LOCUS       NM_001001496            2017 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus gap junction protein, alpha 6 (Gja6), mRNA.
ACCESSION   NM_001001496
VERSION     NM_001001496.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2017)
  AUTHORS   Ito,A., Ichiyanagi,N., Ikeda,Y., Hagiyama,M., Inoue,T.,
            Kimura,K.B., Sakurai,M.A., Hamaguchi,K. and Murakami,Y.
  TITLE     Adhesion molecule CADM1 contributes to gap junctional communication
            among pancreatic islet alpha-cells and prevents their excessive
            secretion of glucagon
  JOURNAL   Islets 4 (1), 49-55 (2012)
   PUBMED   22513384
REFERENCE   2  (bases 1 to 2017)
  AUTHORS   Carette,D., Gilleron,J., Segretain,D. and Pointis,G.
  TITLE     Heteromeric connexin 43/connexin 33 complex endocytosis: a connexin
            phosphorylation independent mechanism
  JOURNAL   Biochimie 92 (5), 555-559 (2010)
   PUBMED   20152878
  REMARK    GeneRIF: findings demonstrate that the interaction of Cx33 with
            Cx43 within a same heteromeric complex may conduce to channel
            instability through alteration of the phosphorylation status of
            Cx43 independently of the control of the c-Src kinase
REFERENCE   3  (bases 1 to 2017)
  AUTHORS   von Maltzahn,J., Euwens,C., Willecke,K. and Sohl,G.
  TITLE     The novel mouse connexin39 gene is expressed in developing striated
            muscle fibers
  JOURNAL   J Cell Sci 117 (Pt 22), 5381-5392 (2004)
   PUBMED   15466892
REFERENCE   4  (bases 1 to 2017)
  AUTHORS   Sohl,G. and Willecke,K.
  TITLE     An update on connexin genes and their nomenclature in mouse and man
  JOURNAL   Cell Commun Adhes 10 (4-6), 173-180 (2003)
   PUBMED   14681012
  REMARK    Review article
REFERENCE   5  (bases 1 to 2017)
  AUTHORS   Coppen,S.R., Severs,N.J. and Gourdie,R.G.
  TITLE     Connexin45 (alpha 6) expression delineates an extended conduction
            system in the embryonic and mature rodent heart
  JOURNAL   Dev Genet 24 (1-2), 82-90 (1999)
   PUBMED   10079513
REFERENCE   6  (bases 1 to 2017)
  AUTHORS   Li,X., Zimmerman,A., Copeland,N.G., Gilbert,D.J., Jenkins,N.A. and
            Yin,H.L.
  TITLE     The mouse thymosin beta 4 gene: structure, promoter identification,
            and chromosome localization
  JOURNAL   Genomics 32 (3), 388-394 (1996)
   PUBMED   8838802
REFERENCE   7  (bases 1 to 2017)
  AUTHORS   Du,L., Desbarats,M., Cornibert,S., Malo,D. and Ecarot,B.
  TITLE     Fine genetic mapping of the Hyp mutation on mouse chromosome X
  JOURNAL   Genomics 32 (2), 177-183 (1996)
   PUBMED   8833143
REFERENCE   8  (bases 1 to 2017)
  AUTHORS   Zhou,E., Favor,J., Silvers,W. and Stambolian,D.
  TITLE     Exclusion of three candidate genes, Grpr, Cxn33, and Pdha1, for the
            X-linked cataract gene on the distal region of the mouse chromosome
            X
  JOURNAL   Mamm Genome 6 (5), 357-359 (1995)
   PUBMED   7626887
REFERENCE   9  (bases 1 to 2017)
  AUTHORS   Schwarz,H.J., Chang,Y.S., Lalley,P.A. and Willecke,K.
  TITLE     Chromosomal assignments of mouse genes for connexin 50 and connexin
            33 by somatic cell hybridization
  JOURNAL   Somat Cell Mol Genet 20 (3), 243-247 (1994)
   PUBMED   7940024
REFERENCE   10 (bases 1 to 2017)
  AUTHORS   Haefliger,J.A., Bruzzone,R., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Paul,D.L.
  TITLE     Four novel members of the connexin family of gap junction proteins.
            Molecular cloning, expression, and chromosome mapping
  JOURNAL   J Biol Chem 267 (3), 2057-2064 (1992)
   PUBMED   1370487
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK146838.1 and AK040693.1.
