LOCUS       NM_175035               1943 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus GTPase, IMAP family member 5 (Gimap5), mRNA.
ACCESSION   NM_175035 XM_904717
VERSION     NM_175035.5
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1943)
  AUTHORS   Drzewiecki,K., Choi,J., Brancale,J., Leney-Greene,M.A., Sari,S.,
            Dalgic,B., Unlusoy Aksu,A., Evirgen Sahin,G., Ozen,A., Baris,S.,
            Karakoc-Aydiner,E., Jain,D., Kleiner,D., Schmalz,M.,
            Radhakrishnan,K., Zhang,J., Hoebe,K., Su,H.C., Pereira,J.P.,
            Lenardo,M.J., Lifton,R.P. and Vilarinho,S.
  TITLE     GIMAP5 maintains liver endothelial cell homeostasis and prevents
            portal hypertension
  JOURNAL   J Exp Med 218 (7) (2021)
   PUBMED   33956074
  REMARK    GeneRIF: GIMAP5 maintains liver endothelial cell homeostasis and
            prevents portal hypertension.
REFERENCE   2  (bases 1 to 1943)
  AUTHORS   Patterson,A.R., Bolcas,P., Lampe,K., Cantrell,R., Ruff,B.,
            Lewkowich,I., Hogan,S.P., Janssen,E.M., Bleesing,J., Khurana
            Hershey,G.K. and Hoebe,K.
  TITLE     Loss of GTPase of immunity-associated protein 5 (Gimap5) promotes
            pathogenic CD4+ T-cell development and allergic airway disease
  JOURNAL   J Allergy Clin Immunol 143 (1), 245-257 (2019)
   PUBMED   30616774
  REMARK    GeneRIF: Activation of Gimap5-deficient CD4(+) T cells is
            associated with increased DNA damage and reduced survival that can
            be overcome by TGF-beta. This leads to selective survival of
            pathogenic TH17 cells but also TH2 cells in human subjects and
            mice, ultimately promoting allergic airway disease.
REFERENCE   3  (bases 1 to 1943)
  AUTHORS   Patterson,A.R., Endale,M., Lampe,K., Aksoylar,H.I., Flagg,A.,
            Woodgett,J.R., Hildeman,D., Jordan,M.B., Singh,H., Kucuk,Z.,
            Bleesing,J. and Hoebe,K.
  TITLE     Gimap5-dependent inactivation of GSK3beta is required for CD4+ T
            cell homeostasis and prevention of immune pathology
  JOURNAL   Nat Commun 9 (1), 430 (2018)
   PUBMED   29382851
  REMARK    GeneRIF: Gimap5 is a critical inhibitor of GSK3-beta in the CD4+ T
            cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1943)
  AUTHORS   Chen,X.L., Serrano,D., Ghobadi,F., Mayhue,M., Hoebe,K.,
            Ilangumaran,S. and Ramanathan,S.
  TITLE     TCR and IL-7 Signaling Are Altered in the Absence of Functional
            GTPase of the Immune Associated Nucleotide Binding Protein 5
            (GIMAP5)
  JOURNAL   PLoS One 11 (3), e0151837 (2016)
   PUBMED   27023180
  REMARK    GeneRIF: functional Gimap5 is required for optimal signaling
            through TCR and IL-7R in T cells.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1943)
  AUTHORS   Endale,M., Aksoylar,H.I. and Hoebe,K.
  TITLE     Central role of gimap5 in maintaining peripheral tolerance and T
            cell homeostasis in the gut
  JOURNAL   Mediators Inflamm 2015, 436017 (2015)
   PUBMED   25944983
  REMARK    GeneRIF: gimap5 has a role in maintaining peripheral tolerance and
            T cell homeostasis in the gut [review]
            Review article
REFERENCE   6  (bases 1 to 1943)
  AUTHORS   Barnes,M.J., Krebs,P., Harris,N., Eidenschenk,C.,
            Gonzalez-Quintial,R., Arnold,C.N., Crozat,K., Sovath,S.,
            Moresco,E.M., Theofilopoulos,A.N., Beutler,B. and Hoebe,K.
