LOCUS       NM_008376               1505 bp    mRNA    linear   ROD 30-JUL-2024
DEFINITION  Mus musculus GTPase, IMAP family member 1 (Gimap1), transcript
            variant 1, mRNA.
ACCESSION   NM_008376
VERSION     NM_008376.3
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 1505)
  AUTHORS   Datta,P., Webb,L.M., Avdo,I., Pascall,J. and Butcher,G.W.
  TITLE     Survival of mature T cells in the periphery is intrinsically
            dependent on GIMAP1 in mice
  JOURNAL   Eur J Immunol 47 (1), 84-93 (2017)
   PUBMED   27792288
  REMARK    GeneRIF: This study shows that GIMAP1 is critical for maintaining
            the peripheral T-cell pool in mice and offers a potent target for
            the treatment of T-cell-mediated diseases.
REFERENCE   2  (bases 1 to 1505)
  AUTHORS   Liu,X., Jiao,Y., Cao,Y., Deng,N., Ma,Y., Hasty,K.A., Kang,A.,
            Chen,H., Stuart,J.M. and Gu,W.
  TITLE     Decreased expression levels of Ifi genes is associated to the
            increased resistance to spontaneous arthritis disease in mice
            deficiency of IL-1RA
  JOURNAL   BMC Immunol 17 (1), 25 (2016)
   PUBMED   27480124
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1505)
  AUTHORS   Webb,L.M., Datta,P., Bell,S.E., Kitamura,D., Turner,M. and
            Butcher,G.W.
  TITLE     GIMAP1 Is Essential for the Survival of Naive and Activated B Cells
            In Vivo
  JOURNAL   J Immunol 196 (1), 207-216 (2016)
   PUBMED   26621859
  REMARK    GeneRIF: The data suggest that GIMAP1 is absolutely essential for
            the survival of peripheral B cells, irrespective of their
            activation state.
REFERENCE   4  (bases 1 to 1505)
  AUTHORS   Saunders,A., Webb,L.M., Janas,M.L., Hutchings,A., Pascall,J.,
            Carter,C., Pugh,N., Morgan,G., Turner,M. and Butcher,G.W.
  TITLE     Putative GTPase GIMAP1 is critical for the development of mature B
            and T lymphocytes
  JOURNAL   Blood 115 (16), 3249-3257 (2010)
   PUBMED   20194894
  REMARK    GeneRIF: These findings show a vital requirement for GIMAP1 in
            mature lymphocyte development/survival
REFERENCE   5  (bases 1 to 1505)
  AUTHORS   Saunders,A., Lamb,T., Pascall,J., Hutchings,A., Dion,C., Carter,C.,
            Hepburn,L., Langhorne,J. and Butcher,G.W.
  TITLE     Expression of GIMAP1, a GTPase of the immunity-associated protein
            family, is not up-regulated in malaria
  JOURNAL   Malar J 8, 53 (2009)
   PUBMED   19338674
  REMARK    GeneRIF: The model of up-regulation of GIMAP1 in response to
            infection/immunization with P. chabaudi is not a robustly
            reproducible experimental system.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1505)
  AUTHORS   Kannan,K., Kaminski,N., Rechavi,G., Jakob-Hirsch,J., Amariglio,N.
            and Givol,D.
  TITLE     DNA microarray analysis of genes involved in p53 mediated
            apoptosis: activation of Apaf-1
  JOURNAL   Oncogene 20 (26), 3449-3455 (2001)
   PUBMED   11423996
REFERENCE   7  (bases 1 to 1505)
  AUTHORS   Daheron,L., Zenz,T., Siracusa,L.D., Brenner,C. and Calabretta,B.
  TITLE     Molecular cloning of Ian4: a BCR/ABL-induced gene that encodes an
            outer membrane mitochondrial protein with GTP-binding activity
  JOURNAL   Nucleic Acids Res 29 (6), 1308-1316 (2001)
   PUBMED   11238997
REFERENCE   8  (bases 1 to 1505)
  AUTHORS   Poirier,G.M., Anderson,G., Huvar,A., Wagaman,P.C., Shuttleworth,J.,
            Jenkinson,E., Jackson,M.R., Peterson,P.A. and Erlander,M.G.
  TITLE     Immune-associated nucleotide-1 (IAN-1) is a thymic selection marker
            and defines a novel gene family conserved in plants
  JOURNAL   J Immunol 163 (9), 4960-4969 (1999)
   PUBMED   10528200
REFERENCE   9  (bases 1 to 1505)
  AUTHORS   Krucken,J., Stamm,O., Schmitt-Wrede,H.P., Mincheva,A., Lichter,P.
            and Wunderlich,F.
  TITLE     Spleen-specific expression of the malaria-inducible intronless
            mouse gene imap38
  JOURNAL   J Biol Chem 274 (34), 24383-24391 (1999)
   PUBMED   10446218
REFERENCE   10 (bases 1 to 1505)
  AUTHORS   Krucken,J., Schmitt-Wrede,H.P., Markmann-Mulisch,U. and
            Wunderlich,F.
  TITLE     Novel gene expressed in spleen cells mediating acquired
            testosterone-resistant immunity to Plasmodium chabaudi malaria
  JOURNAL   Biochem Biophys Res Commun 230 (1), 167-170 (1997)
   PUBMED   9020038
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CAAA01157263.1.
            
            On Dec 10, 2004 this sequence version replaced NM_008376.2.
