LOCUS       NM_001077410            3656 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus GTPase, IMAP family member 8 (Gimap8), transcript
            variant 2, mRNA.
ACCESSION   NM_001077410
VERSION     NM_001077410.1
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 3656)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 3656)
  AUTHORS   Webb,L.M., Pascall,J.C., Hepburn,L., Carter,C., Turner,M. and
            Butcher,G.W.
  TITLE     Generation and characterisation of mice deficient in the
            multi-GTPase domain containing protein, GIMAP8
  JOURNAL   PLoS One 9 (10), e110294 (2014)
   PUBMED   25329815
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3656)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   4  (bases 1 to 3656)
  AUTHORS   Nitta,T., Nasreen,M., Seike,T., Goji,A., Ohigashi,I., Miyazaki,T.,
            Ohta,T., Kanno,M. and Takahama,Y.
  TITLE     IAN family critically regulates survival and development of T
            lymphocytes
  JOURNAL   PLoS Biol 4 (4), e103 (2006)
   PUBMED   16509771
REFERENCE   5  (bases 1 to 3656)
  AUTHORS   Krucken,J., Epe,M., Benten,W.P., Falkenroth,N. and Wunderlich,F.
  TITLE     Malaria-suppressible expression of the anti-apoptotic triple GTPase
            mGIMAP8
  JOURNAL   J Cell Biochem 96 (2), 339-348 (2005)
   PUBMED   16088918
  REMARK    GeneRIF: GIMAP8 exerts an anti-apoptotic effect in the immune
            system and is involved in responses to infections
REFERENCE   6  (bases 1 to 3656)
  AUTHORS   Krucken,J., Schroetel,R.M., Muller,I.U., Saidani,N., Marinovski,P.,
            Benten,W.P., Stamm,O. and Wunderlich,F.
  TITLE     Comparative analysis of the human gimap gene cluster encoding a
            novel GTPase family
  JOURNAL   Gene 341, 291-304 (2004)
   PUBMED   15474311
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK134199.1, AB178029.1, AA289616.1, BB033818.2 and BE456621.1.
            
            Summary: This gene encodes a protein belonging to the GTP-binding
            superfamily and to the immuno-associated nucleotide (IAN) subfamily
            of nucleotide-binding proteins. The encoded protein is larger than
            the other gene family members and includes three AIG1 domains
            (corresponding to the AIG1 protein from Arabidopsis thaliana)
            whereas other family members have one AIG1 domain. In humans, the
            IAN subfamily genes are located in a cluster at 7q36.1. [provided
            by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) represents the longest
            transcript. Variants 1 and 2 encode the same isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK134199.1, ERR3363660.540323.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-688               AK134199.1         2-689
            689-695             AB178029.1         683-689
            696-2304            AK134199.1         697-2305
            2305-2927           AB178029.1         2299-2921
            2928-3051           AA289616.1         347-470
            3052-3620           BB033818.2         88-656
            3621-3656           BE456621.1         1-36                c
FEATURES             Location/Qualifiers
     source          1..3656
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 23.62 cM"
     gene            1..3656
                     /gene="Gimap8"
                     /gene_synonym="Gm457; IAN9; IMAP8"
                     /note="GTPase, IMAP family member 8"
                     /db_xref="GeneID:243374"
                     /db_xref="MGI:MGI:2685303"
     exon            1..52
                     /gene="Gimap8"
                     /gene_synonym="Gm457; IAN9; IMAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            53..173
