LOCUS       NM_153175               1612 bp    mRNA    linear   ROD 10-FEB-2025
DEFINITION  Mus musculus GTPase, IMAP family member 6 (Gimap6), mRNA.
ACCESSION   NM_153175
VERSION     NM_153175.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1612)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 1612)
  AUTHORS   Yao,Y., Du Jiang,P., Chao,B.N., Cagdas,D., Kubo,S.,
            Balasubramaniyam,A., Zhang,Y., Shadur,B., NaserEddin,A.,
            Folio,L.R., Schwarz,B., Bohrnsen,E., Zheng,L., Lynberg,M.,
            Gottlieb,S., Leney-Greene,M.A., Park,A.Y., Tezcan,I., Akdogan,A.,
            Gocmen,R., Onder,S., Rosenberg,A., Soilleux,E.J., Johnson,E.,
            Jackson,P.K., Demeter,J., Chauvin,S.D., Paul,F., Selbach,M.,
            Bulut,H., Clatworthy,M.R., Tuong,Z.K., Zhang,H., Stewart,B.J.,
            Bosio,C.M., Stepensky,P., Clare,S., Ganesan,S., Pascall,J.C.,
            Daumke,O., Butcher,G.W., McMichael,A.J., Simon,A.K. and
            Lenardo,M.J.
  TITLE     GIMAP6 regulates autophagy, immune competence, and inflammation in
            mice and humans
  JOURNAL   J Exp Med 219 (6) (2022)
   PUBMED   35551368
  REMARK    GeneRIF: GIMAP6 regulates autophagy, immune competence, and
            inflammation in mice and humans.
REFERENCE   3  (bases 1 to 1612)
  AUTHORS   Ingham,N.J., Pearson,S.A., Vancollie,V.E., Rook,V., Lewis,M.A.,
            Chen,J., Buniello,A., Martelletti,E., Preite,L., Lam,C.C.,
            Weiss,F.D., Powis,Z., Suwannarat,P., Lelliott,C.J., Dawson,S.J.,
            White,J.K. and Steel,K.P.
  TITLE     Mouse screen reveals multiple new genes underlying mouse and human
            hearing loss
  JOURNAL   PLoS Biol 17 (4), e3000194 (2019)
   PUBMED   30973865
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1612)
  AUTHORS   Pascall,J.C., Webb,L.M.C., Eskelinen,E.L., Innocentin,S.,
            Attaf-Bouabdallah,N. and Butcher,G.W.
  TITLE     GIMAP6 is required for T cell maintenance and efficient autophagy
            in mice
  JOURNAL   PLoS One 13 (5), e0196504 (2018)
   PUBMED   29718959
  REMARK    GeneRIF: The results indicate a requirement for GIMAP6 in the
            maintenance of a normal peripheral adaptive immune system and a
            significant role for the protein in normal autophagic processes.
            Moreover, as GIMAP6 is expressed in a cell-selective manner, this
            indicates the potential existence of a cell-restricted mode of
            autophagic regulation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1612)
  AUTHORS   Dickinson,M.E., Flenniken,A.M., Ji,X., Teboul,L., Wong,M.D.,
            White,J.K., Meehan,T.F., Weninger,W.J., Westerberg,H., Adissu,H.,
            Baker,C.N., Bower,L., Brown,J.M., Caddle,L.B., Chiani,F., Clary,D.,
            Cleak,J., Daly,M.J., Denegre,J.M., Doe,B., Dolan,M.E., Edie,S.M.,
            Fuchs,H., Gailus-Durner,V., Galli,A., Gambadoro,A., Gallegos,J.,
            Guo,S., Horner,N.R., Hsu,C.W., Johnson,S.J., Kalaga,S., Keith,L.C.,
            Lanoue,L., Lawson,T.N., Lek,M., Mark,M., Marschall,S., Mason,J.,
            McElwee,M.L., Newbigging,S., Nutter,L.M., Peterson,K.A.,
            Ramirez-Solis,R., Rowland,D.J., Ryder,E., Samocha,K.E.,
            Seavitt,J.R., Selloum,M., Szoke-Kovacs,Z., Tamura,M., Trainor,A.G.,
            Tudose,I., Wakana,S., Warren,J., Wendling,O., West,D.B., Wong,L.,
            Yoshiki,A., MacArthur,D.G., Tocchini-Valentini,G.P., Gao,X.,
            Flicek,P., Bradley,A., Skarnes,W.C., Justice,M.J., Parkinson,H.E.,
            Moore,M., Wells,S., Braun,R.E., Svenson,K.L., de Angelis,M.H.,
            Herault,Y., Mohun,T., Mallon,A.M., Henkelman,R.M., Brown,S.D.,
            Adams,D.J., Lloyd,K.C., McKerlie,C., Beaudet,A.L., Bucan,M. and
            Murray,S.A.