            
            Summary: This gene encodes a protein belonging to the GTP-binding
            superfamily and to the immuno-associated nucleotide (IAN) subfamily
            of nucleotide-binding proteins. In humans, the IAN subfamily genes
            are located in a cluster at 7q36.1. Sequence analysis identified
            two alternatively spliced variants that encode the same protein.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (1) is the longer and predominant
            variant. Both variants encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK156732.1, BC132601.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849375, SAMN00849380
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-110               CAAA01157263.1     9407-9516           c
            111-208             CAAA01157263.1     7146-7243           c
            209-1505            CAAA01157263.1     4768-6064           c
FEATURES             Location/Qualifiers
     source          1..1505
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /db_xref="taxon:10090"
                     /chromosome="6"
                     /map="6 23.69 cM"
     gene            1..1505
                     /gene="Gimap1"
                     /gene_synonym="IAP38; imap; Imap38"
                     /note="GTPase, IMAP family member 1"
                     /db_xref="GeneID:16205"
                     /db_xref="MGI:MGI:109368"
     exon            1..110
                     /gene="Gimap1"
                     /gene_synonym="IAP38; imap; Imap38"
                     /inference="alignment:Splign:2.1.0"
     exon            111..208
                     /gene="Gimap1"
                     /gene_synonym="IAP38; imap; Imap38"
                     /inference="alignment:Splign:2.1.0"
     CDS             166..1068
                     /gene="Gimap1"
                     /gene_synonym="IAP38; imap; Imap38"
                     /note="immune associated nucleotide family member;
                     immune-associated protein 38; immunity-associated protein
                     1; immunity-associated protein, 38 kDa"
                     /codon_start=1
                     /product="GTPase IMAP family member 1"
                     /protein_id="NP_032402.2"
                     /db_xref="CCDS:CCDS20113.1"
                     /db_xref="GeneID:16205"
                     /db_xref="MGI:MGI:109368"
                     /translation="MGGRKMARDEEDAYGSEDSRAPQMPQLRLILVGRTGTGKSATGN
                     SILGQKCFLSRLGAVPVTRSCTLASRMWAGWQVEVVDTPDIFSSEIPRTDPGCVETAR
                     CFVLSAPGPHALLLVTQLGRFTMQDSQALAAVKRLFGKQVMARTVVVFTRQEDLAGDS
                     LQDYVHCTDNRALRDLVAECGGRVCALNNRATGSEREAQAEQLLGMVACLVREHGGAH
                     YSNEVYELVQDTRCADPQDQVAKVAEIVAERMQRRTRLLAGLWGWRKFYWKGWRRGFS
                     VFLGVAILIYLLFYRKGFGDQNNR"
     exon            209..1505
                     /gene="Gimap1"
                     /gene_synonym="IAP38; imap; Imap38"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      1466
                     /gene="Gimap1"
                     /gene_synonym="IAP38; imap; Imap38"
                     /note="major polyA site"
     regulatory      1485..1490
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gimap1"
                     /gene_synonym="IAP38; imap; Imap38"
                     /note="hexamer: AATAAA"
     polyA_site      1505
                     /gene="Gimap1"
                     /gene_synonym="IAP38; imap; Imap38"
                     /note="major polyA site"
ORIGIN      
        1 gacttcctct atgctcagcc ctgggcaagg agagacttct gcactcacaa gcgaagggaa
       61 ggcgaggccg gggcttctct gggtcacttc agggactgtc agcaagaaag ctgcaggaat
      121 gagcacacaa atgagaaaac caaaaccgag agccttctaa gaagcatggg aggaaggaag
      181 atggcaagag atgaggaaga cgcctatggc tcagaggact ccagggcccc gcagatgccc
      241 cagctgaggc tcatcctagt gggcaggact gggaccggca agagtgccac tggcaacagc
      301 atcctgggtc agaagtgctt cctgtccagg ctgggggcgg tgcctgtcac cagaagttgc
      361 actttggcca gcagaatgtg ggccggctgg caggtggagg tggtggacac cccggatatc
      421 ttcagctccg agatcccgcg gaccgaccct gggtgcgtgg agacagcccg ctgctttgtg
      481 ctgtcggccc ctgggccgca cgcgctgctg ctggtcaccc agctgggtcg cttcaccatg
      541 caggacagcc aggcgctggc cgcggtgaag cggttattcg ggaagcaggt gatggcgcgc
      601 actgtcgtgg tgttcacgcg ccaagaggac ctggctggag actccctgca ggattatgtg
      661 cactgcacgg acaaccgcgc gctgcgggac ctggtggccg agtgcggggg ccgcgtgtgc
      721 gccctcaaca accgcgccac aggcagcgag cgcgaggctc aggctgagca gctgctgggc
      781 atggttgcgt gcttggtgag ggagcacggg ggcgcgcact actccaatga ggtgtatgag
      841 ctggtgcagg acacgcggtg cgctgacccc caggaccaag tagccaaggt ggcagagata
      901 gtggctgagc gcatgcagag gcgcaccagg ttgctagctg ggctgtgggg atggcggaaa
      961 ttctactgga agggctggag gcgtggtttc tctgtcttcc tgggtgtggc catcttgatc
     1021 tacctgctgt tctacagaaa gggctttggg gaccagaata acagataaag ctggtgttag
     1081 aagatgttcc gtttttaaaa aagaaatagt tagaattctg ctcagagctt taatgattca
     1141 cagtgcagtg acttggcatc aactttgcta aggttctgtt gtgtgaggag cgggtgtggc
     1201 ggcagtacca aaggcaccag ggactgcagc taagtcttat ggcttgcacc tgacttcctc
     1261 atacacctga atataagcca caaacatcat gagagctgca caggtgcacc aggatactgg
     1321 tgaatccatt ttgatggaga tatgcccctg ctgccctgat tagctgaagc tgcgtgcctg
     1381 gtgaggtggc gtggcctgct gtgggtggat gggaactgag agtatataag agtgagaggc
     1441 ccagggttcg ggggagatat aaacaagaag aaagatgaag actgaataaa ctgctgttag
     1501 aagga
//