                     /gene="Gimap8"
                     /gene_synonym="Gm457; IAN9; IMAP8"
                     /inference="alignment:Splign:2.1.0"
     CDS             82..2148
                     /gene="Gimap8"
                     /gene_synonym="Gm457; IAN9; IMAP8"
                     /note="isoform 1 is encoded by transcript variant 2;
                     immune-associated nucleotide-binding protein 9;
                     immunity-associated protein 8"
                     /codon_start=1
                     /product="GTPase IMAP family member 8 isoform 1"
                     /protein_id="NP_001070878.1"
                     /db_xref="CCDS:CCDS20108.1"
                     /db_xref="GeneID:243374"
                     /db_xref="MGI:MGI:2685303"
                     /translation="MATSSHQGAAAGSQAEHRSCEASVGQGERPSASQGQEGNFKQNQ
                     GTSTLRLLLLGKQGAGKSATGNTILGKAVFESKFSDHMVTDRCQSESVSVRGKQVIVI
                     DTPDLFSSLSCSEVRQQNLKQCLELLADDHCVLLLVTPIGHYTEEDRETIEGIWGKIG
                     PKAYRHMIVVFTREDELDEDSLWNYIESKESLKELIKNIGSRRCCTFNNKADKKQREL
                     QVFKLLDAIELLMMESPEPYFEPLKMESSGVQGCGNGVTYEGDTLCGSKKRQPQITGP
                     DCDPDMPELRVLLMGKRGVGKSAAGNSILGKQVFKTQFSEKQRVTKAFASHSRVWQGK
                     KVLIIDSPEISSWKLDESAVKNHTFPGPHAFLLVTPLGSSLKSDDDVFSIIKRIFGEK
                     FTKFTIVLFTRKEDFEDQALDKVIKENDALYNLTQKFGERYAIFNYRASVEEEQSQVG
                     KLLSQIEKMVQCHSNKPCVIREKELLNIILLGRSGAGKSATGNTILGRSAFFSQLRAQ
                     PVTSSSQSGKRTLDWQDVVVVDTPSFIQTPGTEKDPSRLKEEIHHCLSLCEEGMKIFV
                     LVLQLGRFTQEDEVVVEQLEASFEENIMKYMIVLFTRKEDLGDGDLHDYTNNTKNKAL
                     KKILKKCNGRVCAFNNKETGEDQETQVKGLLKIANSLKKNYDEHSNSWVGQLKSTLGQ
                     ITMAFK"
     exon            174..831
                     /gene="Gimap8"
                     /gene_synonym="Gm457; IAN9; IMAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            832..874
                     /gene="Gimap8"
                     /gene_synonym="Gm457; IAN9; IMAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            875..1501
                     /gene="Gimap8"
                     /gene_synonym="Gm457; IAN9; IMAP8"
                     /inference="alignment:Splign:2.1.0"
     exon            1502..3654
                     /gene="Gimap8"
                     /gene_synonym="Gm457; IAN9; IMAP8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3633..3638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gimap8"
                     /gene_synonym="Gm457; IAN9; IMAP8"
                     /note="hexamer: AATAAA"
     polyA_site      3654
                     /gene="Gimap8"
                     /gene_synonym="Gm457; IAN9; IMAP8"
                     /note="major polyA site"
ORIGIN      
        1 cccttccgtg ttcatcctat gtgctctgag ctccttctca ggctctactg atgatttgct
       61 tccactgacc tgagggcaga gatggcgact tcatcccacc aaggagcagc tgcaggaagc
      121 caggcagagc acagaagctg tgaagcatca gtaggacagg gggaaagacc gagtgccagc
      181 cagggtcagg agggcaactt caagcagaac cagggaacgt ccacactgcg gctcctcctg
      241 ctagggaaac agggcgcagg caaaagtgcc acaggaaaca ccattctggg caaagccgtg
      301 ttcgagtcca agttcagtga tcacatggta accgacagat gccagagcga gagtgtgtca
      361 gtaagaggga aacaggtcat tgtcatcgat accccagatc ttttctcctc actgagctgt
      421 tcagaggtta ggcagcagaa cctgaagcag tgcttggagc tcttagctga tgatcactgt
      481 gtgctgctcc tggtcactcc cattggccac tatacagagg aggacaggga gaccattgaa
      541 ggcatctggg gtaaaattgg ccctaaagcc tacagacaca tgattgtggt cttcactcgg
      601 gaagatgagc tggatgaaga ctccctgtgg aactacattg agagcaagga gtctctgaag
      661 gagttgatta aaaacattgg aagtcgacga tgttgtactt tcaacaacaa ggcagacaag
