LOCUS       NM_148951               3568 bp    mRNA    linear   ROD 18-JUN-2024
DEFINITION  Mus musculus GIPC PDZ domain containing family, member 3 (Gipc3),
            transcript variant 3, mRNA.
ACCESSION   NM_148951
VERSION     NM_148951.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3568)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3568)
  AUTHORS   Roy,T.A., Bubier,J.A., Dickson,P.E., Wilcox,T.D., Ndukum,J.,
            Clark,J.W., Sukoff Rizzo,S.J., Crabbe,J.C., Denegre,J.M.,
            Svenson,K.L., Braun,R.E., Kumar,V., Murray,S.A., White,J.K.,
            Philip,V.M. and Chesler,E.J.
  TITLE     Discovery and validation of genes driving drug-intake and related
            behavioral traits in mice
  JOURNAL   Genes Brain Behav 23 (1), e12875 (2024)
   PUBMED   38164795
  REMARK    Publication Status: Available-Online prior to print
REFERENCE   3  (bases 1 to 3568)
  AUTHORS   Chatterjee,P., Morgan,C.P., Krey,J.F., Benson,C., Goldsmith,J.,
            Bateschell,M., Ricci,A.J. and Barr-Gillespie,P.G.
  TITLE     GIPC3 couples to MYO6 and PDZ domain proteins, and shapes the hair
            cell apical region
  JOURNAL   J Cell Sci 136 (10) (2023)
   PUBMED   37096733
  REMARK    GeneRIF: GIPC3 couples to MYO6 and PDZ domain proteins, and shapes
            the hair cell apical region.
REFERENCE   4  (bases 1 to 3568)
  AUTHORS   Patmanathan,S.N., Tong,B.T., Teo,J.H.J., Ting,Y.Z.J., Tan,N.S.,
            Sim,S.H.K., Ta,Y.C. and Woo,W.M.
  TITLE     A PDZ Protein GIPC3 Positively Modulates Hedgehog Signaling and
            Melanoma Growth
  JOURNAL   J Invest Dermatol 142 (1), 179-188 (2022)
   PUBMED   34224745
  REMARK    GeneRIF: A PDZ Protein GIPC3 Positively Modulates Hedgehog
            Signaling and Melanoma Growth.
REFERENCE   5  (bases 1 to 3568)
  AUTHORS   Ding,X., Philip,S., Martin,B.K., Pang,Y., Burkett,S., Swing,D.A.,
            Pamala,C., Ritt,D.A., Zhou,M., Morrison,D.K., Ji,X. and Sharan,S.K.
  TITLE     Survival of BRCA2-Deficient Cells Is Promoted by GIPC3, a Novel
            Genetic Interactor of BRCA2
  JOURNAL   Genetics 207 (4), 1335-1345 (2017)
   PUBMED   29021281
  REMARK    GeneRIF: the physiological significance of GIPC3 as a genetic
            interactor of BRCA2 is supported by the observation that Brca2-null
            embryos with Gipc3 overexpression are developmentally more advanced
            than their control littermates. Taken together, we have uncovered a
            novel role for GIPC3 as a BRCA2 genetic interactor.
REFERENCE   6  (bases 1 to 3568)
  AUTHORS   La Torre,A., Hoshino,A., Cavanaugh,C., Ware,C.B. and Reh,T.A.
  TITLE     The GIPC1-Akt1 Pathway Is Required for the Specification of the Eye
            Field in Mouse Embryonic Stem Cells
  JOURNAL   Stem Cells 33 (9), 2674-2685 (2015)
   PUBMED   26013465
REFERENCE   7  (bases 1 to 3568)
  AUTHORS   Charizopoulou,N., Lelli,A., Schraders,M., Ray,K., Hildebrand,M.S.,
            Ramesh,A., Srisailapathy,C.R., Oostrik,J., Admiraal,R.J.,
            Neely,H.R., Latoche,J.R., Smith,R.J., Northup,J.K., Kremer,H.,
            Holt,J.R. and Noben-Trauth,K.
