LOCUS       NM_146112               5743 bp    mRNA    linear   ROD 24-SEP-2024
DEFINITION  Mus musculus GRB10 interacting GYF protein 2 (Gigyf2), transcript
            variant 1, mRNA.
ACCESSION   NM_146112 XM_897161 XM_919711
VERSION     NM_146112.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 5743)
  AUTHORS   Rybiczka-Tesulov,M., Garritsen,O., Veno,M.T., Wieg,L., Dijk,R.V.,
            Rahimi,K., Gomes-Duarte,A., Wit,M., van de Haar,L.L., Michels,L.,
            van Kronenburg,N.C.H., van der Meer,C., Kjems,J., Vangoor,V.R. and
            Pasterkamp,R.J.
  TITLE     Circular RNAs regulate neuron size and migration of midbrain
            dopamine neurons during development
  JOURNAL   Nat Commun 15 (1), 6773 (2024)
   PUBMED   39117691
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5743)
  AUTHORS   Adams,D.J., Barlas,B., McIntyre,R.E., Salguero,I., van der
            Weyden,L., Barros,A., Vicente,J.R., Karimpour,N., Haider,A.,
            Ranzani,M., Turner,G., Thompson,N.A., Harle,V., Olvera-Leon,R.,
            Robles-Espinoza,C.D., Speak,A.O., Geisler,N., Weninger,W.J.,
            Geyer,S.H., Hewinson,J., Karp,N.A., Fu,B., Yang,F., Kozik,Z.,
            Choudhary,J., Yu,L., van Ruiten,M.S., Rowland,B.D., Lelliott,C.J.,
            Del Castillo Velasco-Herrera,M., Verstraten,R., Bruckner,L.,
            Henssen,A.G., Rooimans,M.A., de Lange,J., Mohun,T.J., Arends,M.J.,
            Kentistou,K.A., Coelho,P.A., Zhao,Y., Zecchini,H., Perry,J.R.B.,
            Jackson,S.P. and Balmus,G.
  CONSRTM   Sanger Mouse Genetics Project
  TITLE     Genetic determinants of micronucleus formation in vivo
  JOURNAL   Nature 627 (8002), 130-136 (2024)
   PUBMED   38355793
REFERENCE   3  (bases 1 to 5743)
  AUTHORS   Niu,F., Li,Z., Ren,Y., Li,Z., Guan,H., Li,Y., Zhang,Y., Li,Y.,
            Yang,J., Qian,L., Shi,W., Fan,X., Li,J., Shi,L., Yu,Y. and Xiong,Y.
  TITLE     Aberrant hyper-expression of the RNA binding protein GIGYF2 in
            endothelial cells modulates vascular aging and function
  JOURNAL   Redox Biol 65, 102824 (2023)
   PUBMED   37517320
  REMARK    GeneRIF: Aberrant hyper-expression of the RNA binding protein
            GIGYF2 in endothelial cells modulates vascular aging and function.
REFERENCE   4  (bases 1 to 5743)
  AUTHORS   Xie,J., Wei,Q., Deng,H., Li,G., Ma,L. and Zeng,H.
  TITLE     Negative regulation of Grb10 Interacting GYF Protein 2 on
            insulin-like growth factor-1 receptor signaling pathway caused
            diabetic mice cognitive impairment
  JOURNAL   PLoS One 9 (9), e108559 (2014)
   PUBMED   25268761
  REMARK    GeneRIF: Negative regulation of Grb10 Interacting GIGYF2 protein on
            IGF-1 receptor signaling pathway caused diabetic mice cognitive
            impairment.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5743)
  AUTHORS   Koscielny,G., Yaikhom,G., Iyer,V., Meehan,T.F., Morgan,H.,
            Atienza-Herrero,J., Blake,A., Chen,C.K., Easty,R., Di Fenza,A.,
            Fiegel,T., Grifiths,M., Horne,A., Karp,N.A., Kurbatova,N.,
            Mason,J.C., Matthews,P., Oakley,D.J., Qazi,A., Regnart,J.,
            Retha,A., Santos,L.A., Sneddon,D.J., Warren,J., Westerberg,H.,
            Wilson,R.J., Melvin,D.G., Smedley,D., Brown,S.D., Flicek,P.,
            Skarnes,W.C., Mallon,A.M. and Parkinson,H.
