LOCUS       NM_008124               1613 bp    mRNA    linear   ROD 17-DEC-2024
DEFINITION  Mus musculus gap junction protein, beta 1 (Gjb1), transcript
            variant 1, mRNA.
ACCESSION   NM_008124
VERSION     NM_008124.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1613)
  AUTHORS   Chen,L., Fang,H., Li,X., Yu,P., Guan,Y., Xiao,C., Deng,Z., Hei,Z.,
            Chen,C. and Luo,C.
  TITLE     Connexin32 gap junction channels deliver miR155-3p to mediate
            pyroptosis in renal ischemia-reperfusion injury
  JOURNAL   Cell Commun Signal 22 (1), 121 (2024)
   PUBMED   38347637
  REMARK    GeneRIF: Connexin32 gap junction channels deliver miR155-3p to
            mediate pyroptosis in renal ischemia-reperfusion injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1613)
  AUTHORS   Huang,F., Deng,Z., Zhang,Q., Zhang,Z., Li,X., Zeng,W., Wang,Y.,
            Hei,Z. and Yuan,D.
  TITLE     Dual-regulation by Cx32 in hepatocyte to trigger and worsen liver
            graft injury
  JOURNAL   Transl Res 262, 44-59 (2023)
   PUBMED   37507007
  REMARK    GeneRIF: Dual-regulation by Cx32 in hepatocyte to trigger and
            worsen liver graft injury.
REFERENCE   3  (bases 1 to 1613)
  AUTHORS   Li,S., Xiao,H., Sun,X., Chen,Z., Lin,Z., Li,C., Zeng,J., Xu,Z.,
            Cheng,Y. and Huang,H.
  TITLE     Connexin32 Promotes the Activation of Foxo3a to Ameliorate Diabetic
            Nephropathy via Inhibiting the Polyubiquitination and Degradation
            of Sirt1
  JOURNAL   Antioxid Redox Signal 39 (4-6), 241-261 (2023)
   PUBMED   36601735
  REMARK    GeneRIF: Connexin32 Promotes the Activation of Foxo3a to Ameliorate
            Diabetic Nephropathy via Inhibiting the Polyubiquitination and
            Degradation of Sirt1.
REFERENCE   4  (bases 1 to 1613)
  AUTHORS   Abrams,C.K., Lancaster,E., Li,J.J., Dungan,G., Gong,D.,
            Scherer,S.S. and Freidin,M.M.
  TITLE     Knock-in mouse models for CMTX1 show a loss of function phenotype
            in the peripheral nervous system
  JOURNAL   Exp Neurol 360, 114277 (2023)
   PUBMED   36403785
REFERENCE   5  (bases 1 to 1613)
  AUTHORS   Martinez-Ramirez,A.S., Borders,T.L., Paul,L., Schipma,M., Wang,X.,
            Korobova,F., Wright,C.V. and Sosa-Pineda,B.
  TITLE     Specific Temporal Requirement of Prox1 Activity During Pancreatic
            Acinar Cell Development
  JOURNAL   Gastro Hep Adv 1 (5), 807-823 (2022)
   PUBMED   37829188
REFERENCE   6  (bases 1 to 1613)
  AUTHORS   Miragall,F., Hwang,T.K., Traub,O., Hertzberg,E.L. and Dermietzel,R.
  TITLE     Expression of connexins in the developing olfactory system of the
            mouse
  JOURNAL   J Comp Neurol 325 (3), 359-378 (1992)
   PUBMED   1332989
REFERENCE   7  (bases 1 to 1613)
  AUTHORS   Laird,D.W., Yancey,S.B., Bugga,L. and Revel,J.P.
  TITLE     Connexin expression and gap junction communication compartments in
            the developing mouse limb
  JOURNAL   Dev Dyn 195 (3), 153-161 (1992)
   PUBMED   1338686
REFERENCE   8  (bases 1 to 1613)
  AUTHORS   Schwarz,H.J., Chang,Y.S., Hennemann,H., Dahl,E., Lalley,P.A. and
            Willecke,K.
