LOCUS       NM_177330               4433 bp    mRNA    linear   ROD 12-NOV-2024
DEFINITION  Mus musculus growth hormone secretagogue receptor (Ghsr), mRNA.
ACCESSION   NM_177330
VERSION     NM_177330.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (bases 1 to 4433)
  AUTHORS   Hewawasam,N., Sarkar,D., Bolton,O., Delishaj,B., Almutairi,M.,
            King,A.J.F., Dereli,A.S., Despontin,C., Gilon,P., Reeves,S.,
            Patterson,M. and Hauge-Evans,A.C.
  TITLE     The GHSR1a antagonist LEAP2 regulates islet hormone release in a
            sex-specific manner
  JOURNAL   J Endocrinol 263 (2), e240135 (2024)
   PUBMED   39292603
  REMARK    GeneRIF: The GHSR1a antagonist LEAP2 regulates islet hormone
            release in a sex-specific manner.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4433)
  AUTHORS   Zhang,M., Yang,L., Jia,J., Xu,F., Gao,S., Han,F., Deng,M., Wang,J.,
            Li,V., Yu,M., Sun,Y., Yuan,H., Zhou,Y. and Li,N.
  TITLE     Increased GHS-R1a expression in the hippocampus impairs memory
            encoding and contributes to AD-associated memory deficits
  JOURNAL   Commun Biol 7 (1), 1334 (2024)
   PUBMED   39415032
  REMARK    GeneRIF: Increased GHS-R1a expression in the hippocampus impairs
            memory encoding and contributes to AD-associated memory deficits.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4433)
  AUTHORS   Liu,J., Li,N., Wei,C., Han,F., Deng,M., Ma,J., Zou,X., Zhou,Y.,
            Yang,R. and Yuan,H.
  TITLE     GHS-R1a deficiency protects against lipopolysaccharide-induced
            spatial memory impairment in mice
  JOURNAL   Biochem Biophys Res Commun 727, 150270 (2024)
   PUBMED   38917617
  REMARK    GeneRIF: GHS-R1a deficiency protects against
            lipopolysaccharide-induced spatial memory impairment in mice.
REFERENCE   4  (bases 1 to 4433)
  AUTHORS   Cornejo,M.P., Fernandez,G., Cabral,A., Barrile,F., Heredia,F.,
            Garcia Romero,G., Zubimendi Sampieri,J.P., Quelas,J.I., Cantel,S.,
            Fehrentz,J.A., Alonso,A., Pla,R., Ferran,J.L., Andreoli,M.F., De
            Francesco,P.N. and Perello,M.
  TITLE     GHSR in a Subset of GABA Neurons Controls Food Deprivation-Induced
            Hyperphagia in Male Mice
  JOURNAL   Endocrinology 165 (7) (2024)
   PUBMED   38815068
  REMARK    GeneRIF: GHSR in a Subset of GABA Neurons Controls Food
            Deprivation-Induced Hyperphagia in Male Mice.
REFERENCE   5  (bases 1 to 4433)
  AUTHORS   Smith,A., Rodrigues,T., Wallace,C., Mezher,K., MacAulay,B.,
            Prowse,R., Hyland,L. and Abizaid,A.
  TITLE     Growth Hormone Secretagogue Receptor (GHSR) Signaling in the
            Ventral Tegmental Area (VTA) Mediates Feeding Produced by Chronic
            Social Defeat Stress in Male Mice
  JOURNAL   Neuroscience 547, 17-27 (2024)
   PUBMED   38583506
  REMARK    GeneRIF: Growth Hormone Secretagogue Receptor (GHSR) Signaling in
            the Ventral Tegmental Area (VTA) Mediates Feeding Produced by
            Chronic Social Defeat Stress in Male Mice.
REFERENCE   6  (bases 1 to 4433)
  AUTHORS   Chen,H.Y., Trumbauer,M.E., Chen,A.S., Weingarth,D.T., Adams,J.R.,
            Frazier,E.G., Shen,Z., Marsh,D.J., Feighner,S.D., Guan,X.M., Ye,Z.,
            Nargund,R.P., Smith,R.G., Van der Ploeg,L.H., Howard,A.D.,
            MacNeil,D.J. and Qian,S.