  TITLE     Gipc3 mutations associated with audiogenic seizures and
            sensorineural hearing loss in mouse and human
  JOURNAL   Nat Commun 2, 201 (2011)
   PUBMED   21326233
  REMARK    GeneRIF: Gipc3 plays a pivotal role in acoustic signal acquisition
            and propagation in cochlear hair cells, while mutations are
            associated with audiogenic seizures and sensorineural hearing loss.
            Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3568)
  AUTHORS   Johnson,K.R., Zheng,Q.Y. and Noben-Trauth,K.
  TITLE     Strain background effects and genetic modifiers of hearing in mice
  JOURNAL   Brain Res 1091 (1), 79-88 (2006)
   PUBMED   16579977
  REMARK    Review article
REFERENCE   9  (bases 1 to 3568)
  AUTHORS   Drayton,M. and Noben-Trauth,K.
  TITLE     Mapping quantitative trait loci for hearing loss in Black Swiss
            mice
  JOURNAL   Hear Res 212 (1-2), 128-139 (2006)
   PUBMED   16426780
REFERENCE   10 (bases 1 to 3568)
  AUTHORS   Saitoh,T., Mine,T. and Katoh,M.
  TITLE     Molecular cloning and characterization of mouse Gipc3
  JOURNAL   Int J Mol Med 9 (3), 251-256 (2002)
   PUBMED   11836631
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC155937.4.
            
            On Feb 3, 2022 this sequence version replaced NM_148951.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB074494.1, SRR13422597.813638.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMN00849374,
                                           SAMN00849375 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-233               AC155937.4         67869-68101         c
            234-419             AC155937.4         66282-66467         c
            420-600             AC155937.4         65979-66159         c
            601-713             AC155937.4         65055-65167         c
            714-795             AC155937.4         62988-63069         c
            796-3568            AC155937.4         60053-62825         c
FEATURES             Location/Qualifiers
     source          1..3568
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="10"
                     /map="10 39.72 cM"
     gene            1..3568
                     /gene="Gipc3"
                     /gene_synonym="Ahl5; Rgs19ip3"
                     /note="GIPC PDZ domain containing family, member 3"
                     /db_xref="GeneID:209047"
                     /db_xref="MGI:MGI:2387006"
     exon            1..233
                     /gene="Gipc3"
                     /gene_synonym="Ahl5; Rgs19ip3"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..947
                     /gene="Gipc3"
                     /gene_synonym="Ahl5; Rgs19ip3"
                     /note="isoform 3 is encoded by transcript variant 3; PDZ
                     domain-containing protein GIPC3; regulator of G-protein
                     signaling 19 interacting protein 3; age related hearing
                     loss 5"
                     /codon_start=1
                     /product="PDZ domain-containing protein GIPC3 isoform 3"
                     /protein_id="NP_683753.1"
