LOCUS       NM_178856               1061 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus GINS complex subunit 2 (Gins2), mRNA.
ACCESSION   NM_178856
VERSION     NM_178856.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1061)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1061)
  AUTHORS   Bedogni,F. and Hevner,R.F.
  TITLE     Cell-Type-Specific Gene Expression in Developing Mouse Neocortex:
            Intermediate Progenitors Implicated in Axon Development
  JOURNAL   Front Mol Neurosci 14, 686034 (2021)
   PUBMED   34321999
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1061)
  AUTHORS   Liu,C., Wang,R. and Zhang,Y.
  TITLE     GINS complex subunit 2 (GINS2) plays a protective role in
            alcohol-induced brain injury
  JOURNAL   Artif Cells Nanomed Biotechnol 47 (1), 1-9 (2019)
   PUBMED   30513217
  REMARK    GeneRIF: GINS2 plays a protective role in alcohol-induced brain
            injury
REFERENCE   4  (bases 1 to 1061)
  AUTHORS   Westendorp,B., Major,J.L., Nader,M., Salih,M., Leenen,F.H. and
            Tuana,B.S.
  TITLE     The E2F6 repressor activates gene expression in myocardium
            resulting in dilated cardiomyopathy
  JOURNAL   FASEB J 26 (6), 2569-2579 (2012)
   PUBMED   22403008
REFERENCE   5  (bases 1 to 1061)
  AUTHORS   Ouseph,M.M., Li,J., Chen,H.Z., Pecot,T., Wenzel,P., Thompson,J.C.,
            Comstock,G., Chokshi,V., Byrne,M., Forde,B., Chong,J.L., Huang,K.,
            Machiraju,R., de Bruin,A. and Leone,G.
  TITLE     Atypical E2F repressors and activators coordinate placental
            development
  JOURNAL   Dev Cell 22 (4), 849-862 (2012)
   PUBMED   22516201
REFERENCE   6  (bases 1 to 1061)
  AUTHORS   Kang,Y.H., Galal,W.C., Farina,A., Tappin,I. and Hurwitz,J.
  TITLE     Properties of the human Cdc45/Mcm2-7/GINS helicase complex and its
            action with DNA polymerase epsilon in rolling circle DNA synthesis
  JOURNAL   Proc Natl Acad Sci U S A 109 (16), 6042-6047 (2012)
   PUBMED   22474384
REFERENCE   7  (bases 1 to 1061)
  AUTHORS   Labib,K. and Gambus,A.
  TITLE     A key role for the GINS complex at DNA replication forks
  JOURNAL   Trends Cell Biol 17 (6), 271-278 (2007)
   PUBMED   17467990
  REMARK    Review article
REFERENCE   8  (bases 1 to 1061)
  AUTHORS   Lau,N.C., Seto,A.G., Kim,J., Kuramochi-Miyagawa,S., Nakano,T.,
            Bartel,D.P. and Kingston,R.E.
  TITLE     Characterization of the piRNA complex from rat testes
  JOURNAL   Science 313 (5785), 363-367 (2006)
   PUBMED   16778019
COMMENT     PROVISIONAL REFSEQ: This record has not yet been subject to final
            NCBI review. The reference sequence was derived from BC082565.1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC082565.1, AK030758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164134, SAMN01164135
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..1061
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="8"
                     /map="8 69.86 cM"
     gene            1..1061
                     /gene="Gins2"
                     /gene_synonym="2210013I18Rik; 4833427B12Rik; Pfs2; Psf2"
                     /note="GINS complex subunit 2"
                     /db_xref="GeneID:272551"
                     /db_xref="MGI:MGI:1921019"
     exon            1..150
                     /gene="Gins2"
                     /gene_synonym="2210013I18Rik; 4833427B12Rik; Pfs2; Psf2"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..618
                     /gene="Gins2"
                     /gene_synonym="2210013I18Rik; 4833427B12Rik; Pfs2; Psf2"
                     /note="GINS complex subunit 2 (Psf2 homolog)"
                     /codon_start=1
                     /product="DNA replication complex GINS protein PSF2"
                     /protein_id="NP_849187.1"
                     /db_xref="CCDS:CCDS40496.1"
                     /db_xref="GeneID:272551"
                     /db_xref="MGI:MGI:1921019"
                     /translation="MDAAEVEFLAEKELVTIIPNFSLDKIYLIGGDLGPFNPGLPVDV
                     PLWLAINLKQRQKCRLLPPEWMDVEKLEQMRDEERKEETFTPVPSPHYMEITKLLLNH
                     ASDNIPKADTIRTLIKDLWDTRMAKLRVSADSFVRQQEAHAKLDNLTLMEISSSGAFL
                     TQALNHMYKLRTNLQPSESTQSQDF"
     exon            151..265
                     /gene="Gins2"
                     /gene_synonym="2210013I18Rik; 4833427B12Rik; Pfs2; Psf2"
                     /inference="alignment:Splign:2.1.0"
     exon            266..365
                     /gene="Gins2"
                     /gene_synonym="2210013I18Rik; 4833427B12Rik; Pfs2; Psf2"
                     /inference="alignment:Splign:2.1.0"
     exon            366..492
                     /gene="Gins2"
                     /gene_synonym="2210013I18Rik; 4833427B12Rik; Pfs2; Psf2"
                     /inference="alignment:Splign:2.1.0"
     exon            493..1038
                     /gene="Gins2"
                     /gene_synonym="2210013I18Rik; 4833427B12Rik; Pfs2; Psf2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gaggcgctgc ctctgagtcg cggaggggcg gtaacgggcc tgggccgcct actcttcaac
       61 atggatgcgg ccgaggtgga gtttttggcc gaaaaggagt tggtgactat catcccgaac
      121 ttcagtctgg acaagatcta cctgatcggg ggggacctgg ggcccttcaa ccccggctta
      181 cccgtggacg tgcccctgtg gctggccatt aacctgaaac agagacagaa gtgccgcctg
      241 ttacctccgg aatggatgga tgtggagaaa ctggaacaga tgcgtgatga ggagcggaag
      301 gaggagacat tcaccccagt gcccagcccg cactacatgg agatcacgaa gctcctgctg
      361 aatcatgctt ctgacaacat ccccaaagca gacaccatcc ggacactgat caaagacctg
      421 tgggacacac gcatggccaa gcttcgagtg tctgctgaca gttttgtgcg gcagcaagag
      481 gcacatgcca agctggacaa cctgaccttg atggagatca gcagcagcgg ggccttcctc
      541 acccaggccc tcaaccacat gtacaagctc cgcacaaacc tccagccctc cgagagcacc
      601 cagtcgcagg acttctagcc agaggcctct gctgtgcaaa ccctgctgtg tgccctgtgt
      661 ggcggagatt gggggaagag tgtggaacac tggtaaggtt gctgcccgtc tttgtcagag
      721 gtcagccata ctgcaagttc aactccattg aacagagaag ccgccagcct ttctcttcca
      781 cccaaggact gcacgccaag cacagcgagt gttcgggcca gctcagctca agtgtcttca
      841 agcttggccc gtggaaagct gtatgtagtt gaggctgagc gtgagggtgg gggtggtgat
      901 acaaaaagat gaatttcgtc ttaacatgat ttaggaagat tttatttttc gggatgtcag
      961 aaattacagc aatatattca taaataccta attactacat tcaacaaata atattacaat
     1021 acagttaatt caaacaagaa aaaaaaaaaa aaaaaaaaaa a
//
