LOCUS       NM_008120               1686 bp    mRNA    linear   ROD 11-FEB-2025
DEFINITION  Mus musculus gap junction protein, alpha 4 (Gja4), mRNA.
ACCESSION   NM_008120
VERSION     NM_008120.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1686)
  AUTHORS   Skelin,L., Racetin,A., Kelam,N., Ogorevc,M., Znaor,L.,
            Saraga-Babic,M., Filipovic,N., Katsuyama,Y., Pogorelic,Z. and
            Vukojevic,K.
  TITLE     Connexin Expression Is Altered in the Eye Development of Yotari
            Mice: A Preliminary Study
  JOURNAL   Biomolecules 14 (9), 1174 (2024)
   PUBMED   39334940
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1686)
  AUTHORS   Chen,J., Zhang,X., DeLaughter,D.M., Trembley,M.A., Saifee,S.,
            Xiao,F., Chen,J., Zhou,P., Seidman,C.E., Seidman,J.G. and Pu,W.T.
  TITLE     Molecular and Spatial Signatures of Mouse Embryonic Endothelial
            Cells at Single-Cell Resolution
  JOURNAL   Circ Res 134 (5), 529-546 (2024)
   PUBMED   38348657
REFERENCE   3  (bases 1 to 1686)
  AUTHORS   Huo,R., Yang,Y., Xu,H., Zhao,S., Song,D., Weng,J., Ma,R., Sun,Y.,
            Wang,J., Jiao,Y., Zhang,J., He,Q., Wu,R., Wang,S., Zhao,J.Z.,
            Zhang,J., Wang,J. and Cao,Y.
  TITLE     Somatic GJA4 mutation in intracranial extra-axial cavernous
            hemangiomas
  JOURNAL   Stroke Vasc Neurol 8 (6), 453-462 (2023)
   PUBMED   37072338
  REMARK    GeneRIF: Somatic GJA4 mutation in intracranial extra-axial
            cavernous hemangiomas.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1686)
  AUTHORS   Chiang,I.K., Humphrey,D., Mills,R.J., Kaltzis,P., Pachauri,S.,
            Graus,M., Saha,D., Wu,Z., Young,P., Sim,C.B., Davidson,T.,
            Hernandez-Garcia,A., Shaw,C.A., Renwick,A., Scott,D.A.,
            Porrello,E.R., Wong,E.S., Hudson,J.E., Red-Horse,K., Del
            Monte-Nieto,G. and Francois,M.
  TITLE     Sox7-positive endothelial progenitors establish coronary arteries
            and govern ventricular compaction
  JOURNAL   EMBO Rep 24 (10), e55043 (2023)
   PUBMED   37551717
REFERENCE   5  (bases 1 to 1686)
  AUTHORS   Acharya,B.R., Fang,J.S., Jeffery,E.D., Chavkin,N.W., Genet,G.,
            Vasavada,H., Nelson,E.A., Sheynkman,G.M., Humphries,M.J. and
            Hirschi,K.K.
  TITLE     Connexin 37 sequestering of activated-ERK in the cytoplasm promotes
            p27-mediated endothelial cell cycle arrest
  JOURNAL   Life Sci Alliance 6 (8), e202201685 (2023)
   PUBMED   37197981
  REMARK    GeneRIF: Connexin 37 sequestering of activated-ERK in the cytoplasm
            promotes p27-mediated endothelial cell cycle arrest.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1686)
  AUTHORS   Mandelboim,O., Berke,G., Fridkin,M., Feldman,M., Eisenstein,M. and
            Eisenbach,L.
  TITLE     CTL induction by a tumour-associated antigen octapeptide derived
            from a murine lung carcinoma
  JOURNAL   Nature 369 (6475), 67-71 (1994)
   PUBMED   8164742
  REMARK    Erratum:[Nature. 1997 Dec 11;390(6660):643. doi: 10.1038/37678..
            PMID: 9767009]
REFERENCE   7  (bases 1 to 1686)
  AUTHORS   Schwarz,H.J., Chang,Y.S., Hennemann,H., Dahl,E., Lalley,P.A. and
            Willecke,K.
  TITLE     Chromosomal assignments of mouse connexin genes, coding for gap
            junctional proteins, by somatic cell hybridization
  JOURNAL   Somat Cell Mol Genet 18 (4), 351-359 (1992)
   PUBMED   1332196
REFERENCE   8  (bases 1 to 1686)
  AUTHORS   Haefliger,J.A., Bruzzone,R., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Paul,D.L.
  TITLE     Four novel members of the connexin family of gap junction proteins.
            Molecular cloning, expression, and chromosome mapping
  JOURNAL   J Biol Chem 267 (3), 2057-2064 (1992)
   PUBMED   1370487
REFERENCE   9  (bases 1 to 1686)
  AUTHORS   Willecke,K., Heynkes,R., Dahl,E., Stutenkemper,R., Hennemann,H.,
            Jungbluth,S., Suchyna,T. and Nicholson,B.J.
  TITLE     Mouse connexin37: cloning and functional expression of a gap
            junction gene highly expressed in lung
  JOURNAL   J Cell Biol 114 (5), 1049-1057 (1991)
   PUBMED   1651942
REFERENCE   10 (bases 1 to 1686)
  AUTHORS   Willecke,K., Jungbluth,S., Dahl,E., Hennemann,H., Heynkes,R. and
            Grzeschik,K.H.
  TITLE     Six genes of the human connexin gene family coding for gap
            junctional proteins are assigned to four different human
            chromosomes
  JOURNAL   Eur J Cell Biol 53 (2), 275-280 (1990)
   PUBMED   1964417
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK143024.1 and AL626768.21.
