LOCUS       NM_001004144            3670 bp    mRNA    linear   ROD 28-AUG-2024
DEFINITION  Mus musculus GIT ArfGAP 1 (Git1), transcript variant 1, mRNA.
ACCESSION   NM_001004144 XM_126291
VERSION     NM_001004144.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3670)
  AUTHORS   Liu,H., Yi,J., Zhang,C., Li,Y., Wang,Q., Wang,S., Dai,S., Zheng,Z.,
            Jiang,T., Gao,P., Xue,A., Huang,Z., Kong,F., Wang,Y., He,B.,
            Guo,X., Li,Q., Chen,J., Yin,G. and Zhao,S.
  TITLE     Macrophage GIT1 promotes oligodendrocyte precursor cell
            differentiation and remyelination after spinal cord injury
  JOURNAL   Glia 72 (9), 1674-1692 (2024)
   PUBMED   38899731
  REMARK    GeneRIF: Macrophage GIT1 promotes oligodendrocyte precursor cell
            differentiation and remyelination after spinal cord injury.
REFERENCE   2  (bases 1 to 3670)
  AUTHORS   Xu,T., Gao,P., Huang,Y., Wu,M., Yi,J., Zhou,Z., Zhao,X., Jiang,T.,
            Liu,H., Qin,T., Yang,Z., Wang,X., Bao,T., Chen,J., Zhao,S. and
            Yin,G.
  TITLE     Git1-PGK1 interaction achieves self-protection against spinal cord
            ischemia-reperfusion injury by modulating Keap1/Nrf2 signaling
  JOURNAL   Redox Biol 62, 102682 (2023)
   PUBMED   36963288
  REMARK    GeneRIF: Git1-PGK1 interaction achieves self-protection against
            spinal cord ischemia-reperfusion injury by modulating Keap1/Nrf2
            signaling.
REFERENCE   3  (bases 1 to 3670)
  AUTHORS   Schlienger,S., Yam,P.T., Balekoglu,N., Ducuing,H., Michaud,J.F.,
            Makihara,S., Kramer,D.K., Chen,B., Fasano,A., Berardelli,A.,
            Hamdan,F.F., Rouleau,G.A., Srour,M. and Charron,F.
  TITLE     Genetics of mirror movements identifies a multifunctional complex
            required for Netrin-1 guidance and lateralization of motor control
  JOURNAL   Sci Adv 9 (19), eadd5501 (2023)
   PUBMED   37172092
REFERENCE   4  (bases 1 to 3670)
  AUTHORS   Fass,D.M., Lewis,M.C., Ahmad,R., Szucs,M.J., Zhang,Q.,
            Fleishman,M., Wang,D., Kim,M.J., Biag,J., Carr,S.A., Scolnick,E.M.,
            Premont,R.T. and Haggarty,S.J.
  TITLE     Brain-specific deletion of GIT1 impairs cognition and alters
            phosphorylation of synaptic protein networks implicated in
            schizophrenia susceptibility
  JOURNAL   Mol Psychiatry 27 (8), 3272-3285 (2022)
   PUBMED   35505090
  REMARK    GeneRIF: Brain-specific deletion of GIT1 impairs cognition and
            alters phosphorylation of synaptic protein networks implicated in
            schizophrenia susceptibility.
REFERENCE   5  (bases 1 to 3670)
  AUTHORS   Nagahori,K., Kuramasu,M., Kawata,S., Yakura,T., Li,Z., Hirai,S.,
            Qu,N. and Itoh,M.
  TITLE     GIT1 is an untolerized autoantigen involved in immunologic
            disturbance of spermatogenesis
  JOURNAL   Histochem Cell Biol 157 (3), 309-319 (2022)
   PUBMED   35066604
  REMARK    GeneRIF: GIT1 is an untolerized autoantigen involved in immunologic
            disturbance of spermatogenesis.
