LOCUS       NM_016867               1286 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus GIPC PDZ domain containing family, member 2 (Gipc2),
            mRNA.
ACCESSION   NM_016867
VERSION     NM_016867.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1286)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1286)
  AUTHORS   La Torre,A., Hoshino,A., Cavanaugh,C., Ware,C.B. and Reh,T.A.
  TITLE     The GIPC1-Akt1 Pathway Is Required for the Specification of the Eye
            Field in Mouse Embryonic Stem Cells
  JOURNAL   Stem Cells 33 (9), 2674-2685 (2015)
   PUBMED   26013465
REFERENCE   3  (bases 1 to 1286)
  AUTHORS   Lin,Q., Donahue,S.L., Moore-Jarrett,T., Cao,S., Osipovich,A.B. and
            Ruley,H.E.
  TITLE     Mutagenesis of diploid mammalian genes by gene entrapment
  JOURNAL   Nucleic Acids Res 34 (20), e139 (2006)
   PUBMED   17062627
REFERENCE   4  (bases 1 to 1286)
  AUTHORS   Wang,L.H., Kalb,R.G. and Strittmatter,S.M.
  TITLE     A PDZ protein regulates the distribution of the transmembrane
            semaphorin, M-SemF
  JOURNAL   J Biol Chem 274 (20), 14137-14146 (1999)
   PUBMED   10318831
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AF061262.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF061262.1, AK008626.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1286
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 76.97 cM"
     gene            1..1286
                     /gene="Gipc2"
                     /gene_synonym="2200002N01Rik; Semcap2"
                     /note="GIPC PDZ domain containing family, member 2"
                     /db_xref="GeneID:54120"
                     /db_xref="MGI:MGI:1889209"
     exon            1..253
                     /gene="Gipc2"
                     /gene_synonym="2200002N01Rik; Semcap2"
                     /inference="alignment:Splign:2.1.0"
     CDS             14..958
                     /gene="Gipc2"
                     /gene_synonym="2200002N01Rik; Semcap2"
                     /note="semaF cytoplasmic domain associated protein 2;
                     SEMCAP-2"
                     /codon_start=1
                     /product="PDZ domain-containing protein GIPC2"
                     /protein_id="NP_058563.1"
                     /db_xref="CCDS:CCDS17914.1"
                     /db_xref="GeneID:54120"
                     /db_xref="MGI:MGI:1889209"
                     /translation="MPLGLRGKKKAAKSKEAARLVEGERSSGSQGVPGPPAPARKLVF
                     HAQLAHGSATGRVEDFSSISELYAKIAGVFEIAPSEILFCTLNTPKIDMGKLLGGQLG
                     LEDFIFAHVKGTKKEVNVYKSEDSLGLTITDNGVGYAFIKRIKDGSTIDSVKTICVGD
                     HIECINGENIVGWRHFEVAKKLKELKKEELFTLQLIEPKKAFEIGPRSKAGKTSTEKI
                     GTSRGTLRLRSKGPATVEELPSEAKAKAIGKVDDLLELYMGIRDIDLATTMFEAGKDK
                     SNPDEFAVALDETLGDFAFPDEFLFDVWGAISDMKQGR"
     exon            254..439
                     /gene="Gipc2"
                     /gene_synonym="2200002N01Rik; Semcap2"
                     /inference="alignment:Splign:2.1.0"
     exon            440..620
                     /gene="Gipc2"
                     /gene_synonym="2200002N01Rik; Semcap2"
                     /inference="alignment:Splign:2.1.0"
     exon            621..727
                     /gene="Gipc2"
                     /gene_synonym="2200002N01Rik; Semcap2"
                     /inference="alignment:Splign:2.1.0"
     exon            728..809
                     /gene="Gipc2"
                     /gene_synonym="2200002N01Rik; Semcap2"
                     /inference="alignment:Splign:2.1.0"
     exon            810..1264
                     /gene="Gipc2"
                     /gene_synonym="2200002N01Rik; Semcap2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1138..1143
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gipc2"
                     /gene_synonym="2200002N01Rik; Semcap2"
                     /note="hexamer: ATTAAA"
     polyA_site      1159
                     /gene="Gipc2"
                     /gene_synonym="2200002N01Rik; Semcap2"
                     /note="major polyA site"
ORIGIN      
        1 tgggacctgc aagatgccgc ttggactgcg cgggaagaag aaggcggcca agtccaagga
       61 ggccgcgagg ctggtggagg gcgagagatc cagtggcagc cagggtgtcc ccggaccccc
      121 agctccggca cgcaagctgg tgttccacgc acagctggcg cacggcagcg ccacgggccg
      181 agtggaggac ttctccagca tcagcgagct ctacgccaag attgccggcg tgttcgagat
      241 cgcgccatcc gagatcttat tttgtacctt aaatacgcct aaaattgaca tgggaaagct
      301 cctgggtggg cagctgggcc ttgaggattt catatttgcc cacgtgaaag gcacaaaaaa
      361 ggaagtgaat gtttataaat cagaggattc gcttggactc accatcacgg ataacggcgt
      421 gggctatgct tttatcaaga gaattaaaga tggcagcacc attgactcag ttaaaacgat
      481 ctgtgtgggg gatcatatcg aatgtataaa cggagaaaat attgttgggt ggcgtcactt
      541 tgaagtcgct aagaagttaa aggaattgaa aaaggaggag ctctttactt tgcagttaat
      601 agaacccaag aaggcttttg aaataggacc aaggtcgaaa gccggaaaga catcaacaga
      661 aaaaattggt acttcaagag ggaccctccg tctgagatcg aaaggccccg ctacagtaga
      721 agagctgccc tctgaagcca aggcaaaggc aatcggaaag gttgatgatc tccttgagct
      781 gtacatgggg attcgagata ttgacttagc tacaaccatg tttgaagctg ggaaagacaa
      841 gagcaaccca gatgagtttg ctgtcgctct tgacgagact ctgggagact ttgcctttcc
      901 tgatgagttc ctgttcgacg tgtggggagc catcagtgac atgaaacaag gaagatgatg
      961 gcgtggcccg tgttcctgca gagatgacca cagttctgca ggcagccttc tccggggtct
     1021 tagacactgt tatgaactct actttagcct cctgtgtatg agatacagtc ttcgaaatgt
     1081 aattttgatt tatggatgat gtttaatata gtttcttatg tagtgtgttt aaggtaaatt
     1141 aaagtgtgat ccattttaat atttgttcaa aagctttaaa atttttagag gaatctttct
     1201 acataggtga ttttggtccc tgtttgtacc cacggctctt tccacataaa atacttgatt
     1261 acaaaaaaaa aaaaaaaaaa aaaaaa
//