  CONSRTM   International Mouse Phenotyping Consortium; Jackson Laboratory;
            Infrastructure Nationale PHENOMIN, Institut Clinique de la Souris
            (ICS); Charles River Laboratories; MRC Harwell; Toronto Centre for
            Phenogenomics; Wellcome Trust Sanger Institute; RIKEN BioResource
            Center
  TITLE     High-throughput discovery of novel developmental phenotypes
  JOURNAL   Nature 537 (7621), 508-514 (2016)
   PUBMED   27626380
  REMARK    Erratum:[Nature. 2017 Nov 16;551(7680):398. doi:
            10.1038/nature24643.. PMID: 29144450]
REFERENCE   6  (bases 1 to 1612)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   7  (bases 1 to 1612)
  AUTHORS   Zhou,P., Zhang,Y., Ma,Q., Gu,F., Day,D.S., He,A., Zhou,B., Li,J.,
            Stevens,S.M., Romo,D. and Pu,W.T.
  TITLE     Interrogating translational efficiency and lineage-specific
            transcriptomes using ribosome affinity purification
  JOURNAL   Proc Natl Acad Sci U S A 110 (38), 15395-15400 (2013)
   PUBMED   24003143
REFERENCE   8  (bases 1 to 1612)
  AUTHORS   Krucken,J., Schroetel,R.M., Muller,I.U., Saidani,N., Marinovski,P.,
            Benten,W.P., Stamm,O. and Wunderlich,F.
  TITLE     Comparative analysis of the human gimap gene cluster encoding a
            novel GTPase family
  JOURNAL   Gene 341, 291-304 (2004)
   PUBMED   15474311
REFERENCE   9  (bases 1 to 1612)
  AUTHORS   Phillips,R.L., Ernst,R.E., Brunk,B., Ivanova,N., Mahan,M.A.,
            Deanehan,J.K., Moore,K.A., Overton,G.C. and Lemischka,I.R.
  TITLE     The genetic program of hematopoietic stem cells
  JOURNAL   Science 288 (5471), 1635-1640 (2000)
   PUBMED   10834841
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BU699766.1, BC028779.1 and
            AK050328.1.
            
            On Jan 15, 2005 this sequence version replaced NM_153175.2.
            
            Summary: This gene encodes a protein belonging to the GTP-binding
            superfamily and to the immuno-associated nucleotide (IAN) subfamily
            of nucleotide-binding proteins. In humans, the IAN subfamily genes
            are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK050328.1, BC028779.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-283               BU699766.1         1-283
            284-435             BC028779.1         236-387
            436-1120            AK050328.1         378-1062
            1121-1130           BC028779.1         1073-1082
            1131-1612           AK050328.1         1073-1554
FEATURES             Location/Qualifiers
     source          1..1612
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 23.67 cM"
     gene            1..1612
                     /gene="Gimap6"
                     /gene_synonym="4833419H03Rik; Ian6; mFLJ00102"
                     /note="GTPase, IMAP family member 6"
                     /db_xref="GeneID:231931"
                     /db_xref="MGI:MGI:1918876"
     exon            1..286
                     /gene="Gimap6"
                     /gene_synonym="4833419H03Rik; Ian6; mFLJ00102"
                     /inference="alignment:Splign:2.1.0"
     CDS             95..1012
                     /gene="Gimap6"
                     /gene_synonym="4833419H03Rik; Ian6; mFLJ00102"
                     /note="immune associated nucleotide 6; IAN-6; mIAN6;
                     immunity-associated nucleotide 6 protein"
                     /codon_start=1