                     /db_xref="CCDS:CCDS24054.1"
                     /db_xref="GeneID:209047"
                     /db_xref="MGI:MGI:2387006"
                     /translation="MDSAAPREPGATEPPARARPRLVFRTQLAHGSPTGRIEGFTNVR
                     ELYAKIAEAFGIAPTEILFCTLNSHKVDMQKLLGGQIGLEDFIFAHVRGETKEVEVTK
                     TEDALGLTITDNGAGYAFIKRIKEGSIINRIEAVCVGDSIEAINDHSIVGCRHYEVAK
                     MLRELPKSQPFTLRLVQPRRAFDMIGQRSRSSKCPVEAKVSSGRETLRLRSGGAATVE
                     EAPSDVEAAAARRVDDLLESYMGIRDPELAAAVVETARSSAGAQAFARGLDAVLGEFA
                     FPDEFVVEVWAAIGEAHDACG"
     exon            234..419
                     /gene="Gipc3"
                     /gene_synonym="Ahl5; Rgs19ip3"
                     /inference="alignment:Splign:2.1.0"
     exon            420..600
                     /gene="Gipc3"
                     /gene_synonym="Ahl5; Rgs19ip3"
                     /inference="alignment:Splign:2.1.0"
     exon            601..713
                     /gene="Gipc3"
                     /gene_synonym="Ahl5; Rgs19ip3"
                     /inference="alignment:Splign:2.1.0"
     exon            714..795
                     /gene="Gipc3"
                     /gene_synonym="Ahl5; Rgs19ip3"
                     /inference="alignment:Splign:2.1.0"
     exon            796..3568
                     /gene="Gipc3"
                     /gene_synonym="Ahl5; Rgs19ip3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3542..3547
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gipc3"
                     /gene_synonym="Ahl5; Rgs19ip3"
                     /note="hexamer: AATAAA"
     polyA_site      3568
                     /gene="Gipc3"
                     /gene_synonym="Ahl5; Rgs19ip3"
                     /note="major polyA site"
ORIGIN      
        1 gctgtcgcgg gacctccggc gggaggctca ggacgcggcg gaccccacgc accatggaca
       61 gtgctgcgcc ccgcgagccc ggggccaccg agccccccgc ccgcgcgcgc ccgcgcctag
      121 tgttccgcac gcagctggcg cacggcagtc cgaccggcag gatcgagggc ttcaccaatg
      181 tccgcgagct ttacgccaag atcgccgagg ccttcggcat cgctcctacc gagatcctat
      241 tctgcaccct caacagtcac aaagtggaca tgcaaaagtt gctgggggga cagattgggc
      301 tggaagactt catctttgca catgtgcgtg gagagaccaa agaagtggag gtcaccaaaa
      361 cggaggatgc tctaggactg accatcacag acaacggagc cggatacgcc ttcatcaaga
      421 gaatcaagga aggcagcatt atcaaccgga ttgaggctgt gtgcgtgggg gatagcattg
      481 aggccatcaa tgaccactct attgtgggct gccggcacta cgaggtggct aaaatgctcc
      541 gggagctgcc caagtctcag cccttcaccc tgcgtctagt gcagccccgg agagcttttg
      601 atatgattgg ccagaggagc aggagcagca agtgtcctgt ggaagctaaa gtgagcagcg
      661 ggagggaaac attacgcctg cgctcagggg gggctgccac tgtggaggag gcgcccagcg
      721 atgtggaagc ggcagcggcg cgcagggtgg acgacctgct ggagagctac atgggcatcc
      781 gagaccccga gctggcggcc gcggtggtgg agactgctcg gagctcggcg ggagcccagg
      841 ctttcgcacg cggcctggac gccgttctgg gcgagttcgc ctttccagac gagttcgtgg
      901 tggaggtgtg ggcagctatc ggcgaggccc acgacgcttg tggctagcgt gtgtgggagt
      961 ctccagtcct gggcccagcc ccttgcccca acgccactcc agatcccagg acagccctga
     1021 gacaaggccc gccaccagaa cccaacccag ttctgagacc caggtccacc ctgaggccca
