LOCUS       NM_031247               2145 bp    mRNA    linear   ROD 30-APR-2024
DEFINITION  Mus musculus GTPase, IMAP family member 3 (Gimap3), mRNA.
ACCESSION   NM_031247 XM_904735
VERSION     NM_031247.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 2145)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   2  (bases 1 to 2145)
  AUTHORS   Jokinen,R., Lahtinen,T., Marttinen,P., Myohanen,M.,
            Ruotsalainen,P., Yeung,N., Shvetsova,A., Kastaniotis,A.J.,
            Hiltunen,J.K., Ohman,T., Nyman,T.A., Weiler,H. and Battersby,B.J.
  TITLE     Quantitative changes in Gimap3 and Gimap5 expression modify
            mitochondrial DNA segregation in mice
  JOURNAL   Genetics 200 (1), 221-235 (2015)
   PUBMED   25808953
  REMARK    GeneRIF: quantitative changes in expression of Gimap3 and the
            paralogue Gimap5 affect mtDNA segregation in hematopoietic tissues.
            Gimap3 localizes to the endoplasmic reticulum and not mitochondria.
REFERENCE   3  (bases 1 to 2145)
  AUTHORS   Yano,K., Carter,C., Yoshida,N., Abe,T., Yamada,A., Nitta,T.,
            Ishimaru,N., Takada,K., Butcher,G.W. and Takahama,Y.
  TITLE     Gimap3 and Gimap5 cooperate to maintain T-cell numbers in the mouse
  JOURNAL   Eur J Immunol 44 (2), 561-572 (2014)
   PUBMED   24510501
  REMARK    GeneRIF: The defects in T-cell cellularity were more severe in mice
            lacking both Gimap3 and Gimap5.
REFERENCE   4  (bases 1 to 2145)
  AUTHORS   Jokinen,R., Marttinen,P., Sandell,H.K., Manninen,T., Teerenhovi,H.,
            Wai,T., Teoli,D., Loredo-Osti,J.C., Shoubridge,E.A. and
            Battersby,B.J.
  TITLE     Gimap3 regulates tissue-specific mitochondrial DNA segregation
  JOURNAL   PLoS Genet 6 (10), e1001161 (2010)
   PUBMED   20976251
  REMARK    GeneRIF: Data shsow that Gimap3 is important for T cell development
            and survival, suggesting that leukocyte survival may be a key
            factor in the genetic regulation of mtDNA sequence variants and in
            modulating human mitochondrial diseases.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2145)
  AUTHORS   Nitta,T., Nasreen,M., Seike,T., Goji,A., Ohigashi,I., Miyazaki,T.,
            Ohta,T., Kanno,M. and Takahama,Y.
  TITLE     IAN family critically regulates survival and development of T
            lymphocytes
  JOURNAL   PLoS Biol 4 (4), e103 (2006)
   PUBMED   16509771
REFERENCE   6  (bases 1 to 2145)
  AUTHORS   Krucken,J., Schroetel,R.M., Muller,I.U., Saidani,N., Marinovski,P.,
            Benten,W.P., Stamm,O. and Wunderlich,F.
  TITLE     Comparative analysis of the human gimap gene cluster encoding a
            novel GTPase family
  JOURNAL   Gene 341, 291-304 (2004)
   PUBMED   15474311
REFERENCE   7  (bases 1 to 2145)
  AUTHORS   Daheron,L., Zenz,T., Siracusa,L.D., Brenner,C. and Calabretta,B.
  TITLE     Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an
            outer membrane mitochondrial protein with GTP-binding activity
  JOURNAL   Nucleic Acids Res 29 (6), 1308-1316 (2001)
   PUBMED   11238997
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CAAA01170199.1 and AF337052.1.
            
            On or before Dec 7, 2005 this sequence version replaced
            XM_904735.1, NM_031247.2.
            
            Summary: This gene encodes a mitochondrial membrane protein
            belonging to the GTP-binding superfamily and to the
            immuno-associated nucleotide (IAN) subfamily of nucleotide-binding
            proteins. The expression of this gene is induced in
            BCR/ABL-expressing cells. The encoded protein lacks an N-terminal
            mitochondrial signal sequence. Experimental studies showed that
            mitochondrial localization relies on the C-terminal transmembrane
            domain. In humans, the IAN subfamily genes are located in a cluster
            at 7q36.1 [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF337052.1, AB164418.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849374, SAMN00849375
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-210               CAAA01170199.1     27219-27428
            211-1060            AF337052.1         211-1060
            1061-2145           CAAA01170199.1     32523-33607
FEATURES             Location/Qualifiers
     source          1..2145
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 23.72 cM"
     gene            1..2145
                     /gene="Gimap3"
                     /gene_synonym="2010110D23Rik; Gimap5; Ian4"
                     /note="GTPase, IMAP family member 3"
                     /db_xref="GeneID:83408"
                     /db_xref="MGI:MGI:1932723"
     exon            1..210
                     /gene="Gimap3"
                     /gene_synonym="2010110D23Rik; Gimap5; Ian4"
                     /inference="alignment:Splign:2.1.0"