REFERENCE   6  (bases 1 to 3670)
  AUTHORS   Angrand,P.O., Segura,I., Volkel,P., Ghidelli,S., Terry,R.,
            Brajenovic,M., Vintersten,K., Klein,R., Superti-Furga,G.,
            Drewes,G., Kuster,B., Bouwmeester,T. and Acker-Palmer,A.
  TITLE     Transgenic mouse proteomics identifies new 14-3-3-associated
            proteins involved in cytoskeletal rearrangements and cell signaling
  JOURNAL   Mol Cell Proteomics 5 (12), 2211-2227 (2006)
   PUBMED   16959763
REFERENCE   7  (bases 1 to 3670)
  AUTHORS   Yin,G., Zheng,Q., Yan,C. and Berk,B.C.
  TITLE     GIT1 is a scaffold for ERK1/2 activation in focal adhesions
  JOURNAL   J Biol Chem 280 (30), 27705-27712 (2005)
   PUBMED   15923189
  REMARK    GeneRIF: GIT1 has a role as a scaffold for ERK1/2 activation in
            focal adhesions
REFERENCE   8  (bases 1 to 3670)
  AUTHORS   Zhang,H., Webb,D.J., Asmussen,H., Niu,S. and Horwitz,A.F.
  TITLE     A GIT1/PIX/Rac/PAK signaling module regulates spine morphogenesis
            and synapse formation through MLC
  JOURNAL   J Neurosci 25 (13), 3379-3388 (2005)
   PUBMED   15800193
REFERENCE   9  (bases 1 to 3670)
  AUTHORS   Yin,G., Haendeler,J., Yan,C. and Berk,B.C.
  TITLE     GIT1 functions as a scaffold for MEK1-extracellular
            signal-regulated kinase 1 and 2 activation by angiotensin II and
            epidermal growth factor
  JOURNAL   Mol Cell Biol 24 (2), 875-885 (2004)
   PUBMED   14701758
  REMARK    GeneRIF: GIT1 serves as a scaffold protein to facilitate
            c-Src-dependent activation of MEK1-ERK1/2 in response to both G
            protein-coupled receptors and tyrosine kinase-coupled receptors
REFERENCE   10 (bases 1 to 3670)
  AUTHORS   Bagrodia,S., Bailey,D., Lenard,Z., Hart,M., Guan,J.L.,
            Premont,R.T., Taylor,S.J. and Cerione,R.A.
  TITLE     A tyrosine-phosphorylated protein that binds to an important
            regulatory region on the cool family of p21-activated
            kinase-binding proteins
  JOURNAL   J Biol Chem 274 (32), 22393-22400 (1999)
   PUBMED   10428811
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC079870.1.
            
            On Sep 9, 2004 this sequence version replaced XM_126291.6.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC079870.1, SRR7974084.22082.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..3670
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 46.61 cM"
     gene            1..3670
                     /gene="Git1"
                     /gene_synonym="Cat-1; p95Cat"
                     /note="GIT ArfGAP 1"
                     /db_xref="GeneID:216963"
                     /db_xref="MGI:MGI:1927140"
     exon            1..223
                     /gene="Git1"
                     /gene_synonym="Cat-1; p95Cat"
                     /inference="alignment:Splign:2.1.0"
     CDS             172..2484
                     /gene="Git1"
                     /gene_synonym="Cat-1; p95Cat"
                     /EC_number="3.6.5.2"
                     /note="isoform 1 is encoded by transcript variant 1; G
                     protein-coupled receptor kinase-associated ADP
                     ribosylation factor GTPase-activating protein; ARF
                     GTPase-activating protein GIT1; ARF GAP GIT1;