  TITLE     The International Mouse Phenotyping Consortium Web Portal, a
            unified point of access for knockout mice and related phenotyping
            data
  JOURNAL   Nucleic Acids Res 42 (Database issue), D802-D809 (2014)
   PUBMED   24194600
REFERENCE   6  (bases 1 to 5743)
  AUTHORS   Giovannone,B., Tsiaras,W.G., de la Monte,S., Klysik,J., Lautier,C.,
            Karashchuk,G., Goldwurm,S. and Smith,R.J.
  TITLE     GIGYF2 gene disruption in mice results in neurodegeneration and
            altered insulin-like growth factor signaling
  JOURNAL   Hum Mol Genet 18 (23), 4629-4639 (2009)
   PUBMED   19744960
  REMARK    GeneRIF: Primary cultured embryo fibroblasts from Gigyf2 null mice
            exhibit decreased IGF1 signaling.
REFERENCE   7  (bases 1 to 5743)
  AUTHORS   Munton,R.P., Tweedie-Cullen,R., Livingstone-Zatchej,M.,
            Weinandy,F., Waidelich,M., Longo,D., Gehrig,P., Potthast,F.,
            Rutishauser,D., Gerrits,B., Panse,C., Schlapbach,R. and Mansuy,I.M.
  TITLE     Qualitative and quantitative analyses of protein phosphorylation in
            naive and stimulated mouse synaptosomal preparations
  JOURNAL   Mol Cell Proteomics 6 (2), 283-293 (2007)
   PUBMED   17114649
REFERENCE   8  (bases 1 to 5743)
  AUTHORS   Cobellis,G., Nicolaus,G., Iovino,M., Romito,A., Marra,E.,
            Barbarisi,M., Sardiello,M., Di Giorgio,F.P., Iovino,N., Zollo,M.,
            Ballabio,A. and Cortese,R.
  TITLE     Tagging genes with cassette-exchange sites
  JOURNAL   Nucleic Acids Res 33 (4), e44 (2005)
   PUBMED   15741177
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 5743)
  AUTHORS   Giovannone,B., Lee,E., Laviola,L., Giorgino,F., Cleveland,K.A. and
            Smith,R.J.
  TITLE     Two novel proteins that are linked to insulin-like growth factor
            (IGF-I) receptors by the Grb10 adapter and modulate IGF-I signaling
  JOURNAL   J Biol Chem 278 (34), 31564-31573 (2003)
   PUBMED   12771153
  REMARK    GeneRIF: identification of proteins linked to insulin-like growth
            factor (IGF-I) receptors by the Grb10 adapter and modulate IGF-I
            signaling
REFERENCE   10 (bases 1 to 5743)
  AUTHORS   Stryke,D., Kawamoto,M., Huang,C.C., Johns,S.J., King,L.A.,
            Harper,C.A., Meng,E.C., Lee,R.E., Yee,A., L'Italien,L.,
            Chuang,P.T., Young,S.G., Skarnes,W.C., Babbitt,P.C. and Ferrin,T.E.
  TITLE     BayGenomics: a resource of insertional mutations in mouse embryonic
            stem cells
  JOURNAL   Nucleic Acids Res 31 (1), 278-281 (2003)
   PUBMED   12520002
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BY117987.1, BC089036.1 and AC157811.3.