                     /product="GTPase IMAP family member 6"
                     /protein_id="NP_694815.1"
                     /db_xref="CCDS:CCDS20111.1"
                     /db_xref="GeneID:231931"
                     /db_xref="MGI:MGI:1918876"
                     /translation="MDWLYRKTLGSIGSCSIETFPWPFYSFFQRIYISTPPGKPENSP
                     ETSATEVGEQRPSCLSASPVVEEEECEHRPEKNPTRQWPLDSGQGLTKGLKEKKLTPK
                     RLQLLLVGKTGSGKSATGNSILGRQAFESKISARPVTTTFQKGTREFEGKELEVIDTP
                     DIFSPQNQPEATAKKICDLLASPGPHAVLLVIQVGRYTAEDQAVARCLQEIFGNTILA
                     YTILVFTRKEDLAEGSLEEYIQENNNKSLDVLDVACERRHCGFNNKAQGDEQEAQLKK
                     LMEEVELILWENEGHCYTMEFPNVPSKTL"
     exon            287..371
                     /gene="Gimap6"
                     /gene_synonym="4833419H03Rik; Ian6; mFLJ00102"
                     /inference="alignment:Splign:2.1.0"
     exon            372..1612
                     /gene="Gimap6"
                     /gene_synonym="4833419H03Rik; Ian6; mFLJ00102"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1588..1593
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gimap6"
                     /gene_synonym="4833419H03Rik; Ian6; mFLJ00102"
                     /note="hexamer: AATAAA"
     polyA_site      1611
                     /gene="Gimap6"
                     /gene_synonym="4833419H03Rik; Ian6; mFLJ00102"
                     /note="major polyA site"
ORIGIN      
        1 tcatttcctg tttctcattg cacagcgagc tgctattttg aaggacagtt cttgagctca
       61 gatcatattt tgccgacaaa atatggattg aaagatggat tggctttaca gaaaaacact
      121 cgggtccatc ggctcatgtt ctatagaaac ttttccctgg ccattctatt cattctttca
      181 gagaatctac atttcgaccc caccaggaaa gccagaaaat tcaccagaga ccagtgctac
      241 tgaagtcggg gaacagagac cttcttgcct gtcagccagc ccagtggtgg aagaggaaga
      301 gtgtgagcac agacctgaga agaatcccac aaggcagtgg cccctggact ctggacaagg
      361 attgacaaaa ggtctgaagg agaaaaaact caccccaaag agactgcagc tccttctggt
      421 ggggaaaaca ggaagcggga aaagtgcaac agggaacagc atccttggca ggcaagcctt
      481 tgaatccaaa atcagcgctc gaccagtgac cacgacattc cagaaaggga ctagagagtt
      541 tgaggggaaa gaacttgagg tgatcgacac cccagatatt ttttcacctc agaaccagcc
      601 tgaggcaaca gctaagaaga tctgtgacct cttggcctca ccagggcccc atgcagtgct
      661 gctggtgata caggtaggcc ggtacactgc cgaggaccag gcggtagcca ggtgcctcca
      721 ggagatcttt ggaaacacga tcctggctta cactattctg gtgttcaccc ggaaggaaga
      781 cctggctgag ggctccttag aagaatatat tcaagagaac aacaataaga gcctggatgt
      841 tctggatgtt gcatgtgaga ggcgccactg tggcttcaac aacaaggcac aaggggatga
      901 gcaggaggcc cagttgaaga aacttatgga ggaagtcgaa ttgatcttgt gggaaaatga
      961 gggccattgt tacaccatgg aatttccaaa tgttcccagc aagacactgt aaccaaatag
     1021 caaggccctg aggaggcaac cattaaagag tcctggctga aaaggctgtc ccagattcag
     1081 atggcctctg agaagccctg taggtactga ggcagagggc atccatgtga accaagctgg
     1141 ccataagcag gagtgtctta gtcagtgttc tattgctgtg aagagacacc atgactgtgg
     1201 caaatcttat aaaagaaaac atttaattgg ggcttagccc attatctgga ctatttaata
     1261 gattgtgttc tataaccatg ttctaaccat tgacttactt ctaagccctt gagagacttt
     1321 gctgcaatgg catatgtaca gtgactaatt ctgaacagta tatgtctttc ctggggaggg
     1381 gcaggagtag taccatcttt tgtgagctaa gtagagttgg atgtatagga acagattacc
     1441 aagcacaagc aagtcttaca acagagtcaa caagtcttgc aacagatagg caggacacag
     1501 cagagatcct gaggagtcaa atatgagaga gccaacccag agccatcccc tgtgtgctgt
     1561 ctcccctgtg ctccaccata agtccccaat aaagccttca tgtcccattg gt
//