      721 aagcagcggg aactgcaggt gttcaagctg cttgatgcaa ttgaactttt gatgatggaa
      781 agccctgagc catattttga gcccttaaaa atggaaagca gtggagtcca gggttgtggg
      841 aatggagtga catatgaagg ggacactctg tgtggttcaa agaagaggca gcctcagatc
      901 acaggacccg attgtgatcc agacatgcca gagctgaggg tcctcctgat ggggaagcgt
      961 ggtgttggga aaagtgcagc aggaaacagc attctgggga agcaggtctt taagactcag
     1021 ttcagtgaga agcagcgggt caccaaggcc tttgcatccc acagcagggt ctggcaaggg
     1081 aagaaagttc tgattataga ttctccagag atctcatcgt ggaagcttga tgagtctgct
     1141 gtcaagaatc acacctttcc aggtccccat gcctttctgc tggtgacacc actgggttct
     1201 tctttaaaga gtgatgacga tgtgttcagc atcatcaaac gtatttttgg agaaaaattc
     1261 accaagttca caattgttct ctttaccagg aaagaagatt ttgaggatca ggctctagat
     1321 aaggttataa aggaaaatga tgctctctat aatctcaccc agaaatttgg agaaagatac
     1381 gcaatcttca actaccgggc atctgtggag gaggagcaga gccaggtggg caaactactg
     1441 agccaaatcg agaagatggt gcagtgccac agcaacaagc cttgcgtcat cagagagaaa
     1501 gaacttttaa acatcatcct cttgggaagg agtggggctg gaaagagtgc aactgggaac
     1561 actatcctgg ggagatctgc cttcttctcc cagctcagag ctcagccggt caccagtagc
     1621 agccagagtg gtaagaggac actggactgg caggatgttg tggttgtgga cactccatca
     1681 ttcatccaga cgcctggcac tgaaaaggat ccctccaggt taaaggagga gatccatcac
     1741 tgtttgagtc tctgcgaaga aggcatgaag atttttgtcc tggttctcca gttgggacgg
     1801 ttcacccagg aagatgaggt ggtggtggag caactggagg ccagttttga ggaaaacatt
     1861 atgaaatata tgattgtgct gtttacacgg aaggaagacc taggggatgg ggaccttcat
     1921 gattatacta acaacacaaa gaacaaagcc cttaaaaaaa tacttaaaaa gtgcaatggg
     1981 cgagtttgtg cttttaataa caaagaaact ggtgaagacc aggagaccca ggtgaaaggt
     2041 ctgttgaaaa tagccaatag tctcaaaaag aactatgatg agcattcaaa ttcatgggtg
     2101 ggtcaattaa aatcaacact aggccaaatt actatggcat ttaaatgagc tcaagtgagc
     2161 agttttaagg ctgggaacag tttagggatg ccatcagaca gaggaggggg tgggtgcgag
     2221 ggggaaggac tagtggggtg gatcctctca aagaaggttc atgacttgga aggctgaggg
     2281 ataaatgcat ctcatgaagg atgtagatat tcaggtaaat aaattcttaa gttaggtcag
     2341 gcagaaggaa attagaagac aaagagatta tggaagagaa aatgtttttc tttgatttaa
     2401 gttttattgc attatctcaa attatgttaa acataataga cttacaccac atttttcttt
     2461 cccttttgta ccccaactcc tccctgagag ccctccccac ttcaaaacct gcaatatatt
     2521 tcatctttca tcatattctt taaaatttat aaaatattat aaaaataaaa atgagtatta
     2581 taaaagttgt ttgatataat acaacaatca attgaacagt cttacgtcga tgtttgtcta
     2641 catcaatact gaaagtacat acattttcct caatataaat tttaaataac tctgaatata
     2701 ttaactgtat gatattttaa aataatatat cactatttgt ttttttttaa cgaacataaa
     2761 tagataaagt ctgtttgttt gttttgttgt tttgtagagt ttaaaatctt ggctcttact
     2821 gtagtacaaa ctcaaaataa gaacagtttt tggatattgg agttcattgt aataaggctg
     2881 tacttgaatg cccctcgcat caccaaagga ttttacctcc atagtagata agctaagagt
     2941 tgtcagttct gctgcaccaa ggaatgaatt gtaagcatga tttttggata cagatttcct
     3001 gctacagtca aagctatttg acttgagtga ttgtcgtcat tctcagcccg cagggaacag
     3061 gttacattca tttaagaaat ggtgtgtgta ttaaaatggt ctatacatga agtcattcat
     3121 caactgtttc aatgaacaat ggctctgctt ggagggtggc acagatgtta ggtgagggta
     3181 agattctggt tgatttgctg tgttgatttt gaaaatcatt catctcagaa taagagtaac
     3241 ttataaagtc ctctacttca aaattgatac aatcattata aatactttcc cattgcagtc
     3301 aactcctcct agaggaaggg ttgtgtgtgg ttgaatttcc tactcaggta aaatcaaagg
     3361 ttattataaa gtatataaat agtattgaaa agacccccaa gatgcagatt gtgttaagaa
     3421 gagagggtaa tagacatttt aattgtaact acagagctat gattctattc aaatctgata
     3481 agtacaaatg ttttgtcctt tgtcccaact tttttcctat caaagcctaa agattagtat
     3541 aattcccaaa gatggtcttg gactgcctaa acctttgtat ttgtattctt tatagccact
     3601 ctgattaaat ctcttttcag aaattaaaaa aaaataaaaa aaaataaata ccaaaa
//