            
            On Dec 12, 2009 this sequence version replaced NM_001001496.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK146838.1, BC117760.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849379, SAMN00849384
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1735              AK146838.1         1-1735
            1736-2017           AK040693.1         1695-1976
FEATURES             Location/Qualifiers
     source          1..2017
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="X"
                     /map="X 73.95 cM"
     gene            1..2017
                     /gene="Gja6"
                     /gene_synonym="A530015O12Rik; Cnx33; Cx33; Cxnk2; Gja-6"
                     /note="gap junction protein, alpha 6"
                     /db_xref="GeneID:414089"
                     /db_xref="MGI:MGI:95717"
     exon            1..142
                     /gene="Gja6"
                     /gene_synonym="A530015O12Rik; Cnx33; Cx33; Cxnk2; Gja-6"
                     /inference="alignment:Splign:2.1.0"
     exon            143..2017
                     /gene="Gja6"
                     /gene_synonym="A530015O12Rik; Cnx33; Cx33; Cxnk2; Gja-6"
                     /inference="alignment:Splign:2.1.0"
     CDS             199..1050
                     /gene="Gja6"
                     /gene_synonym="A530015O12Rik; Cnx33; Cx33; Cxnk2; Gja-6"
                     /note="gap junction membrane channel protein alpha 6;
                     connexin-33; connexin k2"
                     /codon_start=1
                     /product="gap junction alpha-6 protein"
                     /protein_id="NP_001001496.1"
                     /db_xref="CCDS:CCDS30506.1"
                     /db_xref="GeneID:414089"
                     /db_xref="MGI:MGI:95717"
                     /translation="MSDWSALHQLLEKVQPYSTAGGKVWIKVLFIFRILLLGTAIESA
                     WSDEQFEFHCNTQQPGCENVCYDHAFPISHVRLWVLQVIFVSVPILLYLAHVYYVVRQ
                     NKKLNKQEEELEAAHFNEASVERHLETIAGEQFKCGSEEQSKVKMRGRLLLTYMASIF
                     FKSVFEMAFLLIQWYIYGFTLSALYICEQSPCPRRVDCFLSRPTEKTIFILFMFVVSV
                     VSFVLDIIELFYVLFKAIKNRMRKAEDEVYCDELPCPSHVSSSTVLTTIDSSEQAVPV
                     ELSSVCI"
     regulatory      1998..2003
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gja6"
                     /gene_synonym="A530015O12Rik; Cnx33; Cx33; Cxnk2; Gja-6"
                     /note="hexamer: AATAAA"
     polyA_site      2017
                     /gene="Gja6"
                     /gene_synonym="A530015O12Rik; Cnx33; Cx33; Cxnk2; Gja-6"
                     /note="major polyA site"
ORIGIN      
        1 ggatttcaga tttccggagg ccaagctgca agagtaggag ggtctcttct ccttggagcg
       61 ctcttccaca agctggtctc acttagcact tggcagattt attttcattg ctaatatttt
      121 actctagtgc cttctgcctc aggtgtgcac tcacttgggg tgcccacctt ttaagtgcaa
      181 gaacagcgaa caggcaacat gagtgattgg agtgccttac accagctcct agaaaaggtt
      241 caaccctact ccacagctgg aggaaaggta tggatcaagg ttcttttcat tttccgcatc
      301 ctgctcctgg gcactgctat cgagtcggct tggagtgacg agcagtttga gttccattgc
      361 aacactcagc agcctggttg tgaaaatgtc tgctatgacc atgccttccc aatctctcac
      421 gtgcgcctct gggtcctcca ggtcattttc gtatctgtgc ctattctctt atacctggca
      481 catgtgtact atgtggttcg acagaataag aagttgaaca agcaagagga agaactggaa
      541 gctgctcatt ttaatgaggc cagcgtggaa aggcacttgg agacaattgc aggagagcag
      601 ttcaagtgtg gcagtgaaga acagagtaag gtgaaaatga gaggcagatt gctgctaacc
      661 tacatggcca gcatcttctt caagtctgtc ttcgagatgg ccttcctcct gatccagtgg
      721 tacatttatg gatttactct gagtgccctt tacatctgtg agcagtctcc ttgcccacgt
      781 cgggtggact gcttcctctc tcgccccacc gagaaaacca tcttcatcct cttcatgttt
      841 gtggtgtcag tggtgtcttt tgtcttggat atcattgagc tgttctatgt cttatttaag
      901 gctattaaga atcgtatgag aaaagcggag gatgaggttt actgtgatga gctaccatgc
      961 ccttcccatg tctcttcatc aactgttctc accaccatag attctagtga gcaggcggtt
     1021 ccagtggaac tttcttcagt ttgtatttaa agtgaacaga accatgtcag ttacaatgcg
     1081 tggtcaaaag ggggagggca ggcaggaagt atcctttctg gcttatactc agcattcccc
     1141 ccccccactg tgatgataaa cagaattctc agagggtttt aggtagaaaa gcaaagcaaa
     1201 gatagtggac attaacattg tagagcaatc taacagtagc catgactgta cttaaacagc
     1261 agcttcataa cctagacatt gtgacttgtg cttgaaagca ttgtgaaagc aaattatctt
     1321 ttcccctaaa atatatcttc caatttattg aataatacat aatagttttg ttaattgcga
     1381 tgagttttat ttttctctta tatactatag cagtaatcct attgctatgt attttttgta
     1441 atcctcttgc tatgtagaca atgtattttc cttctccaag gtagatgtat atttaactaa
     1501 atcaattgta ctgaaaacag cacttgggaa cactatacac ttaaagaagt gcttagaggt
     1561 aaactatgaa atgtgcctac atgaacttgg caataatagg cattcttggc tttgttctat
     1621 gtaatgcata ttaattcaga tcttacattc tgcagtgagt tttacagtct tatgggatga
     1681 ctggcatttt tcatgttcat aattaagatt ttatttggag agcagaagaa ggtgaagggg
     1741 gttgcctaat tcctgtgtaa ttgacctgaa acatatacac gaaaaggtac ccatttcttc
     1801 taatgccttt aaaaatattc cacaggtgat tgaaagtgct gagctgcaga cttttcactc
     1861 ttgcatgaca gctccacata ccattttata caagaaatat taatttgttt accatgtgat
     1921 gttaagttac tgttatgttc tgcttcattt cacgcaatgc aggcttaata tatcttgttc
     1981 tagagaattc tttattcaat aaagcctttt gagagtg
//
