LOCUS       NM_174990               1814 bp    mRNA    linear   ROD 01-JUN-2024
DEFINITION  Mus musculus GTPase, IMAP family member 4 (Gimap4), transcript
            variant 1, mRNA.
ACCESSION   NM_174990
VERSION     NM_174990.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1814)
  AUTHORS   Timmermans,S. and Libert,C.
  TITLE     Overview of inactivating mutations in the protein-coding genome of
            the mouse reference strain C57BL/6J
  JOURNAL   JCI Insight 3 (13), 121758 (2018)
   PUBMED   29997285
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1814)
  AUTHORS   Duthie,K.A., Osborne,L.C., Foster,L.J. and Abraham,N.
  TITLE     Proteomics analysis of interleukin (IL)-7-induced signaling
            effectors shows selective changes in IL-7Ralpha449F knock-in T cell
            progenitors
  JOURNAL   Mol Cell Proteomics 6 (10), 1700-1710 (2007)
   PUBMED   17602185
REFERENCE   3  (bases 1 to 1814)
  AUTHORS   Schnell,S., Demolliere,C., van den Berk,P. and Jacobs,H.
  TITLE     Gimap4 accelerates T-cell death
  JOURNAL   Blood 108 (2), 591-599 (2006)
   PUBMED   16569770
  REMARK    GeneRIF: Gimap4 accelerates the execution of programmed cell death
            induced by intrinsic stimuli downstream of caspase-3 activation and
            phosphatidylserine exposure. Apoptosis directly correlates with the
            phosphorylation status of Gimap4.
REFERENCE   4  (bases 1 to 1814)
  AUTHORS   Nitta,T., Nasreen,M., Seike,T., Goji,A., Ohigashi,I., Miyazaki,T.,
            Ohta,T., Kanno,M. and Takahama,Y.
  TITLE     IAN family critically regulates survival and development of T
            lymphocytes
  JOURNAL   PLoS Biol 4 (4), e103 (2006)
   PUBMED   16509771
REFERENCE   5  (bases 1 to 1814)
  AUTHORS   Krucken,J., Schroetel,R.M., Muller,I.U., Saidani,N., Marinovski,P.,
            Benten,W.P., Stamm,O. and Wunderlich,F.
  TITLE     Comparative analysis of the human gimap gene cluster encoding a
            novel GTPase family
  JOURNAL   Gene 341, 291-304 (2004)
   PUBMED   15474311
REFERENCE   6  (bases 1 to 1814)
  AUTHORS   Stamm,O., Krucken,J., Schmitt-Wrede,H.P., Benten,W.P. and
            Wunderlich,F.
  TITLE     Human ortholog to mouse gene imap38 encoding an ER-localizable
            G-protein belongs to a gene family clustered on chromosome 7q32-36
  JOURNAL   Gene 282 (1-2), 159-167 (2002)
   PUBMED   11814688
REFERENCE   7  (bases 1 to 1814)
  AUTHORS   Poirier,G.M., Anderson,G., Huvar,A., Wagaman,P.C., Shuttleworth,J.,
            Jenkinson,E., Jackson,M.R., Peterson,P.A. and Erlander,M.G.
  TITLE     Immune-associated nucleotide-1 (IAN-1) is a thymic selection marker
            and defines a novel gene family conserved in plants
  JOURNAL   J Immunol 163 (9), 4960-4969 (1999)
   PUBMED   10528200
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC153894.8, CA576036.1 and
            BG092483.1.
            
            On Aug 2, 2011 this sequence version replaced NM_174990.3.
            
            Summary: This gene encodes a protein belonging to the GTP-binding
            superfamily and to the immuno-associated nucleotide (IAN) subfamily
            of nucleotide-binding proteins. This gene exists within a cluster
            of other related genes located on mouse chromosome 6. This family
            member encodes a lymphoid signaling protein that functions to
            accelerate programmed T-cell death, which appears to correlate with
            the phosphorylation status of the protein. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, Aug
            2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189682.125307.1,
                                           SRR5286961.62146.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849377
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AC153894.8         149561-149572
            13-245              CA576036.1         1-233
            246-1507            AC153894.8         155481-156742
            1508-1814           BG092483.1         1-307               c
FEATURES             Location/Qualifiers
     source          1..1814
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 23.66 cM"
     gene            1..1814
                     /gene="Gimap4"
                     /gene_synonym="E430007K16Rik; Ian-1; Ian1; Imap4"
                     /note="GTPase, IMAP family member 4"
                     /db_xref="GeneID:107526"
