LOCUS       NP_796304                364 aa            linear   ROD 12-NOV-2024
DEFINITION  growth hormone secretagogue receptor type 1 [Mus musculus].
ACCESSION   NP_796304
VERSION     NP_796304.1
DBSOURCE    REFSEQ: accession NM_177330.4
KEYWORDS    RefSeq; RefSeq Select.
SOURCE      Mus musculus (house mouse)
  ORGANISM  Mus musculus
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha;
            Muroidea; Muridae; Murinae; Mus; Mus.
REFERENCE   1  (residues 1 to 364)
  AUTHORS   Hewawasam,N., Sarkar,D., Bolton,O., Delishaj,B., Almutairi,M.,
            King,A.J.F., Dereli,A.S., Despontin,C., Gilon,P., Reeves,S.,
            Patterson,M. and Hauge-Evans,A.C.
  TITLE     The GHSR1a antagonist LEAP2 regulates islet hormone release in a
            sex-specific manner
  JOURNAL   J Endocrinol 263 (2), e240135 (2024)
   PUBMED   39292603
  REMARK    GeneRIF: The GHSR1a antagonist LEAP2 regulates islet hormone
            release in a sex-specific manner.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 364)
  AUTHORS   Zhang,M., Yang,L., Jia,J., Xu,F., Gao,S., Han,F., Deng,M., Wang,J.,
            Li,V., Yu,M., Sun,Y., Yuan,H., Zhou,Y. and Li,N.
  TITLE     Increased GHS-R1a expression in the hippocampus impairs memory
            encoding and contributes to AD-associated memory deficits
  JOURNAL   Commun Biol 7 (1), 1334 (2024)
   PUBMED   39415032
  REMARK    GeneRIF: Increased GHS-R1a expression in the hippocampus impairs
            memory encoding and contributes to AD-associated memory deficits.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 364)
  AUTHORS   Liu,J., Li,N., Wei,C., Han,F., Deng,M., Ma,J., Zou,X., Zhou,Y.,
            Yang,R. and Yuan,H.
  TITLE     GHS-R1a deficiency protects against lipopolysaccharide-induced
            spatial memory impairment in mice
  JOURNAL   Biochem Biophys Res Commun 727, 150270 (2024)
   PUBMED   38917617
  REMARK    GeneRIF: GHS-R1a deficiency protects against
            lipopolysaccharide-induced spatial memory impairment in mice.
REFERENCE   4  (residues 1 to 364)
  AUTHORS   Cornejo,M.P., Fernandez,G., Cabral,A., Barrile,F., Heredia,F.,
            Garcia Romero,G., Zubimendi Sampieri,J.P., Quelas,J.I., Cantel,S.,
            Fehrentz,J.A., Alonso,A., Pla,R., Ferran,J.L., Andreoli,M.F., De
            Francesco,P.N. and Perello,M.
  TITLE     GHSR in a Subset of GABA Neurons Controls Food Deprivation-Induced
            Hyperphagia in Male Mice
  JOURNAL   Endocrinology 165 (7) (2024)
   PUBMED   38815068
  REMARK    GeneRIF: GHSR in a Subset of GABA Neurons Controls Food
            Deprivation-Induced Hyperphagia in Male Mice.
REFERENCE   5  (residues 1 to 364)
  AUTHORS   Smith,A., Rodrigues,T., Wallace,C., Mezher,K., MacAulay,B.,
            Prowse,R., Hyland,L. and Abizaid,A.
  TITLE     Growth Hormone Secretagogue Receptor (GHSR) Signaling in the
            Ventral Tegmental Area (VTA) Mediates Feeding Produced by Chronic
            Social Defeat Stress in Male Mice
  JOURNAL   Neuroscience 547, 17-27 (2024)
   PUBMED   38583506
  REMARK    GeneRIF: Growth Hormone Secretagogue Receptor (GHSR) Signaling in
            the Ventral Tegmental Area (VTA) Mediates Feeding Produced by
            Chronic Social Defeat Stress in Male Mice.
REFERENCE   6  (residues 1 to 364)
  AUTHORS   Chen,H.Y., Trumbauer,M.E., Chen,A.S., Weingarth,D.T., Adams,J.R.,
            Frazier,E.G., Shen,Z., Marsh,D.J., Feighner,S.D., Guan,X.M., Ye,Z.,
            Nargund,R.P., Smith,R.G., Van der Ploeg,L.H., Howard,A.D.,
            MacNeil,D.J. and Qian,S.
  TITLE     Orexigenic action of peripheral ghrelin is mediated by neuropeptide
            Y and agouti-related protein
  JOURNAL   Endocrinology 145 (6), 2607-2612 (2004)
   PUBMED   14962995
REFERENCE   7  (residues 1 to 364)
  AUTHORS   Lall,S., Balthasar,N., Carmignac,D., Magoulas,C., Sesay,A.,
            Houston,P., Mathers,K. and Robinson,I.
  TITLE     Physiological studies of transgenic mice overexpressing growth
            hormone (GH) secretagogue receptor 1A in GH-releasing hormone
            neurons
  JOURNAL   Endocrinology 145 (4), 1602-1611 (2004)
   PUBMED   14701677
REFERENCE   8  (residues 1 to 364)
  AUTHORS   Wang,Y., Zhang,Z., Yan,Y., Lemon,W.J., LaRegina,M., Morrison,C.,
            Lubet,R. and You,M.
