LOCUS       NM_008119                649 bp    mRNA    linear   ROD 04-JUN-2024
DEFINITION  Mus musculus gastric inhibitory polypeptide (Gip), mRNA.
ACCESSION   NM_008119 XM_001005614
VERSION     NM_008119.2
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 649)
  AUTHORS   Lewis,J.E., Nuzzaci,D., James-Okoro,P.P., Montaner,M.,
            O'Flaherty,E., Darwish,T., Hayashi,M., Liberles,S.D., Hornigold,D.,
            Naylor,J., Baker,D., Gribble,F.M. and Reimann,F.
  TITLE     Stimulating intestinal GIP release reduces food intake and body
            weight in mice
  JOURNAL   Mol Metab 84, 101945 (2024)
   PUBMED   38653401
  REMARK    GeneRIF: Stimulating intestinal GIP release reduces food intake and
            body weight in mice.
REFERENCE   2  (bases 1 to 649)
  AUTHORS   Zinina,V.V., Sauer,M., Nigmatullina,L., Kreim,N. and Soshnikova,N.
  TITLE     TCF7L1 Controls the Differentiation of Tuft Cells in Mouse Small
            Intestine
  JOURNAL   Cells 12 (11), 1452 (2023)
   PUBMED   37296573
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 649)
  AUTHORS   Kiyobayashi,S., Murakami,T., Harada,N., Fujimoto,H., Murata,Y.,
            Fujita,N., Hamamatsu,K., Ikeguchi-Ogura,E., Hatoko,T., Lu,X.,
            Yamane,S. and Inagaki,N.
  TITLE     Noninvasive Evaluation of GIP Effects on beta-Cell Mass Under
            High-Fat Diet
  JOURNAL   Front Endocrinol (Lausanne) 13, 921125 (2022)
   PUBMED   35909510
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 649)
  AUTHORS   Murata,Y., Harada,N., Kishino,S., Iwasaki,K., Ikeguchi-Ogura,E.,
            Yamane,S., Kato,T., Kanemaru,Y., Sankoda,A., Hatoko,T.,
            Kiyobayashi,S., Ogawa,J., Hirasawa,A. and Inagaki,N.
  TITLE     Medium-chain triglycerides inhibit long-chain triglyceride-induced
            GIP secretion through GPR120-dependent inhibition of CCK
  JOURNAL   iScience 24 (9), 102963 (2021)
   PUBMED   34466786
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 649)
  AUTHORS   Boer,G.A., Hartmann,B. and Holst,J.J.
  TITLE     Pharmacokinetics of exogenous GIP(1-42) in C57Bl/6 mice; Extremely
            rapid degradation but marked variation between available assays
  JOURNAL   Peptides 136, 170457 (2021)
   PUBMED   33245951
  REMARK    GeneRIF: Pharmacokinetics of exogenous GIP(1-42) in C57Bl/6 mice;
            Extremely rapid degradation but marked variation between available
            assays.
REFERENCE   6  (bases 1 to 649)
  AUTHORS   Mohlke,K.L., Purkayastha,A.A., Westrick,R.J. and Ginsburg,D.
  TITLE     Comparative mapping of distal murine chromosome 11 and human
            17q21.3 in a region containing a modifying locus for murine plasma
            von Willebrand factor level
  JOURNAL   Genomics 54 (1), 19-30 (1998)
   PUBMED   9806826
REFERENCE   7  (bases 1 to 649)
  AUTHORS   Boylan,M.O., Jepeal,L.I., Jarboe,L.A. and Wolfe,M.M.
  TITLE     Cell-specific expression of the glucose-dependent insulinotropic
            polypeptide gene in a mouse neuroendocrine tumor cell line
  JOURNAL   J Biol Chem 272 (28), 17438-17443 (1997)
   PUBMED   9211887
REFERENCE   8  (bases 1 to 649)
  AUTHORS   Ding,W.G. and Gromada,J.
  TITLE     Protein kinase A-dependent stimulation of exocytosis in mouse
            pancreatic beta-cells by glucose-dependent insulinotropic
            polypeptide
  JOURNAL   Diabetes 46 (4), 615-621 (1997)
   PUBMED   9075801
REFERENCE   9  (bases 1 to 649)
  AUTHORS   Mohlke,K.L., Nichols,W.C., Westrick,R.J., Novak,E.K., Cooney,K.A.,
            Swank,R.T. and Ginsburg,D.
