LOCUS       NM_030198               2412 bp    mRNA    linear   ROD 02-MAY-2024
DEFINITION  Mus musculus GINS complex subunit 3 (Gins3), mRNA.
ACCESSION   NM_030198
VERSION     NM_030198.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2412)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2412)
  AUTHORS   McQuaid,M.E., Ahmed,K., Tran,S., Rousseau,J., Shaheen,R.,
            Kernohan,K.D., Yuki,K.E., Grover,P., Dreseris,E.S., Ahmed,S.,
            Dupuis,L., Stimec,J., Shago,M., Al-Hassnan,Z.N., Tremblay,R.,
            Maass,P.G., Wilson,M.D., Grunebaum,E., Boycott,K.M., Boisvert,F.M.,
            Maddirevula,S., Faqeih,E.A., Almanjomi,F., Khan,Z.U.,
            Alkuraya,F.S., Campeau,P.M., Kannu,P., Campos,E.I. and Wurtele,H.
  TITLE     Hypomorphic GINS3 variants alter DNA replication and cause
            Meier-Gorlin syndrome
  JOURNAL   JCI Insight 7 (10), e155648 (2022)
   PUBMED   35603789
  REMARK    GeneRIF: Hypomorphic GINS3 variants alter DNA replication and cause
            Meier-Gorlin syndrome.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2412)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2412)
  AUTHORS   Zhou,L., Dai,H., Wu,J., Zhou,M., Yuan,H., Du,J., Yang,L., Wu,X.,
            Xu,H., Hua,Y., Xu,J., Zheng,L. and Shen,B.
  TITLE     Role of FEN1 S187 phosphorylation in counteracting oxygen-induced
            stress and regulating postnatal heart development
  JOURNAL   FASEB J 31 (1), 132-147 (2017)
   PUBMED   27694478
REFERENCE   5  (bases 1 to 2412)
  AUTHORS   Kang,Y.H., Galal,W.C., Farina,A., Tappin,I. and Hurwitz,J.
  TITLE     Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its
            action with DNA polymerase epsilon in rolling circle DNA synthesis
  JOURNAL   Proc Natl Acad Sci U S A 109 (16), 6042-6047 (2012)
   PUBMED   22474384
REFERENCE   6  (bases 1 to 2412)
  AUTHORS   Sansom,S.N., Griffiths,D.S., Faedo,A., Kleinjan,D.J., Ruan,Y.,
            Smith,J., van Heyningen,V., Rubenstein,J.L. and Livesey,F.J.
  TITLE     The level of the transcription factor Pax6 is essential for
            controlling the balance between neural stem cell self-renewal and
            neurogenesis
  JOURNAL   PLoS Genet 5 (6), e1000511 (2009)
   PUBMED   19521500
REFERENCE   7  (bases 1 to 2412)
  AUTHORS   Labib,K. and Gambus,A.
  TITLE     A key role for the GINS complex at DNA replication forks
  JOURNAL   Trends Cell Biol 17 (6), 271-278 (2007)
   PUBMED   17467990
  REMARK    Review article
REFERENCE   8  (bases 1 to 2412)
  AUTHORS   Hayashi,R., Arauchi,T., Tategu,M., Goto,Y. and Yoshida,K.
  TITLE     A combined computational and experimental study on the
            structure-regulation relationships of putative mammalian DNA
            replication initiator GINS
  JOURNAL   Genomics Proteomics Bioinformatics 4 (3), 156-164 (2006)
   PUBMED   17127213
  REMARK    GeneRIF: expression of mammalian GINS is regulated by
            17beta-Estradiol-stimulated estrogen receptor alpha, and PSF3 acts
            as a gene responsive to transcription factor E2F1
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from AC113951.13.
            
            On May 1, 2007 this sequence version replaced NM_030198.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK019225.1, AK160606.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               AC113951.13        126244-126468       c
            226-459             AC113951.13        121984-122217       c
            460-2412            AC113951.13        114968-116920       c
FEATURES             Location/Qualifiers
     source          1..2412
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 47.12 cM"
     gene            1..2412
                     /gene="Gins3"
                     /gene_synonym="2700085M18Rik; Psf3"
                     /note="GINS complex subunit 3"
                     /db_xref="GeneID:78833"
                     /db_xref="MGI:MGI:1926083"
     exon            1..225
                     /gene="Gins3"
                     /gene_synonym="2700085M18Rik; Psf3"
                     /inference="alignment:Splign:2.1.0"
     CDS             40..690
                     /gene="Gins3"
                     /gene_synonym="2700085M18Rik; Psf3"
                     /note="GINS complex subunit 3 (Psf3 homolog)"
                     /codon_start=1
                     /product="DNA replication complex GINS protein PSF3"
                     /protein_id="NP_084474.1"
                     /db_xref="CCDS:CCDS22564.1"
                     /db_xref="GeneID:78833"
                     /db_xref="MGI:MGI:1926083"
                     /translation="MSEAYFPVESGALGPEENFLSLDDILMSQEKLPVRVETPMPRLG