     exon            211..320
                     /gene="Gimap3"
                     /gene_synonym="2010110D23Rik; Gimap5; Ian4"
                     /inference="alignment:Splign:2.1.0"
     exon            321..607
                     /gene="Gimap3"
                     /gene_synonym="2010110D23Rik; Gimap5; Ian4"
                     /inference="alignment:Splign:2.1.0"
     exon            608..642
                     /gene="Gimap3"
                     /gene_synonym="2010110D23Rik; Gimap5; Ian4"
                     /inference="alignment:Splign:2.1.0"
     CDS             615..1520
                     /gene="Gimap3"
                     /gene_synonym="2010110D23Rik; Gimap5; Ian4"
                     /note="immune associated nucleotide 4; IAN-4;
                     immunity-associated nucleotide 4 protein"
                     /codon_start=1
                     /product="GTPase IMAP family member 3"
                     /protein_id="NP_112537.2"
                     /db_xref="CCDS:CCDS20115.1"
                     /db_xref="GeneID:83408"
                     /db_xref="MGI:MGI:1932723"
                     /translation="METLQNVVTGGKKGGCTSGSRPLRILLVGKSGCGKSATGNSLLR
                     RPAFESRLRGQSVTRTSQAETGTWEGRSILVVDTPPIFESKAQNQDMDKDIGDCYLLC
                     APGPHVLLLVTQLGRFTAEDVMAVRMVKEVFGVGVMRHMIVLFTRKEDLAEKSLEEFV
                     THTDNRSLRSLVQECGRRYCAFNNRASGEEQQGQLAELMALVRRLEQECEGSFHSNDL
                     FLHAETLLREGYSVHQEAYRCYLAKVRQEVEKQRWELEEQEGSWVLKVLPIGKKLEVL
                     HSDFCWYLVLAILIFFVFFFLLFYV"
     exon            643..2145
                     /gene="Gimap3"
                     /gene_synonym="2010110D23Rik; Gimap5; Ian4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2119..2124
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gimap3"
                     /gene_synonym="2010110D23Rik; Gimap5; Ian4"
     polyA_site      2145
                     /gene="Gimap3"
                     /gene_synonym="2010110D23Rik; Gimap5; Ian4"
                     /experiment="experimental evidence, no additional details
                     recorded"
ORIGIN      
        1 agaaactcat gtacatcacc ctttcccacc cctcaggaga caccgtcttc ctccccctgg
       61 aagacagatc ttgtgagctg gccttcacct cttgtagctc ttgtactttt acgaaagact
      121 acaaaccaat gtgagaggct gcctaggcct ggaaggtagc tccacagtgg ctatagatct
      181 tgaatggaaa gatcctcagg aactcaccag gcttgattct gagatggcag cagtttaagg
      241 ctctcaattt ggaggaatga cctgccacca gttgcttggc caaaggcatt gtatgagtac
      301 tcctgcctga gagactgttg ggagaccaat ttctaatctg gatccttgag atgggaagat
      361 tcacctttaa cctgggtcat accgtcacac catctgctgg cagccatgga agaaggaagc
      421 ttgctctctt tgcttcatta ctctcattct cactgtcaag tgcattcctt cactggcatt
      481 agagcatatt tcttcaggat tccagtgtat actacagacc atctgagatg tccagactca
      541 tggactgaac aactactgga cttcccattg gtaaacaggc atagttggac tggctggacc
      601 agagactaaa aaaaatggaa acacttcaga atgttgtaac aggcggaaag aaaggtggct
      661 gcacctcagg gtcaaggcca ctgaggatcc tcctggtggg caaatctggc tgcggtaaaa
      721 gcgccacagg gaacagcctc ctccgacgac cagcattcga gtccaggctc agaggccagt
      781 ctgtgacaag gaccagccag gcagagacag gcacatggga ggggaggagc atcctagtgg
      841 tagacacacc ccccatcttt gagtcaaagg cccagaacca agacatggac aaggacatcg
      901 gagactgcta cctgctgtgt gccccaggcc cccatgtgtt gttgctggtg acccagctgg
      961 gacgcttcac agctgaagat gtcatggctg tgaggatggt gaaggaggtc tttggggtag
     1021 gggtcatgag gcacatgatc gtcctcttca cccgcaagga agacctggca gagaagtcct
     1081 tggaagagtt tgtgacccac actgacaacc gcagcctgcg cagcctggtt caggagtgtg
     1141 ggaggaggta ctgtgccttc aacaacaggg cctctgggga ggagcagcaa gggcagctgg
     1201 cagagctcat ggccctggtg aggaggctgg aacaggagtg tgaaggctcc ttccacagca
     1261 atgacctctt ccttcatgcc gagacactcc ttagagaagg ttacagtgtg caccaggaag
     1321 cctataggtg ctacctggcc aaggtgaggc aggaggtgga gaaacagagg tgggagctgg
     1381 aggagcagga gggcagctgg gtcctcaagg tcctccccat aggcaaaaag ttggaggtgt
     1441 tgcattcaga tttttgttgg tatttggtgt tggccatatt aatcttcttc gttttctttt
     1501 ttctcttatt ttatgtttaa tgctctgcat tttattgtgg attgggatca ctcacaaata
     1561 ttgtgttttc tacctatggg aaaaaaagtg tgaagtgtgg tatgtcctgg tgttttcaat
     1621 tgttaattaa gccagcaaca ggctagcagg atatgtaaag gtttgtcatt tcctgccccc
     1681 aaaaagaaag gcaagctgcc ttggggaagg tgatcttcct ccatgtagcc cccaaagctg
     1741 ttggagacca taccgtgaga aagggagctt ttcacagtct cccaccctga caggccaaat
     1801 ggccttgtgc taaggagccg gttgtcactc ccttctccct gtttccttcc tggcaccaga
     1861 gtctgtaaaa gctgaattat agtcccctct tcctgactcc catgacatcc aaggacagtt
     1921 atgcgctgag cccggcctga cacccaaggc tgttaaggag gatctatgtt ccggagataa
     1981 gactcagagt gcccgccacc tggcgcctga cttcagccct catgtcccct gatgcccact
     2041 tctttgttct ttgttaattc cccctcaacc cctccctata cccctcaatg cgtgctttaa
     2101 aactcggcgt ttcagcctaa taaacagaga ccttgatagg aaaga
//