            
            On Nov 2, 2007 this sequence version replaced NM_146112.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer protein (isoform a).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC089036.1, AY176043.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN00849380, SAMN00849381
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-44                BY117987.1         1-44
            45-5729             BC089036.1         1-5685
            5730-5743           AC157811.3         97548-97561
FEATURES             Location/Qualifiers
     source          1..5743
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="1"
                     /map="1 44.23 cM"
     gene            1..5743
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /note="GRB10 interacting GYF protein 2"
                     /db_xref="GeneID:227331"
                     /db_xref="MGI:MGI:2138584"
     exon            1..95
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            96..160
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            161..243
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     CDS             203..4078
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /note="isoform a is encoded by transcript variant 1; PERQ
                     amino acid-rich with GYF domain-containing protein 2;
                     trinucleotide repeat containing 15"
                     /codon_start=1
                     /product="GRB10-interacting GYF protein 2 isoform a"
                     /protein_id="NP_666224.3"
                     /db_xref="CCDS:CCDS15133.1"
                     /db_xref="GeneID:227331"
                     /db_xref="MGI:MGI:2138584"
                     /translation="MAAETQTLNFGPEWLRALSSGGSITSPPLSPALPKYKLADYRYG
                     REEMLALFLKDYKIPFDLLEKEFLPILQEEPLPPLALVPFTEEEQRNFSMSVNSAAVL
                     RLTGRGGGGGTVVGAPRGRSSSRGRGRGRGECGFYQRSFDEVEGVFGRGGGREMHRSQ
                     SWEERGDRRFEKPGRKDVGRPNFEESGPTSVGRKHEFIRSESENWRIFREEQNGEDED
                     GGWRLAGSRRDGERWRPHSPDGPRSTGWREHMERRRRFEFDFRDRDDERGYRRVRSGS
                     GSIDDDRDSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVEEGEE
                     RSDSDSSHNEEAKEPDKTNRREGEKTDRAGAEASEEVPQTSLSSARPGTPSDHQPQEA
                     TQFERKDEPKAEQVEKAEEENRSENSLSAKVPSRGDETVPASQQPSTPLPPDTASPLL
                     ILSPPVPTPSSASRPVETAAVEAPGMSSVSTEPDDEEGLKHLEQQAEKMVAYLQDSAL
                     DDERLTSKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTM
                     SLLVKRACDESFQPLGDIMKMWGRVPFSPGPAPPPHMGELDQERLTRQQELTALYQMQ
                     HLQYQQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQQFQALKMRMSDQNIIPSVTR
                     SVSVPDTGSIWELQPAASQPAVWEGGSVWDLPLDTTAPGPSLEQLQQLEKAKAAKLEQ
                     ERREAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQEEALRRQ
                     REQEIALRRQREEEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEE
                     EAQRRLEENRLRMEEEAARLRHEEEERKRKELELQRQKDLMRQRQQQQEALRRLQQQQ
                     QQQQLAQMKLPSSSTWGQQSNTATCQSQATLSLAEIQKLEEERERQLREEQRRQQREL
                     MKALQQQQQQQQQQKLSGWGNVSKPAGTTKSLLEIQQEEARQMQKQQQQQQQQQQQHQ
                     QSNRARNSTHSNLHTSLGNSVWGSINTGPSNQWASELVSSIWSNADTKNSNMGFWDDA