  TITLE     A novel modifier gene for plasma von Willebrand factor level maps
            to distal mouse chromosome 11
  JOURNAL   Proc Natl Acad Sci U S A 93 (26), 15352-15357 (1996)
   PUBMED   8986815
REFERENCE   10 (bases 1 to 649)
  AUTHORS   Schieldrop,P.J., Gelling,R.W., Elliot,R., Hewitt,J., Kieffer,T.J.,
            McIntosh,C.H. and Pederson,R.A.
  TITLE     Isolation of a murine glucose-dependent insulinotropic polypeptide
            (GIP) cDNA from a tumor cell line (STC6-14) and quantification of
            glucose-induced increases in GIP mRNA
  JOURNAL   Biochim Biophys Acta 1308 (2), 111-113 (1996)
   PUBMED   8764827
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK008308.1.
            
            On or before May 4, 2006 this sequence version replaced
            XM_001005614.1, NM_008119.1.
            
            Summary: This gene encodes an incretin hormone that belongs to the
            glucagon superfamily. The encoded preproprotein undergoes
            proteolytic processing to generate mature peptides that function as
            potent stimulators of insulin secretion and inhibit gastric acid
            secretion. Transgenic mice overexpressing the encoded protein
            exhibit a significant increase in the expression of markers of bone
            formation, a decrease in the expression of markers of bone
            resorption and, an increase in the bone mass. [provided by RefSeq,
            Nov 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK008308.1, BY708239.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849377, SAMN00849378
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..649
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="11"
                     /map="11 59.21 cM"
     gene            1..649
                     /gene="Gip"
                     /note="gastric inhibitory polypeptide"
                     /db_xref="GeneID:14607"
                     /db_xref="MGI:MGI:107504"
     exon            1..80
                     /gene="Gip"
                     /inference="alignment:Splign:2.1.0"
     exon            81..188
                     /gene="Gip"
                     /inference="alignment:Splign:2.1.0"
     CDS             103..537
                     /gene="Gip"
                     /note="glucose-dependent insulinotropic polypeptide"
                     /codon_start=1
                     /product="gastric inhibitory polypeptide preproprotein"
                     /protein_id="NP_032145.2"
                     /db_xref="CCDS:CCDS25287.1"
                     /db_xref="GeneID:14607"
                     /db_xref="MGI:MGI:107504"
                     /translation="MVALKTCSLLLVLLFLAVGLGEKEEVEFRSHAKFAGPRPRGPRY
                     AEGTFISDYSIAMDKIRQQDFVNWLLAQRGKKSDWKHNITQREARALVLAGQSQGKED
                     KEAQESSLPKSLSDDDVLRDLLIQELLAWMVDQTELCRLRSQ"
     exon            189..335
                     /gene="Gip"
                     /inference="alignment:Splign:2.1.0"
     exon            336..425
                     /gene="Gip"
                     /inference="alignment:Splign:2.1.0"
     exon            426..527
                     /gene="Gip"
                     /inference="alignment:Splign:2.1.0"
     exon            528..649
                     /gene="Gip"
                     /inference="alignment:Splign:2.1.0"
     regulatory      629..634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gip"
                     /note="putative"
     polyA_site      649
                     /gene="Gip"
                     /note="putative"
ORIGIN      
        1 gaggcaagat cctgagagcc aacaggtagg aggagaagac ctcatcctgc cctcctggaa
       61 gagctaagaa gaactgttgg ctaggggaca caatctagga agatggtggc tttgaagacc
      121 tgctctctgt tgctggtgct cctgttcctg gctgttgggc tgggagaaaa agaagaggtt
      181 gagttccgat cccatgctaa atttgctggc cctcgacctc gaggtccaag gtacgcagag
      241 gggactttca tcagtgatta cagcatcgcc atggacaaga tccgacaaca agacttcgtg
      301 aactggctgc tggcacagag ggggaagaag agtgactgga aacacaacat cacccagaga
      361 gaggcccggg ctttggtgct ggcagggcaa tctcagggaa aggaggacaa agaggcacag
      421 gagagctctt tgcccaagag cctcagtgat gatgatgtgc tgagagacct tctgattcaa
      481 gagctactgg cctggatggt ggaccaaaca gagctctgcc gactcaggtc tcagtgactg
      541 acctagccca gagcaggact ggactctgac cttagcttgc ttggctcctg cttccgccct
      601 ggtccaaagt ctctgagaga accaaaccaa taaagcctta agctgaagt
//