  TITLE     A chemically induced model for squamous cell carcinoma of the lung
            in mice: histopathology and strain susceptibility
  JOURNAL   Cancer Res 64 (5), 1647-1654 (2004)
   PUBMED   14996723
REFERENCE   9  (residues 1 to 364)
  AUTHORS   Kawamura,K., Sato,N., Fukuda,J., Kodama,H., Kumagai,J.,
            Tanikawa,H., Nakamura,A., Honda,Y., Sato,T. and Tanaka,T.
  TITLE     Ghrelin inhibits the development of mouse preimplantation embryos
            in vitro
  JOURNAL   Endocrinology 144 (6), 2623-2633 (2003)
   PUBMED   12746326
REFERENCE   10 (residues 1 to 364)
  AUTHORS   Vassilatis,D.K., Hohmann,J.G., Zeng,H., Li,F., Ranchalis,J.E.,
            Mortrud,M.T., Brown,A., Rodriguez,S.S., Weller,J.R., Wright,A.C.,
            Bergmann,J.E. and Gaitanaris,G.A.
  TITLE     The G protein-coupled receptor repertoires of human and mouse
  JOURNAL   Proc Natl Acad Sci U S A 100 (8), 4903-4908 (2003)
   PUBMED   12679517
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC116585.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK049671.1, SRR9219381.347779.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN01164138, SAMN01164139
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            RefSeq Select criteria :: based on conservation
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..364
                     /organism="Mus musculus"
                     /strain="C57BL/6"
                     /db_xref="taxon:10090"
                     /chromosome="3"
                     /map="3 10.86 cM"
     Protein         1..364
                     /product="growth hormone secretagogue receptor type 1"
                     /note="G-protein coupled receptor; ghrelin receptor;
                     GH-releasing peptide receptor"
                     /calculated_mol_wt=40838
     Site            13
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99P50.3)"
     Site            26
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99P50.3)"
     Site            41..66
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P50.3)"
     Region          44..332
                     /region_name="7tmA_GHSR"
                     /note="growth hormone secretagogue receptor, member of the
                     class A family of seven-transmembrane G protein-coupled
                     receptors; cd15131"
                     /db_xref="CDD:320259"
     Region          44..70
                     /region_name="TM helix 1"
                     /note="TM helix 1 [structural motif]"
                     /db_xref="CDD:320259"
     Site            73..96
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P50.3)"
     Region          77..102
                     /region_name="TM helix 2"
                     /note="TM helix 2 [structural motif]"
                     /db_xref="CDD:320259"
     Site            order(102,119,181,196..199,280..281,284..285,299,303)
                     /site_type="other"
                     /note="putative peptide ligand binding site [polypeptide
                     binding]"
                     /db_xref="CDD:320259"
     Region          115..145
                     /region_name="TM helix 3"
                     /note="TM helix 3 [structural motif]"
                     /db_xref="CDD:320259"
     Site            118..139
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P50.3)"
     Region          157..179
                     /region_name="TM helix 4"
                     /note="TM helix 4 [structural motif]"
                     /db_xref="CDD:320259"
     Site            163..183
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P50.3)"
     Site            187
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (Q99P50.3)"
     Region          208..237
                     /region_name="TM helix 5"
                     /note="TM helix 5 [structural motif]"
                     /db_xref="CDD:320259"
     Site            212..235
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P50.3)"
     Region          254..284
                     /region_name="TM helix 6"
                     /note="TM helix 6 [structural motif]"
                     /db_xref="CDD:320259"
     Site            264..285
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P50.3)"
     Region          300..325
                     /region_name="TM helix 7"
                     /note="TM helix 7 [structural motif]"
                     /db_xref="CDD:320259"
     Site            303..326
                     /site_type="transmembrane region"
                     /note="propagated from UniProtKB/Swiss-Prot (Q99P50.3)"
     CDS             1..364
                     /gene="Ghsr"
                     /gene_synonym="C530020I22Rik; GHRP; GHS-R; Ghsr1a"
                     /coded_by="NM_177330.4:251..1345"
                     /db_xref="CCDS:CCDS17273.1"
                     /db_xref="GeneID:208188"
                     /db_xref="MGI:MGI:2441906"
ORIGIN      
        1 mwnatpseep epnvtldldw daspgndsls dellplfpap llagvtatcv alfvvgisgn
       61 lltmlvvsrf relrtttnly lssmafsdll iflcmpldlv rlwqyrpwnf gdllcklfqf
      121 vsesctyatv ltitalsver yfaicfplra kvvvtkgrvk lvilviwava fcsagpifvl
      181 vgvehengtd prdtnecrat efavrsgllt vmvwvssvff flpvfcltvl ysligrklwr
      241 rrgdaavgss lrdqnhkqtv kmlavvvfaf ilcwlpfhvg rylfsksfep gsleiaqisq
      301 ycnlvsfvlf ylsaainpil ynimskkyrv avfkllgfes fsqrklstlk dessrawtks
      361 sint
//