                     VKEVGPRNSTNKNKNNASLSKSVGVSNRQNKKVEEEEKLLKLFQGVNKAQDGFTQWCE
                     QMLHALNTANNLDVPTFVSFLKEVESPYEVHDYTRAYLGDTSEAKEFAKQFLERRAKQ
                     KVNQQRQQQQQQQQQQDSVWGMNHSTLHSVFQTNQSNNQQSNFEAVQSGKKKKKQKMV
                     RADPSLLGFSVNASSERLNMGEIETLDDY"
     exon            244..373
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            374..469
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            470..584
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            585..696
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            697..737
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            738..917
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            918..1135
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..1298
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            1299..1487
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            1488..1684
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            1685..1844
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            1845..2011
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            2012..2103
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            2104..2211
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            2212..2312
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..2413
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            2414..2575
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            2576..2734
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            2735..2971
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            2972..3094
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            3095..3319
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            3320..3525
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            3526..3680
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            3681..3862
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            3863..4010
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     exon            4011..5743
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5708..5713
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /note="hexamer: AATAAA"
     polyA_site      5729
                     /gene="Gigyf2"
                     /gene_synonym="2610016F01Rik; A830080H02Rik; mKIAA0642;
                     Tnrc15"
                     /note="major polyA site"
ORIGIN      
        1 ggtcacgtga cgtgcgtggc gacgtgtcgg ccatcttgtg ttgttgaggc tgaggattga
       61 cttgggttct gagagactcc tgtcccggac cgcagtgtta aaaagacctg aacacatttg
      121 ctgaaacctc ttgctgtgag atagcagaac ttttgagcag gtttctctac acataaaaat
      181 cttttcaaaa atacggagaa gaatggcagc agaaacacag acactaaact ttgggcctga
      241 atggctccgt gctctgtcca gtggtgggag tatcacgtcc cctcctcttt ctccggccct
      301 gccaaagtat aaattagcag attatcgata tggccgagaa gaaatgttag cacttttcct
      361 taaagactac aagataccct ttgatcttct ggagaaagaa ttcctgccta tcctacagga
      421 ggagcccttg ccaccattgg ctctagtacc ctttacagaa gaagagcaga gaaacttttc
      481 catgtctgta aatagtgccg ctgtcctgcg attgacagga cgaggaggag gaggaggaac