                     GRK-interacting protein 1; G protein-coupled receptor
                     kinase-interactor 1"
                     /codon_start=1
                     /product="ARF GTPase-activating protein GIT1 isoform 1"
                     /protein_id="NP_001004144.1"
                     /db_xref="CCDS:CCDS25080.1"
                     /db_xref="GeneID:216963"
                     /db_xref="MGI:MGI:1927140"
                     /translation="MSRKGPRAEVCADCSAPDPGWASISRGVLVCDECCSVHRSLGRH
                     ISIVKHLRHSAWPPTLLQMVHTLASNGANSIWEHSLLDPAQVQSGRRKANPQDKVHPI
                     KSEFIRAKYQMLAFVHKLPCRDDDGVTAKDLSKQLHSSVRTGNLETCLRLLSLGAQAN
                     FFHPEKGTTPLHVAAKAGQTLQAELLVVYGADPGSPDVNGRTPIDYARQAGHHELAER
                     LVECQYELTDRLAFYLCGRKPDHKNGHYIIPQMADRSRQKCMSQSLDLSELAKAAKKK
                     LQALSNRLFEELAMDVYDEVDRRENDAVWLATQNHSTLVTERSAVPFLPVNPEYSATR
                     NQGRQKLARFNAREFATLIIDILSEAKRRQQGKSLSSPTDNLELSARSQSELDDQHDY
                     DSVASDEDTDQEPLPSAGATRNNRARSMDSSDLSDGAVTLQEYLELKKALATSEAKVQ
                     QLMKVNSSLSDELRRLQREIHKLQAENLQLRQPPGPVPPPSLPSERAEHTLMGPGGST
                     HRRDRQAFSMYEPGSALKPFGGTPGDELATRLQPFHSTELEDDAIYSVHVPAGLYRIR
                     KGVSASSVPFTPSSPLLSCSQEGSRHASKLSRHGSGADSDYENTQSGDPLLGLEGKRF
                     LELSKEDELHPELESLDGDLDPGLPSTEDVILKTEQVTKNIQELLRAAQEFKHDSFVP
                     CSEKIHLAVTEMASLFPKRPALEPVRSSLRLLNASAYRLQSECRKTVPPEPGAPVDFQ
                     LLTQQVIQCAYDIAKAAKQLVTITTREKKQ"
     exon            224..357
                     /gene="Git1"
                     /gene_synonym="Cat-1; p95Cat"
                     /inference="alignment:Splign:2.1.0"
     exon            358..470
                     /gene="Git1"
                     /gene_synonym="Cat-1; p95Cat"
                     /inference="alignment:Splign:2.1.0"
     exon            471..576
                     /gene="Git1"
                     /gene_synonym="Cat-1; p95Cat"
                     /inference="alignment:Splign:2.1.0"
     exon            577..794
                     /gene="Git1"
                     /gene_synonym="Cat-1; p95Cat"
                     /inference="alignment:Splign:2.1.0"
     exon            795..889
                     /gene="Git1"
                     /gene_synonym="Cat-1; p95Cat"
                     /inference="alignment:Splign:2.1.0"
     exon            890..932
                     /gene="Git1"
                     /gene_synonym="Cat-1; p95Cat"
                     /inference="alignment:Splign:2.1.0"
     exon            933..959
                     /gene="Git1"
                     /gene_synonym="Cat-1; p95Cat"
                     /inference="alignment:Splign:2.1.0"
     exon            960..1008
                     /gene="Git1"
                     /gene_synonym="Cat-1; p95Cat"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1081
                     /gene="Git1"
                     /gene_synonym="Cat-1; p95Cat"
                     /inference="alignment:Splign:2.1.0"
     exon            1082..1179
                     /gene="Git1"
                     /gene_synonym="Cat-1; p95Cat"
                     /inference="alignment:Splign:2.1.0"
     exon            1180..1291