     1081 gcctggttct agcacccagt tcagctctaa gagccagcca gaaccccatc cctgttctgg
     1141 aacccaggtt agctccgagg gccagaccag ctctagaacc aatactgaag tccagcccag
     1201 ctctagaacc cgacccagtt ctttgaccca ggcccaccct gagactcagc ttggttctag
     1261 cacccagtca gaattccagg ctggttctgg aacccaggtt agccccaagg ccagctcctg
     1321 ctctagaacc aaagttgatg tcttgcccag ctctagaacc cgagccagtt ctgtgaccca
     1381 ggcccatccc aaggcccagc ctgattctag cacccagctc agctctgaga cccagctgga
     1441 atccctggtc ggccctgaat tccagtcctg ctctaaaacc aaaattgaag cccaggataa
     1501 ctctagaacc caacccagtt ctgtgaccca ggcccacccc aaggcccagc ttggttctgt
     1561 aacccttgtt tctgaagtcc agccagcctt tagatcccag cctagtcctg gggtacagtc
     1621 tgactccaga acacaggtca gctccgaggc tcaggctggc tttggaaccc agagcagccc
     1681 caggcctgag ccttgttcta aaactcatct tgaacctgac tgccaaccca tccctagaac
     1741 ccagcctggc tctgaggtcc agccaggctt tgaggccaca ccccattctg gagcccaggg
     1801 aaattctgac actcatgccc gacttagaac ccaagccagc cctcaggtca acttctgctt
     1861 ggagaccaag tccacttcca gaacacagtc aggctctgag agtgggcttg gttctagaac
     1921 acagatccac ccagatagga aaccatgctc tagagcccag ccagacattg ggaccaaccc
     1981 tgatgctgca gcccaggtca tggctgaccc tcagccttcc agaatgcagc caagccccgt
     2041 cccacagcca cactccggaa tccagacaaa tgttaggaga cagctgggct cagagcacca
     2101 ccccagcagc cagtctcaga agccaggttc tgagagccag cccaggtatg agacagccac
     2161 caccatggcc tggcccttcc ctgagacttg gagtggttta ggaagaaggg cttgcttggg
     2221 accccaagca aggtccagcg agccgctgac tgatgaaacc caagtaggct ccagtagcca
     2281 gccatcttcc acacccctgc ctagtgcagg cactcagagc catactgcta cccagtccaa
     2341 actcaaacct cagccttgtt ccccagcaca gctacctacc agtgcctccc aaagccctga
     2401 accccaagct agccccagtg atgagtctga ctctgaggct cagcccaggg gcaggagcag
     2461 gaaggctctg acagcagagc cccaccccca aatgccatgc actcccaaat cgaggcccag
     2521 cttagggttg tctcagagtg ctgaccccac tccacccaga agatggcatg caggctccag
     2581 gacacagtcc gactctggga cccagaccga cttccaggcc tggcctagct ccggagccta
     2641 cgtaggttgg gccagacatc gaaggtccca gctacagtca ttgacagaga aggagcccag
     2701 ctccaggtcc ctctctagtt ctggaggcag aaaacagcac tcggtgacaa ctggagccag
     2761 ctgtgtcccc cagcagaaca cagggcagtg gcttggctct gcagcccact cagcctcgag
     2821 aacccaagtc agtcttcagg ttccatcacg cactggagcc cagcccagcg ctgggaagga
     2881 ttccagttcc agaacccggc tagactccag ccccagcccc agccccagcc ccagccccag
     2941 ccccagcccc agccccagcc ccagccccag ccccagcccc agccccagcc ccagccccag
     3001 ccccgacact tctggaagtc agcccagcac agtagcccgc cccctcagct ttagagacag
     3061 tcgccgccca cagacccctg gccttcagcc tataaaggag cctaagcccc tgacccgacc
     3121 tcagtctcca agcccactga ccccaagagc ccccacccct gccccgagca aggtcgctgg
     3181 gccttggcct caagatggaa cccaggccac agcgggcccc aggccaggcc cctcactctc
     3241 tctcctgggc cctgggtcac caggcccaga cactccccag aagccagccc ttttgcccaa
     3301 gccccagctg ggatgccaga agcccaaccc ccccaccata tgcatcactc ctagcccctc
     3361 ccctgggtct gggtccctcc cccaccccag cctgtgactt gactcatccc agcaggatta
     3421 caggatggta gaaactgaag cttgggtttc agggacctgg ctacgaaccc caaagcccct
     3481 gtaagaggac ccagccatag aaggcatagg ggtgggaggc tcctaggaga tcttggtggg
     3541 caataaagga gcccgcacct ccacagcc
//
