LOCUS       NM_001080815            1792 bp    mRNA    linear   ROD 07-OCT-2024
DEFINITION  Mus musculus gastric inhibitory polypeptide receptor (Gipr), mRNA.
ACCESSION   NM_001080815 XM_884678
VERSION     NM_001080815.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1792)
  AUTHORS   Akindehin,S., Liskiewicz,A., Liskiewicz,D., Bernecker,M.,
            Garcia-Caceres,C., Drucker,D.J., Finan,B., Grandl,G., Gutgesell,R.,
            Hofmann,S.M., Khalil,A., Liu,X., Cota,P., Bakhti,M., Czarnecki,O.,
            Bastidas-Ponce,A., Lickert,H., Kang,L., Maity,G., Novikoff,A.,
            Parlee,S., Pathak,E., Schriever,S.C., Sterr,M., Ussar,S., Zhang,Q.,
            DiMarchi,R., Tschop,M.H., Pfluger,P.T., Douros,J.D. and Muller,T.D.
  TITLE     Loss of GIPR in LEPR cells impairs glucose control by GIP and
            GIP:GLP-1 co-agonism without affecting body weight and food intake
            in mice
  JOURNAL   Mol Metab 83, 101915 (2024)
   PUBMED   38492844
  REMARK    GeneRIF: Loss of GIPR in LEPR cells impairs glucose control by GIP
            and GIP:GLP-1 co-agonism without affecting body weight and food
            intake in mice.
REFERENCE   2  (bases 1 to 1792)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 1792)
  AUTHORS   Furber,E.C., Hyatt,K., Collins,K., Yu,X., Droz,B.A., Holland,A.,
            Friedrich,J.L., Wojnicki,S., Konkol,D.L., O'Farrell,L.S.,
            Baker,H.E., Coskun,T., Scherer,P.E., Kusminski,C.M., Christe,M.E.,
            Sloop,K.W. and Samms,R.J.
  TITLE     GIPR Agonism Enhances TZD-Induced Insulin Sensitivity in Obese IR
            Mice
  JOURNAL   Diabetes 73 (2), 292-305 (2024)
   PUBMED   37934926
REFERENCE   4  (bases 1 to 1792)
  AUTHORS   Yammine,L., Picatoste,B., Abdullah,N., Leahey,R.A., Johnson,E.F.,
            Gomez-Banoy,N., Rosselot,C., Wen,J., Hossain,T., Goncalves,M.D.,
            Lo,J.C., Garcia-Ocana,A. and McGraw,T.E.
  TITLE     Spatiotemporal regulation of GIPR signaling impacts glucose
            homeostasis as revealed in studies of a common GIPR variant
  JOURNAL   Mol Metab 78, 101831 (2023)
   PUBMED   37925022
REFERENCE   5  (bases 1 to 1792)
  AUTHORS   Takahashi,Y., Fujita,H., Seino,Y., Hattori,S., Hidaka,S.,
            Miyakawa,T., Suzuki,A., Waki,H., Yabe,D., Seino,Y. and Yamada,Y.
  TITLE     Gastric inhibitory polypeptide receptor antagonism suppresses
            intramuscular adipose tissue accumulation and ameliorates
            sarcopenia
  JOURNAL   J Cachexia Sarcopenia Muscle 14 (6), 2703-2718 (2023)
   PUBMED   37897141
  REMARK    GeneRIF: Gastric inhibitory polypeptide receptor antagonism
            suppresses intramuscular adipose tissue accumulation and
            ameliorates sarcopenia.
REFERENCE   6  (bases 1 to 1792)
  AUTHORS   Pamir,N., Lynn,F.C., Buchan,A.M., Ehses,J., Hinke,S.A.,
            Pospisilik,J.A., Miyawaki,K., Yamada,Y., Seino,Y., McIntosh,C.H.
            and Pederson,R.A.
  TITLE     Glucose-dependent insulinotropic polypeptide receptor null mice
            exhibit compensatory changes in the enteroinsular axis
  JOURNAL   Am J Physiol Endocrinol Metab 284 (5), E931-E939 (2003)
   PUBMED   12540373
  REMARK    GeneRIF: GIPR(-/-) mice exhibit altered islet structure and
            topography and increased islet sensitivity to glucagon-like
            peptide-1 despite a decrease in pancreatic insulin content and gene
            expression
REFERENCE   7  (bases 1 to 1792)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   8  (bases 1 to 1792)
  AUTHORS   Miyawaki,K., Yamada,Y., Ban,N., Ihara,Y., Tsukiyama,K., Zhou,H.,
            Fujimoto,S., Oku,A., Tsuda,K., Toyokuni,S., Hiai,H., Mizunoya,W.,
            Fushiki,T., Holst,J.J., Makino,M., Tashita,A., Kobara,Y.,
            Tsubamoto,Y., Jinnouchi,T., Jomori,T. and Seino,Y.