                     /gene="Git1"
                     /gene_synonym="Cat-1; p95Cat"
                     /inference="alignment:Splign:2.1.0"
     exon            1292..1425
                     /gene="Git1"
                     /gene_synonym="Cat-1; p95Cat"
                     /inference="alignment:Splign:2.1.0"
     exon            1426..1809
                     /gene="Git1"
                     /gene_synonym="Cat-1; p95Cat"
                     /inference="alignment:Splign:2.1.0"
     exon            1810..1863
                     /gene="Git1"
                     /gene_synonym="Cat-1; p95Cat"
                     /inference="alignment:Splign:2.1.0"
     exon            1864..1950
                     /gene="Git1"
                     /gene_synonym="Cat-1; p95Cat"
                     /inference="alignment:Splign:2.1.0"
     exon            1951..2024
                     /gene="Git1"
                     /gene_synonym="Cat-1; p95Cat"
                     /inference="alignment:Splign:2.1.0"
     exon            2025..2207
                     /gene="Git1"
                     /gene_synonym="Cat-1; p95Cat"
                     /inference="alignment:Splign:2.1.0"
     exon            2208..2271
                     /gene="Git1"
                     /gene_synonym="Cat-1; p95Cat"
                     /inference="alignment:Splign:2.1.0"
     exon            2272..3650
                     /gene="Git1"
                     /gene_synonym="Cat-1; p95Cat"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3625..3630
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Git1"
                     /gene_synonym="Cat-1; p95Cat"
                     /note="hexamer: AATAAA"
     polyA_site      3647
                     /gene="Git1"
                     /gene_synonym="Cat-1; p95Cat"
                     /note="major polyA site"
ORIGIN      
        1 gcacggcggg ttccgggcca gccccggggg cggacggttg gccgcgcgcg cggagcctcg
       61 ccggggcctt gcgggagccg ggccgggccg cagggccgcc gccgccgccc gggcccgccg
      121 cccgcgcccc ccacgctggc ccagagggct gcggccgcgt cgccgctgag gatgtcccgg
      181 aaggggccgc gagcggaggt gtgtgcggac tgcagcgctc cggaccctgg ctgggcatct
      241 atcagcagag gtgtgctggt ttgtgacgag tgctgcagtg tgcaccggag cctgggacga
      301 cacatctcca ttgtcaagca cctgcgccac agcgcctggc ctcctacgct gctccagatg
      361 gtgcacacgc ttgccagcaa cggggccaac tccatctggg agcactccct gctggaccct
      421 gcgcaagtgc aaagtggccg gcgcaaagcc aacccccaag ataaagtcca ccccatcaag
      481 tcagagttca tcagggcaaa gtaccagatg ctggcgttcg tgcacaagct tccctgccgt
      541 gatgatgatg gggtcaccgc caaagacctc agcaagcaac tgcactcaag tgtgcgaaca
      601 ggcaacttgg aaacatgtct gcgcctgctt tccttgggtg cccaggccaa cttttttcac
      661 ccagaaaagg gcactacacc tctacatgtg gctgccaagg cagggcagac actgcaggct
      721 gagctgctgg tagtgtatgg ggctgacccc gggtctcctg atgtcaatgg ccgcacaccc
      781 atcgactatg ccaggcaggc ggggcaccat gaactggcag aaaggctagt tgagtgccag
      841 tatgagctca ctgaccggtt ggccttctat ctctgtggac gaaagcctga tcacaagaat
      901 gggcattaca tcatcccaca gatggctgac agatctcggc aaaagtgcat gtctcagagc
      961 ttggatctgt ctgaattggc caaagctgcc aagaagaagc tgcaagcgct cagcaaccgg
     1021 ctttttgagg aacttgccat ggatgtgtat gatgaggtgg atcggagaga aaatgatgct
