LOCUS       NM_026250               2785 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus gypsy retrotransposon integrase 1 (Gin1), transcript
            variant 1, mRNA.
ACCESSION   NM_026250
VERSION     NM_026250.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2785)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2785)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
REFERENCE   3  (bases 1 to 2785)
  AUTHORS   Llorens,C. and Marin,I.
  TITLE     A mammalian gene evolved from the integrase domain of an LTR
            retrotransposon
  JOURNAL   Mol Biol Evol 18 (8), 1597-1600 (2001)
   PUBMED   11470852
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK014287.1, AK169361.1 and AC102191.11.
            
            On Jul 18, 2015 this sequence version replaced NM_026250.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK014287.1, AK015243.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849382, SAMN00849383
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                AK014287.1         6-49
            45-1836             AK169361.1         1-1792
            1837-2785           AC102191.11        121793-122741       c
FEATURES             Location/Qualifiers
     source          1..2785
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 47.76 cM"
     gene            1..2785
                     /gene="Gin1"
                     /gene_synonym="4930429M06Rik; 8430411H10Rik; Gin-1; Zh2c2"
                     /note="gypsy retrotransposon integrase 1"
                     /db_xref="GeneID:252876"
                     /db_xref="MGI:MGI:2182036"
     exon            1..84
                     /gene="Gin1"
                     /gene_synonym="4930429M06Rik; 8430411H10Rik; Gin-1; Zh2c2"
                     /inference="alignment:Splign:2.1.0"
     exon            85..230
                     /gene="Gin1"
                     /gene_synonym="4930429M06Rik; 8430411H10Rik; Gin-1; Zh2c2"
                     /inference="alignment:Splign:2.1.0"
     CDS             92..1648
                     /gene="Gin1"
                     /gene_synonym="4930429M06Rik; 8430411H10Rik; Gin-1; Zh2c2"
                     /note="isoform 1 is encoded by transcript variant 1; gypsy
                     retrotransposon integrase-like protein 1; zinc finger H2C2
                     domain-containing protein; zinc finger, H2C2 domain
                     containing"
                     /codon_start=1
                     /product="gypsy retrotransposon integrase-like protein 1
                     isoform 1"
                     /protein_id="NP_080526.2"
                     /db_xref="CCDS:CCDS35679.1"
                     /db_xref="GeneID:252876"
                     /db_xref="MGI:MGI:2182036"
                     /translation="MVRSGKNGDLHLKQIAYYKRTGEYHPTTLPSERSGIRRAAKKFV
                     FKEKKLFYVGKDRKQNRLVVVSEEEKKKVLRECHENGPGVHHGISRTLTLVESGYYWT
                     SVTNDVKQWVYACQHCQVAKNTVIVAPQQHLPMVGNPWSVVTVDLMGPFHTSNRSHVY
                     AIIMTDLFTKWVMILPLCDVSASEISKAIINIFFLYGPPQKIIMDQRDEFIEQINVEL
                     YRLFGAKEIVISRASGSVNPAENTPSTIKTFLSKHCADHPNSWDEHLPALSFAFNVTH
                     LEPNKNTPYFQMFNRNPCVLECPPEEGSEGTSVFARIVAAIREADGVVENKTPASSQM
