LOCUS       NM_001271623            2668 bp    mRNA    linear   ROD 05-AUG-2024
DEFINITION  Mus musculus gap junction protein, alpha 3 (Gja3), transcript
            variant 2, mRNA.
ACCESSION   NM_001271623
VERSION     NM_001271623.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2668)
  AUTHORS   Pineros,J., Zhu,X., Ding,B. and Frisina,R.D.
  TITLE     Connexins 30 and 43 expression changes in relation to age-related
            hearing loss
  JOURNAL   Hear Res 444, 108971 (2024)
   PUBMED   38359484
  REMARK    GeneRIF: Connexins 30 and 43 expression changes in relation to
            age-related hearing loss.
REFERENCE   2  (bases 1 to 2668)
  AUTHORS   Sun,Q., Li,J., Ma,J., Zheng,Y., Ju,R., Li,X., Ren,X., Huang,L.,
            Chen,R., Tan,X. and Luo,L.
  TITLE     JAM-C Is Important for Lens Epithelial Cell Proliferation and Lens
            Fiber Maturation in Murine Lens Development
  JOURNAL   Invest Ophthalmol Vis Sci 64 (15), 15 (2023)
   PUBMED   38095908
REFERENCE   3  (bases 1 to 2668)
  AUTHORS   Zhou,Y., Bennett,T.M., White,T.W. and Shiels,A.
  TITLE     Charged multivesicular body protein 4b forms complexes with gap
            junction proteins during lens fiber cell differentiation
  JOURNAL   FASEB J 37 (4), e22801 (2023)
   PUBMED   36880430
REFERENCE   4  (bases 1 to 2668)
  AUTHORS   Jara,O., Minogue,P.J., Berthoud,V.M. and Beyer,E.C.
  TITLE     Levels and Modifications of Both Lens Fiber Cell Connexins Are
            Affected in Connexin Mutant Mice
  JOURNAL   Cells 11 (18), 2786 (2022)
   PUBMED   36139360
  REMARK    GeneRIF: Levels and Modifications of Both Lens Fiber Cell Connexins
            Are Affected in Connexin Mutant Mice.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2668)
  AUTHORS   Li,Y., Parkinson,D.Y., Feng,J., Xia,C.H. and Gong,X.
  TITLE     Quantitative X-ray tomographic analysis reveals calcium
            precipitation in cataractogenesis
  JOURNAL   Sci Rep 11 (1), 17401 (2021)
   PUBMED   34465795
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2668)
  AUTHORS   Anderson,C.L., Zundel,M.A. and Werner,R.
  TITLE     Variable promoter usage and alternative splicing in five mouse
            connexin genes
  JOURNAL   Genomics 85 (2), 238-244 (2005)
   PUBMED   15676282
REFERENCE   7  (bases 1 to 2668)
  AUTHORS   Wang,Y., Macke,J.P., Abella,B.S., Andreasson,K., Worley,P.,
            Gilbert,D.J., Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A large family of putative transmembrane receptors homologous to
            the product of the Drosophila tissue polarity gene frizzled
  JOURNAL   J Biol Chem 271 (8), 4468-4476 (1996)
   PUBMED   8626800
REFERENCE   8  (bases 1 to 2668)
  AUTHORS   Schwarz,H.J., Chang,Y.S., Hennemann,H., Dahl,E., Lalley,P.A. and
            Willecke,K.
  TITLE     Chromosomal assignments of mouse connexin genes, coding for gap
            junctional proteins, by somatic cell hybridization
  JOURNAL   Somat Cell Mol Genet 18 (4), 351-359 (1992)
   PUBMED   1332196
REFERENCE   9  (bases 1 to 2668)
  AUTHORS   Haefliger,J.A., Bruzzone,R., Jenkins,N.A., Gilbert,D.J.,
            Copeland,N.G. and Paul,D.L.
  TITLE     Four novel members of the connexin family of gap junction proteins.
            Molecular cloning, expression, and chromosome mapping
  JOURNAL   J Biol Chem 267 (3), 2057-2064 (1992)
   PUBMED   1370487
REFERENCE   10 (bases 1 to 2668)
  AUTHORS   Hsieh,C.L., Kumar,N.M., Gilula,N.B. and Francke,U.