     1081 gtgtggctag ctacccaaaa tcatagcacc ctggtgacgg agcgcagtgc tgtgcccttc
     1141 ctgccagtca accctgaata ctcagccact cggaatcagg gacgacagaa attggcccgt
     1201 ttcaatgccc gagagtttgc caccttgatc atcgacattc tcagtgaggc caaacggagg
     1261 cagcagggca agagtctaag cagccccaca gacaaccttg agctgtctgc acggagccag
     1321 agcgagctgg atgaccagca cgactacgac agcgtggctt ccgacgaaga cacggaccag
     1381 gagcccttgc ccagtgcagg cgccacgcgg aacaaccgtg ccaggagcat ggactcctca
     1441 gatctgtcag atggggcagt gacactgcag gagtacctgg agctgaagaa ggctctggct
     1501 acctccgagg ccaaggtgca acagctcatg aaggtcaaca gcagcctgag tgacgagctg
     1561 cggcggctgc aaagggagat ccacaaattg caggcagaga acctgcagct tcggcagcca
     1621 cccggaccag tgcctccacc ctcacttccc agtgaacggg cagaacacac cctcatgggg
     1681 cctggtggaa gcacccaccg cagggaccgc caggccttct ctatgtatga gccaggctct
     1741 gcattgaagc cctttggagg tacacctggg gacgagctcg ccacccggct ccagcctttc
     1801 cacagcacgg agctcgaaga cgatgccatc tactcagtgc atgtccctgc cggcctttat
     1861 cggatccgga agggggtgtc tgcctcttct gtgcccttca ctccctcctc cccactgctg
     1921 tcgtgctccc aagaaggaag tcgccacgcg agcaagctct cacgccacgg cagtggtgcg
     1981 gacagtgact atgagaacac acagagtggg gaccctctgc ttgggcttga agggaagcga
     2041 ttcctagagc tgagcaagga ggatgagctg caccctgagc tggagagctt agatggagac
     2101 ctcgaccccg ggctccccag caccgaagac gtcatcctaa agacagagca ggtcaccaag
     2161 aacattcagg aactattgcg ggcagcccag gagttcaaac atgacagctt tgtaccctgt
     2221 tcagaaaaga tacatttggc tgtgactgag atggcttctc tcttcccaaa gaggccagcc
     2281 ctggagcctg tgcgcagttc actgcggctg ctcaacgcca gcgcctaccg gcttcagagc
     2341 gagtgccgga agacagtgcc tccagagccg ggcgcccctg tggacttcca gctgctgact
     2401 cagcaggtga tccagtgcgc ctatgacatc gccaaggctg ccaagcagct ggtcaccatc
     2461 accacccgag agaagaaaca gtgaccactt tccctgccct tacccacacc ctgggacctc
     2521 actggccatg ggagctgggc cactccagac actaacccac ccccaacaga gccactggca
     2581 caagtgccct tagtgccacc gttttcctct ggcatccagg tgccctggtg ccctcccctc
     2641 aagccccaag gacagaaatg tgaggtgaca ggagcctctg tctcccacat tccataccct
     2701 ccctctgtac atagcatccc tgccctgctg atgtgcagga gcctcaagga acccctccca
     2761 gctcttcacc tgccttccag gcgccctcag caaagggtgt ggggcaggga cactccagat
     2821 ggggcagctc cgcctactgc accctatccc catgagccag tttagccctg gggggccgag
     2881 caggggcacc ccctcctttg tacattatct ctggatgtct ctgtcctgta gccagcagcc
     2941 cccccttgct gctctttcat gccaaacggc ccctgcctag agcacaggcc ccaacttgtg
     3001 tgccagggtc cccagcagca aacactggaa agtcttttcc tctccctacc ccttaatttt
     3061 aactctgtgg taactgagtg tccctgcgtt cctgcaactg aggatgtgag cggcagtgcc
     3121 gttccagaga cctggcccac ctggagctct gaggagcagg ggaaccagag tagtggaacc
     3181 agcattggaa gtcagcccct ctccccccac ctgggacagg gagactgtca gggtcaccag
     3241 ctgtggtcca gttgctgccc ctacttgtat ccctgtccta taaacttaaa aggaaaacca
     3301 cttccctcca tctctccccg acccctatgg gaagtgtgct ggccaggcag aggacagcac
     3361 ctgcgcctgg ggctggctcc ccagggtccc caactcagct ggtggctgtg gaactgagcc
     3421 cctcccccta gcctctgcaa ggccagcacc cacatcacta cctgcaccta cagtgaccca
     3481 cccctgaagg cctggggatc tggctgcagc tgggaaggcc ggcaaggcac tgacagcacc
     3541 caccagctct tctccccaac caccttccct agcctgtggt ggtgggtagc tgtcagaacg
     3601 tgtgtcatgt acatttgtat caaaaataaa taagtgacca tgtgccactt aaaaaaaaaa
     3661 aaaaaaaaaa
//