            
            On Oct 27, 2012 this sequence version replaced NM_008120.2.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK143024.1, BC056613.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849387, SAMN01164142
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1681              AK143024.1         4-1684
            1682-1686           AL626768.21        70342-70346         c
FEATURES             Location/Qualifiers
     source          1..1686
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="4"
                     /map="4 61.47 cM"
     gene            1..1686
                     /gene="Gja4"
                     /gene_synonym="Cnx37; Cx37; Cxnh1; Gja-4"
                     /note="gap junction protein, alpha 4"
                     /db_xref="GeneID:14612"
                     /db_xref="MGI:MGI:95715"
     exon            1..120
                     /gene="Gja4"
                     /gene_synonym="Cnx37; Cx37; Cxnh1; Gja-4"
                     /inference="alignment:Splign:2.1.0"
     exon            121..1686
                     /gene="Gja4"
                     /gene_synonym="Cnx37; Cx37; Cxnh1; Gja-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             138..1139
                     /gene="Gja4"
                     /gene_synonym="Cnx37; Cx37; Cxnh1; Gja-4"
                     /note="connexin-37; connexin h1; gap junction membrane
                     channel protein alpha 4"
                     /codon_start=1
                     /product="gap junction alpha-4 protein"
                     /protein_id="NP_032146.1"
                     /db_xref="CCDS:CCDS18667.1"
                     /db_xref="GeneID:14612"
                     /db_xref="MGI:MGI:95715"
                     /translation="MGDWGFLEKLLDQVQEHSTVVGKIWLTVLFIFRILILGLAGESV
                     WGDEQSDFECNTAQPGCTNVCYDQAFPISHIRYWVLQFLFVSTPTLIYLGHVIYLSRR
                     EERLRQKEGELRALPSKDLHVERALAAIEHQMAKISVAEDGRLRIRGALMGTYVVSVL
                     CKSVLEAGFLYGQWRLYGWTMEPVFVCQRAPCPHIVDCYVSRPTEKTIFIIFMLVVGV
                     ISLVLNLLELVHLLCRCVSREIKARRDHDARPAQGSASDPYPEQVFFYLPMGEGPSSP
                     PCPTYNGLSSTEQNWANLTTEERLTSSRPPPFVNTAPQGGRKSPSRPNSSASKKQYV"
     regulatory      1664..1669
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gja4"
                     /gene_synonym="Cnx37; Cx37; Cxnh1; Gja-4"
                     /note="hexamer: AATAAA"
     polyA_site      1685
                     /gene="Gja4"
                     /gene_synonym="Cnx37; Cx37; Cxnh1; Gja-4"
                     /note="major polyA site"
ORIGIN      
        1 aaacccgcag ctgcgcgcta tttaaggcgt cctgcgggag gcgcggtcct gcaggattcc
       61 cgcaggcgca gcttcggcca cggtcgtccc ctctacctgg gccagccggg caagcaggcg
      121 agagaggccc tggaaacatg ggcgactggg gcttcctgga gaagttgcta gaccaggtcc
      181 aggaacactc gaccgtggtg ggcaagatct ggttaacggt gctcttcatc ttccgcatcc
      241 tcatcctggg gctggctggc gagtcggtgt ggggcgacga gcagtctgat tttgagtgta
      301 acacagccca gccgggctgc accaacgtct gctatgacca ggccttcccc atctcccaca
      361 tccgatactg ggtgctgcag ttcctcttcg tcagcacacc caccctgatc tacctgggcc
      421 acgtcatcta cctgtctcgg cgggaagagc ggttgcggca gaaagaggga gagctccggg
      481 cgctgccatc caaggaccta catgtagagc gggcactggc tgccatcgaa catcagatgg
      541 ccaagatctc ggtggcagag gacggtcgtc ttcggattcg tggggcgctc atgggtacct
      601 atgtggtcag cgtgctgtgt aagagtgtgc tggaggcagg cttcctctat ggccagtggc
      661 gcctctatgg ctggaccatg gagccggtgt ttgtgtgcca gcgtgcgccc tgcccccaca
      721 tcgtggactg ctatgtctct cgacccactg agaagactat cttcatcatc ttcatgctgg
      781 tggtaggagt catctccctg gtgctcaacc tgctggagct ggttcacctg ctgtgtcggt
      841 gtgtcagccg ggagataaag gcacgaaggg accacgacgc ccgcccggcc cagggcagtg
      901 cctcagaccc ttaccctgaa caggttttct tctacctccc catgggcgag ggaccctctt
      961 ccccaccgtg tcccacctac aacgggctct catccactga gcagaactgg gccaacttga
     1021 ccacagagga gagactgacc tcttccagac ctcccccatt tgtaaacaca gctccccagg
     1081 gtggccgaaa gtcccctagc cgccccaaca gctctgcatc caagaagcag tatgtgtagg
     1141 gatctggggc taatgtcact caacagagct gccccgagga gcacgcacgt gtaccttggc
     1201 tgcctctctg gcggtccact cctcaaaggc acctcagaga caactgggcc agggaggtgg
     1261 acattcgctg ggcagaggac ctggtcacag atggttctgg aatacctgga gcctttgtga
     1321 tgaccagagg acactggctg cttaccagaa tgtgacacta cccagactgg gtcacagcag
     1381 gtgggagtgc tcttgactaa gtgttctgtg aaccctcgat ccttttcacc tgttgctgag
     1441 ggacccagcg ccaagttgac tttcgagcct cccctattag acgagtcact gaaccctggg
     1501 ttttcatcac accccacttc tcctgggaaa aagcactgat gcaggctgct ggctcagcct
     1561 cgtcacctgg acagacacag cctgcgccgg agctggccct tgccagggga actggttgat
     1621 gtcttgtttt tctcacttct agttccactg tttatgatcc tcaaataaac aggactccat
     1681 cataag
//
