300
REFERENCE   10 (bases 1 to 1876)
  AUTHORS   Willecke,K., Hennemann,H., Dahl,E., Jungbluth,S. and Heynkes,R.
  TITLE     The diversity of connexin genes encoding gap junctional proteins
  JOURNAL   Eur J Cell Biol 56 (1), 1-7 (1991)
   PUBMED   1666038
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL626768.21.
            
            On Aug 30, 2022 this sequence version replaced NM_001160012.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC024387.1, SRR13948564.4284850.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-339               AL626768.21        89424-89762         c
            340-1876            AL626768.21        84157-85693         c
FEATURES             Location/Qualifiers
     source          1..1876
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 61.48 cM"
     gene            1..1876
                     /gene="Gjb3"
                     /gene_synonym="Cnx31; Cx31; Cxnc; D4Wsu144e; Gjb-3"
                     /note="gap junction protein, beta 3"
                     /db_xref="GeneID:14620"
                     /db_xref="MGI:MGI:95721"
     exon            1..339
                     /gene="Gjb3"
                     /gene_synonym="Cnx31; Cx31; Cxnc; D4Wsu144e; Gjb-3"
                     /inference="alignment:Splign:2.1.0"
     exon            340..1876
                     /gene="Gjb3"
                     /gene_synonym="Cnx31; Cx31; Cxnc; D4Wsu144e; Gjb-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             374..1186
                     /gene="Gjb3"
                     /gene_synonym="Cnx31; Cx31; Cxnc; D4Wsu144e; Gjb-3"
                     /note="connexin-31; gap junction membrane channel protein
                     beta 3; connexin c"
                     /codon_start=1
                     /product="gap junction beta-3 protein"
                     /protein_id="NP_001153484.1"
                     /db_xref="CCDS:CCDS18668.1"
                     /db_xref="GeneID:14620"
                     /db_xref="MGI:MGI:95721"
                     /translation="MDWKKLQDLLSGVNQYSTAFGRIWLSVVFVFRVLVYVVAAERVW
                     GDEQKDFDCNTRQPGCTNVCYDNFFPISNIRLWALQLIFVTCPSMLVILHVAYREERE
                     RKHRQKHGEQCAKLYSHPGKKHGGLWWTYLFSLIFKLIIELVFLYVLHTLWHGFTMPR
                     LVQCASIVPCPNTVDCYIARPTEKKVFTYFMVGASAVCIILTICEICYLIFHRIMRGI
                     SKGKSTKSISSPKSSSRASTCRCHHKLLESGDPEADPASEKLQASAPSLTPI"
     regulatory      1855..1860
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gjb3"
                     /gene_synonym="Cnx31; Cx31; Cxnc; D4Wsu144e; Gjb-3"
                     /note="hexamer: AATAAA"
     polyA_site      1876
                     /gene="Gjb3"
                     /gene_synonym="Cnx31; Cx31; Cxnc; D4Wsu144e; Gjb-3"
                     /note="major polyA site"
ORIGIN      
        1 aacagtttgc aaggtgtttc acaccctaat gtcattgcag tccttgcaac agccctgcca
       61 gtggccacca atgcccccat tccacaggcg agcacgcgga gcctccgcaa aggagcctgc
      121 tgttccctag tcagcgcagc tgctcctgga ttagaacttg catccctgag gcgactccgg
      181 gctcctcccc ggccgcccct cctccacgct gcctctggct gtgctggcca ggagcctcac
      241 cgaggccaca gagctcggct tggctcccgc ctcgttcctc ctctgctgtg ggtcttgggc
      301 acgtggagcc aggctcccac ggtggcggcg ccgctgactg tgggcacagc cccccgaacc
      361 ctgagcaggc accatggact ggaagaagct ccaagaccta ttgagtggcg tgaaccagta
      421 ctccacggca tttgggcgca tctggctgtc agtagtgttc gtcttccggg tgctggtgta
      481 tgtggtggct gccgagcgtg tgtggggtga cgagcaaaaa gactttgact gtaacaccag
      541 gcaacccggc tgtaccaacg tgtgctatga caacttcttc cccatctcca acatccgact
      601 ctgggccctg cagctcatct tcgtcacgtg tccgtctatg ctggtcatcc tgcatgtagc
      661 ctaccgcgag gagcgggaac ggaagcatcg ccagaagcac ggggagcaat gcgccaaact
      721 gtacagccac ccgggcaaga agcatggcgg cctgtggtgg acctacttgt ttagcctcat
      781 cttcaagctc atcatcgaat tggtcttcct gtacgttctc cacacgctct ggcatggctt
      841 caccatgccg cgtctggtac agtgcgccag catagtaccc tgccccaaca ccgtggattg
      901 ctacatcgct cggcccacgg agaagaaggt ctttacctac ttcatggtag gcgcttctgc
      961 cgtctgcatt attctcacca tctgtgagat ctgctacctc atcttccaca ggatcatgcg
     1021 aggcataagc aagggcaagt ccacaaagag catcagctcc ccgaagtcct ccagccgggc
     1081 ctccacctgt cgctgtcacc acaagctgct ggagagtggc gatccggaag cagacccagc
     1141 cagtgaaaag ctgcaggctt cagcgcccag cctgaccccc atttgaacca ggtgctagag
     1201 aaggggtgaa gccgggaggt gctgcaggtg aaggggtcct gggggcgcca agtgctccca
     1261 ctttgaattc actaagctag ccaattgtgt ttgaagcagg tatttgtggg tgctgggctc
     1321 tgtgctggct acctggttta ggtagcataa cagacccagc ttccgagaga catttagatt
     1381 agcaaattta ctacaagcat gcaagggtct actagcgctg ggatggtaca cagggcttct
     1441 acctactgca ggggactgcc cggctgggca ccctctcaga aaaagcacag tgaaagaaag
     1501 gagatggggc tctccatcag acatagcaac agcaaaaaga actgggggat ctcagaggag
     1561 aggtgctggc tttggactgg ggacagccag ccagagggag gctttactac tcaaccatga
     1621 gaaggtttgg cacaaccttc tggaggccaa agagcaagtg tggctagcag gtctactgct
     1681 gcttgagaca cacccacggg tccctctcaa tccccctttg ccaacctcta ccttctccct
     1741 cccaccaggg tgctgagccc tctgcaccct gtagccagga ccttggaggc atgcgtatcc
     1801 tgtcatatcc ccggcgtata tccttgacat atccaagtcc gtttccttaa aagcaataaa
     1861 gttgtgtttt atacaa
//