  TITLE     Orexigenic action of peripheral ghrelin is mediated by neuropeptide
            Y and agouti-related protein
  JOURNAL   Endocrinology 145 (6), 2607-2612 (2004)
   PUBMED   14962995
REFERENCE   7  (bases 1 to 4433)
  AUTHORS   Lall,S., Balthasar,N., Carmignac,D., Magoulas,C., Sesay,A.,
            Houston,P., Mathers,K. and Robinson,I.
  TITLE     Physiological studies of transgenic mice overexpressing growth
            hormone (GH) secretagogue receptor 1A in GH-releasing hormone
            neurons
  JOURNAL   Endocrinology 145 (4), 1602-1611 (2004)
   PUBMED   14701677
REFERENCE   8  (bases 1 to 4433)
  AUTHORS   Wang,Y., Zhang,Z., Yan,Y., Lemon,W.J., LaRegina,M., Morrison,C.,
            Lubet,R. and You,M.
  TITLE     A chemically induced model for squamous cell carcinoma of the lung
            in mice: histopathology and strain susceptibility
  JOURNAL   Cancer Res 64 (5), 1647-1654 (2004)
   PUBMED   14996723
REFERENCE   9  (bases 1 to 4433)
  AUTHORS   Kawamura,K., Sato,N., Fukuda,J., Kodama,H., Kumagai,J.,
            Tanikawa,H., Nakamura,A., Honda,Y., Sato,T. and Tanaka,T.
  TITLE     Ghrelin inhibits the development of mouse preimplantation embryos
            in vitro
  JOURNAL   Endocrinology 144 (6), 2623-2633 (2003)
   PUBMED   12746326
REFERENCE   10 (bases 1 to 4433)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116585.3.
            
            On May 2, 2007 this sequence version replaced NM_177330.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049671.1, SRR9219381.347779.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-92                AC116585.3         105648-105739       c
            93-1040             AC116585.3         104504-105451       c
            1041-4433           AC116585.3         99080-102472        c
FEATURES             Location/Qualifiers
     source          1..4433
                     /organism="Mus musculus"
                     /mol_type="mRNA"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 10.86 cM"
     gene            1..4433
                     /gene="Ghsr"
                     /gene_synonym="C530020I22Rik; GHRP; GHS-R; Ghsr1a"
                     /note="growth hormone secretagogue receptor"
                     /db_xref="GeneID:208188"
                     /db_xref="MGI:MGI:2441906"
     exon            1..92
                     /gene="Ghsr"
                     /gene_synonym="C530020I22Rik; GHRP; GHS-R; Ghsr1a"
                     /inference="alignment:Splign:2.1.0"
     exon            93..1040
                     /gene="Ghsr"
                     /gene_synonym="C530020I22Rik; GHRP; GHS-R; Ghsr1a"
                     /inference="alignment:Splign:2.1.0"
     CDS             251..1345
                     /gene="Ghsr"
                     /gene_synonym="C530020I22Rik; GHRP; GHS-R; Ghsr1a"
                     /note="G-protein coupled receptor; ghrelin receptor;
                     GH-releasing peptide receptor"
                     /codon_start=1
                     /product="growth hormone secretagogue receptor type 1"
                     /protein_id="NP_796304.1"
                     /db_xref="CCDS:CCDS17273.1"
                     /db_xref="GeneID:208188"
                     /db_xref="MGI:MGI:2441906"
                     /translation="MWNATPSEEPEPNVTLDLDWDASPGNDSLSDELLPLFPAPLLAG