      541 agtggtgggg gctcctagag gtcgaagttc ttcaagaggg cgaggcagag gtagaggtga
      601 atgtggtttc taccaaagaa gttttgatga agtagagggt gtgtttgggc gaggaggtgg
      661 cagggaaatg catagatcac agagctggga agaaaggggt gacaggcgct ttgaaaaacc
      721 aggaagaaaa gatgtaggga gaccaaattt tgaggaaagt ggaccaacgt ctgtggggag
      781 aaagcatgaa tttatacggt cagaaagtga aaactggcga atctttagag aggaacagaa
      841 tggagaagat gaagatggag gttggcggtt agctggatca agaagggatg gagagagatg
      901 gcggcctcac agtcctgatg gccctcgttc tacaggctgg cgggaacaca tggaacgccg
      961 tcggaggttt gagtttgatt ttcgagaccg agatgatgag cgtggttacc gaagggtgcg
     1021 ctctggcagt gggagcatag atgacgacag ggatagcttg ccggagtggt gcttagagga
     1081 tgctgaggaa gaaatgggca cgtttgactc ttctggggca ttcctctctc taaaaaaagt
     1141 gcagaaagaa cctattcctg aagagcagga aatggacttt aggcctgtgg aggagggaga
     1201 ggagcgctct gactctgaca gcagccataa cgaagaggcc aaagaaccgg ataagacaaa
     1261 ccgaagagag ggggagaaaa cagacagagc aggggctgaa gctagtgagg aagtacctca
     1321 gacgtcattg tcatctgcta gaccaggtac cccttcagat catcagcctc aagaagccac
     1381 acagtttgag aggaaagatg aacccaaagc tgaacaagtg gaaaaggctg aagaagagaa
     1441 tcggtcagaa aatagtctct cagccaaggt ccccagcaga ggggatgaaa cggtgcctgc
     1501 ctcccagcaa ccctccacac cgcttcctcc agacacagcc tctcctctcc tcatcctgtc
     1561 gcctcctgtt cctactccta gttctgcctc tcggccagtt gagacagcag ccgtcgaagc
     1621 tcctggtatg agcagtgttt ccacagagcc agatgatgaa gagggcctca aacacttgga
     1681 acagcaagct gagaagatgg tggcttatct ccaagacagt gcactagacg acgaaagatt
     1741 gacatcaaaa ctgcaagagc accgagctaa aggagtgtca atcccactga tgcatgaagc
     1801 aatgcagaag tggtattaca aagaccctca gggggagatt caaggtccct ttaacaatca
     1861 ggagatggcc gagtggtttc aggcgggcta ttttactatg tctttgctgg tgaagagagc
     1921 atgtgatgaa agcttccagc cccttggtga tatcatgaaa atgtggggaa gggttccttt
     1981 ctctccaggc ccagctcccc ctcctcatat gggagaattg gaccaggaac gcctgaccag
     2041 acagcaggaa ctcactgcct tataccagat gcagcacctc cagtaccagc agttcttaat
     2101 ccaacaacag tatgcacagg ttttggctca acagcagaaa gcagctttgt catctcagca
     2161 gcaacaacaa ttggctcttc ttctgcagca gttccaggct ctgaagatga gaatgtctga
     2221 tcagaacatc attccctcag taactaggtc tgtgtcagtg ccagatactg gctctatctg
     2281 ggagcttcag ccagcagcct cacagcctgc agtttgggaa ggtggtagtg tatgggatct
     2341 tcccctggac accacagcac caggtccttc cctggaacag cttcagcagc tagagaaggc
     2401 caaagctgca aagttagaac aggagagaag agaggcagaa atgagggcaa aaagggaaga
     2461 ggaggagcga aagaggcaag aagaactccg aagacaacag gaggaaatcc ttcggaggca
     2521 gcaggaggaa gaaaggaaaa gacgggaaga agaggaactt gctcgaagga agcaggagga
     2581 ggctctgcgg cgccaacggg agcaagagat tgcgctaagg cggcagcgag aagaggagga
     2641 aagacagcag caggaagaag ctcttagacg attggaggag cggaggagag aagaggagga
     2701 aaggcggaag caggaagaac tgctgcgcaa gcaggaagag gaggctgcca aatgggcccg
     2761 ggaagaggaa gaagcccagc gccgactgga agagaaccgg ctgcgcatgg aggaggaggc
     2821 tgccagactt cggcatgaag aagaagaaag aaaacggaag gaattggagc tgcagaggca
     2881 gaaggatctg atgcgtcaga gacagcagca gcaagaggct ctccgaaggc tgcagcagca
     2941 acagcagcag caacagcttg cacaaatgaa gcttccctct tcgtcaacgt ggggtcagca
     3001 gtctaacaca gcaacatgtc agtcccaggc cacgctgtca ttggctgaga tccagaagct
     3061 ggaagaagaa cgagaacgcc agcttcgtga agagcaaaga cgtcagcaga gggaattgat
     3121 gaaagctctc cagcagcagc agcagcagca gcaacaacaa aaactctcag gttgggggaa