                     /db_xref="MGI:MGI:1349656"
     exon            1..46
                     /gene="Gimap4"
                     /gene_synonym="E430007K16Rik; Ian-1; Ian1; Imap4"
                     /inference="alignment:Splign:2.1.0"
     exon            47..118
                     /gene="Gimap4"
                     /gene_synonym="E430007K16Rik; Ian-1; Ian1; Imap4"
                     /inference="alignment:Splign:2.1.0"
     CDS             61..1047
                     /gene="Gimap4"
                     /gene_synonym="E430007K16Rik; Ian-1; Ian1; Imap4"
                     /note="isoform a is encoded by transcript variant 1;
                     immune associated nucleotide 1; immunity-associated
                     protein 4"
                     /codon_start=1
                     /product="GTPase IMAP family member 4 isoform a"
                     /protein_id="NP_778155.2"
                     /db_xref="CCDS:CCDS20110.1"
                     /db_xref="GeneID:107526"
                     /db_xref="MGI:MGI:1349656"
                     /translation="MEVQCGGAGFIPESSRSSHELGNQDQGIPQLRIVLLGKTGAGKS
                     STGNSILGEKVFNSGICAKSITKVCEKRVSTWDGKELVVVDTPGIFDTEVPDADTQRE
                     ITRYVALTSPGPHALLLVVPLGRYTVEEHKATQKILDMFGKQARRFMILLLTRKDDLE
                     DTDIHEYLEKAPKFFQEVMHEFQNRYCLFNNRASGAEKEEQKMQLLTLVQSMVRENGG
                     RCFTNKMYESAECVIQKETLRMQELYREELEREKARIRREYEEQIKDLRDELEREIRR
                     ARMEREFKEREAIFTKNQQNARKEVENTSMILELIIKAWEIASFIFNQFMKD"
     exon            119..1810
                     /gene="Gimap4"
                     /gene_synonym="E430007K16Rik; Ian-1; Ian1; Imap4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1783..1788
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gimap4"
                     /gene_synonym="E430007K16Rik; Ian-1; Ian1; Imap4"
                     /note="hexamer: AATAAA"
     polyA_site      1808
                     /gene="Gimap4"
                     /gene_synonym="E430007K16Rik; Ian-1; Ian1; Imap4"
                     /note="major polyA site"
ORIGIN      
        1 agtattgttt cgaaatcaga gaaggtcaaa ggacccagat tttcaggaag ccgagctaca
       61 atggaagtcc agtgcggtgg tgcggggttc atcccagaaa gttcaaggag cagccatgag
      121 cttggaaacc aagatcaagg aattccccaa ctgagaattg tcttacttgg aaaaactgga
      181 gcaggaaaga gttcaacagg gaacagtatc cttggggaaa aagtgtttaa ttctggcatt
      241 tgtgcaaaat ccatcaccaa ggtctgtgaa aaaagggtga gcacctggga tgggaaagag
      301 cttgttgtcg tggatacacc tggtattttt gacactgagg taccagatgc tgacacacaa
      361 agggagatca ctcgctatgt tgccctgacc tctccagggc ctcatgctct gctcctggta
      421 gttccactgg ggcgttatac tgtggaagaa cacaaggcta cacagaaaat tctggacatg
      481 tttggaaaac aggctagaag attcatgatt ctcttgctca ccaggaagga tgacttagaa
      541 gacactgata tccatgagta cttagagaag gctcctaaat tctttcaaga ggtgatgcat
      601 gagttccaga atcgctactg tttgttcaac aacagagcct caggcgctga aaaggaagag
      661 cagaagatgc aattgttgac cttggtccag agcatggtga gggaaaatgg tggaagatgc
      721 tttactaata agatgtatga aagtgccgag tgtgtgatcc agaaagagac cttgaggatg
      781 caagaattat acagagagga gctagagagg gagaaagcac ggataagacg ggagtatgaa
      841 gaacagatta aagatctgag agatgaactg gagagggaaa taagaagggc acgtatggag
      901 agggaattca aggagaggga ggctatcttt acaaagaatc aacaaaatgc taggaaggaa
      961 gttgagaaca caagtatgat acttgaatta attataaaag catgggagat tgcttccttt
     1021 atcttcaacc agtttatgaa agactaggct tagtctataa gactagacct tatttctatt
     1081 ttctgcattt cccttgataa ccctgcccta tagtgctcac cccccccgat gcccaaatgc
     1141 tctagtttct gtcttccagg atgaagtaat gaagtaaagt ttaccactga tagttgttca
     1201 attgacttat cgagacaatg accaatcttc aatttgtgaa actccaaagc tgaacgtatt
     1261 actgcctgct gccttgagtt cttcctcaaa tgaaaaccac ccaggaggcc acagaaaatg
     1321 actgtaagat gaacccattt ctccactgga ttctcaacag taatcttcac ctgcagcttc
     1381 cacacatgat acccatattt tggacaactg ccttgtatgt tttattagga agttccaatc
     1441 tttgcatgag gtaatcttta gtcagagata gatagcatac agttctcaat ggacatcagg
     1501 tttgtttaat tatattttca caaatggcat caagttgttc cccagctggc ctttgaaggc
     1561 caagaagatc tcacaagtca aataatccag gttgaacaca agttagcagc tcagcaggtg
     1621 acatcacaat gtttgctctg ttcaggtgtc caaccttttc accagtgtga tcagtagtca
     1681 gctctctcct tgagaaacga tctggctact gtagccagaa ccactacata tccaatcatg
     1741 ctgcttctgc ccccacccag ctcaattgct tattgctgtt ataataaact tttctgttgc
     1801 ctcacacata aaaa
//