                     ENNNSDELSKSKVVKKKAKQLNPFHLKVGHEVLRQRKNWWKDGRFQSEWVGPCVIDYI
                     TESGCAVLRDNTGTRLKRPIKMSHLRPYVRESSEQDSLYLLQGSIVADHDYIGLPEIP
                     VGTYQANILVEDATIGIADNELLISSKDHELLEYRNSKISALVEDHSSLEKQTFSLLD
                     SSNQVLEYLS"
     exon            231..424
                     /gene="Gin1"
                     /gene_synonym="4930429M06Rik; 8430411H10Rik; Gin-1; Zh2c2"
                     /inference="alignment:Splign:2.1.0"
     exon            425..730
                     /gene="Gin1"
                     /gene_synonym="4930429M06Rik; 8430411H10Rik; Gin-1; Zh2c2"
                     /inference="alignment:Splign:2.1.0"
     exon            731..922
                     /gene="Gin1"
                     /gene_synonym="4930429M06Rik; 8430411H10Rik; Gin-1; Zh2c2"
                     /inference="alignment:Splign:2.1.0"
     exon            923..1090
                     /gene="Gin1"
                     /gene_synonym="4930429M06Rik; 8430411H10Rik; Gin-1; Zh2c2"
                     /inference="alignment:Splign:2.1.0"
     exon            1091..1373
                     /gene="Gin1"
                     /gene_synonym="4930429M06Rik; 8430411H10Rik; Gin-1; Zh2c2"
                     /inference="alignment:Splign:2.1.0"
     exon            1374..2785
                     /gene="Gin1"
                     /gene_synonym="4930429M06Rik; 8430411H10Rik; Gin-1; Zh2c2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1821..1826
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gin1"
                     /gene_synonym="4930429M06Rik; 8430411H10Rik; Gin-1; Zh2c2"
                     /note="hexamer: AATAAA"
     polyA_site      1843
                     /gene="Gin1"
                     /gene_synonym="4930429M06Rik; 8430411H10Rik; Gin-1; Zh2c2"
                     /note="major polyA site"
     regulatory      1900..1905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gin1"
                     /gene_synonym="4930429M06Rik; 8430411H10Rik; Gin-1; Zh2c2"
                     /note="hexamer: AATAAA"
     polyA_site      1934
                     /gene="Gin1"
                     /gene_synonym="4930429M06Rik; 8430411H10Rik; Gin-1; Zh2c2"
     regulatory      2016..2021
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gin1"
                     /gene_synonym="4930429M06Rik; 8430411H10Rik; Gin-1; Zh2c2"
                     /note="hexamer: AATAAA"
     regulatory      2043..2048
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gin1"
                     /gene_synonym="4930429M06Rik; 8430411H10Rik; Gin-1; Zh2c2"
                     /note="hexamer: AATGAA"
     polyA_site      2054
                     /gene="Gin1"
                     /gene_synonym="4930429M06Rik; 8430411H10Rik; Gin-1; Zh2c2"
     polyA_site      2066
                     /gene="Gin1"
                     /gene_synonym="4930429M06Rik; 8430411H10Rik; Gin-1; Zh2c2"
ORIGIN      
        1 ccccggcagt tccgcttccg gtagcaccag ataaatcgcg agaggagagt taaaaacctg
       61 ccgtttgcac ttaggaccac ttcggttcgt gatggtccgt agtgggaaaa atggtgacct
      121 tcatcttaaa cagattgcat actataagcg cacaggggaa tatcacccca ctacactgcc
      181 gagtgagaga agcggcataa gacgagcagc taagaaattt gtcttcaaag aaaaaaagct