  TITLE     Distribution of genes for gap junction membrane channel proteins on
            human and mouse chromosomes
  JOURNAL   Somat Cell Mol Genet 17 (2), 191-200 (1991)
   PUBMED   1849321
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC119952.12, BQ554641.1, BC138492.1, AK136383.1 and BM125285.1.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: FO719742.1, CX730292.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849383, SAMN00849385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-18                AC119952.12        119411-119428
            19-532              BQ554641.1         6-519
            533-1531            BC138492.1         561-1559
            1532-2597           AK136383.1         374-1439
            2598-2668           BM125285.1         1-71                c
FEATURES             Location/Qualifiers
     source          1..2668
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="14"
                     /map="14 29.82 cM"
     gene            1..2668
                     /gene="Gja3"
                     /gene_synonym="Cnx46; Cx43; Cx46; Cxnj1; Gja-3"
                     /note="gap junction protein, alpha 3"
                     /db_xref="GeneID:14611"
                     /db_xref="MGI:MGI:95714"
     exon            1..197
                     /gene="Gja3"
                     /gene_synonym="Cnx46; Cx43; Cx46; Cxnj1; Gja-3"
                     /inference="alignment:Splign:2.1.0"
     exon            198..2668
                     /gene="Gja3"
                     /gene_synonym="Cnx46; Cx43; Cx46; Cxnj1; Gja-3"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..1468
                     /gene="Gja3"
                     /gene_synonym="Cnx46; Cx43; Cx46; Cxnj1; Gja-3"
                     /note="connexin j1; connexin-46; gap junction membrane
                     channel protein alpha 3; alpha 3 connexin"
                     /codon_start=1
                     /product="gap junction alpha-3 protein"
                     /protein_id="NP_001258552.1"
                     /db_xref="CCDS:CCDS27152.1"
                     /db_xref="GeneID:14611"
                     /db_xref="MGI:MGI:95714"
                     /translation="MGDWSFLGRLLENAQEHSTVIGKVWLTVLFIFRILVLGAAAEEV
                     WGDEQSDFTCNTQQPGCENVCYDRAFPISHIRFWALQIIFVSTPTLIYLGHVLHIVRM
                     EEKKKEREEELLRRDNPQHGRGREPMRTGSPRDPPLRDDRGKVRIAGALLRTYVFNII
                     FKTLFEVGFIAGQYFLYGFQLQPLYRCDRWPCPNTVDCFISRPTEKTIFVIFMLAVAC
                     ASLVLNMLEIYHLGWKKLKQGVTNHFNPDASEARHKPLDPLPTATSSGPPSVSIGFPP
                     YYTHPACPTVQAKAIGFPGAPLSPADFTVVTLNDAQGRNHPVKHCNGHHLTTEQNWTR
                     QVAEQQTPASKPSSAASSPDGRKGLIDSSGSSLQESALVVTPEEGEQALATTVEMHSP
                     PLVLLDPGRSSKSSNGRARPGDLAI"
     regulatory      2578..2583
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gja3"
                     /gene_synonym="Cnx46; Cx43; Cx46; Cxnj1; Gja-3"
                     /note="hexamer: AATAAA"
     polyA_site      2601
                     /gene="Gja3"
                     /gene_synonym="Cnx46; Cx43; Cx46; Cxnj1; Gja-3"
ORIGIN      
        1 acagggcagc ggcgtggggc gccaagtgcg gtgcgtaccg cggtggtggg gatggcggcc
       61 ggggcggaga ggcccggccc tagcgcgggg cgctcgtggg aagaaggggc accgcacgag