  TITLE     Commitment to the regulatory T cell lineage requires CARMA1 in the
            thymus but not in the periphery
  JOURNAL   PLoS Biol 7 (3), e51 (2009)
   PUBMED   19260764
REFERENCE   7  (bases 1 to 1943)
  AUTHORS   Schulteis,R.D., Chu,H., Dai,X., Chen,Y., Edwards,B., Haribhai,D.,
            Williams,C.B., Malarkannan,S., Hessner,M.J.,
            Glisic-Milosavljevic,S., Jana,S., Kerschen,E.J., Ghosh,S., Wang,D.,
            Kwitek,A.E., Lernmark,A., Gorski,J. and Weiler,H.
  TITLE     Impaired survival of peripheral T cells, disrupted NK/NKT cell
            development, and liver failure in mice lacking Gimap5
  JOURNAL   Blood 112 (13), 4905-4914 (2008)
   PUBMED   18796632
  REMARK    GeneRIF: mouse gimap5 is necessary for the survival of peripheral T
            cells, NK/NKT-cell development, and the maintenance of normal liver
            function
REFERENCE   8  (bases 1 to 1943)
  AUTHORS   Nitta,T., Nasreen,M., Seike,T., Goji,A., Ohigashi,I., Miyazaki,T.,
            Ohta,T., Kanno,M. and Takahama,Y.
  TITLE     IAN family critically regulates survival and development of T
            lymphocytes
  JOURNAL   PLoS Biol 4 (4), e103 (2006)
   PUBMED   16509771
REFERENCE   9  (bases 1 to 1943)
  AUTHORS   Krucken,J., Schroetel,R.M., Muller,I.U., Saidani,N., Marinovski,P.,
            Benten,W.P., Stamm,O. and Wunderlich,F.
  TITLE     Comparative analysis of the human gimap gene cluster encoding a
            novel GTPase family
  JOURNAL   Gene 341, 291-304 (2004)
   PUBMED   15474311
REFERENCE   10 (bases 1 to 1943)
  AUTHORS   Phillips,R.L., Ernst,R.E., Brunk,B., Ivanova,N., Mahan,M.A.,
            Deanehan,J.K., Moore,K.A., Overton,G.C. and Lemischka,I.R.
  TITLE     The genetic program of hematopoietic stem cells
  JOURNAL   Science 288 (5471), 1635-1640 (2000)
   PUBMED   10834841
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC153894.8 and AC115045.13.
            
            On Aug 4, 2006 this sequence version replaced NM_175035.4.
            
            Summary: This gene encodes a protein belonging to the GTP-binding
            superfamily and to the immuno-associated nucleotide (IAN) subfamily
            of nucleotide-binding proteins. In humans, the IAN subfamily genes
            are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB126961.1, AK052694.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-234               AC153894.8         211180-211413
            235-283             AC153894.8         215437-215485
            284-1943            AC115045.13        125405-127064       c
FEATURES             Location/Qualifiers
     source          1..1943
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 23.71 cM"
     gene            1..1943
                     /gene="Gimap5"
                     /gene_synonym="D630024P16; E230026N22Rik"
                     /note="GTPase, IMAP family member 5"
                     /db_xref="GeneID:317757"
                     /db_xref="MGI:MGI:2442232"
     exon            1..234
                     /gene="Gimap5"
                     /gene_synonym="D630024P16; E230026N22Rik"
                     /inference="alignment:Splign:2.1.0"
     exon            235..283
                     /gene="Gimap5"
                     /gene_synonym="D630024P16; E230026N22Rik"
                     /inference="alignment:Splign:2.1.0"
     CDS             241..1167
                     /gene="Gimap5"
                     /gene_synonym="D630024P16; E230026N22Rik"
                     /note="immunity-associated protein 3; immunity-associated
                     nucleotide 4-like 1 protein; GTPase of the
                     immunity-associated protein 5"
                     /codon_start=1
                     /product="GTPase IMAP family member 5"
                     /protein_id="NP_778200.1"
                     /db_xref="CCDS:CCDS20114.1"