  TITLE     Inhibition of gastric inhibitory polypeptide signaling prevents
            obesity
  JOURNAL   Nat Med 8 (7), 738-742 (2002)
   PUBMED   12068290
REFERENCE   9  (bases 1 to 1792)
  AUTHORS   Miyawaki,K., Yamada,Y., Yano,H., Niwa,H., Ban,N., Ihara,Y.,
            Kubota,A., Fujimoto,S., Kajikawa,M., Kuroe,A., Tsuda,K.,
            Hashimoto,H., Yamashita,T., Jomori,T., Tashiro,F., Miyazaki,J. and
            Seino,Y.
  TITLE     Glucose intolerance caused by a defect in the entero-insular axis:
            a study in gastric inhibitory polypeptide receptor knockout mice
  JOURNAL   Proc Natl Acad Sci U S A 96 (26), 14843-14847 (1999)
   PUBMED   10611300
REFERENCE   10 (bases 1 to 1792)
  AUTHORS   Gelling,R.W., Wheeler,M.B., Xue,J., Gyomorey,S., Nian,C.,
            Pederson,R.A. and McIntosh,C.H.
  TITLE     Localization of the domains involved in ligand binding and
            activation of the glucose-dependent insulinotropic polypeptide
            receptor
  JOURNAL   Endocrinology 138 (6), 2640-2643 (1997)
   PUBMED   9165060
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC145199.3.
            
            On Jan 28, 2007 this sequence version replaced XM_884678.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: single sample supports all introns SAMN01164139
                              [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-66                AC145199.3         43735-43800
            67-223              AC145199.3         44738-44894
            224-326             AC145199.3         45240-45342
            327-434             AC145199.3         45717-45824
            435-538             AC145199.3         46249-46352
            539-642             AC145199.3         46891-46994
            643-787             AC145199.3         47169-47313
            788-947             AC145199.3         49108-49267
            948-1008            AC145199.3         49471-49531
            1009-1078           AC145199.3         49832-49901
            1079-1167           AC145199.3         50028-50116
            1168-1306           AC145199.3         50209-50347
            1307-1348           AC145199.3         52175-52216
            1349-1792           AC145199.3         52294-52737
FEATURES             Location/Qualifiers
     source          1..1792
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="7"
                     /map="7 9.46 cM"
     gene            1..1792
                     /gene="Gipr"
                     /gene_synonym="GIP-R; Gm1081; Gm160"
                     /note="gastric inhibitory polypeptide receptor"
                     /db_xref="GeneID:381853"
                     /db_xref="MGI:MGI:1352753"
     exon            1..66
                     /gene="Gipr"
                     /gene_synonym="GIP-R; Gm1081; Gm160"
                     /inference="alignment:Splign:2.1.0"
     exon            67..223
                     /gene="Gipr"
                     /gene_synonym="GIP-R; Gm1081; Gm160"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1549
                     /gene="Gipr"
                     /gene_synonym="GIP-R; Gm1081; Gm160"
                     /note="glucose-dependent insulinotropic polypeptide
                     receptor"
                     /codon_start=1
                     /product="gastric inhibitory polypeptide receptor
                     precursor"
                     /protein_id="NP_001074284.1"
                     /db_xref="CCDS:CCDS39795.1"
                     /db_xref="GeneID:381853"
                     /db_xref="MGI:MGI:1352753"
                     /translation="MPLRLLLLLLWLWGLQWAETDSEGQTTTGELYQRWEHYGQECQK
                     MLETTEPPSGLACNGSFDMYACWNYTAANTTARVSCPWYLPWFRQVSAGFVFRQCGSD
                     GQWGSWRDHTQCENPEKNGAFQDQTLILERLQIMYTVGYSLSLTTLLLALLILSLFRR
                     LHCTRNYIHMNLFTSFMLRAAAILTRDQLLPPLGPYTGDQAPTPWNQALAACRTAQIM
                     TQYCVGANYTWLLVEGVYLHHLLVIVGRSEKGHFRCYLLLGWGAPALFVIPWVIVRYL
                     RENTQCWERNEVKAIWWIIRTPILITILINFLIFIRILGILVSKLRTRQMRCPDYRLR
                     LARSTLTLVPLLGVHEVVFAPVTEEQVEGSLRFAKLAFEIFLSSFQGFLVSVLYCFIN
                     KEVQSEIRQGWRHRRLRLSLQEQRPRPHQELAPRAVPLSSACREAAVGNALPSGMLHV
                     PGDEVLESYC"
     exon            224..326
                     /gene="Gipr"
                     /gene_synonym="GIP-R; Gm1081; Gm160"
                     /inference="alignment:Splign:2.1.0"
     exon            327..434
                     /gene="Gipr"