                     AFFLERGAGSEPDHPLPQGTKLELPLWLAKGLFDHKRRILSVELPKMYQEGWRTVFSA
                     DANVVDLHKMGPHFYGFGSQLLHFDSPENADISQSLLKTFIGRFRRIMDSSQNSYNED
                     TSALVARLDETERGLFQIGQRSLNDFQSWEKGQASQITASSLVQNYKKRKFTNMED"
     exon            226..459
                     /gene="Gins3"
                     /gene_synonym="2700085M18Rik; Psf3"
                     /inference="alignment:Splign:2.1.0"
     exon            460..2412
                     /gene="Gins3"
                     /gene_synonym="2700085M18Rik; Psf3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1845..1850
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gins3"
                     /gene_synonym="2700085M18Rik; Psf3"
                     /note="hexamer: AATAAA"
     polyA_site      1866
                     /gene="Gins3"
                     /gene_synonym="2700085M18Rik; Psf3"
                     /note="major polyA site"
     regulatory      2326..2331
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gins3"
                     /gene_synonym="2700085M18Rik; Psf3"
                     /note="hexamer: AATAAA"
     regulatory      2340..2345
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gins3"
                     /gene_synonym="2700085M18Rik; Psf3"
                     /note="hexamer: ATTAAA"
     polyA_site      2350
                     /gene="Gins3"
                     /gene_synonym="2700085M18Rik; Psf3"
     polyA_site      2365
                     /gene="Gins3"
                     /gene_synonym="2700085M18Rik; Psf3"
ORIGIN      
        1 ggcgcgccct cctcatccct gactgtgctg cgagctgcca tgtccgaggc gtatttccca
       61 gtggagtcgg gcgctctggg gccggaggag aacttcctgt ctttggacga catcctgatg
      121 tcgcaggaga agctgccggt gcgggtcgag acgcccatgc cgcgcctggg agccttcttc
      181 ctggagcggg gcgcgggctc cgagccggac catccgctcc ctcagggtac aaaacttgaa
      241 cttcccctgt ggctggctaa aggactcttt gaccacaagc ggcgcatcct ttctgtggaa
      301 cttcccaaaa tgtaccaaga gggatggagg actgtattca gtgcagatgc taatgtcgtg
      361 gacctccaca aaatggggcc ccatttctat gggtttggct cacaactcct gcattttgac
      421 agtccggaga atgcagatat ttcccagtct ctgctgaaga cttttattgg acggttccgc
      481 cgcatcatgg actcctccca gaattcttac aatgaagaca cttcagcgct ggtagccagg
      541 ttagatgaga cagagagggg cttatttcaa atcgggcaga gaagtctaaa tgactttcag
      601 agttgggaaa aaggacaagc ttctcagatt acagcttcca gcctcgtcca gaattataag
      661 aaaaggaaat tcacaaacat ggaagactaa aagccgaaca caaactgcaa cttgtggatt
      721 tatctctgtg cccttgataa gaccagttaa cttcatggga gaccaaatgt gtactgcttc
      781 agggctttta accttcacca gtctcaaagc ttggaactac ctggttgggg cggatgtggt
      841 tgcccatgac cctgttggtc ttctggactg tagctacctg ctagcctcac agcataggct
      901 tttggcccag gaatgcagct gaggaggagc cagactccat cttaagcaag gagcacagac
      961 atgttgcata cacagtcaag ttggaactca gattcctcgg atgtctggtc tcgttggctg
     1021 caaagtgagt catctctgcc tgttcacaac tttctcttaa gcttatttgc cttatcttcc
     1081 tcatggttgg acaaaggaca gcatctccac aatgctgcct acctgctggg acttagccca
     1141 gtttttaaaa caggaaactg gggagaaaag tggaaagtca gatgaatggc agaacagaaa
     1201 ggagaaggca ctgagctttt gtgccctgta ttcagggctt ttgaactaga atcacatccc
     1261 ttcagtctac tcagaggggc catgtacttg tgtttgtcag gaatctttag agcggtggca
     1321 cactcattcc gttccctgtc tagaaaaact ctccaggcag ccatcttcca gtaacttgcc
     1381 aaaatgaccc aacacaaagg gaaagaggta ttatgttctc caggcccttt aggaaacatg
     1441 gatttgttcc tttggccaca tatatgcgaa tctataagaa aggtgatgtt gacatcaagg
     1501 gaatgggcac tgttcaaaag gaatgtccta taagtgttac cacagcaaaa aaaaaggaag
     1561 agtctatgat gtcacccagc atgcggtggg catcactgta aacaaggagg ttaagggcaa
     1621 gattctggct aagaagatca atgtgcggat tgagcacttg aagagcagag acagcttcct
     1681 gaagcaggtg aaggagaacg agaagccaaa gagaagggcg cctggttcag ctaaagcgcc
     1741 agcctgcgcc acccagagaa gcacgttttg tgaggactaa cggaaaggag cctgagctgt
     1801 tggagcccgt tccatatgag ttcatggcct aatgtacaaa gagaaataaa ggatctggcc
     1861 tgcaaagtgt ttttctttaa agaaagaaag gaaagctatc agggaggtgt taggaattgc
     1921 aaagtagtta tgaaaggatg tttgccaacc tttgtataat tgcatcaggg gcttacaggt
     1981 tgggaagagc ccttgctgaa aaacagcttg gcaagtttta gtagagaaga ctcttttaca
     2041 ttaatttttt tctccaggaa atactgcaac tttaatgcaa aaagcacccc tgaccactta
     2101 ctgggagtct ctttaaacat gcaccaaact gagagggaca agttccccag accataagct
     2161 aaataaaaaa gtctcatttc ctggagccct ttggattgtc tggtgggcag attctccaca
     2221 ccactggcca cccctggtat cctatgacca ctgaaaaata tcttcattgt aattaaggag
     2281 agctttgggt gtccagataa cacagttgtt taatggaaac ttaaaaataa aagacatgca
     2341 ttaaaatgcc tgtcttagca taaaattgtc ttttatcatt cgactttcat cctaaataaa
     2401 tgatgggttt tg
//