      241 gttttatgtt ggaaaagaca gaaaacaaaa tcgtttggta gttgtttcgg aagaggagaa
      301 gaagaaagta ctgagagagt gccatgagaa tggccctggt gtccatcacg gcatttccag
      361 aaccctcact ctagtggagt ctggctacta ctggacgtcc gtgaccaatg acgtcaagca
      421 gtgggtatat gcttgtcagc attgccaagt agcaaaaaat acagttatcg tagcacctca
      481 gcagcacctt cccatggtgg gaaacccgtg gagtgtagtt actgttgatc tgatgggacc
      541 tttccataca agcaacagaa gtcatgtgta tgctataatc atgacagatt tgttcacaaa
      601 atgggttatg attttgcctt tatgtgatgt ttcagcatca gaaatttcta aagctattat
      661 caatatattt tttctatatg gacctcctca gaaaataata atggaccaaa gagatgaatt
      721 cattgaacag atcaatgtag aactatatag attatttggt gcaaaagaga ttgtaatttc
      781 tcgtgcttct ggaagtgtta atccagctga aaacacacct agcaccatca aaacattcct
      841 ctccaaacac tgtgccgacc accccaacag ctgggatgag catctgccag ccctttcctt
      901 tgccttcaat gtcactcact tggagcctaa taaaaacaca ccgtatttcc aaatgttcaa
      961 tcggaatcct tgcgtgttgg agtgtcctcc tgaagagggc agtgaaggta caagtgtgtt
     1021 tgccagaatc gtagctgcga ttagagaggc tgatggcgtg gtggagaaca agacaccagc
     1081 atcgagccag atggagaaca acaattcgga tgaactgagt aaaagcaaag ttgttaaaaa
     1141 gaaagcaaag cagttaaatc cctttcattt gaaagtgggt catgaggttt tacgacagag
     1201 gaagaactgg tggaaggatg gccgcttcca gtctgagtgg gtcgggcctt gtgtcatcga
     1261 ctacattaca gaaagtggat gtgctgtcct cagagataac acgggaacca gactcaaacg
     1321 acctatcaaa atgtcccacc ttaggcccta tgtgagagag tccagtgagc aggacagtct
     1381 ttatctcttg caaggttcga tagtggcaga tcacgactac attggattac ctgagatccc
     1441 agttggaaca taccaggcaa atattctggt agaagatgca actattggga tagctgataa
     1501 tgaactattg atatcaagca aggatcatga actcttagaa tatagaaatt ccaaaatctc
     1561 tgcattggta gaagaccaca gttctcttga gaaacagact tttagcctac tggattcttc
     1621 aaatcaagtt ctcgagtact taagttagta aataccaaaa ttaatgtaaa atgcttgcac
     1681 agaatgtata tatttctagt ttgtaagtat tttatctatt aaaataggtt gtatagaaga
     1741 gagatcttgg tactatgtta ataactaaat tctgaaagct tattttaaac cttcctaaag
     1801 ttgttacatg tttgaataca aataaatata tgtaacagaa gtataccatg cgtagaattc
     1861 agaaatttct cagaaaacag acaaaatacg ttgttagaaa ataaattctc gtggagaagt
     1921 ctcacctttt tctatatggg tactacattt tctcttttaa cttttcagca atacataccc
     1981 cttttaaata aatttaaact aattatagct tagttaataa atgttgagtg aacaataaca
     2041 taaatgaaac gaaactttat ctgtgacatt ggaacttttt aaatttgtat ttgtgtgtgt
     2101 ctgtgtgtgt ctgtgtgtgc gcgcgcgcat gtgcatgtat acgtgtgttt ctgagtgagg
     2161 ctttatgtat gtgagtacag tgccctagtg taaaggctag gcaagggtat tggatatgct
     2221 gaagctgaag ttacaggtga ttgggcacca accaggttga gtactgggaa ccacactagg
     2281 atccactgca ccagcagagc acactccagc tgaaggacaa gtgactgtca gggaaagaat
     2341 gaagtctctg accttgtaca caaaccaaag acattgcaga tagaattcta gaaagaaact
     2401 aaaacagagt ggtgctagta ggctttgcct actctcctct acagagcaga gttcaggaag
     2461 ggagcctact gcagtgccta catggtcgat aaagtgattg tctctttgtc acctcaatga
     2521 agtcactttc ttctaagatt cttttcgaga tcatctgact tgaatttgtc ctattttact
     2581 tgttctattt aaggaggcca attagctttc agattgattt ctcggtggaa gattctaaat
     2641 agctaaaaat aatgttttcc cttcctaagt aatttcccat cagatttttg ctttgtgtgt
     2701 atgtgagtca tatcaggcta cattattctt cttgcaaatc atccccagat cttagtagct
     2761 taaaacaata aagctttatt tcttg
//