     3181 tgtcagcaaa cctgcaggta ccaccaagtc tctactagag atccagcagg aagaggccag
     3241 gcagatgcag aagcagcagc agcagcaaca acaacaacaa cagcaacacc agcaatcaaa
     3301 cagagcccgg aacagcacac attccaacct gcataccagc cttgggaatt ctgtatgggg
     3361 ctctataaac acaggtcctt ctaaccagtg ggcgtctgag ctagtcagta gtatctggag
     3421 taatgcagac accaaaaact ccaacatggg gttttgggat gatgcagtga aagaggtggg
     3481 acctagaaat tcaacaaata aaaataaaaa caacgccagt ctcagtaaat ctgtaggtgt
     3541 gtctaaccgg cagaataaga aagtagaaga agaagaaaag ttgctgaagc tctttcaggg
     3601 agtaaataaa gcccaagatg gatttaccca gtggtgtgaa cagatgcttc atgcccttaa
     3661 tacggcaaat aacttggatg ttcccacgtt tgtttctttc ttgaaagaag tggagtctcc
     3721 ttatgaagtc catgactata ccagggccta tttaggagat acttccgagg ccaaggagtt
     3781 tgccaagcag ttccttgaac gccgtgccaa acagaaagtc aaccagcagc gtcagcagca
     3841 gcagcagcag cagcagcagc aggactctgt ctgggggatg aaccatagta cactccattc
     3901 ggtatttcag accaatcaaa gcaacaacca acaatcaaat tttgaggctg tgcaaagtgg
     3961 caagaagaag aaaaagcaga agatggttcg agcagatccc agtttattag ggttttcagt
     4021 caacgcctcg tcagagcgac tgaacatggg tgagattgag actctggatg actactgagt
     4081 tcctgccgct gtgccagcct tcccactccc gcctagtgac catggtttct cctcattgga
     4141 cacaacatac gttcaccatt ttctctgtca ctctgcaaca aatcacagaa ccaatcatct
     4201 caggcttttt tttttcctag ccctttgtgt ccaagattac tttagatcac tgttggtgag
     4261 catctcagac tgtacctagt ggaccagccc ttgtctcagg gtggcagttg gggctgctcc
     4321 ccagcagagc taatgttgcc agcacacatt cactgtgcgt tgatttcatc tactgtctcc
     4381 tggaagtgtg ttggaatctg ccaatagcag atcactttct cttatcactt ttcttgttct
     4441 gttttgttct ttctccccac ccctctattc caccccatac cggcaaaggg ccttaactgg
     4501 tgcagtcatg aagagagtta atggttaata gacattggcc agcaacaaat caccccctgg
     4561 acagtaactt ctctattgcc acaggcaggc ataactctgt ctgtaggttg catgaccatt
     4621 gttaacgtgg ggattgcatc agaggcctga gaggggtgta gattggcttg tttgatgttg
     4681 cacaccctcg ctgttctttc tgaagaaagg atgcgtgtgt tcttcattag atagtaactt
     4741 tctaagcaag ctgtgttctc cctaacatat tccaacgtta ctactggaca aaagaaaccc
     4801 tatggcctgg gacagggact taattttcct ttcatataaa aactgatctc ccctcctccc
     4861 ataaatattt ttacttcaag gactaggacc agtttgtttt gggcccttat gtgaaaattt
     4921 gtctcgttta agaggcatct ttaccatatg tatgaatttg tgtaatttca actcggatag
     4981 ggataaactt ttgcttctga taaaagctgg gaatttcatc tgttcctcag agcaccgtgt
     5041 gcatgttttg ccatggccct gaaaaggtct tgtgaaaaga ttctgggatg gcaagttgtt
     5101 tgccttttct gaaaagagaa catacaaagc ctgaccatct ttaagacctt catccgtgga
     5161 aaccactatg caggaggatg caatggggta tggggatggc aggcacagga gtgggaggcc
     5221 tgctccatag caaggccaag tgtactcaag ctctgtacag acagactctg actgcttctg
     5281 ctcctcgcct agtgaacatc acctgggata gtcgaacacc tcggcggcag ctgtgggtca
     5341 gctgggcctg tgcaagaggt gctgtggtgg gcagctcggc atctgtgcct ggacaaggct
     5401 ggagttgctc tcagagcagt ttggtattgg aagattatat ttggtttcta tttttattat
     5461 tttgcatcac cattctccct atcctttctt gcctctctcc ctcctaaatg tgtacaataa
     5521 ctatacagag actgctacaa acttgtaaat agtttttgga tcaaatagca taaggagata
     5581 ggaaccatta aaatgtgaga ctcctctcct ttgctttgta aattcaaaag ggggggtggg
     5641 gaagagggat agttaaaatg tttacaaaac tttaagctcc ctcggaactt ttgccagtgt
     5701 ggaggaaaat aaaaaaaaat taaataaaat gtgttgtggt ctc
//