                     /gene_synonym="GIP-R; Gm1081; Gm160"
                     /inference="alignment:Splign:2.1.0"
     exon            435..538
                     /gene="Gipr"
                     /gene_synonym="GIP-R; Gm1081; Gm160"
                     /inference="alignment:Splign:2.1.0"
     exon            539..642
                     /gene="Gipr"
                     /gene_synonym="GIP-R; Gm1081; Gm160"
                     /inference="alignment:Splign:2.1.0"
     exon            643..787
                     /gene="Gipr"
                     /gene_synonym="GIP-R; Gm1081; Gm160"
                     /inference="alignment:Splign:2.1.0"
     exon            788..947
                     /gene="Gipr"
                     /gene_synonym="GIP-R; Gm1081; Gm160"
                     /inference="alignment:Splign:2.1.0"
     exon            948..1008
                     /gene="Gipr"
                     /gene_synonym="GIP-R; Gm1081; Gm160"
                     /inference="alignment:Splign:2.1.0"
     exon            1009..1078
                     /gene="Gipr"
                     /gene_synonym="GIP-R; Gm1081; Gm160"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1167
                     /gene="Gipr"
                     /gene_synonym="GIP-R; Gm1081; Gm160"
                     /inference="alignment:Splign:2.1.0"
     exon            1168..1306
                     /gene="Gipr"
                     /gene_synonym="GIP-R; Gm1081; Gm160"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1348
                     /gene="Gipr"
                     /gene_synonym="GIP-R; Gm1081; Gm160"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1792
                     /gene="Gipr"
                     /gene_synonym="GIP-R; Gm1081; Gm160"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1578
                     /gene="Gipr"
                     /gene_synonym="GIP-R; Gm1081; Gm160"
     regulatory      1654..1659
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gipr"
                     /gene_synonym="GIP-R; Gm1081; Gm160"
                     /note="hexamer: AACAAG"
     polyA_site      1672
                     /gene="Gipr"
                     /gene_synonym="GIP-R; Gm1081; Gm160"
                     /note="major polyA site"
ORIGIN      
        1 agagctctct ggcaggcgag gcagggcagc tgtgtcagtg gagattgcga acaggactcc
       61 gtgcaggtga gcactgactt ggactgaagc ccaagagttg gttctgcctt gggaccctcc
      121 agcccaactg cctccgagtg gccagagttt ccatcacctt tcaaggatgc ccctgcggtt
      181 gctgcttctg ctgctgtggt tgtggggact ccagtgggcg gagacagact ctgaggggca
      241 gaccaccacg ggggagctgt accagcgctg ggagcactac ggccaggagt gccaaaagat
      301 gttggagacc acagaacctc cctcaggcct ggcctgtaac ggttccttcg atatgtatgc
      361 ctgctggaac tacacggccg ccaacaccac tgctcgggtg tcttgcccct ggtatctgcc
      421 ctggttccgt caggtgtctg caggctttgt cttccgccag tgtggcagtg atggccagtg
      481 gggatcttgg agagaccaca ctcagtgtga gaatccagag aagaatgggg cttttcagga
      541 ccagacgctg atcctggagc gcctgcagat catgtatacc gtgggctact ccctgtccct
      601 gacgactctg ctgctagccc tactcatctt aagtttgttc aggcggctgc actgcactcg
      661 taattacatt cacatgaacc tgttcacgtc tttcatgctg cgggcagcag ccatcctcac
      721 ccgagatcag ctgctgcctc cactgggtcc ctacactgga gaccaggccc ctaccccgtg
      781 gaaccaggcc ctagctgcct gccgcacggc ccagatcatg acccaatatt gtgtgggagc
      841 caattacacc tggctactgg tggagggtgt ttatctgcac catctgctgg tgatcgtggg
      901 acgctcagaa aagggccact tccgctgcta cctgcttctt ggctgggggg cccccgcgct
      961 tttcgtcatt ccctgggtga tcgtcaggta cctgcgcgag aacacacagt gctgggagcg
     1021 caacgaagtc aaagccattt ggtggatcat tcgcactccc atcctaataa ccatcttgat
     1081 caatttcctc atcttcatcc gcatccttgg catccttgtt tcaaagctga ggacacggca
     1141 gatgcgctgc cccgactacc gactaaggct ggctcgctcc acgctgacac tggtgcccct
     1201 gctgggtgtc cacgaggtgg tgtttgcgcc tgtgacggag gaacaggttg aaggctccct
     1261 gcgcttcgcc aaactggcct ttgaaatctt cctaagttcc ttccagggtt tcctggtgag
     1321 cgtgctctac tgcttcatca acaaagaggt gcagtcggag atccgccagg gttggcgcca
     1381 ccgccgcctg cgtctcagtc ttcaagagca gcgtccacgt ccgcaccagg aactcgcccc
     1441 ccgggctgtg cctttgagct ctgcgtgccg agaagctgcc gttggcaacg ccttgccctc
     1501 tgggatgctg catgtgcctg gggatgaggt cttggaaagt tactgctagg taaagggacc
     1561 cccgtgtctg tacagttagc atgtattcag agcctactgt gtaccagccc caagtggagc
     1621 aatgctgggg aaatggaggc gaaggaaccg gaaaacaagg tccccacgtg tatatatttg
     1681 tggaggaatc gtttatgaaa agaattgagg tgtctaggac aatcaactgg aaggcaattg
     1741 ggatagacat gatgcttagg tcatgggtca tgtttgaaag aagtgactgg ag
//