      121 taaagaggga gcctccttta cagagcaggc cgagcccgac tgggcgagga gcgccggtgc
      181 cgccgcggcc gagcggggtt agctgttggg agcaatgggc gactggagct tcctggggcg
      241 gctgctggag aacgcacagg agcactctac agtcatcggc aaagtgtggc tgaccgtgct
      301 gttcatcttc cgcattctgg tgttaggggc ggcagccgag gaggtgtggg gcgacgagca
      361 atcggacttc acctgcaaca cacagcagcc aggctgtgag aacgtctgct acgaccgcgc
      421 tttccccatt tcgcacatcc gcttctgggc gctgcaaatc atcttcgtgt ctacgcccac
      481 cctcatctat ctgggccacg tgctacacat cgtgcgcatg gaggagaaga agaaagagcg
      541 ggaggaagag ctgctgagga gagacaaccc tcagcacggc cgtggtcgcg agccaatgcg
      601 tacagggagc ccgcgggacc ctccactacg cgatgaccgt ggcaaggtgc gcatcgcagg
      661 tgcgctgctg cggacctacg tcttcaacat catcttcaag acactcttcg aagtggggtt
      721 catcgcgggc cagtactttc tatacggctt ccagctgcag ccactttacc gctgcgaccg
      781 ctggccctgc cccaacactg tggactgttt catctccagg cccacagaga agaccatctt
      841 tgtcatcttc atgctggctg tggcctgtgc gtcactggta ctcaacatgc tggagattta
      901 ccacctgggc tggaagaagc tcaagcaggg agttactaac cacttcaacc cagatgcctc
      961 agaagccagg cacaagccct tggaccccct acccacggcc accagctctg gcccgcccag
     1021 cgtctccatc gggttcccac cttattacac acaccctgcc tgtcccacag tacaggcaaa
     1081 ggccataggg tttcctgggg ccccactatc accagcagac ttcacagtgg tgactctaaa
     1141 cgatgctcaa ggcagaaacc acccagtcaa acactgcaat ggccaccacc tgacgacaga
     1201 gcagaactgg accaggcaag tggcagagca gcagactcca gccagcaagc cctcttcagc
     1261 agcatccagc cctgatggcc gcaaggggct cattgacagc agtggcagca gcttacagga
     1321 gagtgccttg gtagtgacgc cagaggaggg ggaacaggct ttggccacca cagtggagat
     1381 gcactcgcca ccgttggtcc tcctggaccc aggaaggtcc agcaagtcca gcaacggacg
     1441 tgccagacca ggtgacttgg ccatctagcc atagtcattc cagatacctt tataaacctt
     1501 ctctttaccc cttagaaacc aaaaacactc aaaaagcatt tctaatcaac aggtagaaag
     1561 agagagagag aaaaaaacca aaacaaaaac ctgacagtgc tggattcccc tgagggaaac
     1621 actgagcaaa ctggatcagt ctggttttaa tgcttgctgt tcttgtcgct gtgggacagg
     1681 gtgggggtga ccccagtgtc tgagatcgag gtgggggcag agcaaggttg ttggctccca
     1741 gcagtgcttg ctcttgttcg gcctcctcca ctattctgtc atgatgaagc aacaggtgtt
     1801 agcagccctt cagtgggggg acaattcagt ttccattcct aagctctcca agcagcccag
     1861 agagtcacag aggcacttaa gctctatctc tgcttgagac ttttaactta gagttcaatt
     1921 tcattttggg atatttgcca aactgtacta aaaaaagact tggaatctat ctagtgtcgc
     1981 ttgagcttct ggaattgcat gtgaggtcca ggacatccaa ctgcaggctg caggacacag
     2041 cgacagagaa cagttgtcct ccagtgctgt ttccatggga caaggccaca ggcattcctg
     2101 gtagaggcag gtggagatgc agagaccctg gaaagccctt caacagagga ggaagatggt
     2161 ggtgtggcag gtattgccgt aggtgttcat ttatttcttt gatgatattt tgtgcttagc
     2221 ctggatggtg aaagtattta cccccctccc ccacatacac atattttgcc tttcattaaa
     2281 aaaaatagtg ccattaaaat gactactgat cagggagatg tttaattagt taagatttga
     2341 ctttccttta aaacaaatcc accttccatg tcagccaact aatcactatg aggatgtcta
     2401 ggtaaaaaat taaccactgt gagaatgtac gctagataaa acttggggta ggggattcac
     2461 atgcgtttta agtacttgaa gttttaaaag tttctgaatc ggaggttcac tactgttaca
     2521 aggaaaaatg tttatgcaga tgaatcattg atgacttaca cttaaaagaa agtacacaat
     2581 aaaacacttc aaactcccgg accttttatt tatttatttt tttgtgacta tttgctttct
     2641 aaagtgtaaa taaaattgtc ttgatttt
//