  TITLE     Chromosomal assignments of mouse connexin genes, coding for gap
            junctional proteins, by somatic cell hybridization
  JOURNAL   Somat Cell Mol Genet 18 (4), 351-359 (1992)
   PUBMED   1332196
REFERENCE   9  (bases 1 to 1613)
  AUTHORS   Stutenkemper,R., Geisse,S., Schwarz,H.J., Look,J., Traub,O.,
            Nicholson,B.J. and Willecke,K.
  TITLE     The hepatocyte-specific phenotype of murine liver cells correlates
            with high expression of connexin32 and connexin26 but very low
            expression of connexin43
  JOURNAL   Exp Cell Res 201 (1), 43-54 (1992)
   PUBMED   1319348
REFERENCE   10 (bases 1 to 1613)
  AUTHORS   Hennemann,H., Kozjek,G., Dahl,E., Nicholson,B. and Willecke,K.
  TITLE     Molecular cloning of mouse connexins26 and -32: similar genomic
            organization but distinct promoter sequences of two gap junction
            genes
  JOURNAL   Eur J Cell Biol 58 (1), 81-89 (1992)
   PUBMED   1322820
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL683892.12, BY105229.1,
            BY087537.1, AK134742.1, AA423068.1 and AI849881.1.
            
            On Oct 24, 2014 this sequence version replaced NM_008124.2.
            
            Summary: This gene is a member of the gap junction protein
            (connexin) family. The encoded protein is a component of gap
            junctions, which are composed of arrays of intercellular channels
            that provide a route for the diffusion of ions and small molecules
            between cells. Mutations in a similar gene in human cause X-linked
            Charcot-Marie-Tooth disease, an inherited peripheral neuropathy.
            Alternative splicing results in multiple transcript variants
            encoding the same protein. [provided by RefSeq, Oct 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC026833.1, BI145868.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-38                AL683892.12        116801-116838
            39-98               BY105229.1         2-61
            99-462              BY087537.1         28-391
            463-899             AK134742.1         189-625
            900-1023            AK134742.1         627-750
            1024-1082           AA423068.1         1-59
            1083-1083           AL683892.12        124675-124675
            1084-1261           AA423068.1         60-237
            1262-1613           AI849881.1         6-357               c
FEATURES             Location/Qualifiers
     source          1..1613
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 44.06 cM"
     gene            1..1613
                     /gene="Gjb1"
                     /gene_synonym="Cnx32; connexin-32; Cx32; Cxng"
                     /note="gap junction protein, beta 1"
                     /db_xref="GeneID:14618"
                     /db_xref="MGI:MGI:95719"
     exon            1..125
                     /gene="Gjb1"
                     /gene_synonym="Cnx32; connexin-32; Cx32; Cxng"
                     /inference="alignment:Splign:2.1.0"
     exon            126..1603
                     /gene="Gjb1"
                     /gene_synonym="Cnx32; connexin-32; Cx32; Cxng"
                     /inference="alignment:Splign:2.1.0"
     CDS             142..993
                     /gene="Gjb1"