                     VTATCVALFVVGISGNLLTMLVVSRFRELRTTTNLYLSSMAFSDLLIFLCMPLDLVRL
                     WQYRPWNFGDLLCKLFQFVSESCTYATVLTITALSVERYFAICFPLRAKVVVTKGRVK
                     LVILVIWAVAFCSAGPIFVLVGVEHENGTDPRDTNECRATEFAVRSGLLTVMVWVSSV
                     FFFLPVFCLTVLYSLIGRKLWRRRGDAAVGSSLRDQNHKQTVKMLAVVVFAFILCWLP
                     FHVGRYLFSKSFEPGSLEIAQISQYCNLVSFVLFYLSAAINPILYNIMSKKYRVAVFK
                     LLGFESFSQRKLSTLKDESSRAWTKSSINT"
     exon            1041..4433
                     /gene="Ghsr"
                     /gene_synonym="C530020I22Rik; GHRP; GHS-R; Ghsr1a"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2711..2716
                     /regulatory_class="polyA_signal_sequence"
                     /gene="Ghsr"
                     /gene_synonym="C530020I22Rik; GHRP; GHS-R; Ghsr1a"
                     /note="hexamer: AATAAA"
     polyA_site      2741
                     /gene="Ghsr"
                     /gene_synonym="C530020I22Rik; GHRP; GHS-R; Ghsr1a"
                     /note="major polyA site"
ORIGIN      
        1 acgcactcgg acgctgtggg gagcacgaca ggctgctggg gcgagatctc cagtgccagg
       61 cactgctggt ggcgccgccg atagagtgac aggcttcttc tcacttctct cttccccaag
      121 catccttcct gctgctcgcg cccattcctc cccccacgcc gccccccgcc cggcccccac
      181 tcttccgcgc ctaggaggac ctcctcaggg gaccagattt ccgcgcggct gcgaccccaa
      241 gcctggcaac atgtggaacg cgacgcccag cgaggagccg gagcctaacg tcacgctgga
      301 cctggactgg gacgcttctc ccggcaacga ctcactctct gacgaactgc tgccactgtt
      361 ccccgcgccg ctgctggcgg gcgtcactgc cacctgcgtg gcgctcttcg tggtgggcat
      421 ctcgggcaac ctgctcacca tgctggtggt gtcccgcttc cgcgagctgc gcaccaccac
      481 caacctctac ctatccagca tggccttctc cgatctgctc atcttcctgt gcatgccgct
      541 ggacctcgtc cgcctctggc agtatcggcc ctggaacttc ggcgacctgc tctgcaaact
      601 cttccagttt gtcagcgaga gctgcaccta cgccacggtc ctcaccatca ccgcgctgag
      661 cgtcgagcgc tacttcgcca tctgcttccc gctgcgggcc aaggtggtgg tcaccaaggg
      721 ccgtgtgaag ctggtcatcc ttgtcatttg ggccgtggcc ttctgcagcg cggggcccat
      781 cttcgtgctg gtgggcgtgg agcacgagaa cggcacagat ccccgggaca ccaacgagtg
      841 ccgcgccacc gagttcgctg tgcgctctgg gctgctcacc gtgatggtat gggtgtcgag
      901 cgtcttcttc ttcctgccgg tcttctgcct cactgtgctc tacagtctca tcgggaggaa
      961 gctgtggcgg aggcgcggcg acgcggcggt gggctcctcg ctcagggacc agaaccacaa
     1021 acagacagtg aagatgcttg ctgtggtggt gtttgctttc atcctctgct ggctgccctt
     1081 ccacgtggga agatatctgt tttccaagtc tttcgagcct ggctctctgg agatcgcgca
     1141 gatcagtcag tactgcaacc tggtgtcctt tgtcctcttc tacctcagcg ctgccatcaa
     1201 ccccattctc tacaacatca tgtccaagaa gtaccgggtg gccgtgttca aacttctagg
     1261 atttgaatcc ttctcccaga gaaagctttc cactctgaag gatgagagtt cccgggcctg
     1321 gacaaagtcg agcatcaata catgacatcg cagcgcatct ctccgtcatc gctcattgct
     1381 ccacaccaga agccatagcc aagcgggact tgggaggagg cagaacgtca gtttggggat
     1441 tagagacaaa tggatctgga aacaattggg ggtggggagt agagccagat gggcagggtc
     1501 cgtgcagatt gatctatttg tgcgcccacc agagcactca tgtgcagccc ctgcacacct
     1561 gtgtctgtga ttttgcgaat ttgcatttgg agcttctgac agctttgcag ctcgaaggag
     1621 ggaggggcgc agagcaggca acggccgtcc ttcttggtgt gtaacactaa actccatttg
     1681 cttttctcat cataatagaa gtgacatgag attccaaaca gcaacttaag acatgacctt
     1741 tcaaaagcta gcagtctcca caaagctcca tcacacgcac cccaaagcac cataacgtaa