                     /db_xref="GeneID:317757"
                     /db_xref="MGI:MGI:2442232"
                     /translation="MEHLQKSTYGTIVQGPEAHCVQESSCLRILLVGKSGCGKSATGN
                     SILRRPAFQSRLRGQSVTRTSQAETGTWEGRSILVVDTPPIFESKAQNQDMDKDIGDC
                     YLLCAPGPHVLLLVTQLGRFTAEDAMAVRMVKEVFGVGVMRHMIVLFTRKEDLEEKSL
                     EEFVTHTDNRSLRSLTQECGRRYCAFNNRASGEEQQGQLAELMALVRRLEQECEGSFH
                     SNDLFLHAEALLREGYSVHQEAYRCYLAKVRQEVEKQRRELEEQEGSWIAKMICTVKS
                     CWSSHTAACALLIVLGLTLLTTFINLCISRCK"
     exon            284..1943
                     /gene="Gimap5"
                     /gene_synonym="D630024P16; E230026N22Rik"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1318..1323
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gimap5"
                     /gene_synonym="D630024P16; E230026N22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1337
                     /gene="Gimap5"
                     /gene_synonym="D630024P16; E230026N22Rik"
                     /note="major polyA site"
     regulatory      1563..1568
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gimap5"
                     /gene_synonym="D630024P16; E230026N22Rik"
                     /note="hexamer: AATAAA"
     polyA_site      1591
                     /gene="Gimap5"
                     /gene_synonym="D630024P16; E230026N22Rik"
ORIGIN      
        1 tgttcaaggc ctttccacct acccgagggg atatagtctg cagggcagtg tgtattccgt
       61 caccatgggc tttcttttcc tgccttcgga ctctggattc atggctctgc atgtagctgt
      121 tctgtgagag cactgctcag caggcacagg cccaccgcat acctgtaagg gtaaagagga
      181 acccgccagg gcgctgacag ccgcttggga gccagggagc cgctgtgcac tcggaagaga
      241 atggaacacc ttcagaagag cacatatgga actatagttc aaggaccaga agcccactgt
      301 gtacaagaat ctagctgcct gaggatcctc ctggtgggca aatctggctg cggtaaaagc
      361 gccacaggga acagcatcct ccgacgacca gcattccagt ccaggctcag aggccagtct
      421 gtgaccagga ccagccaggc agagacaggc acatgggagg ggaggagcat cctagtggta
      481 gacacacccc ccatctttga gtcaaaggcc cagaaccaag acatggacaa ggacatcgga
      541 gactgctacc tgctgtgtgc cccaggaccc catgtgttgt tactggtgac ccagctggga
      601 cgcttcacag ctgaagatgc catggctgtg aggatggtga aggaggtctt tggggtaggg
      661 gtcatgaggc acatgatcgt cctcttcacc cgcaaggaag acctggaaga gaagtccttg
      721 gaagagtttg tgacccacac tgacaaccgc agcctgcgca gcctgactca ggagtgtggg
      781 aggaggtact gtgccttcaa caacagggcc tctggggagg agcagcaggg gcagctggca
      841 gagctcatgg ccctggtgag gaggctggaa caggagtgtg agggctcctt ccacagcaat
      901 gacctcttcc ttcatgctga ggcactcctt agagaaggtt acagtgtgca ccaggaagcc
      961 tataggtgct acctggccaa ggtgaggcag gaggtggaga agcagaggcg ggagctggag
     1021 gagcaggagg gcagctggat agctaaaatg atttgcacag tcaagtcctg ctggagctcc
     1081 cacactgcag catgtgctct tcttattgtg cttggtttga ctcttctcac cactttcatt
     1141 aacttgtgta ttagcaggtg taaatgagcc ttttttgggt gatttcttcc atcatccttg
     1201 tcccccaaag ttccccatct catgtcaggg aacctcagtc ttcaattaat ttcactctca
     1261 tttgattccc atggatcaga catgccaggg aatcttcttt taaatacagt tagattaaat
     1321 aaaggatgaa agaaaaatgt atttctctct ttgttgaagt tgtgaggata gatgatgaag
     1381 caagtagcta ccattataaa ggtctggggg cttgcacaaa ggaagacaca tggactgttg
     1441 tggcagtggg tgtatcactt ctagatcccc acttcctaca gatgtgatgt caagaggaga
     1501 aatacacaaa gctgagagca gagtcatact ttagtcaagt ataccctgac tttcatggta
     1561 ccaataaagt cagaactcca tcataattcc accccgagaa agataaagat ggtgtgcatg
     1621 aagcactgag gtgggagggc caggacatga gtggggacca agtgaagagg ttacaggagc
     1681 agggtaggtc ttatcccaga aaaagcaggg tcagcagtca agaatcacat gagccagaaa
     1741 gtctatggtc agagatacaa agggccagag gtgtgtatct tgggcttgga agattgtgtg
     1801 gtgagcatta taggccctca acaactcatg caggcaaaag ccactatgat acataaacct
     1861 gatgagcact aagtttttga agtacatgta attttcatgt atgacactag aacattgttc
     1921 tcctgaatcc ttcagctatt taa
//