                     /gene_synonym="Cnx32; connexin-32; Cx32; Cxng"
                     /note="gap junction membrane channel protein beta 1;
                     connexin-43; connexin 32; connexin g"
                     /codon_start=1
                     /product="gap junction beta-1 protein"
                     /protein_id="NP_032150.2"
                     /db_xref="CCDS:CCDS30314.1"
                     /db_xref="GeneID:14618"
                     /db_xref="MGI:MGI:95719"
                     /translation="MNWTGLYTLLSGVNRHSTAIGRVWLSVIFIFRIMVLVVAAESVW
                     GDEKSSFICNTLQPGCNSVCYDHFFPISHVRLWSLQLILVSTPALLVAMHVAHQQHIE
                     KKMLRLEGHGDPLHLEEVKRHKVHISGTLWWTYVISVVFRLLFEAVFMYVFYLLYPGY
                     AMVRLVKCEAFPCPNTVDCFVSRPTEKTVFTVFMLAASGICIILNVAEVVYLIIRACA
                     RRAQRRSNPPSRKGSGFGHRLSPEYKQNEINKLLSEQDGSLKDILRRSPGTGAGLAEK
                     SDRCSAC"
     regulatory      1577..1582
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gjb1"
                     /gene_synonym="Cnx32; connexin-32; Cx32; Cxng"
                     /note="hexamer: ATTAAA"
     polyA_site      1603
                     /gene="Gjb1"
                     /gene_synonym="Cnx32; connexin-32; Cx32; Cxng"
                     /note="major polyA site"
ORIGIN      
        1 ggtcctgggc ttgttgtccc tcccctgggt tgggctttga cagtacctag tggcactgag
       61 cagacacgcc tgcatacatt ccctgggaaa aggcagttgc aaccaggtgt ggcagtgcca
      121 gggaggtgtg aatgaggcag gatgaactgg acaggtctat acaccttgct cagtggcgtg
      181 aatcggcact ctacagccat tggccgagta tggctgtctg tcatcttcat cttcagaatc
      241 atggtgctgg tggtggctgc tgagagcgtg tggggggatg agaagtcctc tttcatctgt
      301 aacaccctcc agccgggctg caacagcgtc tgctatgacc attttttccc catctcccac
      361 gtgcgcctat ggtccctgca gcttatcttg gtttccaccc cagctctcct cgtggcaatg
      421 cacgtagctc accaacagca catagaaaag aaaatgctac ggcttgaggg gcatggggac
      481 ccccttcacc tggaagaggt aaagagacac aaggtgcaca tctcagggac actgtggtgg
      541 acctatgtca tcagtgtggt gttccggctg ctgttcgagg ctgtcttcat gtatgtcttc
      601 tatctgctct accccggcta tgccatggtg cggctggtca agtgtgaagc cttcccctgc
      661 cccaacacag tggactgctt cgtgtcccgc cccaccgaga aaaccgtctt cactgtcttt
      721 atgctcgcag cctccggcat ctgcattatc ctcaacgtgg cggaggtggt gtacctcatc
      781 atccgggcct gtgcccgccg tgctcagcgc cgctccaatc cgccctcccg caagggctcg
      841 ggcttcggcc accgcctctc acctgaatac aagcagaatg agatcaacaa gctgctgagc
      901 gagcaggatg gctctctgaa agacatactg cgccgcagcc ctggcacagg ggccgggctc
      961 gctgaaaaga gcgaccgatg ctcagcctgc tgatgccagt accaggcaac ctcccatccc
     1021 acccctccct caccctgccc agacctgccc ctccttctcc tatgccggtg agcaggcttc
     1081 tgcctgatag ggattattac tccatcaaac cttccctccc ttcctactcc ccttcctcag
     1141 agagccttct gtcaaagacc tggccggctg gggagtgggg agccacttct acaacagggc
     1201 tcaaggttat taatggtgtg ggcaattctt tctgcctata ccctttcctc ttccctctcc
     1261 ctgaaacgag ggatgagatg ttctgaaggt gtttccaatt aggaaactaa tcttaacccc
     1321 catgctgtct ggtaccccac tttgggagtc atgtcggtgg ggagggatgt gggcaagcag
     1381 agtggaggag gggctctgcc ttgtggatgg agaagggatg ggagcttgcc ttgctgcctg
     1441 ccacggggga gaagaggaca catctagggt gagggagtta tggagagaga agcaggcaga
     1501 taaatcggag tggggattgg tcagggctgc ccccagtccc cagttcccaa ggcccctctc
     1561 tctgcaagtg ttacacatta aacaggattt tacagtaaat gaaaaaaaaa aaa
//