     1801 ggcatatata tatataatca ataggcaatg attgatgaga aatctccacc tttcctcagc
     1861 gtagtaaacc tgaagtctag tatgttccct atacacgcag cccacttgca gttgggcagt
     1921 tagtttcatt agtaatatcg gatgcattta atttgagcat ggaaaagcag atccaatggc
     1981 ttaagttttg tgagcacact taaaactttt aagtaacaca ctttacaaag tttttgtttt
     2041 aattcagagt taattaaaac aagcaattca gtcctttggt tgtactaggt agtatatttc
     2101 aagtattcaa cagacaaatg tggctcatgg ttctcatacc aggcagatac tccagagtac
     2161 atgcaaaata attgttaatc tcatataaaa attttaaata tgtacctgtt cctttcaact
     2221 gtttttttaa aaaatagtat tttagcatac cagcatttta gagtaataaa tcctaaggtc
     2281 atacctaaat gctctacctt catgatggga agagagtggg aaacatctta aaattaagtt
     2341 atacatttca aaaatatgtt taattgcatg tattaattca ggaatatttt ataatatttc
     2401 tgaaatgttt ttgaaaaaca tagctaatca cagactgcct tttggactta atagatgaac
     2461 taattacaag cctttaattt gtgaataagt tatttattat ttattctggc cagtttatat
     2521 aacctaaaga atatcagaaa gttacaaatg gtaaagcagg ctcagaattt ccacaacatt
     2581 tctgcctatt tctatttcaa cttgtctctg ccttgtctga tctacccaca tgccactctt
     2641 caagtgatag acacgatcaa tggagttcta gtctccttgg tcatcataat tatgaatgta
     2701 tacacctttt aataaatatt gtgcatttgg gttctaaaaa actaaatttt catttataaa
     2761 ggtactccct tctctattca acaggatgac ctaaatctat cattccaaaa tgatttcttg
     2821 catcccatga gcagctccta ctgagaggac tgttaaggcc gttgaaggaa gttcatgtca
     2881 tgattgtttt gcacctgctt aaaaagaatg atttttatgc tgaagcgata gattgcctat
     2941 ttacgttgga aacatcaaaa gccaaccaca actagaagca cttttaaaga aatatttttc
     3001 aaatccattt gaacacaaca gtcactctaa atggccaacg ttaaccagct gactcttccg
     3061 ctagttcttg ggagtgcgtt agcaggcaca ctgatgcact tggttctgtg agatacgtgc
     3121 taggcatcca gagcctagct cctcattcgt gctcagtaaa ttaaaaggag tcattttggt
     3181 ttcctggggc ttcagagttg tgtctataaa tactttacac ttgaacagaa acacatttaa
     3241 ttagtttctt aatctcttca cttagcccca tctcttgggg tccacaccag aagtcctgaa
     3301 cttacatcct gagactgaat tacagagaaa gggccaccct atttcccact ggctaacctg
     3361 aaaagtgaaa gaatgtgttt agagaaagga atctaatttg tcctctttac ttattatctt
     3421 ttaaaaaatt gcttacaagt tctttatgtt attacatttc ttgttttgtt taagactcag
     3481 ggcagaagaa aattacactg acaccaattg tttgggaaag ctcccctttg gtcaacattt
     3541 tggatgtgcc tgctatgttc tgagctacaa gaaattaaca agccaaagat tttatttatt
     3601 cttagtgatc tcactatcac ctctgggtct tgttgctgtg gaaaatggat aaagatgttt
     3661 gagttatgga gtagacattt ctagtgggca ctctatcaga tttccccacc acaggactac
     3721 aatgagccat tcagcccact cgtgtgttgt atacttggct gcaaatatat ttgaataggc
     3781 tgtcactaca atctttgtag acagagctaa tatgtctgct agtgagaatc acactgaagg
     3841 cattcagaaa ggaaagaagc cagcttctct tttatcctta tttccaatgc cctggtcacc
     3901 cagaagtaag gtttctgtca cagtttaggc agtctcaaag tcaaggttat ggtcctcaat
     3961 atagacagta actgtgacat gagcaggagt gttttgaatg atcactttaa acatgcatgc
     4021 ctgccaatta ttttaaattg gaaagtctag ctgggtgtgg tggtacatac ttgtgacgcc
     4081 agcacttggg aagttgaggc agggggatta ccaggagttc aaggactgcc tgagtggttt
     4141 agtgagctct gccacagcct gggatgcaga gtgggagcct atctcaataa gcaagcaagc
     4201 aaacaaacaa taatgttaaa atctgtagaa aggaaattta gaaacacttc tagtactgcc
     4261 tagaaaaatc acttcttagt gaacttttag ctgcggtgca ggctgttgtg gttatgatgt
     4321 tgaggttatg atggacagac ttaacactct agttcctttt ttccatgcaa atactttttt
     4381 ttttaagtca ctttgttttt gtaaaattta tccatatact tgaatttaat atc
//
